Aplastic Anemia: A literature Review

Kezia Michella Yusak Maringka; Ima Arum Lestarini

doi:10.29303/jbt.v24i4.7695

Aplastic Anemia: A literature Review

Authors

Kezia Michella Yusak Maringka , Ima Arum Lestarini

DOI:

10.29303/jbt.v24i4.7695

Published:

2024-10-28

Issue:

Vol. 24 No. 4 (2024): Oktober - Desember

Keywords:

Aplastic anemia, clinical manifestation, etiology, pathofisiology, therapy.

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Maringka, K. M. Y., & Lestarini, I. A. (2024). Aplastic Anemia: A literature Review. Jurnal Biologi Tropis, 24(4), 624–631. https://doi.org/10.29303/jbt.v24i4.7695

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Abstract

Aplastic anemia (AA) is a rare but serious hematologic disorder characterized by bone marrow failure, leading to pancytopenia and a reduction in all blood cell lines. This study aims to explore the definition, etiology, pathophysiology, diagnosis, and treatment of AA. A comprehensive literature review was conducted using electronic databases such as PubMed, ProQuest, ScienceDirect, MDPI, and Google Scholar, focusing on studies and reviews related to AA. The findings indicate that the primary causes of AA include immune-mediated destruction of hematopoietic stem cells, with potential triggers such as drugs, chemicals, and autoimmune disorders. The diagnosis is confirmed through clinical evaluation, blood tests, and bone marrow biopsy. Treatment strategies consist of immunosuppressive therapy, hematopoietic stem cell transplantation (HSCT), and supportive care. In conclusion, early diagnosis and appropriate treatment are essential for improving the prognosis of patients with AA.

References

Del Pozzo, J. et al. (2023) ‘Importance of the Third Trimester Complete Blood Count: A Case Report on Aplastic Anemia in Pregnancy’, Journal of Hematology, 12(3), pp. 114–117. Available at: https://doi.org/10.14740/jh1131.

Dewarrat, N. et al. (2024) ‘[Aplastic anemia]’, Revue Medicale Suisse, 20(880), pp. 1271–1275. Available at: https://doi.org/10.53738/REVMED.2024.20.880.1271.

DeZern, A.E. and Churpek, J.E. (2021) ‘Approach to the diagnosis of aplastic anemia’, Blood Advances, 5(12), pp. 2660–2671. Available at: https://doi.org/10.1182/bloodadvances.2021004345.

Furlong, E. and Carter, T. (2020) ‘Aplastic anaemia: Current concepts in diagnosis and management’, Journal of Paediatrics and Child Health, 56(7), pp. 1023–1028. Available at: https://doi.org/10.1111/jpc.14996.

Gale, R.P. et al. (2023) ‘What causes aplastic anaemia?’, Leukemia, 37(6), pp. 1191–1193. Available at: https://doi.org/10.1038/s41375-023-01892-2.

Georges, G.E., Doney, K. and Storb, R. (2018) ‘Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment’, Blood Advances, 2(15), pp. 2020–2028. Available at: https://doi.org/10.1182/bloodadvances.2018021162.

Giudice, V. and Selleri, C. (2022) ‘Aplastic anemia: Pathophysiology’, Seminars in Hematology, 59(1), pp. 13–20. Available at: https://doi.org/10.1053/j.seminhematol.2021.12.002.

Hoffbrand, A.V. and Moss, P.A.H. (2011) in Essential Haematology. Wiley-Blackwell (6).

Javan, M.R., Saki, N. and Moghimian-Boroujeni, B. (2021) ‘Aplastic anemia, cellular and molecular aspects’, Cell Biology International, 45(12), pp. 2395–2402. Available at: https://doi.org/10.1002/cbin.11689.

Kulasekararaj, A. et al. (2024) ‘Guidelines for the diagnosis and management of adult aplastic anaemia: A British Society for Haematology Guideline’, British Journal of Haematology, 204(3), pp. 784–804. Available at: https://doi.org/10.1111/bjh.19236.

Li, S.-S. et al. (2019) ‘Incidence and treatment outcome of aplastic anemia in Taiwan-real-world data from single-institute experience and a nationwide population-based database’, Annals of Hematology, 98(1), pp. 29–39. Available at: https://doi.org/10.1007/s00277-018-3486-3.

Moore, C.A. and Krishnan, K. (2023) ‘Aplastic Anemia’, in StatPearls. Treasure Island (FL): StatPearls Publishing. Available at: http://www.ncbi.nlm.nih.gov/books/NBK534212/ (Accessed: 15 May 2023).

Onishi, Y. (2024) ‘Aplastic anemia: history and recent developments in diagnosis and treatment’, International Journal of Hematology, 119(3), pp. 217–219. Available at: https://doi.org/10.1007/s12185-024-03715-1.

Proskuriakova, E. et al. (2023) ‘A Case of Severe Aplastic Anemia in a 35-Year-Old Male With a Good Response to Immunosuppressive Therapy’, Cureus, 15(6), p. e40210. Available at: https://doi.org/10.7759/cureus.40210.

Setiasi, S., Alwi, I. and Sudoyo, A.W. (2017) ‘Buku Ajar Ilmu Penyakit Dalam’, in. Jakarta: Interna Publishing (6).

Shallis, R.M., Ahmad, R. and Zeidan, A.M. (2018) ‘Aplastic anemia: Etiology, molecular pathogenesis, and emerging concepts’, European Journal of Haematology, 101(6), pp. 711–720. Available at: https://doi.org/10.1111/ejh.13153.

Shimano, K.A. et al. (2021) ‘Diagnostic work-up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium’, American Journal of Hematology, 96(11), pp. 1491–1504. Available at: https://doi.org/10.1002/ajh.26310.

Sutanegara, K.D.P. (2022) ‘Anemia Aplastik: dari Awitan hingga Tatalaksana’, Unram Medical Journal, 11(3), pp. 1094–1099. Available at: https://doi.org/10.29303/jku.v11i3.768.

Urbanowicz, I., Nahaczewska, W. and Celuch, B. (2021) ‘Narrative review of aplastic anemia-the importance of supportive treatment’, Annals of Palliative Medicine, 10(1), pp. 694–699. Available at: https://doi.org/10.21037/apm-20-1957.

Usuki, K. (2021) ‘[Diagnosis and treatment for aplastic anemia]’, [Rinsho Ketsueki] The Japanese Journal of Clinical Hematology, 62(8), pp. 922–930. Available at: https://doi.org/10.11406/rinketsu.62.922.

Vaht, K. et al. (2017) ‘Incidence and outcome of acquired aplastic anemia: real-world data from patients diagnosed in Sweden from 2000-2011’, Haematologica, 102(10), pp. 1683–1690. Available at: https://doi.org/10.3324/haematol.2017.169862.

Wang, H.Q. and Shao, Z.H. (2022) ‘[Exclusive diagnosis of aplastic anemia]’, Zhonghua Yi Xue Za Zhi, 102(12), pp. 830–832. Available at: https://doi.org/10.3760/cma.j.cn112137-20211207-02728.

Wang, L. and Liu, H. (2019) ‘Pathogenesis of aplastic anemia’, Hematology, 24(1), pp. 559–566. Available at: https://doi.org/10.1080/16078454.2019.1642548.

Yoshida, N. et al. (2014) ‘First-line treatment for severe aplastic anemia in children: bone marrow transplantation from a matched family donor versus immunosuppressive therapy’, Haematologica, 99(12), pp. 1784–1791. Available at: https://doi.org/10.3324/haematol.2014.109355.

Young, N.S. (2018) ‘Aplastic Anemia’, The New England Journal of Medicine, 379(17), pp. 1643–1656. Available at: https://doi.org/10.1056/NEJMra1413485

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