Problem Profile of Drugs (DRPs) in Antidiabetic Therapy for Type 2 Diabetes Mellitus Patients in The Inpatient Ward
DOI:
10.29303/jbt.v26i1.11571Published:
2026-02-17Downloads
Abstract
The occurrence of type 2 diabetes mellitus keeps rising worldwide each year, and this includes Indonesia. Individuals with type 2 diabetes mellitus frequently encounter Drug-Related Problems (DRPs) due to multiple medications resulting from related health issues. Thus, recognizing DRPs is essential to enhance treatment success. The Mataram City Regional General Hospital stands out as one of the hospitals with the most significant number of type 2 diabetes mellitus cases each year from 2021 to 2023, showing an increase of 18.81%. The objective of this study was to analyze the profile of DRPs (Drug-Related Problems) in antidiabetic therapy among type 2 diabetes mellitus patients in the inpatient ward of Mataram City General Hospital during the period of April 2025. Data gathering was performed retrospectively by reviewing medical documents and conducting patient interviews. The medical documents were examined using the Cipolle classification, and the findings were illustrated in a diagram format with Microsoft Excel. The findings indicated that drug-related issues (DRPs) were present in hospitalized patients with type 2 diabetes mellitus at the Mataram City Regional General Hospital in April 2025. Among the 55 diabetes patients, 7 were found to have DRPs (12.72%), with DRPs manifesting as indications lacking medication (9.09%) and medications prescribed without indications (3.64%).
Keywords:
Antidiabetes Cipolle Classification Drug-Related Problems (DRPs) Diabetes MellitusReferences
Alpian, M. (2022). Diabetes Mellitus Tipe 2 (Dua) Dan Pengobatannya: Suatu Tinjauan Literatur. Journal of Public Health and Medical Studies, 1(1), 13-23. https://doi.org/10.56282/jphms.v1i1.254
American Society of Health-System Pharmacists (ASHP). (2018). ASHP Guidelines on Preventing Medication Errors.
Annisa. (2021b). Profil penggunaan obat antidiabetes pada pasien diabetes mellitus tipe 2 di instalasi rawat jalan RSUD Provinsi NTB tahun 2018. Sasambo Journal of Pharmacy, 2(1). 10.29303/sjp.v2i1.74
Ansori, R. M. (2019). Kajian Efektivitas Dan Biaya Ondansetron Dan Kombinasi Ondansetron Dan Deksametason Untuk Profilaksis Post Operative Induced Nausea Vomiting (Ponv) Pada Pasien Pasca Operasi Cholecystectomy (Doctoral Dissertation, Fakultas Kedokteran Dan Ilmu Kesehatan Universitas Muhammadiyah Yogyakarta). https://etd.umy.ac.id/id/eprint/68050/
Cipolle, R. J., Strand, L. M., & Morley, P. C. (2012). Pharmaceutical care practice: the patient-centered approach to medication management services. Manag. Serv, 1, 20. https://services.just.edu.jo/CourseQA/Uploads/Syllabus/305692.pdf
DiPiro, J. T. (2020). Preparing for the next generation pharmacists. Pharmacy Practice (Granada), 18(2). 10.18549/PharmPract.2020.2.1988.
Firmansyah, D., Pasim Sukabumi, S., & Al Fath Sukabumi, S. (2022). Teknik Pengambilan Sampel Umum dalam Metodologi Penelitian: Literature Review. Jurnal Ilmiah Pendidikan Holistik (JIPH), 1(2), 85–114. https://doi.org/10.55927
Gitawati, R. (2014). Bahan aktif dalam kombinasi obat flu dan batuk-pilek, dan pemilihan obat flu yang rasional. Media Penelitian dan Pengembangan Kesehatan, 14(1), 10-18. https://repository.badankebijakan.kemkes.go.id/id/eprint/5330/
Gurning, Y., & Aryanti, D. (2025). Gambaran Tingkat Pengetahuan Pasien Diabetes Melitus Tentang Terjadinya Ulkus Diabetikum Di RS Royal Prima Medan. JONS: Journal of Nursing, 3(01), 9-14. https://journal.medicpondasi.com/index.php/nursing/article/view/97
Gusti, E. (2014). Hubungan Faktor Risiko Usia, Jenis Kelamin, Kegemukan dan Hipertensi dengan Kejadian Diabetes Mellitus Tipe 2 di Wilayah Kerja Puskesmas Mataram. Media Bina Ilmiah, 8(1), 39-44.
Hahr, A. J., & Molitch, M. E. (2015). Management of diabetes mellitus in patients with chronic kidney disease. Clinical diabetes and endocrinology, 1(1), 2. 10.1186/s40842-015-0001-9
Hidhayah, D, A., Kamal, S., & Hidayah, N. (2021). Hubungan lama sakit dengan kejadian luka pada penderita Diabetes Melitus di Kabupaten Magelang tahun 2020. Borobudur Nursing Review, 1(1), 1-11. https://doi.org/10.31603/bnur.4947
Hunter, C. B., Kenney, C., Mejia, N., Davidson, A., & Jankovic, J. (2019). Medications associated with the onset of tardive dyskinesia. Neurology.
IDF. (2022). IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Researchand Clinical Practice,183https://doi.org/10.1016/j.diabres.2021.109119
Imelda, S. I. (2019). Faktor-faktor yang mempengaruhi terjadinya diabetes melitus di Puskesmas Harapan Raya tahun 2018. Scientia Journal, 8(1), 28-39. 10.5281/scj.v8i1.406
Katzung, B. G. (2001). Introduction to autonomic pharmacology. Basic and clinical pharmacology, 13, 87-109.
Kusnanto, K., Sundari, P. M., Asmoro, C. P., & Arifin, H. (2019). Hubungan tingkat pengetahuan dan diabetes self-management dengan tingkat stres pasien diabetes melitus yang menjalani diet. Jurnal Keperawatan Indonesia, 22(1), 31-42. 10.7454/jki.v22i1.780
Kusumiati, M., Atmaja, S. P., & Murdiana, H. E. (2024). Evaluasi Drug Related Problems (DRPS) Pada Pasien Diabetes Melitus Tipe II dengan Komplikasi Penyakit Ginjal Kronik di RS X Yogyakarta. MAHESA: Malahayati Health Student Journal, 4(2), 494-506. https://doi.org/10.33024/mahesa.v4i2.13381
Kusumiati, M., Christiani, G. J., & Atmaja, S. P. (2024). Evaluasi Drug Related Problems (DRPs) Pada Pasien Hipertensi Primer Di Puskesmas Depok Ii Kalasan Sleman. Jurnal Farmamedika (Pharmamedika Journal), 9(1), 16-22. https://doi.org/10.47219/ath.v9i1.319
Livana, P. H., Sari, I. P., & Hermanto, H. (2018). Gambaran Tingkat Depresi Pasien Diabetes Mellitus Di Kabupaten Kenda. Jurnal Kesehatan, 11(2), 60-69. https://doi.org/10.32763/qtzht266
Maimanah, S., Andarini, Y. D., & Kusumaningtyas, N. M. (2020). Identifikasi Drug Related Problems (DRPs) Pada Pasien Diabetes Mellitus Tipe 2 Komplikasi Hipertensi Di RSUP Dr. Soeradji Tirtonegoro Klaten Tahun 2018. Pharmasipha, 4(2), 48-56. https://doi.org/10.21111/pharmasipha.v4i2.4961
Mutmainnah, Z. (2023). Profil Drug Related Problems (Drps) Pada Pasien Diabetes Mellitus Tipe 2 Di Instalasi Rawat Jalan Rumah Sakit Universitas Mataram. https://eprints.unram.ac.id/43722/
Naki, M. I., Usmar, R. A. T., & Sumariangen, A. B. (2025). Diabetes Mellitus Tipe 2: Prevalensi, Etiologi, dan Pelaksanaannya. Diabetes, 5(1). https://doi.org/10.55642/phasij.v5i01.981
PB PERKENI. (2021). Pedoman Pengelolaan Dan Pencegahan Diabetes Mellitus Tipe 2 Dewasa Di Indonesia-2021 Perkeni i Penerbit PB. Perkeni.
Prastika, M. D., Wati, M., & Suyidno, S. (2019). The effectiveness of problem-based learning in improving students scientific literacy skills and scientific attitudes. Berkala Ilmiah Pendidikan Fisika, 7(3), 194-204. http://dx.doi.org/10.20527/bipf.v7i3.7027
Putra, J. R., Rahayu, U., & Shalahuddin, I. (2021). Self Care For Patients With Diabetes Mellitus Complementary Diseases of Hypertension in Public Health Center. Jgk, 13(1), 54-69. https://doi.org/10.35473/jgk.v13i1.99
Rif’at, I. D., Hasneli, Y., & Indriati, G. (2023). Gambaran komplikasi diabetes melitus pada penderita diabetes melitus. Jurnal Keperawatan Profesional, 11(1), 52-69. https://doi.org/10.33650/jkp.v11i1.5540
Saleh, F., Teodoriu, C., Salehi, S., & Ezeakacha, C. (2020, February). Geothermal drilling: A review of drilling challenges with mud design and lost circulation problem. In Proceedings of 45th Annual Stanford Geothermal Workshop, Stanford University, Stanford, CA.
Smeltzer, S., & Bare, B. (2013). Brunnerand Suddarth´ s Textbook of Medical. Surgical Nursing. practice [10NUR-6, 10COMP-6], 5, 5L7C3.
Sugiyono, T. (2018). Metode Penelitian Evaluasi (Pendekatan Kuantitatif, Kualitatif dan Kombinasi). Bandung: Alfabeta.
Susanti, E. F. N., Hudiyawati, N. D., & Kep, M. (2019). Gambaran faktor risiko terjadinya diabetes melitus pada penderita diabetes melitus tipe 2 (Doctoral dissertation, Universitas Muhammadiyah Surakarta). https://eprints.ums.ac.id/71368/
Tambirang, R. M. (2018). Evaluasi Penggunaan Dan Outcome Terapi Obat Antinyeri Pada Pasien Diabetik Neuropati Di Instalasi Rawat Inap RSUP Prof. Dr. RD Kandou Manado. Pharmacon, 7(3). https://doi.org/10.35799/pha.7.2018.20242
Winarsi, H., & Purwanto, A. (2010). Soy germed protein plus Zn as an inducer insulin secretion on Type-2 Diabetes Mellitus. Hayati Journal Of Biosciences, 17(3), 120-124.
Yosmar, R., Almasdy, D., & Rahma, F. (2018). Survei risiko penyakit diabetes melitus terhadap masyarakat Kota Padang. Jurnal sains farmasi & klinis, 5(2). https://doi.org/10.25077/jsfk.5.3.169-175.2018
Yosmar, R., Inanta, N. P., & Sari, Y. O. (2018). Studi Prospektif Adverse Drug Reactions (ADRS) Obat Hipoglikemik Oral Terhadap Pasien Diabetes Mellitus Tipe 2 di Suatu Rumah Sakit, Padang. Jurnal Sains Farmasi & Klinis, 5(3), 169-175.
License
Copyright (c) 2026 Luluk Alfhina, Herpan Syafii Harahap, Raisya Hasina Alaydrus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
