The Effectiveness of Prolactin Hormone Administration on Ovulation in Postpartum Female Mice (Mus musculus)

I Wayan Merta; Kusmiyati Kusmiyati

doi:10.29303/jbt.v25i4.10395

The Effectiveness of Prolactin Hormone Administration on Ovulation in Postpartum Female Mice (Mus musculus)

Authors

I Wayan Merta , Kusmiyati Kusmiyati

DOI:

10.29303/jbt.v25i4.10395

Published:

2025-11-06

Issue:

Vol. 25 No. 4 (2025): Oktober-Desember

Keywords:

Prolactin Hormone, Ovulation, Postpartum, Mice (Mus musculus).

Articles

Downloads

pdf

How to Cite

Merta, I. W., & Kusmiyati, K. (2025). The Effectiveness of Prolactin Hormone Administration on Ovulation in Postpartum Female Mice (Mus musculus). Jurnal Biologi Tropis, 25(4), 6103–6108. https://doi.org/10.29303/jbt.v25i4.10395

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

The prolactin hormone produced by the anterior pituitary gland plays an important role in the reproductive system, such as stimulating breast milk production and regulating the menstrual cycle in women, as well as stimulating sperm production and sex drive in men. This study aims to 1) examine the effectiveness of prolactin hormone administration on ovulation in postpartum female mice (Mus musculus). 2) contribute to the study material of animal physiology courses, particularly on endocrine topics. This research employed a true experimental design using a completely randomized design (CRD). The research samples were female Mus musculus mice of the BALB/C strain, approximately 4 months old, weighing between 25–30 grams, healthy, and non-pregnant. The data obtained were analyzed using a one-way analysis of variance (ANOVA) (F-test) with a significance level of 0.05, followed by a Least Significant Difference (LSD) test. The results showed that the significance value (p) = 0.001 < α = 0.05, indicating that the administration of prolactin hormone had a significant effect in reducing ovulation in postpartum female Mus musculus mice.

References

Affandi (2014). Buku Panduan Praktis Pelayanan Kontrasepsi. Jakarta: Bina Pustaka Sarwono Prawirohardjo. 300 p.

Agrisera (2004). Polyclonal Antibody Production Program Distated by Customer's Requirements. Aves Labs, Inc.

Ajiningrum, P. S., Amilah, S., & Widyaningtyas, P. G. (2020). Efektivitas Ekstrak Rimpang Pacing (Costus Speciosus), Daun Srikaya (Annona Squamosa L.) dan Ekstrak Kombinasinya terhadap Penurunan Jumlah Folikel Tersier dan Folikel De Graff pada Mencit Betina (Mus Musculus). Journal Pharmasci, 5(1), 33-37. P-ISSN: 2527-6328, E-ISSN: 2549-3558

Crane, M. B., Bartolome, J., Melendez, P., deVries, A., Risco, C. & Archbald, L. F. (2005). Comparison of synchronization of ovulation with timed insemination and exogenous progesterone as therapeutic strategies for ovarian cysts in lactating dairy cows. Theriogenology 65: 1563-157

Freeman, M.E. Kanyieka B., Ilerant A., & Nagy O. (2000). Prolactin, Structure, Function and Regulation of Secretion. Physiol Rev. Oct;80(4):1523-631.

Hafez, E.S.E. (1993). Hormones, growth factor, and reproduction. In: The Reproduction in Farm Animal. 6 Edition. Lea and Fibiger Philadelphia.

Hall. JE. Guyton and Hall. (2016). Textbook of Medical Physiology. 13th ed. Philadelphia (PA): Elsevier, Inc.

Hardjopranjoto.S. (2003). Ilmu Kemajiran Pada Ternak. Penerbit Airlangga Universitas Press.

Hill, P. D., Aldag, J. C., Demirtas, H., Naeem, V., Parker, N. P., Zinaman, M. J. & Chatterton, R. T. (2009). Association of serum prolactin and oxytocin with milk production in mothers of preterm and term infants. Biological research for nursing, 10, 340- 349.

Irianto, Koes. (2014). Biologi Reproduksi. Bandung: Penerbit Alfabeta.

Jabbour. H.N. and Kelly P.A. (1997). Prolacitn receptor sub types: a possible mode of tissue specific Regulation of Prolactin Function. Journals of Reproduction and Fertility; 2, 14-18.

Knobi E. D. Neil. Ewing, C.L. Market, G.S. Greenwald and D.W Pfilff. (1988). The Phisiology of Reproduction. Vol. 2. Raven Press, New York. P. 1379-1385.

Kurniati (2009). Hubungan Pemberian ASI Eksklusif Dengan Kembalinya MenstruasiI Di wilayah Kerja Puskesmas Purbaratu Kota Tasikmalaya. Jurnal Kesehatan komunitas Indonesia Vol 16 no 1 Maret 2020

Langan. E. A. (2024). Prolactin: A Mammalian Stress Hormone and Its Role in Cutaneous Pathophysiology. International Journal of Molecular Sciences, 25(13), pp. 7100.

Marhiyanto. B. (2000). Sukses Beternak Ayam Arab. Cetakan I. Difa Publisher. Indonesia, 9–11 & 88i–97

Martinez, M. F., Kastelic, J. P., Bo, G. A., Caccia, M. and Mapletoft, R. J. (2005) Effect of oestradiol and some of its esters on gonadotrophin release and ovarian follicular dynamics in CIDR treated beef cattle. J. Anim. Sci. 86: 37-52.

Melmed, S. (2011). Prolaktin Diagnosis and Management. Journal Of Clinical Endocrinology And Metabolism.

Ningtyas, N.S.I.I, (2017). Pengaruh Pemberian Minyak Buah Merah (Pandanus Conoideus Lam. Terhadap Histopatologi Folikel De Graaf Pada Mencit (Mus musculus) Model Infertil. Jurnal Sangkareang Mataram,3(3),36-38.

Ramdhani.S.A., Supriatna.L., Karja, N.W.K & Winarto, A. (2017). Pengendalian Folikulogenesis Ovarium Dengan Pemberian Ekstra Biji Kapas. Jurnal Sain Veteriner, 35 (1),71 – 80.

Ramesh. R., Kuenzel WJ, and Proudman JA. (2001). Increased Proliferative Activity and Programmed Cellular Death in the Turkey Hen Pituitary Gland Following Interruption of Incubation Behavior. Regular Article Biology of Reproduction, 64:611–618.

Riordan, J. (2005). Anatomy and physiology of lactation. Breastfeeding and human lactation, 67-95.

Siagian. L. J. (2019). Hubungan Pemberian ASI Eksklusif Dan Pola Pemberian ASI Dengan Lama Kembalinya Menstruasi Pada Ibu Yang Memiliki Bayi 6 - 24 Bulan Di Desa Purwodadi Kecamatan Sunggal Kabupaten Deli Serdang. Repository Helvetia AcId

Snyder, P. J. (2023). Patient Education: High Prolactin Levels and Prolactinomas (Beyond the Basics).

Steel R.G.D, & Torrie J.H. (1995). Principles and procedures of statistics A biometrical Approach. International Student Edition. McGraw-Hill Koga Kusha, LTD. P. 137–167. Upstate B. 2002. Anti-Prolactin (Rabbit Antiserum) and Immunoblot Protocol., 1-2. Upstate Biotechnology. Certificate of Analysis. www.upstatebiotech.com.

Sudjana (1992). Metode Statistik. Edisi ke-5. Penerbit Tarsito Bandung. 302.

Szukiewicz D. (2024). Current Insights in Prolactin Signaling and Ovulatory Function. International Journal of Molecular Sciences,25(4), pp.1976.

Tachibana T. G. W. Burgess Ed. Saito S., Tomonaga S., Takagi T., Saito E.S., Nakanishi T., Koutoku T., Tsukada A., Ohkubo T., Boswell T., … & Furuse M., (2003). Effect of Central Administration of Prolactin-Releasing Peptide on Feeding in Chicks. Article in Press. Physiology and Behavior. Elsevier.

Urhan.E., and Karaca. Z. (2024). Diagnosis of Hypoprolactinemia. Reviews in Endocrine & Metabolic Disorders, 10.1007/s11154-024-09896-8.

Uzunl (2024). The Diagnosis and Prevalence of Hypoprolactinemia in Patients with Panhypopituitarism and the Effects on Depression and Sexual Functions. Pituitary, 27(3), pp. 277–286.

Yamamoto Wakita M., and Tanaka M. (2003). Tissue Distribution of Prolactin Receptor mRNA during Late Stage Embryogenesis of the Chick. Poultry Science 82:155-157.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

The Effectiveness of Prolactin Hormone Administration on Ovulation in Postpartum Female Mice (Mus musculus)

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow