Pseudocyesis: From Psycho-Social Conflict to Somatic Reality, A Literature Review
DOI:
10.29303/jbt.v25i4.10539Published:
2025-10-30Downloads
Abstract
Pseudocyesis or pseudopregnancy is a psychosomatic condition that can occur in certain extreme situations when mental anguish, neuroendocrine malfunction, and social stress intersect. Pseudocyesis is often associated with affective disorders such as major depressive disorder, which can modulate the activity of the hypothalamic-pituitary-ovarian axis. This literature review aims to comprehensively discuss the basic concept of pseudocyesis, its etiology and pathophysiology, its relationship to depression and socio-cultural factors, and highlight the importance of a multidisciplinary approach to diagnosis and management in understanding this phenomenon as a complex biopsychosocial disorder. This article was written using the Literature Review method and compiled with the PRISMA approach. Pseudocyesis is still reported to be quite common in developing countries, particularly in rural communities in Africa and Asia. Pseudocyesis occurs due to several factors, including psychological and hormonal, as well as social and cultural factors. The pathophysiology of pseudocyesis lies in dysregulation of the Hypothalamic-Pituitary-Ovarian (HPO) axis, which is the primary control system for the female reproductive cycle. Women with pseudocyesis exhibit an endocrine profile that shares many similarities with Polycystic Ovarian Syndrome (PCOS) and Major Depressive Disorder. The most commonly reported symptoms include menstrual disorders such as amenorrhea (cessation of menstruation) or oligomenorrhea (irregular menstrual cycles), morning sickness, vomiting, and weight gain. Pseudocyesis can be managed through a combination of supportive psychotherapy, cognitive-behavioral therapy (CBT), and psychoanalytic therapy. Furthermore, family involvement, especially the partner, in the therapy process plays a vital role.
Keywords:
Hypothalamic-pituitary-ovary Pseudocyesis PseudopregnancyReferences
Abdelhafez, M. A., Ahmed, K. M., Ahmed, N. M., Ismail, M., Daud, M. N. B. M., Ping, N. P. T., ... & Malek, E. H. A. (2023). Psychiatric illness and pregnancy: A literature review. Heliyon, 9(11). https://doi.org/10.1016/j.heliyon.2023.e20958.
Azizi, M. and Elyasi, F. (2017) ‘Biopsychosocial view to pseudocyesis: A narrative review’, International Journal of Reproductive BioMedicine, 15(9), pp. 535–542. Available at: https://doi.org/10.29252/ijrm.15.9.535.
Campos, S.J. and Link, D. (2016) ‘Pseudocyesis’, Journal for Nurse Practitioners, 12(6), pp. 390–394. Available at: https://doi.org/10.1016/j.nurpra.2016.03.009.
Costa, B. and Vale, N. (2024) ‘Advances in Psychotropic Treatment for Pregnant Women: Efficacy, Adverse Outcomes, and Therapeutic Monitoring’, Journal of Clinical Medicine, 13(15). Available at: https://doi.org/10.3390/jcm13154398.
Das, S., Prasad, S., Ajay Kumar, S., Denise Makonyonga, R., Saadoun, M., & Mergler, R. (2023). Delusion of pregnancy: A case report and literature review. Clinical Medicine Insights: Case Reports, 16, 11795476231161169. https://doi.org/10.1177/11795476231161169.
Espiridion, E. D., Fleckenstein, C., Boyle, P., & Oladunjoye, A. O. (2020). A rare case of pseudocyesis in a patient with bipolar disorder. Cureus, 12(9). https://doi.org/10.7759/cureus.10352.
Facão, R., Estalagem, A., Lobo, M. I., & Polido, F. (2024). Pregnant Without a Uterus: A Case of Pseudocyesis Preceding Psychosis. Revista Portuguesa de Psiquiatria e Saúde Mental, 10(1), 30-32. https://doi.org/10.51338/rppsm.524.
Fadilah, M. A., Erdenwarmansyah, R. P., Saputri, R. S., & Lestari, L. I. (2024). Menelusuri Penyebab, Dampak, dan Solusi dalam kasus Pseudocyesis: Sebuah Tinjauan Literatur. Flourishing Journal, 4(9), 439-448. https://doi.org/10.17977/um070v4i92024p439-448.
Ghimire, K., Pandit, S. and Roka, D.S. (2020) ‘Delusion of Pregnancy and Pseudocyesis : A Diagnostic Dilemma’, 3(3), pp. 1–4.
Gogia, S., Grieb, A., Jang, A., Gordon, M. R., & Coverdale, J. (2022). Medical considerations in delusion of pregnancy: A systematic review. Journal of Psychosomatic Obstetrics & Gynecology, 43(1), 51-57. https://doi.org/10.1080/0167482X.2020.1779696.
Gruszczyńska-Sińczak, I., Wachowska, K., Bliźniewska-Kowalska, K., & Gałecki, P. (2023). Psychiatric treatment in pregnancy: a narrative review. Journal of Clinical Medicine, 12(14), 4746. https://doi.org/10.3390/jcm12144746.
Harry, N. M., Folorunsho, I., Anona, K., Okafor, N., & Anugwom, G. O. (2024). A Comprehensive Review of Pseudocyesis and Its Associated Psychiatric Disorders. Journal of Advances in Medicine and Medical Research, 36(6), 86-96. https://doi.org/10.9734/jammr/2024/v36i65454.
K Kassim, F. M., Wasihun, M. T., Jimma, M. A., & Megersa, S. W. (2024). The role of sociocultural factors in rare medical conditions: The first case report of pseudocyesis in an Ethiopian woman with major depressive disorder. Clinical Case Reports, 12(5), e8888. https://doi.org/10.1002/ccr3.8888.
Murewanhema, G., Ziruma, A. and Madziyire, G. (2021) ‘Hope or desperation? A pseudocyesis in advanced maternal age in a woman with recurrent miscarriages: a case report and literature review Grant Murewanhema, Asaph Ziruma, Munyaradzi Innocent Nyakanda, Mugove Gerald Madziyire Hope or desperation? A pseudocy’. Available at: https://www.clinical-medicine.panafrican-med-journal.com//content/article/6/18/full.
Porfyri, G. N., Konsta, A., Tsolaki, A., Diakogiannis, I., & Ierodiakonou-Benou, I. (2020). Pseudocyesis as a healing mechanism for psychological trauma. Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan, 14(1).
Resindra, I.M.W., Mogi, J.G. and Lintuuran, R.M.W. (2024) ‘Post-Menopausal Women with Pseudocyesis in Rural Areas: A Socio-Cultural Perspective’, Journal Of The Indonesian Medical Association, 74(3), pp. 148–153. Available at: https://doi.org/10.47830/jinma-vol.74.3-2024-1231.
Seeman, M. V (2014) ‘Pseudocyesis, delusional pregnancy, and psychosis: The birth of a delusion’, World Journal of Clinical Cases, 2(8), p. 338. Available at: https://doi.org/10.12998/wjcc.v2.i8.338.
Sharma, M., Shankar, P., Kukreti, P., & Kataria, D. (2023). A rare case report of pseudo-pregnancy in a menopausal female. Indian Journal of Psychiatry, 65(7), 789-792. https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_430_22.
Tarín, J. J., Hermenegildo, C., García-Pérez, M. A., & Cano, A. (2013). Endocrinology and physiology of pseudocyesis. Reproductive Biology and Endocrinology, 11(1), 39. Available at: https://doi.org/10.1186/1477-7827-11-39.
Tewari, U., Mishra, A. K., Kapoor, A., Kundu, K., & Pandey, S. (2025). Pseudocyesis And Delusional Pregnancy: A Conundrum Of False Pregnancies. Int J Acad Med Pharm, 7(4), 1313-1317. https://doi.org/10.47009/jamp.2025.7.4.249.
Vaghela, D. A., Chavda, V. P., Kushwaha, A., & Sah, S. (2025). Pseudopregnancy: when the body mimics pregnancy without a fetus. International Journal of Surgery, 111(6), 4119-4121. https://doi.org/10.1097/JS9.0000000000002395.
Vazifdar, S. and Gavali, U. (2022) ‘Impregnated With Delusion: A Case Of Pseudocyesis’, Indian Journal of Case Reports, 8(2), pp. 30–32. Available at: https://doi.org/10.32677/ijcr.v8i2.3257.
West, T. et al. (2023) ‘No Little Feet: Managing Pseudocyesis in a Homeless, Acutely Manic Patient with Schizoaffective Disorder, Bipolar Type’, Case Reports in Psychiatry, 2023. Available at: https://doi.org/10.1155/2023/2504871.
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