Study of Flavonoids from Genus Artocarpus and Potency of Artocarpus odoratissimus as an Antimalarial

Dwi Laksmiwati, Aliefman Hakim

Abstract


Abstract: Malaria remains a serious threat in Indonesia. Resistances of Plasmodium falciparum to malaria drugs, like chloroquine, are one of the  causes of malaria incidence. Therefore, it is  necessary to search a more effective malaria drug. Artocarpus has been traditionally used for the treatment of malaria. Indonesia is reported to have 30 species of Artocarpus genus from 50 species that exist in around the world. Artocapus contais flavonoid that has some particularities ie prenylated on C-3 and B ring oxygenated at C-4' or C-2', C-4' or C-2', C-4', C-5'. In addition prenilated can also  occur at C-6, and C-8. Such patterns are very rare in other plant considering the biosynthesis of  flavonoids derived from a combination of acetate malonate pathway and shikimic pathway. Some flavonoids with that framework have an antimalarial activity. Antimalarial test against Plasmodium falciparum strains 3D7 and K1 showed that prenilated in C8 improve antimalarial activity of flavonoid compounds from Artocarpus. Scrining phytochemical against the roots of Artocarpus odoratissimus indicate the presence of flavonoid. Based on the chemotaxonomic flavonoids contained in the bark of A. odoratissimus must be have the same pattern, so flavonoids of A. odoratissimus will be potentially for an antimalarial.

Key words: Artocarpus odoratissimus, prenylated, oxygenated, flavonoid, antimalarial.


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