Review Article: Drug-Related Problems in Hypertensive Patients in Pharmaceutical Practice
DOI:
10.29303/jbt.v26i1.11407Published:
2026-01-26Downloads
Abstract
Hypertension is a chronic disease with a high global prevalence and often requires combination therapy, which increases the risk of Drug-Related Problems (DRPs). This review aims to identify the types of DRPs, the most frequently implicated medications, causative factors, and pharmaceutical interventions based on various studies conducted in hypertensive patients. The literature review results indicate that common DRPs include drug interactions, ineffective therapy, the need for additional therapy, adverse drug reactions (ADRs), and inappropriate medication selection. Amlodipine, candesartan, valsartan, beta-blockers, and diuretics are among the medications most frequently associated with DRPs. Polypharmacy, non-adherence, comorbidities, and inadequate monitoring are the main contributing factors. Pharmaceutical interventions such as medication review, therapy monitoring, patient counseling, and adherence to clinical guidelines have been shown to be effective in reducing DRPs. The role of pharmacists is crucial to ensure the safety and effectiveness of hypertension therapy.
Keywords:
Drug related problems Drug interactions Hypertension Polypharmacy Pharmaceutical careReferences
Anggraeni, D., Hapsari, I., & Galistiani, G. F. (2025). Kepatuhan Pasien Hipertensi dan Polifarmasi. Journal of Syntax Literate, 10(5). https://doi.org/10.36418/syntax-literate.v10i5.59095
Faisal, D. R., Lazuana, T., Ichwansyah, F., & Fitria, E. (2022). Faktor Risiko Hipertensi Pada Usia Produktif Di Indonesia Dan Upaya Penanggulangannya. Buletin Penelitian Sistem Kesehatan, 25(1), 32-41. 10.22435/hsr.v25i1.5124
Ginting, A., Saragih, H., & Sinaga, E. (2024). Gambaran Kejadian Hipertensi di Dusun III Wilayah Kerja Puskesmas Gunung Tinggi Kecamatan Pancur Batu Tahun 2023. Innovative: Journal Of Social Science Research, 4(1), 7225-7238. https://doi.org/10.31004/innovative.v4i1.8428
He, Y., Tang, W., Yanling, J., Tao, J., Zhend, Y., Huang, X., Xing, B., He, K., & Wang, X. (2025). Global Burden Of Chronic Kidney Disease Due To Hypertension (1990–2021): A Systematic Analysis Of Epidemiological Trends, Risk Factors, And Projections To 2036 From The GBD 2021 Study. BMC Nephrology, 26(448), 1–15.
Lukitaningtyas, D., & Cahyono, E. A. (2023). Hipertensi; Artikel Review. Pengembangan Ilmu Dan Praktik Kesehatan, 2(2), 100-117. https://doi.org/10.56586/pipk.v2i2.272
Mantang, A., Useng, Y., & Pusmarani, J. (2023). Hubungan Drug Related Problems (DRP) Kategori Interaksi Obat Pada Penggunaan Obat Pasien Hipertensi di Puskesmas Lalonggasumeeto Kabupaten Konawe. Jurnal Pharmacia Mandala Waluya, 2(5), 286-294. https://doi.org/10.54883/jpmw.v2i5.60
Mantang, A., Useng, Y., & Pusmarani, J. (2023). Hubungan Drug Related Problems (DRP) Kategori Interaksi Obat Pada Penggunaan Obat Pasien Hipertensi di Puskesmas Lalonggasumeeto Kabupaten Konawe. Jurnal Pharmacia Mandala Waluya, 2(5), 286-294. https://doi.org/10.54883/jpmw.v2i5.60
Mills, K. T., Stefanescu, A., & He, J. (2020). The Global Epidemiology Of Hypertension. Nature Reviews. Nephrology, 16(4), 223–237. https://doi.org/10.1038/s41581-019-0244-2
Muliana, H., Azzahra, N., & Adil, F. D. (2024). Pola Pengobatan dan Kepatuhan Mengkonsumsi Obat Antihipertensi pada Pasien Lanjut Usia. JURNAL LENTERA ILMIAH KESEHATAN, 2(1), 1-8.
Nurochman, M. A., Sudaryanto, W. T., & Debi, S. S. (2024). Penyuluhan Hipertensi Kepada Pengunjung Posyandu RW 14 Kelurahan Sumber. Cakrawala: Jurnal Pengabdian Masyarakat Global, 3(1), 126-132. https://doi.org/10.30640/cakrawala.v3i1.2122
Pratiwi, D. A. B., Fatihah, N., Murti, D. Y. S., & Fitriati, R. (2025). Gambaran pengunaan obat dan drug related problems (DRPs) pasien rawat inap dengan hipertensi. Health Sciences and Pharmacy Journal, 9(1), 1-8. https://doi.org/10.32504/hspj.v9i1.1235
Puspitasari, C. E., Widiyastuti, R., Dewi, N. M. A. R., Woro, O. Q. L., & Syamsun, A. (2022). Profil Drug Related Problems (DRPs) pada Pasien Hipertensi di Instalasi Rawat Jalan Rumah Sakit Pemerintah di Kota Mataram Tahun 2018. Jurnal Sains Dan Kesehatan, 4(1), 77–87. https://doi.org/10.25026/jsk.v4ise-1.1692
Ridwan, B. A., & Rachmah, I. M. (2023). Hubungan Kejadian Drug Related Problems (DRPs) Dengan Ketercapaian Target Tekanan Darah Pasien Hipertensi Di Puskesmas Lalonggasumeeto Kabupaten Konawe. Jurnal Farmasi Dan Kesehatan Indonesia, 3(2), 103–113.
Sari, E. T., Fadilla, N. A. F., Indriansyah, T. A. G., & Arini, L. D. D. (2025). Pengaruh Kesakitan pada Nefron Terhadap Terjadinya Penyakit Gagal Ginjal. Student Scientific Creativity Journal, 3(2), 01-14. https://doi.org/10.55606/sscj-amik.v3i2.5498
Septiani, V., Karnadi, P., Islamiyah, A. N., W., A. A. H. S., & Rudiyanti, I. (2021). Identification of Drug-Related Problems in Hypertension Comorbid Type 2 Diabetes Mellitus Patients at Primary Health Care Center Batununggal District Bandung. Borneo Journal of Pharmacy, 4(3), 229–235. https://doi.org/10.33084/bjop.v4i3.1971
Setyaningsih, I. B., Hapsari, I., & Genatrika, E. (2025). Pengaruh Konseling Apoteker pada Pasien Prolanis Hipertensi Terhadap Penurunan Tekanan Darah dan Kepatuhan Minum Obat. Syntax Literate: Jurnal Ilmiah Indonesia, 10(9), 7237–7255.
Setyaningsih, I. B., Hapsari, I., & Genatrika, E. (2025). Pengaruh Konseling Apoteker pada Pasien Prolanis Hipertensi Terhadap Penurunan Tekanan Darah dan Kepatuhan Minum Obat. Journal of Syntax Literate, 10(9). https://doi.org/10.36418/syntax-literate.v10i9.61490
Tanzil, I., Riviati, N., & Saleh, I. (2022). Korelasi Antara Polifarmasi Dengan Lama Rawat Inap Pada Pasien Geriatri Di RS Mohammad Hoesin Palembang. Jurnal Penyakit Dalam Indonesia, 8(4), 204. https://doi.org/10.7454/jpdi.v8i4.640
Wahidah, L. K., Wahyuni, N. T., & Ughfiroh, D. (2022). Identifikasi Drug Related Problems (DRPs) Penggunaan Antihipertensi Pasien Hipertensi di RSU Azzahra Kalirejo Lampung Tengah. Jurnal Farmasi Lampung, 11(1), 28–36.
Wahyudi, J. T., & Mustika, M. (2024). Self Efficacy Pencegahan Komplikasi Pada Pasien Hipertensi Di Rs Muhammadiyah Palembang: Studi Deskriptif. Jurnal Inspirasi Kesehatan, 2(2), 156-167. https://doi.org/10.52523/jika.v2i2.113
Widiyanto, A., Atmojo, J. T., Fajriah, A. S., Putri, S. I., & Akbar, P. S. (2020). Pendidikan Kesehatan Pencegahan Hipertensi. Jurnal Empathy Pengabdian Kepada Masyarakat, 1(2), 172-181. https://doi.org/10.37341/jurnalempathy.v1i2.27
World Health Organization. (2025). Hypertension. https://www.who.int/health-topics/hypertension
Wu, X., Sha, J., Yin, Q., Gu, Y., & He, X. (2025). Global Burden Of Hypertensive Heart Disease And Attributable Risk Factors, 1990-2021: Insights From The Global Burden Of Disease Study 2021. Scientific Reports, 15(1), 14594. https://doi.org/10.1038/s41598-025-99358-1
License
Copyright (c) 2026 Eti Agustiani, Keysha Nabilla Putri Marasabessy, Dhea Syafitri Dwiyanti, Ulfatul Mutthoimah, Tuhfatul Ulya
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
