Literature Review: Natural Anthelmintic from Moringa Leaves (Moringa oleifera) for Controlling Haemonchus contortus in Goats
DOI:
10.29303/jbt.v25i4a.10939Published:
2025-12-27Downloads
Abstract
Haemonchus contortus remains one of the most pathogenic gastrointestinal nematodes in goats, causing substantial productivity losses in small ruminant farming. The increasing resistance and residue concerns associated with synthetic anthelmintics highlight the need for safer, plant-based alternatives. This study aims to review the potential of Moringa oleifera leaves as a natural anthelmintic for controlling Haemonchus contortus infections in goats. A non-systematic literature review was conducted by screening scientific articles published between 2019 and 2024 through Google Scholar using keywords related to alternative natural anthelmintics, control of goat parasites, Haemonchus contortus infection, Moringa oleifera, and plant phytochemical compounds. Relevant in vitro and in vivo studies were analyzed descriptively to evaluate the plant’s phytochemical profile, mechanisms of action, and effectiveness. Findings indicate that Moringa oleifera leaves contain tannins, saponins, flavonoids, alkaloids, and terpenoids that inhibit egg hatching, disrupt larval development, and impair adult worm survival. In vitro studies consistently demonstrate high ovicidal, larvicidal, and vermicidal activity, with inhibition rates comparable to albendazole at higher concentrations. In vivo results also show significant reductions in fecal egg counts (FEC), particularly at doses of 200–400 mg/kg body weight, without reported adverse effects. These outcomes underline the effectiveness and safety of Moringa oleifera leaves as a promising natural anthelmintic. In conclusion, Moringa oleifera represents a viable, environmentally friendly option for integrated parasite control in goats, particularly for reducing infections caused by Haemonchus contortus. Further standardized dosing studies and long-term evaluations are recommended to optimize its practical application in small ruminant health management.
Keywords:
Control of goat parasites Haemonchus contortus Moringa oleifera Natural anthelminticReferences
Abosse, J. S., Terefe, G., & Teshale, B. M. (2022). Comparative study on pathological changes in sheep and goats experimentally infected with Haemonchus Contortus. Surgical and Experimental Pathology, 5(1), 14. https://doi.org/10.1186/s42047-022-00116-8
Adduci, I., Sajovitz, F., Hinney, B., Lichtmannsperger, K., Joachim, A., Wittek, T., & Yan, S. (2022). Haemonchosis in sheep and goats, control strategies and development of vaccines against Haemonchus contortus. Animals, 12(18), 2339. https://doi.org/10.3390/ani12182339
Athaillah, F., Fahrimal, Y., Hambal, M., & Hanafiah, M. (2022). Parasitologi Veteriner. Syiah Kuala University Press.
Arifin, K., Kusnoto, K., Yudhana, A., Sunarso, A., Purnama, M. T. E., & Praja, R. N. (2019). Prevalensi Haemonchiasis Pada Kambing Peranakan Etawah di Kecamatan Kalipuro, Banyuwangi. Jurnal Medik Veteriner, 2(2), 108. DOI: 10.20473/jmv.vol2.iss2.2019.108-111
Arsenopoulos, K. V., Fthenakis, G. C., Katsarou, E. I., & Papadopoulos, E. (2021). Haemonchosis: A challenging parasitic infection of sheep and goats. Animals, 11(2), 363. https://doi.org/10.3390/ani11020363
Asrul, N. A. M., Rivai, A. T. O., Syisnawati, S., & Haristiani, R. (2023). Ekstrak Moringa oleifera Mempercepat Proses Penyembuhan Luka: Systematic Review. Jurnal Farmasetis, 12(2), 187-194. https://doi.org/10.32583/far.v12i2.1109
Bhavsar, Z. A., Acharya, P. T., Jethava, D. J., & Patel, H. D. (2020). Recent advances in development of anthelmintic agents: Synthesis and biological screening. Synthetic Communications, 50(7), 917-946. https://doi.org/10.1080/00397911.2019.1695276
Carson, A., Reichel, R., Bell, S., Collins, R., Smith, J., & Bartley, D. (2023). Haemonchus contortus: an overview. Veterinary Record, 192(1), 26-28. https://doi.org/10.1002/vetr.2613
Cruz-Tamayo, A. A., López-Arellano, M. E., Gonzalez-Garduno, R., Torres-Hernandez, G., De la Mora-Valle, A., Becerril-Perez, C., ... & Huchin-Cab, M. (2021). Haemonchus contortus infection induces a variable immune response in resistant and susceptible Pelibuey sheep. Veterinary Immunology and Immunopathology, 234, 110218. https://doi.org/10.1016/j.vetimm.2021.110218
da Silva, G. D., de Lima, H. G., de Sousa, N. B., de Jesus Genipapeiro, I. L., Uzêda, R. S., Branco, A., Costa, S. L., Batatinha, M. J. M., & Botura, M. B. (2021). In vitro anthelmintic evaluation of three alkaloids against gastrointestinal nematodes of goats. Veterinary Parasitology, 296. https://doi.org/10.1016/j.vetpar.2021.109505
Degla, L. H., Kuiseu, J., Olounlade, P. A., Attindehou, S., Hounzangbe-Adote, M. S., Edorh, P. A., & Lagnika, L. (2022). Use of medicinal plants as alternative for the control of intestinal parasitosis: assessment and perspectives. Agrobiol Rec, 7, 1-9. https://doi.org/10.47278/journal.abr/2021.011
Dehuri, M., Palai, S., Mohanty, B., & Malangmei, L. (2021). Anti-helminthic Activity of Plant Extracts against Gastrointestinal Nematodes in Small Ruminants-A Review. Pharmacognosy Reviews, 15(30). DOI : 10.5530/phrev.2021.15.14
Elghandour, M. M. M. Y., Maggiolino, A., Vázquez-Mendoza, P., Alvarado-Ramírez, E. R., Cedillo-Monroy, J., De Palo, P., & Salem, A. Z. M. (2023). Moringa oleifera as a natural alternative for the control of gastrointestinal parasites in equines: a review. Plants, 12(9), 1921. https://doi.org/10.3390/plants12091921
Fauziah, N. M., Maulidiyah, M., Hartanto, T. P., Putri, S. N. D., San Sabhira, A., Mukarromah, I. W., ... & Ningsih, A. W. (2023). Artikel Review: Studi Fitokimia Dan Farmakologi Tanaman Kelor (Moringa Oleifera Lam). The Journal General Health and Pharmaceutical Sciences Research, 1(4), 45-52. https://doi.org/10.57213/tjghpsr.v1i4.110
Flay, K. J., Hill, F. I., & Muguiro, D. H. (2022). A Review: Haemonchus contortus infection in pasture-based sheep production systems, with a focus on the pathogenesis of anaemia and changes in haematological parameters. Animals, 12(10), 1238. https://doi.org/10.3390/ani12101238
Ghormode, P. B., Waghmare, S. P., Pajai, K. S., Kuralkar, S. V., Ingawale, M. V., Hajare, S. W., & Hatzade, R. I. (2023). Efficacy of Moringa oleifera leaves powder as a haematinic preparation in helminth infected anaemic goats. https://doi.org/10.22271/tpi.2023.v12.i2b.18476
Hanafiah, M., Ferasyi, T. R., Abrar, M., Helmi, T. Z., & Aliza, D. (2025). Penyakit Parasit pada Sapi: Kajian Morfologi, Patologi, dan Molekuler. USK Press.
Hanif, F., & Berawi, K. N. (2022). Literature review: daun kelor (Moringa oleifera) sebagai makanan sehat pelengkap nutrisi 1000 hari pertama kehidupan. Jurnal Kesehatan, 13(2), 398-407.DOI:10.26630/jk.v13i2.1415
Khasanah, R., Jumari., dan Nurchayati, Y.(2023). Etnobotani Tumbuhan Kelor (Moringa Oelifera L.) di Kabupaten Pemalang Jawa Tengah. Jurnal Ilmu Lingkungan, 21(4), DOI: 870-880. doi:10.14710/jil.21.4.870-880
Kuiseu, J., ZINSOU, F. E. T., Olounlade, P. A., ALOWANOU, G. E. G., Adenile, A. D., Dansou, C. C., ... & Edorh, P. A. (2021). Prevalence, effects and alternative control methods of Haemonchus contortus in small ruminants: a review. Journal of Veterinary Medicine and Animal Health, 13(2), 84-97. https://doi.org/10.5897/JVMAH2020.0868
Kumar, V., Sharma, A., & Singh, R. (2022). Phytochemical Constituents and Pharmacological Activities of Moringa oleifera: An Overview. International Journal of Herbal Medicine, 10(3), 89–95. Retrieved from https://www.florajournal.com/
Niciura, S. C. M., Cardoso, T. F., Ibelli, A. M. G., Okino, C. H., Andrade, B. G., Benavides, M. V., ... & Gondro, C. (2024). Multi-omics data elucidate parasite-host-microbiota interactions and resistance to Haemonchus contortus in sheep. Parasites & Vectors, 17(1), 102. https://doi.org/10.1186/s13071-024-06205-9
Ni'mah, T., & Mahdalena, V. (2022). Kajian Pustaka: Potensi Ekstrak Tanaman Di Indonesia Sebagai Kandidat Antelmintik Terhadap Ascaris. MEDFARM: Jurnal Farmasi dan Kesehatan, 11(1), 78-92. https://doi.org/10.48191/medfarm.v11i1.69
Liu, Y., Wang, X., Luo, X., Wang, R., Zhai, B., Wang, P., ... & Yang, X. (2023). Transcriptomics and proteomics of Haemonchus contortus in response to ivermectin treatment. Animals, 13(5), 919. https://doi.org/10.3390/ani13050919
Luju, M. T., Bollyn, Y. M. F., & Rinca, K. F. (2024). Peningkatan Manajemen Pemeliharaan Ternak dengan Pemberdayaan Masyarakat melalui Pelatihan Pembuatan Rekording Ternak. International Journal of Community Service Learning, 8(2), 212-219. https://doi.org/10.23887/ijcsl.v8i2.76719
Maqbool, M., Khan, M. A., & Hussain, M. (2022). Nutritional and Phytochemical Composition of Moringa oleifera Parts: A Comprehensive Review. Journal of Agricultural and Food Chemistry, 70(15), 4567–4578. Retrieved from https://pubs.acs.org/
Manjusa, A., & Pradeep, K. (2022). Herbal anthelmintic agents: a narrative review. Journal of Traditional Chinese Medicine, 42(4), 641. DOI: https://doi.org/10.19852/j.cnki.jtcm.2022.04.007
Mbogning Tayo, G., Wabo Poné, J., Komtangi, M. C., Yondo, J., Ngangout, A. M., & Mbida, M. (2014). Anthelmintic activity of Moringa oleifera leaf extracts evaluated in vitro on four developmental stages of Haemonchus contortus from goats. American Journal of Plant Sciences, 5(11), 1702–1710. https://doi.org/10.4236/ajps.2014.511185
Medeiros, M. L. S., Alves, R. R. V., Oliveira, B. F., Napoleão, T. H., Paiva, P. M. G., Coelho, L. C. B. B., Bezerra, A. C. D. S., & Silva, M. D. C. (2020). Anthelmintic effect of a water soluble Moringa oleifera lectin in rodents experimentally infected with Haemonchus contortus. Experimental Parasitology, 218, 108004. https://doi.org/10.1016/j.exppara.2020.108004
Mumed, H. S., Nigussie, D. R., Musa, K. S., & Demissie, A. A. (2022). In vitro anthelmintic activity and phytochemical screening of crude extracts of three medicinal plants against Haemonchus contortus in sheep at Haramaya Municipal Abattoir, Eastern Hararghe. Journal of Parasitology Research, 2022(1), 6331740. https://doi.org/10.1155/2022/6331740
Mustafa, S., Alharbi, L. M., Abdelraheem, M. Z., Mobashar, M., Qamar, W., A. Al-Doaiss, A., & Abbas, R. Z. (2024). Role of silver nanoparticles for the control of anthelmintic resistance in small and large ruminants. Biological Trace Element Research, 202(12), 5502-5521. https://doi.org/10.1007/s12011-024-04132-5
Ndaong, N., Foeh, N., Detha, A., Datta, F. U., & Gana, P. (2022). In vitro evaluation of anthelmintic activities of kelor (Moringa oleifera Lam) plants against gastrointestinal nematodes of indigenous goats, East Nusa Tenggara. Veterinary Practitioner, 23(1, Suppl. 1), 250–252. Retrieved from https://www.ivri.org.in/
Ni'mah, T., & Mahdalena, V. (2022). Kajian Pustaka: Potensi Ekstrak Tanaman Di Indonesia Sebagai Kandidat Antelmintik Terhadap Ascaris. MEDFARM: Jurnal Farmasi dan Kesehatan, 11(1), 78-92. https://doi.org/10.48191/medfarm.v11i1.69
Páez-León, S. Y., Carrillo-Morales, M., Gómez-Rodríguez, O., López-Guillén, G., Castañeda-Ramírez, G. S., Hernández-Núñez, E., Wong-Villarreal, A., & Aguilar-Marcelino, L. (2022). Nematicidal activity of leaf extract of Moringa oleifera Lam. against Haemonchus contortus and Nacobbus aberrans. Journal of Helminthology, 96, e13. https://doi.org/10.1017/S0022149X22000025
Parvin, S., Dey, A. R., Shohana, N. N., Talukder, M. H., & Alam, M. Z. (2024). Haemonchus contortus, an obligatory haematophagus worm infection in small ruminants: Population genetics and genetic diversity. Saudi Journal of Biological Sciences, 31(8), 104030. https://doi.org/10.1016/j.sjbs.2024.104030
Pitaksakulrat, O., Chaiyasaeng, M., Artchayasawat, A., Eamudomkarn, C., Thongsahuan, S., & Boonmars, T. (2021). The first molecular identification of benzimidazole resistance in Haemonchus contortus from goats in Thailand. Veterinary World, 14(3), 764. DOI: https://doi.org/10.14202/vetworld.2021.764-768
Putri, R. R., Ningrum, A. L. Y., Septiyani, E., & Kholik, K. (2022). Efektifitas pemberian albendazol dan ivermectin terhadap cacing saluran pencernaan sapi bali. Jurnal Ilmu dan Teknologi Peternakan, 10(2), 59-63. https://doi.org/10.20956/jitp.v10i2.19640
Priya, R. M., Sirisha, K. S., & Nagarajan, G. (2020). Phytochemical and Anthelmintic Screening of Moringa Oleifera Stemethanolic Extract. Indo-American Journal of Life Sciences and Biotechnology, 17(4), 34-43. https://doi.org/10.33394/bioscientist.v11i1.7472
Rahayu, S. (2023). Pemanfaatan Tanaman Kelor (Moringa oleifera) sebagai Obat Tradisional di Dusun Aek Kulim Mandalasena Kabupaten Labuhanbatu Selatan. Tugas_ Akhir (Artikel) Bioscientist: Jurnal Ilmiah Biologi, 11(1), 386-393. https://doi.org/10.33394/bioscientist.v11i1.7472
Ramdani, D., Yuniarti, E., Jayanegara, A., & Chaudhry, A. S. (2023). Roles of Essential Oils, Polyphenols, and Saponins of Medicinal Plants as Natural Additives and Anthelmintics in Ruminant Diets: A Systematic Review. In Animals (Vol. 13, Issue 4). https://doi.org/10.3390/ani13040767
Riyanti, S., Jariya, A., & Syahputri, E. Q. (2024). Mini Review Tinjauan Farmakognosi dan Pemanfaatan Tanaman Kelor (Moringa oleifera L.) Sebagai Antidiabetes. Majalah Farmasetika, 9(7),1-10. https://doi.org/10.24198/mfarmasetika.v9i7.59281
Sillanpää, M., Engström, M. T., Tähtinen, P., Green, R. J., Käpylä, J., Näreaho, A., & Karonen, M. (2023). Tannins Can Have Direct Interactions with Anthelmintics: Investigations by Isothermal Titration Calorimetry. Molecules, 28(13). https://doi.org/10.3390/molecules28135261
Sultana, B., Anwar, F., & Ashraf, M. (2023). Bioactive Compounds of Drumstick (Moringa oleifera Lam.). Journal of Food Science and Technology, 60(4), 1234–1245. DOI: https://doi.org/10.1007/978-3-030-30182-8_41
Tagne, M. A. F. (2021). In vitro anthelmintic properties of ethanolic extracts of Terminalia macroptera (Combretaceae) on gastrointestinal strongyles, Haemonchus contortus (Trichostrongyloidae). Journal of Experimental and Applied Tropical Biology, 1(2), 24-36. https://doi.org/10.1016/j.sajb.2023.11.053
Toklo, P. M., Ladekan, E. Y., Linden, A., Hounzangbe-Adote, S., Kouam, S. F., & Gbenou, J. D. (2021). Anthelmintic flavonoids and other com¬pounds from Combretum glutinosum Perr. ex DC (Combretaceae) leaves. Acta Crystallographica Section C: Structural Chemistry, 77. https://doi.org/10.1107/S2053229621007841
Widiarso, B. P., & Ikbar, V. (2024). Potensi Daun Bambu Petung (Dendrocalamus Asper) Terhadap Vermisidal dan Morfometri Cacing Haemonchus contortus pada Domba Ekor Gemuk Secara In Vitro: Potential of Petung Bamboo Leaves (Dendrocalamus Asper) Against Vermicidal and Morphometry of Haemonchus contortus Worms in Fat Tail Sheep In Vitro. Journal of Livestock and Animal Health, 7(1), 19-26. https://doi.org/10.32530/jlah.v7i1.45
Widiarso, B. P., Dewi, D. A., Sarwendah, K., & Pratiwi, D. E. (2021). In vitro potency of a crude aqueous extract of artocarpus heterophyllus leaves as an anthelmintic against haemonchus contortus in jawarandu goats. Adv. Anim. Vet. Sci, 9(9), 1498-1503. DOI: https://doi.org/10.17582/journal.aavs%2F2021%2F9.9.1498.1503
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