Antidiabetic and Antioxidant Activities of Peperomia pellucida: A Literature Review
DOI:
10.29303/jbt.v26i2.12068Published:
2026-06-30Downloads
Abstract
Diabetes mellitus is a chronic metabolic disorder marked by persistent hyperglycemia, oxidative stress, and inflammation, driving interest in natural alternatives to synthetic antidiabetic drugs such as Peperomia pellucida. This literature review synthesizes evidence from PubMed and Google Scholar (last five years) using the terms “Peperomia pellucida”, “ethanol extract”, and “diabetes mellitus”; included studies were original in vitro, in vivo, or review articles reporting phytochemical profiles, enzyme inhibition assays, glycemic outcomes, pancreatic histopathology, inflammatory markers, or antioxidant activity, while studies lacking primary data or methodological detail were excluded. Descriptive and thematic synthesis of selected papers indicates that P. pellucida consistently contains flavonoids, phenolics, alkaloids, tannins, saponins, and terpenoids, and demonstrates antidiabetic effects via α‑amylase and α‑glucosidase inhibition, reduction of blood glucose in animal models, pancreatic tissue protection, and modulation of proinflammatory cytokines, together with robust free‑radical scavenging antioxidant activity. These findings support the plant’s potential as a phytopharmaceutical candidate; however, to enable clinical translation we recommend standardized extract characterization with marker compounds, dose‑response and pharmacokinetic studies, comprehensive acute and chronic toxicity testing, mechanistic investigations in clinically relevant models, and randomized controlled trials with predefined endpoints, alongside development of quality‑control protocols and formulation studies to determine optimal delivery and dosing.
Keywords:
α-glucosidase inhibition α-amylase inhibition Blood glucose Diabetes mellitus Peperomia pellucidaReferences
Aboelmaaty M., Ak H. E., Gaddam N., Aqueel M., Ahmed M., Mirza M. S. S. & Ahmed, K. (2025). Complications of diabetes: cardiovascular, renal, and neurological implications. Journal of Advances in Medicine and Medical Research, 37(6): 103–112. DOI: https://doi.org/10.9734/jammr/2025/v37i65855
Adejori A. O., Ibitoye A. G., Henry V. A., Onifade,I. L., Anadozie S. O. & Adewale O. B. (2025). Antioxidant activity, phytochemical composition of extracts of Peperomia pellucida and its effect on Drosophila melanogaster. Abuad International Journal Natural and Applied Sciences, 5(2): 82-90. DOI: https://doi.org/10.53892.aijnas.2025.05.02.02-j.
Almira N. R., Ahidin D. & Indawati I. (2023). Phytochemicals screening and antioxidant activity test of ethyl Acetate fraction of Peperomia pellucida L. Medical Sains: Jurnal Ilmiah Kefarmasian, 8(3): 1067-1078. https:/ojs.stfmuhammadiyahcirebon.ac.id/index.php/iojs.
Arsianti A., Gill S. & Kristanty, D. (2025). Phytochemistry and antioxidant activity of ethanol, ethyl acetate, and n-hexane extracts of suruhan leaves (Peperomia pellucida). Indonesian Journal of Medical Chemistry and Bioinformatics, 4(1), Article 5. DOI: https://doi.org/10.7454/ijmcb.v4i1.1047
Babu Y. T. R., Satapathy P., Krishna C. M., Ramalakshmana J. & Padal S. B. (2023). GC-MS analysis and screening of antimicrobial potentialities of the medicinal herb Peperomia pellucida (L.) Kunth. Journal of Xidian University, 17(8). DOI: https://doi.org/10.37896/jxu17.8/118
Banday M. Z., Sameer A. S. & Nissar, S. (2020). Pathophysiology of diabetes: an overview. Avicenna Journal of Medicine, 10(04): 174–188. DOI: https://doi.org/10.4103/ajm.ajm_53_20
Blahova J., Martiniakova M., Babikova M., Kovacova V., Mondockova V. & Omelka, R. (2021). Pharmaceutical drugs and natural therapeutic products for the treatment of type 2 diabetes mellitus. Pharmaceuticals, 14(8): 806. DOI: https://doi.org/10.3390/ph14080806.
Caturano A., D’Angelo M., Mormone A., Russo, V., Mollica M. P., Salvatore T., Galiero R., Rinaldi L., Vetrano E., Marfella R., Monda M., Giordano A. & Sasso, F. C. (2023). Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications. Current issues in molecular biology, 45(8): 6651–6666. DOI: https://doi.org/10.3390/cimb45080420
Dirir A. M., Daou M., Yousef A. F. & Yousef L. F. (2022). A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes. Phytochemistry Reviews, 21(4): 1049–1079. DOI: https://doi.org/10.1007/s11101-021-09773-1
Fadipe A. O., Adeosun G., Oyedeji O., Ogunleye O. & Adegbenro, M. (2024) Antidiabetic and anti-inflammatory properties of some selected plant leaves: a transcriptomic approach. Sokoto Journal of Medical Laboratory Science; 9(4): 40 – 53. DOI: https://doi.org/10.4314/sokjmls.v9i4.5
Hakim E. P., Siahaan J. M., Anto E. J. & Eyanoer, P. C. (2024). Effect of ethanol extract of suruhan leaves (Peperomia pellucida L. Kunth) on blood sugar levels and macroscopic wounds in male white rats of the wistar strain (Rattus norvegicus) diabetic ulcer model. Indonesian Journal of Medicine, 9(2): 192-206. DOI: https://doi.org/10.26911/theijmed.2024.9.2.733
Hendra R., Army M. K., Frimayanti N., Teruna H. Y., Abdulah R. & Nugraha A. S. (2024). α-glucosidase and α-amylase inhibitory activity of flavonols from Stenochlaena palustris (Burm.f.) Bedd. Saudi Pharmaceutical Journal, 32(2): 101940. DOI: https://doi.org/10.1016/j.jsps.2023.101940
Hidayati S., Agustin A. T., Sari E. K., Sari S. M., Destiawan R. A. & Silvana W. A. (2023). Phytochemical profiling and antidiabetic evaluation of Peperomia pellucida as a potential alpha glucosidase inhibitor. Biodiversitas Journal of Biological Diversity, 24(11). DOI: https://doi.org/10.13057/biodiv/d241116
Hidayati S., Shinta Mayasari S., Setyaningrum L., Wardani A. D. & Aini Q. (2022). In vitro antidiabetic activity of Peperomia pellucida extract and fraction by alpha-amylase inhibition pathway. Pharmaciana, 12(2): 156. DOI: https://doi.org/10.12928/pharmaciana.v12i2.21874
Hussain, A. (2025). Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus. Cardiovascular Diabetology – Endocrinology Reports, 11(1): 39. DOI: https://doi.org/10.1186/s40842-025-00247-3
Ibe–Diala J. C. & Igwe O. U. (2022). Phytochemical composition and antioxidant activity screening of chloroform leaves extract of man-to-man (Peperomia pellucida) Harvested from Umunomo Ihitteafoukwu in imo State, South Eastern Nigeria. J. Appl. Sci. Environ. Manage, 26 (12): 2067-2074. DOI: https://doi.org/10.4314/jasem.v26i12.22
International Diabetes Federation (IDF). (2025). IDF Diabetes Atlas (10th edition): Global diabetes data and projections. https://diabetesatlas.org (Accessed on 05 May, 2026)
Maryana H. D., Nainggolan H. & Hanifa N. R. (2024). Effect of suruhan leaves (Peperomia pellucida l. kunth) extract on triglyceride blood level in diabetic rats. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 11(1): 53-60. DOI: https://doi.org/10.20473/jfiki.v11i12024.53-60
Men T. T., Tu L. T. K., Anh N. T. K., Phien H. H., Nhu N. T. B., Uyen N. T. T., Thu N. T. A., Quy T. N. & Khang, D. T. (2022). Antioxidant and in vitro antidiabetic activities of Peperomia pellucida (L.) Kunth extract. Veterinary Integrative Sciences, 20(3): 683 - 693. DOI: https://doi.org/10.12982/VIS.2022.052.
Norisham N. S., Mulfazir F. H. M., Zulpakar M. Z. F. P., Paharudin L. N. H., Shaffie A. H., Adnan L. A., Ngadi E. & Ahmad R. (2023). Functional group and phytochemical properties detection of Peperomia pellucida leaves extract. Asian Journal of Fundamental and Applied Sciences, 4(4): 1–9. DOI: https://doi.org/10.55057/ajfas.2023.4.4.1
Sadik F., Anwar M. & Nasir M. (2025). The antioxidant activity of ethanol extract of Chinese betel leaf (Peperomia pellucida) using the DPPH method with potential as an antidiabetic agent. Jurnal βeta Kimia, 5(1): 28-36. DOI: https://doi.org/10.35508/jbk.v5i1.21159
Saini A., Benjamin M. A. Z., Rusdi N. A., Aziz A. H. A. & Awang, M. A. (2025). Effect of natural deep eutectic solvents and conventional solvents on extraction yield, antioxidant activity, and toxicity of Peperomia pellucida (L.) Kunth. Malaysian Journal of Science, 44 (1): 34-41. DOI: https//doi.org/10.22452/mjs.vol44no1.5.
Silalahi, M. (2022). Peperomia pellucida (L.) Kunth: traditional medicinal and its bioactivity. World Journal of Biology Pharmacy and Health Sciences, 9(3): 060–066. DOI: https://doi.org/10.30574/wjbphs.2022.9.3.0057
Oktavia R., Anto E. J., & Siahaan J. M. (2025). Antidiabetic and anti-inflammatory effects of Peperomia pellucida leaf extract: modulation of blood glucose, il-1β, and pancreatic histopathology in stz-induced diabetic rats. Indonesian Journal of Medicine, 10(3): 229–236. DOI: https://doi.org/10.26911/theijmed.2025.10.3.870.
Pagasian J. A., Abrajano S. M. M., Serenom J. K. L. & Saldo, I. J. P. (2025). Phytochemical analysis and antioxidant capacity of ulasimang bato (Peperomia pellucida) leaf extracts. International Journal of Medicinal Plants and Natural Products, 11(1): 1-8. DOI: https://doi.org/10.20431/2454- 7999.1101001.
Phong H. Q., Thuyen N. T. B., Tran Thanh Men T. T., Dat N. V., Thong L. P., Quoc L. K., Nhu H. & Huong H. L. (2025). Effect of extraction solvents on yield, chemical composition and antioxidant activity of Peperomia pellucida (l.) kunth seed extract. CTU Journal of Innovation and Sustainable Development, 17(2025): 75-80. DOI: https://doi.org/10.22144/ctujoisd.2025.010
Saeedi P., Petersohn I., Salpea P., Malanda B., Karuranga S., Unwin N., Colagiuri S., Guariguata L., Motala A. A., Ogurtsova K., Shaw J. E., Bright D. & Williams R. (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the international diabetes federation diabetes atlas, 9th edition. Diabetes Research and Clinical Practice, 157: 107843. DOI: https://doi.org/10.1016/j.diabres.2019.107843
Saepudin S. & Susilawati Y. (2022). Alpha-glucosidase inhibitor activities and phytochemicals screening of the peperomia genus cultivated in indonesia. International Journal of Applied Pharmaceutics, 117–122. DOI: https://doi.org/10.22159/ijap.2022.v14s5.23
Sari G. K. (2025). Identification of chemical compounds of 70% ethanol extract of chinese betel leaves (Peperomia pellucida) from Blora Regency. Journal of Health Management and Pharmacy Exploration, 2(2): 57-66. DOI: https://doi.org/10.52465/johmpe.v2i2.441
Sheikh S., Sikder S., Paul S. K., Hasan A. M. R., Rahaman M. M. & Kundu, S. P. (2013). Hypoglycemic, anti-inflammatory and analgesic activity of Peperomea pellucida (L.) Hbk (Piperaceae). Int J Pharm Sci Res, 4(1): 458-463. DOI: http://dx.doi.org/10.13040/IJPSR.0975-8232.4(1).458-63
Susilawati, Y., Indradi, R. B., Asnawi, A. & Febrina, E. (2024). Molecular docking and dynamics studies of 8,9-dimethoxy ellagic acid contained in Peperomia pellucida (L.) Kunth against various diabetes mellitus receptors. Journal of Pharmacy & Pharmacognosy Research, 12(5): 929–942. DOI: https://doi.org/10.56499/jppres23.1936_12.5.929
Teodhora, Hendriani R., Sumiwi S. & Levita J. (2026). Nutritional and phytochemical compositions of Peperomia pellucida (L). Kunth from Bogor, West Java, indonesia, and its hypoglycemic effects in normoglycemic sprague-dawley rats subjected to an acute glucose load. Journal of Experimental Pharmacology, 18: 1–26. DOI: https://doi.org/10.2147/JEP.S566863
Teruna H. Y., Hendra R. & Almurdani, M. (2022). α-glucosidase inhibitory activities of Loranthus ferrugineus and Peperomia pellucida extracts. Pharmacy Education, 22(2): 5–8. DOI: https://doi.org/10.46542/pe.2022.222.58
Tuan C. T. & Men, T. T. (2024). Peperomia pellucida ’s ingredients, antioxidant properties, and safe usage as food and herbal medicine. Journal of Microbiology and Biotechnology, 34(11): 2321–2330. DOI: https://doi.org/10.4014/jmb.2406.06025
World Health Organization (WHO). (2024). Diabetes fact sheet. https://www.who.int/news-room/fact-sheets/detail/diabetes (Accessed on 05 May, 2026)
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