Literature Study: Primary Immunodeficiency
DOI:
10.29303/jbt.v25i4.10168Published:
2025-10-01Downloads
Abstract
Abnormalities in immune system development and function result in increased susceptibility to infection and reactivation of latent infections. Other immunodeficiencies can result in mild infections and may first be detected in adulthood. This literature review aims to discuss primary immunodeficiencies, including their definition, causes, treatment, and examples of the diseases they cause. This literature review was compiled through a literature search method by reviewing various scientific journals obtained from databases such as PubMed, Google Scholar, and ScienceDirect. The results Primary immunodeficiency disease (PID) results from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system. PID is broadly classified as either a disorder of adaptive immunity (T-cell, B-cell, or combined immune deficiencies) or innate immunity (phagocyte and complement deficiencies). Patients with PID may experience a variety of lung problems, including recurrent lower respiratory tract infections, lung parenchymal abnormalities, asthma, ventilation abnormalities, and bronchiectasis (BE). In conclusion, primary immunodeficiency disease (PID) refers to a large, heterogeneous group of disorders characterized by abnormalities in the development and/or function of the immune system. These conditions result from immune system defects caused by mutations in the genetic code that codes for components of the body's immune system.
Keywords:
Adaptive immunity, innate immunity, Primary immunodeficiency.References
Abbas, A. K. (2023). Imunologi dasar abbas: Fungsi dan kelainan sistem imun.
Adijaya, O., & Bakti, A. P. (2021). Peningkatan sistem imunitas tubuh dalam menghadapi Pandemi Covid-19. Jurnal Kesehatan Olahraga, 9(3), 51-60. https://doi.org/10.26740/jurnal-kesehatan-olahraga.v9i3.40767
Akar-Ghibril, N. (2022). Defects of the innate immune system and related immune deficiencies. Clinical Reviews in Allergy & Immunology, 63(1), 36-54. 10.1007/s12016-021-08885-y
Atmanto, Y. K. A. A., Nurulita, A., & Bahrun, U. (2022). Bubble Boy Disease/Severe Combined Immunodeficiency. Jurnal Medika Hutama, 3(04 Juli), 2815-2825. https://jurnalmedikahutama.com/index.php/JMH/article/view/569
Kusumo, P. D. (2012). Gangguan Imunodefisiensi Primer (PID). Widya Kedokteran.
Feteih, A., Zhang, L., Alizadehfar, R., & Tsoukas, C. (2021). General Approach to Primary Immunodeficiency (PID) in Adults. In The Manual of Allergy and Clinical Immunology (pp. 191-198). CRC Press. 10.1201/9781003174202-29
Forrester, J. V., Mölzer, C., & Kuffova, L. (2022). Immune privilege furnishes a niche for latent infection. Frontiers in Ophthalmology, 2, 869046. https://doi.org/10.3389/fopht.2022.869046
Huang, C. C., Huang, C. C., Lin, S. Y., Chang, C. Y. Y., Lin, W. C., Chung, C. H., ... & Chien, W. C. (2019). Association of pelvic inflammatory disease (PID) with ectopic pregnancy and preterm labor in Taiwan: a nationwide population-based retrospective cohort study. PLoS One, 14(8), e0219351. 10.1371/journal.pone.0219351
Justiz Vaillant, A. A., & Qurie, A. (2023). Immunodeficiency Continuing Education Activity. https://www.ncbi.nlm.nih.gov/books/NBK500027/
Karnaukhova, E. (2022). C1-inhibitor: structure, functional diversity and therapeutic development. Current Medicinal Chemistry, 29(3), 467-488. 10.2174/0929867328666210804085636
Lazar, V., Ditu, L. M., Pircalabioru, G. G., Gheorghe, I., Curutiu, C., Holban, A. M., ... & Chifiriuc, M. C. (2018). Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer. Frontiers in immunology, 9, 1830. 10.3389/fimmu.2018.01830
Mahendra, C. (2021). Imunodefisiensi primer dan deteksi dininya. Jambi Medical Journal: Jurnal Kedokteran dan Kesehatan, 9(2), 159-167. https://doi.org/10.22437/jmj.v9i1.12473
McCusker, C., Upton, J., & Warrington, R. (2018). Primary immunodeficiency. Allergy, Asthma and Clinical Immunology, 14. https://doi.org/10.1186/s13223-018-0290-5
Moodley, S., Goddard, E., Levin, M., Scott, C., Van Eyssen, A., Davidson, A., ... & Eley, B. (2020). A retrospective description of primary immunodeficiency diseases at Red Cross War Memorial Children’s Hospital, Cape Town, South Africa, 1975-2017. South African Medical Journal, 110(3), 197-203. 10.7196/SAMJ.2020.v110i3.14200
Nugraha, I. B. A., Wawan, I. W., & Suardamana, K. (2022). A Literature Review (Imunodefisiensi Primer). Jurnal Medika Hutama, 3(03 April), 2621-2633. https://jurnalmedikahutama.com/index.php/JMH/article/view/492
Padron, G. T., & Hernandez-Trujillo, V. P. (2023). Autoimmunity in primary immunodeficiencies (PID). Clinical Reviews in Allergy & Immunology, 65(1), 1-18. 10.1007/s12016-022-08942-0
Pilania, R. K., Chaudhary, H., Jindal, A. K., Rawat, A., & Singh, S. (2020). Current status and prospects of primary immunodeficiency diseases in Asia. In Genes and Diseases (Vol. 7, Issue 1, pp. 3–11). Chongqing University. https://doi.org/10.1016/j.gendis.2019.09.004
Sánchez-Ramón, S., Bermúdez, A., González-Granado, L. I., Rodríguez-Gallego, C., Sastre, A., Soler-Palacín, P., & ID-Signal Onco-Haematology Group. (2019). Primary and secondary immunodeficiency diseases in oncohaematology: warning signs, diagnosis, and management. Frontiers in immunology, 10, 586. 10.3389/fimmu.2019.00586
Skokowa, J., Dale, D. C., Touw, I. P., Zeidler, C., & Welte, K. (2017). Severe congenital neutropenias. Nature Reviews Disease Primers, 3(1), 1-18. 10.1038/nrdp.2017.32
Vaillant, A. A. J., & Qurie, A. (2023). Immunodeficiency. In StatPearls [Internet]. StatPearls Publishing.
Wawan, W., Bagus, I., Nugraha, A., & Suardamana, K. (2022). IMUNODEFISIENSI
Yazdanpanah, N., & Rezaei, N. (2024). The multidisciplinary approach to diagnosing inborn errors of immunity: a comprehensive review of discipline-based manifestations. Expert Review of Clinical Immunology, 20(10), 1237-1259. 10.1080/1744666X.2024.2372335
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