Literature Review: The Potential of Soft Coral Lobophytum sp. as a Source of Pharmaceutical Ingredients
DOI:
10.29303/jbt.v26i1.11469Published:
2026-02-03Downloads
Abstract
Lobophytum sp. is a soft coral found in Indonesian waters, mainly distributed on coral reef slopes. Lobophytum sp. contains various terpenoid compounds, including sesquiterpenes and terpenoid glycosides, which have a variety of biological activities. This literature review examines the pharmacological potential of Lobophytum sp. based on ten studies reporting its pharmacological activities, such as antibacterial, antimicrobial, hepatoprotective, anti-arthritic, antioxidant, anti-inflammatory, antimalarial, and neuroprotective properties. The diterpene cembranoids in Lobophytum sp. show potential as candidate active substances for the development of pharmaceutical products through various in vitro and in vivo studies. The antioxidant activity of cembranoids has the potential to be developed as an anti-aging agent. In addition, its anti-inflammatory, antibacterial, and cytotoxic activities can be developed in the form of topical preparations. However, the development of Lobophytum sp. As a source of active ingredients still faces various challenges, especially the limited isolation of cembranoids, which requires a biotechnological approach.
Keywords:
Cembranoid diterpene Lobophytum sp. Lobophytum bioactive compounds Soft coraReferences
Arfan, Rayani, N., & Aman, L. O. (2024). Penelusuran in Silico Potensi Antimalaria dari Karang Lunak Lobophytum sp. sebagai Inhibitor Dihydroorotate Dehydrogenase dari Plasmodium falciparum. Jurnal Farmasi Galenika, 11(2), 134–151. https://doi.org/10.70410/jfg.v11i2.341
Asnah, N., Megawati, M., & Parbuntari, H. (2024). Analisis In Vitro Aktivitas Antioksidan Ekstrak Aseton dari Ranting Horsfieldia macrothyrsa Menggunakan Beragam Metode. Jurnal Sumberdaya Hayati, 10(2). https://doi.org/10.29244/jsdh.10.2.48-53
Bakhsh, H. T., Baih, D. H. A., Baih, R. H. A., Saber, E. A., Altemani, F. H., Algehainy, N. A., Alanazi, M. A., Mokhtar, F. A., Bringmann, G., Abdelmohsen, U. R., & Mordy, F. M. A. E.-M. (2024). Unveiling Lobophytum sp . the Neuroprotective Potential of Parkinson’s Disease Through Multifaceted Mechanisms , Supported by Metabolomic Analysis and Network Pharmacology. Scientific Reports, 14(21810). https://doi.org/10.1038/s41598-024-66781-9
Fonseca, S., Amaral, M. N., Reis, C. P., & Custodio, L. (2023). Marine Natural Products as Innovative Cosmetic Ingredients. Marine Drugs, 21(170), 1–23. https://doi.org/10.3390/md21030170
Fristiohady, A., Nurpajriani, N., Malaka, M. H., Muhammad, I., Pascayantri, A., Haruna, L. A., Purnama, L. O. M. J., Julian, Asasutjarit, R., Sahidin, I., & Yodha, A. W. M. (2024). In Vivo Anti-arthritic Activity of Soft Coral Lobophytum sp . From Southeast Sulawesi in Freund ’ s Complete Adjuvant Induced Arthritis. Indonesia Journal of Marine Sciences, 29(3), 385–392. https://doi.org/10.14710/ik.ijms.29.3.385-392
Hassan, M. H. A., Mohammed, R., Hetta, M. H., Abdelaziz, T. A., & Sleim, M. A. (2016). Biological and Chemical Investigation of the Soft Coral Lobophytum pauciflorum Collected from the Egyptian Red Sea. International Journal of Phrmacognosy and Phytochemical Research, 8(6), 906–911. https://www.researchgate.net/publication/304776688_Biological_and_chemical_investigation_of_the_soft_coral_lobophytum_pauciflorum_collected_from_the_Egyptian_Red_Sea
Kowal, A. L., Angkouw, E. D., Kawung, N. J., Kemer, K., Manoppo, H., & Sumilat, D. A. (2018). Potensi Aantibakteri Karang Lunak Lobophytum sp . dari Pseudomonas aeruginosa dan Staphylococcus aureus. Jurnal Ilmiah Platax, 6(2), 89–97. https://doi.org/10.35800/jip.6.2.2018.20638
Lima, Á. A. N., Koester, S., & Veiga-junior, V. F. (2021). Formulating Bioactive Terpenes. Biomolecules, 11(1745), 9–12. https://doi.org/10.3390/biom11121745
Loing, Q. N. H., Wewengkang, D. S., & Abidjulu, J. (2016). Aktivitas Antibakteri Ekstrak dan Fraksi Karang Lunak Lobophytum sp . Terhadap Bakteri Escherichia coli dan Staphylococcus aureus. PHARMACON Jurnal Ilmiah Farmasi-UNSRAT, 5(1), 115–124. https://doi.org/10.31258/jpk.25.2.151-157
Martinez, H., SANTOS, M., Pedraza, L., & Testera, A. M. (2025). Advanced Technologies for Large Scale Supply of Marine Drugs. Marine Drugs, 23(69). https://doi.org/10.3390/md23020069
Mu’nisa, A. (2023). Antioxidant Activities and Bioactive Compound in The Extract of Lobophytum sp. Journal Bionature, 24(1), 173–179. https://doi.org/10.35580/bionature.v24i1.44786
Munasari, D., Fristiohady, A., Malik, F., & Sadarun, B. (2024). Aktivitas Hepatoprotektor Ekstrak Etanol Karang Lunak Lobophytum sp. Pada Mencit Putih yang Diinduksi CCL4. Lansau: Jurnal Ilmu Kefarmasian, 2(1), 62–70. https://doi.org/10.33772/lansau.v2i1.25
Nurrachma, M. Y., Sakaraga, D., Nugraha, A. Y., Rahmawati, S. I., Bayu, A., Sukmarini, L., Atikana, A., Prasetyoputri, A., Izzati, F., Warsito, M. F., & Putra, M. Y. (2021). Cembranoids of Soft Corals: Recent Updates and Their Biological Activities. Natural Products and Bioprospecting, 11, 243–306. https://doi.org/10.1007/s13659-021-00303-2
Putra, A. W., Priawandiputra, W., Litaay, M., & Atmowidi, T. (2022). Comparison of shallow water soft coral (Octocorallia) diversity and distribution among three islands in Makassar Strait, Indonesia. Biodiversitas, 23(11), 5951–5961. https://doi.org/10.13057/biodiv/d231149
Putra, M. Y., Murniasih, T., Swasono, R. T., Wibowo, J. T., Saputri, A. N. C., Widhiana, M. R., & Shinta, A. I. (2016). Secondary Metabolites and Their Biological Activities in Indonesian Soft Coral of the Genus Lobophytum. Asian Pacific Journal of Tropical Biomedicine, 6(11), 909–913. https://doi.org/10.1016/j.apjtb.2016.08.011
Tanjung, M. J. P., Yoswaty, D., & Effendi, I. (2020). Aktivitas Antibakteri Ekstrak Karang Lunak Lobophytum sp . Terhadap bakteri patogen (Escherichia coli , Staphylococcus aureus , dan Pseudomonas aeruginosa). Jurnal Perikanan Dan Kelautan, 25(2), 151–157. https://doi.org/10.31258/jpk.25.2.151-157
Wahdaniah, Erika, M., & Purwaningsih, I. (2020). Aktivitas Antioksidan Fraksi Metanol Daun Jeringau Merah (Acorus Sp.) Metode DPPH. Jurnal Laboratorium Khatulistiwa, 4(1). https://doi.org/10.30602/jlk.v4i1.941
Wanda, E., & Sadarun, B. R. (2018). Keanekaragaman dan Kepadatan Karang Lunak Di Perairan Waworaha Kecamatan Soropia. , 3(1), 9-15. Jurnal Sapa Laut Halu Oleo, 3(1), 9–15. http://dx.doi.org/10.33772/jsl.v3i1.6504
Ke, L.-M., Zhang, Z.-R., Li, S.-W., Zeng, Y.-B., Su, M.-Z., & Guo, Y.-W. (2025). Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral Lobophytum sp. and Sponge Xestospongia sp. Marine Drugs, 23(1), 36. https://doi.org/10.3390/md23010036
Xia, Z.-Y., Sun, M.-M., Jin, Y., Yao, L.-G., Su, M.-Z., Liang, L.-F., Wang, H., & Guo, Y.-W. (2023). Lobosteroids A–F: Six New Highly Oxidized Steroids from the Chinese Soft Coral Lobophytum sp. Marine Drugs, 21(8), 457. https://doi.org/10.3390/md21080457
Zhang, D., Wang, Z., Han, X., Li, X.-L., Lu, Z.-Y., Dou, B.-B., Zhang, W.-Z., Tang, X.-L., Li, P.-L., & Li, G.-Q. (2022). Four Bioactive New Steroids from the Soft Coral Lobophytum pauciflorum Collected in South China Sea. Beilstein Journal of Organic Chemistry, 18, 374–380 https://doi.org/10.3762/bjoc.18.42
Blunt, J. W., Copp, B. R., Keyzers, R. A., Munro, M. H. G., & Prinsep, M. R. (2018). Marine natural products. Natural Product Reports, 35(1), 8–53. https://doi.org/10.1039/C7NP00052A
Carballo, J. L., & Hernández-Inda, Z. (2020). Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities. Marine Drugs, 18(613), 1–34. https://doi.org/10.3390/md18120613
Singh, G., & Reddy, A. (2021). Marine Natural Products as Emerging Resources for Drug Discovery: A Review of Recent Advances. Journal of Natural Products, 84(10), 2762–2783. https://doi.org/10.3390/md22080348
Lai, K. H., You, W. J., Lin, C. C., El-Shazly, M., & Liao, Z. J. (2017). Anti-inflammatory cembranoids from the soft coral Lobophytum crassum. Marine Drugs, 15(10), 327.
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