Relationship Between C-Reactive Protein Levels and Leucocytes Counts in Typhoid Fever Pediatric Patients
DOI:
10.29303/jbt.v26i3.12813Published:
2026-08-03Downloads
Abstract
Typhoid fever was an infectious disease caused by Salmonella enterica serovar Typhi and Enteritidis. Laboratory tests most commonly performed in cases of typhoid fever included leukocyte count and C-reactive protein (CRP) measurement. Leukocytes played a role in the immune response to infection, while CRP increased as a result of the inflammatory response and was therefore used as an indicator of disease activity. This research intended to examine the correlation amongst C-reactive protein (CRP) levels and leukocyte count in pediatric patients with typhoid fever. This was an observational analytic descriptive study with a cross-sectional design. The study sample consisted of CRP levels and leukocyte count results obtained from the medical records of 84 pediatric patients aged 6 to 17 years diagnosed with typhoid fever at RSIA Brawijaya Duren Tiga during the period of July to December 2025, selected utilizing a purposive sampling technique. The findings of univariate and bivariate analyses showed that most pediatric typhoid patients were female, totalling 48 (57%) children, and the longest duration of fever was 7 days, observed in 53 (63%) children. The most common CRP finding was abnormal levels in 46 (55%) children, with the highest level reaching 168.80 mg/L. The leukocyte count was most commonly within the normal range in 44 (52%) children. Correlation test results indicated a significant correlation amongst CRP levels and leukocyte count, with a moderately strong positive correlation, as evidenced by a significance value of 0.002 and a correlation coefficient of r = 0.326.
Keywords:
C-Reactive Protein Leucocytes counts Typhoid FeverReferences
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