The Effect of Young Papaya Seed Extract on The Motility and Abnormality of Male Mice Spermatozoes (Mus musculus)

Authors

Tannya Efritzka Louise Calame , Kusmiyati Kusmiyati , I Wayan Merta

DOI:

10.29303/jpm.v16i4.2790

Published:

2021-09-28

Issue:

Vol. 16 No. 4 (2021): September 2021

Keywords:

Young papaya seeds, Quality of spermatozoa, Mice.

Articles

Downloads

Additional Files

How to Cite

Calame, T. E. L., Kusmiyati, K., & Merta, I. W. (2021). The Effect of Young Papaya Seed Extract on The Motility and Abnormality of Male Mice Spermatozoes (Mus musculus). Jurnal Pijar Mipa, 16(4), 555–561. https://doi.org/10.29303/jpm.v16i4.2790

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Papaya fruit has many benefits, one of which is papaya seed can be used as antifertility drugs, especially young papaya seeds. Young papaya seeds contain secondary metabolites of alkaloid glycosides and proteolytic enzymes such as papain which can interfere with spermatogenesis. The study aims to determine the effect of young papaya seed extract on the sperm motility and abnormality of male mice (Mus musculus). Mice were randomly selected to represent 4 dose groups: control group (P0), extract 30mg/grBW (PI), extract 60mg/grBW (PII) and extract 90mg/grBW (PIII). Each treatment group was carried out with six repetitions. The treatment was given intravenously by injecting it in the tail of the mice for 15 consecutive days. The observed spermatozoa quality variables included a percentage of motile sperm and abnormal sperm. Data analysis using one-way ANOVA test with a significance level of 5% (0,000) and continued with the LSD (Least Significant Difference) with a 95% confidence level. The study on the Quality of spermatozoic showed a significant effect at the doses of 60mg/grBW (PII) and 90mg/grBW (PIII). The higher dose of young papaya seed extract increasingly affects the Quality of sperm. This research concluded that the extract of young papaya seeds has a significant impact on mice spermatozoa (Mus musculus) quality.

References

McDonald, P. (2014). A population projection for Indonesia, 2010ââ¬â2035. Bulletin of Indonesian Economic Studies, 50(1), 123-129.

Hartanto. (2004). Keluarga Berencana dan Kontrasepsi. Jakarta: Pustaka Sinar Harapan.

Setiadi, D., & Bachri, S. (2013). Pengaruh Air Rebusan Akar Aru (Caesalpinia Bonduc) Terhadap Kualitas Sperma Epididimis Mencit (Mus Musculus): Dasar Pengembangan Obat K0ntrasepsi Tradisional Bagi Laki-laki. Jurnal Biologi Tropis, 13(2).

Katno, P. S. (2009). Tingkat manfaat dan keamanan tanaman obat dan obat tradisional. Yogyakarta: Fakultas Farmasi UGM.

Yamin, M., & Burhanudin, J. (2018). Pengobatan dan Obat Tradisional Suku Sasak di Lombok. Jurnal Biologi Tropis, 18(1), 1-12.

Udoh, P. B., Udoh, F. V., Umoren, E. B., James, U. W., Okeke, C. P., & Agwu, B. (2009). Effect of caricapryl-99 seed alkaloid extract on the serum levels of sex hormones and pituitary gonadotrophins in male albino rats. Nigerian Journal of Physiological Sciences, 24(1).

Raji, Y. (2005). Impact of the Chloroform Extract of Carica papaya Seed on Oestrous Cycle and Fertility in Female Albino Rats* Y. Raji," AO. Morakinyo," AK. Oloyo," OS Akinsomisoye," Olufadekemi, T. Kunle-Alabi," PRC Esegbue-Peters and ââ¬ÅFO. Awobajo. J. Med Sci, 5(4), 337-343.

Susilawati, S., Jamaluddin, J., & Bachtiar, I. (2017). Pengaruh model pembelajaran berbasis masalah (PBM) berbantuan multimedia terhadap kemampuan berpikir kritis peserta didik kelas vii smp negeri 2 mataram ditinjau dari kemampuan akademik. Jurnal Pijar Mipa, 12(2), 64-70.

Afsari, R. (2016). Pengaruh Pemberian Ekstrak Daun Sirih Merah (Piper Crocatum) Terhadap Penurunan Kadar Gula Darah Mencit (Mus musculus). Jurnal Biologi Tropis, 16(1).

Pratiwi, A. (2010). Pengaruh pemberian ekstrak biji pepaya (carica papaya) peroral terhadap jumlah sel spermatid mencit (mus musculus).

Harahap, I., & Erris, E. (2014). Pengaruh Kebisingan terhadap Kuantitas dan Kualitas Spermatozoa Tikus Putih (Rattus Norvegicus) Jantan Dewasa. Media Penelitian dan Pengembangan Kesehatan, 24(3), 20704.

Nuraini, T., Kusmana, D., & Afifah, E. (2012). Injection of carica papaya l. seed extract of cibinong variety to Macaca fascicularis l. and its effect to quality of spermatozoa and level of testosterone hormone. Makara Journal of Health Research, 9-16.

Nandari, R. (2006). Pengaruh Pemberian Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.) terhadap Kadar Testosteron Bebas dan Libido Tikus Jantan Galur Wistar (Doctoral dissertation, Diponegoro University).

Kusmiyati, K., Khairuddin, K., Sedijani, P., & Merta, I. W. (2020). Pengenalan Struktur Fungsi Organ Reproduksi Sebagai Upaya Pencegahan Kekerasan Seksual Pada Anak. Jurnal Pendidikan dan Pengabdian Masyarakat, 3(3).

Fatmawati, D., Isradji, I., Yusuf, I., & Suparmi, S. (2016). Kualitas Spermatozoa Mencit Balb/C Jantan Setelah Pemberian Ekstrak Buah Kepel (Stelechocarpus Burahol). Majalah Kedokteran Bandung, 48(3), 155-159.

Wiji Astutik, I. S. N. I. (2006). Pengaruh Filtrat Buah Pepaya Muda (Carica Papaya L.) Terhadap Jumlah Sel Spermatozoa Pada Tikus (Rattus Norvegicus) Wistar Jantan (Doctoral dissertation, University of Muhammadiyah Malang).

Amir, A. (2014). Ekspresi gen family Bcl-2 dan Ekspresi gen protein kanal ion vdac1 pada oligozoospermia. Jurnal kesehatan Andalas, 3(2).

Cahya Hanggitasari, R. I. S. K. I. Pengaruh Ekstrak Daun Pepaya (Carica Papaya L.) Varietas Thailand Terhadap Penurunan Fertilitas Mencit (Mus Musculus L.) Jantan Strain Balb-c Dan Pemanfaatannya Sebagai Booklet Penyuluhan Masyarakat.

Satriyasa, B. K. (2008). Fraksi heksan ekstrak biji pepaya muda dapat menghambat proses spermatogenesis mencit jantan lebih besar daripada fraksi metanol ekstrak biji papaya muda. Indonesian Journal of Biomedical Science, 2(2), 224836.

Nurliani, A., & Santoso, H. B. (2005). Perkembangan sel spermatogenik mencit (Mus musculus L.) setelah pemberian ekstrak kulit kayu durian (Durio zibethinus Murr.). Berkala Penelitian Hayati, 11(1), 77-79.

Pebriana, R. B., Wardhani, B. W. K., Widayanti, E., Wijayanti, N. L. S., Wijayanti, T. R., Riyanto, S., & Meiyanto, E. (2008). Pengaruh ekstrak metanolik daun kenikir (Cosmos caudatus Kunth.) terhadap pemacuan apoptosis sel kanker payudara.

Author Biographies

Tannya Efritzka Louise Calame, Program Studi Pendidikan Biologi FKIP Universiats Mataram

Kusmiyati Kusmiyati, Program Studi Pendidikan Biologi FKIP Universiats Mataram

I Wayan Merta, Program Studi Pendidikan Biologi FKIP Universiats Mataram

License

The following terms apply to authors who publish in this journal:
1. Authors retain copyright and grant the journal first publication rights, with the work simultaneously licensed under a Creative Commons Attribution License 4.0 International License (CC-BY License) that allows others to share the work with an acknowledgment of the work's authorship and first publication in this journal.

2. Authors may enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., posting it to an institutional repository or publishing it in a book), acknowledging its initial publication in this journal.
3. Before and during the submission process, authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website), as this can lead to productive exchanges as well as earlier and greater citation of published work (See The Effect of Open Access).

Similar Articles

1 2 3 4 5 6 7 8 > >> 

You may also start an advanced similarity search for this article.