Vol. 25 No. 3 (2025): Juli-September
Open Access
Peer Reviewed

Hypothyroidism: A Literature Review

Authors

Excell Defry Hardiant , Muhammad Fikri Adidaifa , Tsania Zulfa Salsabila , Muhammad Rafi Maulana , Baiq Ghefira Rojwani Putri Salsabila , Lania Pradiva Untari , Elsa Indah Suryani , Andi Frieskha Naurah Paradiesta , Puti Amelia Savitri , Basuki Rahmat

DOI:

10.29303/jbt.v25i3.10033

Published:

2025-08-27

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Abstract

Hypothyroidism is a condition in which the thyroid gland is unable to produce enough hormones to meet the body's needs. This condition causes a slowed metabolism, which can lead to various symptoms such as fatigue, weight gain, dry skin, hair loss, constipation, cold intolerance, and facial puffiness. Given the widespread impact of hypothyroidism and the potential for serious complications, special attention is needed for early detection, diagnosis, and effective treatment of hypothyroidism. This literature review was conducted using journal review methods and data searches through sources such as PubMed, Google Scholar, and ScienceDirect. The search used the keywords "hypothyroidism," "hypothyroid," "thyroid gland," and "Hashimoto's thyroiditis." The results of the literature review found that the main cause of hypothyroidism is Hashimoto's thyroiditis, an autoimmune disease in which antibodies attack the thyroid gland. Hypothyroidism is diagnosed by examining elevated TSH and decreased free T4 levels, as well as anti-TPO antibody tests to detect Hashimoto's thyroiditis. Treatment for hypothyroidism generally involves administering levothyroxine, a synthetic thyroid hormone, to replace the deficient hormone and normalize metabolic function. Healthy lifestyle support, such as diet and stress management, is also important to help optimally manage this condition. In conclusion, hypothyroidism is characterized by a decrease in thyroid hormone production and preventive management is pharmacological in the form of levothyroxine, while non-pharmacological management is in the form of regulating food intake.

Keywords:

Hypothyroidism Hashimoto's thyroiditis Levothyroxine TSH T4 Thyroid gland

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Author Biographies

Excell Defry Hardiant, Universitas Mataram

Author Origin : Indonesia

Muhammad Fikri Adidaifa, Universitas Mataram

Author Origin : Indonesia

Tsania Zulfa Salsabila, Universitas Mataram

Author Origin : Indonesia

Muhammad Rafi Maulana, Universitas Mataram

Author Origin : Indonesia

Baiq Ghefira Rojwani Putri Salsabila, Universitas Mataram

Author Origin : Indonesia

Elsa Indah Suryani, Universitas Mataram

Author Origin : Indonesia

Andi Frieskha Naurah Paradiesta, Universitas Mataram

Author Origin : Indonesia

Puti Amelia Savitri, Universitas Mataram

Author Origin : Indonesia

Basuki Rahmat, Universitas Mataram

Author Origin : Indonesia

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How to Cite

Hardiant, E. D., Adidaifa, M. F., Salsabila, T. Z., Maulana, M. R., Salsabila, B. G. R. P., Untari, L. P., … Rahmat, B. (2025). Hypothyroidism: A Literature Review. Jurnal Biologi Tropis, 25(3), 4685–4692. https://doi.org/10.29303/jbt.v25i3.10033

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