Necrotizing Enterocolitis: Stem Cell as Future Potential Therapy

Bq. Annisa Salmaadani Syafitri; Carolina Janicca Winda Manafe; Lale Nandita Hulfifa; Zirly Vera Aziri; Fiza Afifah; Syahla Marsellita Wahyudi; Disa Fadil Musyarof

doi:10.29303/jbt.v24i4.7529

Necrotizing Enterocolitis: Stem Cell as Future Potential Therapy

Authors

Bq. Annisa Salmaadani Syafitri , Carolina Janicca Winda Manafe , Lale Nandita Hulfifa , Zirly Vera Aziri , Fiza Afifah , Syahla Marsellita Wahyudi , Disa Fadil Musyarof

DOI:

10.29303/jbt.v24i4.7529

Published:

2024-10-10

Issue:

Vol. 24 No. 4 (2024): Oktober - Desember

Keywords:

Future therapy, necrotizing enterocolitis, stem cell.

Articles

Downloads

pdf

How to Cite

Syafitri, B. A. S., Manafe, C. J. W., Hulfifa, L. N., Aziri, Z. V., Afifah, F., Wahyudi, S. M., & Musyarof, D. F. (2024). Necrotizing Enterocolitis: Stem Cell as Future Potential Therapy. Jurnal Biologi Tropis, 24(4), 260–270. https://doi.org/10.29303/jbt.v24i4.7529

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Necrotizing enterocolitis (NEC) is an inflammatory bowel condition in infants and considered as one of the leading causes of death in infants, especially premature infants. The high mortality rate due to NEC in recent decades has become a problem because there is no current therapy that can optimally treat NEC. Currently, NEC is treated using Bell's Staging as a guide and surgery is a common procedure, especially if necrosis has occurred. However, complications arising from surgery not only reduce the patient's quality of life but can also result in death. Therefore, it is necessary to find new therapy in order to treat NEC effectively and minimize the possibility of side effects in NEC patients. Stem cells are known for their regenerative abilities which is potential to overcome tissue damage due to excessive inflammation in NEC. Previous studies also show that stem cells have become new therapy to treat other intestinal diseases which have similar features with NEC. This study aims to explain mainly on stem cells’s promising mechanism of action in treating NEC. The method used for this study is a literature review design by selecting and reviewing relevant previous literature using databases such as Google Scholar, PubMed and Science Direct. This paper summarizes pathophysiology, clinical manifestation, current therapy and mechanism of action of stem cells and their derivatives as future potential therapy for NEC. Based on evidence found, stem cells and their derivatives are potential to be used as NEC therapy in the future. However, the data obtained is not sufficient to support its use in humans. Given the urgency in finding an effective NEC management and the potency of stem cells, further research is needed to support the use of stem cells as NEC therapy.

References

Alganabi, M., Lee, C., Bindi, E., Li, B. and Pierro, A. (2019) ‘Recent advances in understanding necrotizing enterocolitis’, F1000Research, 8(107), pp. 1-8. Available at: https://doi.org/10.12688/f1000research.17228.1.

Balsamo, F., Tian, Y., Pierro, A. and Li, B. (2022) ‘Amniotic fluid stem cells: A novel treatment for necrotizing enterocolitis’, Frontiers in Pediatrics, 10(1020986), pp. 1-10. Available at: https://doi.org/10.3389/fped.2022.1020986.

Bellodas Sanchez, J. and Kadrofske, M. (2019) ‘Necrotizing enterocolitis’, Neurogastroenterology and Motility, 31(3), pp: 1-6. Available at: https://doi.org/10.1111/nmo.13569.

Bethune, R., Adderley, N. and Yusuf, K. (2019) ‘Neonatal Necrotizing Enterocolitis (NEC): Patoghenesis and Clincal Findings’, The Calgary Guide to Understanding Disease.

Bowen, C.M., Ditmars, F.S., Gupta, A., Reems, J. and Fagg, W.S. (2022) ‘Cell-Free Amniotic Fluid and Regenerative Medicine: Current Applications and Future Opportunities’, Biomedicines, 10(2960), pp. 1–18. Available at: https://doi.org/10.3390/biomedicines10112960.

D’Angelo, G., Impellizzeri, P., Marseglia, L., Montalto, A.S., Russo, T., Salamone, I., Falsaperla, R., Corsello, G., Romeo, C. and Gitto, E. (2018) ‘Current status of laboratory and imaging diagnosis of neonatal necrotizing enterocolitis’, Italian Journal of Pediatrics, 44(84), pp: 1-6. Available at: https://doi.org/10.1186/s13052-018-0528-3.

Drucker, N.A., McCulloh, C.J., Li, B., Pierro, A., Besner, G.E. and Markel, T.A. (2018) ‘Stem Cell Therapy in Necrotizing Enterocolitis: Current State and Future Directions’, Semin Pediatr Surg, 27(1), pp. 57–64. Available at: https://doi.org/10.4049/jimmunol.1801473.The.

Ergenekon, E., Tayman, C. and Ozkan, H. (2021). ‘Turkish Neonatal Society Necrotizing Enterocolitis Diagnosis, Treatment and Prevention Guidelines’, Turkish Archives of Pediatrics, 56(5), pp. 513–524.

Gomart, A., Vallée, A. and Lecarpentier, Y. (2021) ‘Necrotizing Enterocolitis: LPS/TLR4-Induced Crosstalk Between Canonical TGF-β/Wnt/β-Catenin Pathways and PPARγ’, Frontiers in Pediatrics, 9(713344), pp: 1-14. Available at: https://doi.org/10.3389/fped.2021.713344.

Hu, X., Zhang, R., Liang, H., An, J., Yang, Y., Huo, J., Chen, Z., Quan, W., Jiang, L., Li, C., Li, J., Li, F., Xu, Y. and Zhu, X. (2023) ‘Comparison and Investigation of Exosomes from Human Amniotic Fluid Stem Cells and Human Breast Milk in Alleviating Neonatal Necrotizing Enterocolitis’, Stem Cell Reviews and Reports, 19(3), pp. 754–766. Available at: https://doi.org/10.1007/s12015-022-10470-5.

Sidauruk, R.J.M., Amir, I., Kadim, M. and Said, M. (2014) ‘Faktor Risiko yang Memengaruhi Kolonisasi Mikroflora Saluran Cerna Neonatus Kurang Bulan dengan Enterokolitis Nekrotikans’, Sari Pediatri, 15(6), pp. 353–360.

Kaban, R.K., Rohsiswatmo, R., Kautsar, A., Sutrisno, A.A., Hikmahrachim, H.G. and Hardiyanti, N. (2022) ‘Risk factors of necrotizing enterocolitis-related mortality in preterm neonates: a preliminary prospective study’, Paediatrica Indonesiana, 62(3), pp. 186–91. Available at: https://doi.org/10.14238/pi62.3.2022.186-91.

Kaplina, A., Kononova, S., Zaikova, E., Pervunina, T., Petrova, N. and Sitkin, S. (2023) ‘Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites’, International Journal of Molecular Sciences, 24(2471), pp: 1-55. Available at: https://doi.org/10.3390/ijms24032471.

de Kroon, R.R., de Baat, T., Senger, S. and van Weissenbruch, M.M. (2022) ‘Amniotic Fluid: A Perspective on Promising Advances in the Prevention and Treatment of Necrotizing Enterocolitis’, Frontiers in Pediatrics, 10(859805), pp: 1-8. Available at: https://doi.org/10.3389/fped.2022.859805.

Kunisaki, S.M. (2018) ‘Amniotic Fluid Stem Cells for the Treatment of Surgical Disorders in the Fetus and Neonate’, Stem Cells Translational Medicine, 7(11), pp. 767–773. Available at: https://doi.org/10.1002/sctm.18-0018.

Li, B., Lee, C., Cadete, M., O’Connel, J., Alganabi, M., Lee, D., Ganji, N., Miyake, H., Botts, S.R., Johnson-Henry, K.C., Maattanen, P., Sherman, P.M. and Pierro, A. (2022) ‘Amniotic fluid stem cell administration can prevent epithelial injury from necrotizing enterocolitis’, Pediatric Research, 91(1), pp. 101–106. Available at: https://doi.org/10.1038/s41390-021-01657-6.

Lopez, C.M., Sampah, M.E.S., Duess, J.W., Ishiyama, A., Ahmad, R., Sodhi, C.P. and Hackam, D.J. (2023) ‘Models of necrotizing enterocolitis’, Seminars in Perinatology, 47(1). Available at: https://doi.org/10.1016/j.semperi.2022.151695.

Maheshwari, A. (2021) ‘Role of platelets in neonatal necrotizing enterocolitis’, Pediatric Research. Springer Nature, pp. 1087–1093. Available at: https://doi.org/10.1038/s41390-020-1038-8.

Markel, T.A., Martin, C.A., Chaaban, H., Canvasser, J., Tanner, H., Denchik, H. and Good, M. (2020) ‘New directions in necrotizing enterocolitis with early-stage investigators’, Pediatric Research, 88(Suppl 1), pp. 35–40. Available at: https://doi.org/10.1038/s41390-020-1078-0.

McCulloh, C.J., Olson, J.K., Wang, Y., Vu, J., Gartner, S. and Besner, G.E. (2017) ‘Evaluating the Efficacy of Different Types of Stem Cells in Preserving Gut Barrier Function in NEC’, J Surg Res, 214, pp. 278–285. Available at: https://doi.org/10.4049/jimmunol.1801473.The.

McCulloh, C.J., Olson, J.K., Zhou, Y., Wang, Y. and Besner, G.E. (2017) ‘Stem Cells and Necrotizing Enterocolitis: A Direct Comparison of the Efficacy of Multiple Types of Stem Cells’, J Pediatr Surg, 52(6), pp. 1–11. Available at: https://doi.org/10.4049/jimmunol.1801473.The.

McCulloh, C.J., Olson, J.K., Wang, Y., Zhou, Y., Huibregtse, N., Deshpande, S. and Besner, G.E. (2018) ‘Treatment of Experimental Necrotizing Enterocolitis with Stem Cell-Derived Exosomes’, J Pediatr Surg, 53(6), pp. 1–14. Available at: https://doi.org/10.4049/jimmunol.1801473.The.

Meister, A.L., Doheny, K.K. and Travagli, R.A. (2020) ‘Necrotizing enterocolitis: It’s not all in the gut’, Experimental Biology and Medicine, 245, pp. 85–95. Available at: https://doi.org/10.1177/1535370219891971.

Moschino, L., Duci, M., Leon, F.F., Bonadies, L., Priante, E., Baraldi, E. and Verlato, G. (2021) ‘Optimizing nutritional strategies to prevent necrotizing enterocolitis and growth failure after bowel resection’, Nutrients, 13(340), pp. 1–22. Available at: https://doi.org/10.3390/nu13020340.

Nitkin, C.R., Rajasingh, J., Pisano, C., Besner, G.E., Thebaud, B. and Sampath, V. (2020) ‘Stem Cell Therapy for Preventing Neonatal Diseases in the 21st Century: Current Understanding and Challenges Christopher’, Pediatr Res, 87(2), pp. 265–276. Available at: https://doi.org/10.1038/s41390-019-0425-5.Stem.

OConnell, J.S., Li, B., Zito, A., Ahmed, A., Cadete, M., Ganji, N., Lau, E., Alganabi, M., Farhat, N., Lee, C., Eaton, S., Mitchell, R., Ray, Steve., Coppi, P.D., Patel, K. and Pierro, A. (2021) ‘Treatment of necrotizing enterocolitis by conditioned medium derived from human amniotic fluid stem cells’, PLoS ONE, 16(12 December), pp. 1–15. Available at: https://doi.org/10.1371/journal.pone.0260522.

Krishna, R.O.H, Aleem, M.A., Kotaiah, M. and Kota, R.R. (2021) ‘A Study of Histopathological Findings in Neonatal Necrotizing Enterocolitis in Early and Late Term Infants’, Journal of Evidence Based Medicine and Healthcare, 8(04), pp. 184–189. Available at: https://doi.org/10.18410/jebmh/2021/35.

Pammi, M., De Plaen, I.G. and Maheswari, A. (2020) ‘Recent Advances in Necrotizing Enterocolitis Research Strategies for Implementation in Clinical Practice Mohan’, Clin Perinatol, 47(2), pp. 383–397. Available at: https://doi.org/10.4049/jimmunol.1801473.The.

Siahaan, E.S.E.D., Adriansyah, W., Sasmita, A.P., Fauzi, A.R., Dwihantoro, A. and Gunadi. (2021) ‘Outcomes and Prognostic Factors for Survival of Neonates With Necrotizing Enterocolitis’, Frontiers in Pediatrics., 9(744504), pp: 1-6. Available at: https://doi.org/10.3389/fped.2021.744504.

Thänert, R., Keen, E.C., Dantas, G., Warner, B.B. and Tarr, P.I. (2021) ‘Necrotizing enterocolitis and the microbiome: Current status and future directions’, Journal of Infectious Diseases, 223(Suppl 3), pp. S257–S263. Available at: https://doi.org/10.1093/infdis/jiaa604.

Venkatraman, A., Yu, W., Nitkin, C. and Sampath, V. (2021) ‘Intestinal stem cell development in the neonatal gut: Pathways regulating development and relevance to necrotizing enterocolitis’, Cells, 10(312), pp. 1–17. Available at: https://doi.org/10.3390/cells10020312.

Villamor-Martinez, E., Hundscheid, T., Kramer, B.W., Hoojiman, C.R. and Villamor, E. (2020) ‘Stem Cells as Therapy for Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis of Preclinical Studies’, Frontiers in Pediatrics, 8(December), pp. 1–12. Available at: https://doi.org/10.3389/fped.2020.578984.

Wu, H., Guo, K., Zhuo, Z., Zeng, R., Luo, Y., Yang, Q., Li, J., Jiang, R., Huang, Z., Sha, W. and Chen, H. (2022) ‘Current therapy option for necrotizing enterocolitis: Practicalities and challenge’, Frontiers in Pediatrics, 10(954735), pp: 1-10. Available at: https://doi.org/10.3389/fped.2022.954735.

Zani, A., Cananzi, M., Fascetti-Leon, F., Lauriti, G., Smith, V.V., Bollini, S., Ghionzoli, M., D’Arrigo, A., Pozzobon, M., Piccoli, M., Hicks, A., Wells, J., Siow, B., Sebire, N.J., Bishop, C., Leon, A., Atala, A., Lythgoe, M.F., Pierro, A., Eaton, S., Coppi, P.D. (2014) ‘Amniotic fluid stem cells improve survival and enhance repair of damaged intestine in necrotising enterocolitis via a COX-2 dependent mechanism’, Gut, 63(2), pp. 300–309. Available at: https://doi.org/10.1136/gutjnl-2012-303735.

Zeng, R.. Wang, J., Zhuo, Z., Luo, Y., Sha, W. and Chen, H. (2021) ‘Stem cells and exosomes: promising candidates for necrotizing enterocolitis therapy’, Stem Cell Research and Therapy, 12(323), pp. 1–14. Available at: https://doi.org/10.1186/s13287-021-02389-4.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Necrotizing Enterocolitis: Stem Cell as Future Potential Therapy

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow