Association of Patient Characteristics and Polypharmacy with the Potential for Drug Interactions among Hypertensive Patients at Bakunase Community Health Center
DOI:
10.29303/jbt.v26i3.12884Published:
2026-07-29Downloads
Abstract
Chronic hypertension frequently has comorbidities, necessitating the use of several drugs (polypharmacy), which raises the possibility of drug interactions. This study aimed to determine the prevalence of polypharmacy, potential drug interactions, and the association between patient characteristics, polypharmacy, and potential drug interactions among hypertensive patients at Bakunase Primary Health Center. 572 hypertensive patients' medical data from January to December 2025 were used in this analytical observational study, which used a retrospective cross-sectional approach. Drugs.com® and Medscape® were used to identify potential drug interactions, and the Chi-square test was used to evaluate the results. According to the findings, 32.3% of patients had polypharmacy and 63.7% of patients had possible drug interactions. While polypharmacy was substantially linked to possible drug interactions (p = 0.001), age was significantly linked to both polypharmacy and potential drug interactions (p = 0.003). We conclude that among hypertension patients, age and polypharmacy are strongly linked to a higher likelihood of possible medication interactions.
Keywords:
Antihypertensive Drugs Drug Interactions Hypertension PolypharmacyReferences
Abuelazm, M., Ali, S., Saleh, O., Badr, A., Altobaishat, O., AlBarakat, M. M., ... & Abdelazeem, B. (2023). The safety and efficacy of quadruple ultra-low-dose combination (quadpill) for hypertension treatment: a systematic review and meta-analysis of randomized controlled trials. Clinical Drug Investigation, 43(11), 813-826. https://doi.org/10.1007/s40261-023-01313-3
Avula, A., Johal, L. K., Ali, F., Amir, S., Yadav, Avula, A., Johal, L. K., Ali, F., Amir, S., Yadav, S., Murtuza, M., ... & Khan, R. (2025). ACE Inhibitors and ARBs in Chronic Kidney Disease: A Systematic Review of Randomized Controlled Trials on Albuminuria Reduction, eGFR Decline, and Safety. Cureus, 17(10). https://doi.org/10.7759/cureus.93707
Baxter, K., & Preston, C. L. (Eds.). (2010). Stockley's drug interactions (9th ed.). Pharmaceutical Press.
Bulqiah, A., Ardiana, S. M., Suprapti, K. B., & Alsagaff, M. Y. (2023). Penggunaan obat pada pasien hipertensi rawat jalan. Jurnal Kesehatan, 6(2), xx–xx.
Dhrik, M., Prasetya, A. A. N. P. R., & Ratnasari, P. M. D. (2023). Analisis hubungan pengetahuan terkait hipertensi dengan kepatuhan minum obat dan kontrol tekanan darah pada pasien hipertensi. Jurnal Ilmiah Medicamento, 9(1), 70–77.
DiPiro, J. T., Yee, G. C., Posey, L. M., Haines, S. T., Nolin, T. D., & Ellingrod, V. L. (2015). Pharmacotherapy handbook (9th ed.). McGraw-Hill Education.
Hall, J. E., & Hall, M. E. (2021). Guyton and Hall textbook of medical physiology (14th ed.). Elsevier.
Hamadouk, R. M., Alshareif, E. M., Hamad, H. M., & Yousef, B. A. (2023). The prevalence and severity of potential drug–drug interactions in internal medicine ward at Soba Teaching Hospital. Drug, Healthcare and Patient Safety, 15, 149–157. https://doi.org/10.2147/DHPS.S436458
Hengky, A. (2023). Single pill combination sebagai lini pertama terapi hipertensi dan proteksi kardiovaskular. Cermin Dunia Kedokteran, 50(2), 108–112.
Kario, K., Okura, A., Hoshide, S., & Mogi, M. (2024). The WHO global report 2023 on hypertension: Warning the emerging hypertension burden in the globe and its treatment strategy. Hypertension Research, 47, 1099–1102. https://doi.org/10.1038/s41440-024-01622-w
Kementerian Kesehatan Republik Indonesia. (2021). Pedoman nasional pelayanan kedokteran tata laksana hipertensi dewasa.
Kementerian Kesehatan Republik Indonesia. (2024). Buku pedoman praktik hipertensi di fasilitas kesehatan tingkat pertama (PPH FKTP).
Kementerian Kesehatan Republik Indonesia. (2025). Pedoman nasional pelayanan klinis tata laksana osteoartritis.
Kidney Disease: Improving Global Outcomes. (2024). KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease.
Lia Amalia, Irma, Abdulkadir, W. S., Gustin, R. K., Rasdianah, et al. (2023). Epidemiologi penyakit tidak menular. CV Eureka Media Aksara.
Lukito, A. A., Harmeiwaty, E., & Umami, V. (Eds.). (2018). Konsensus penatalaksanaan hipertensi. Perhimpunan Dokter Hipertensi Indonesia.
Mair, A., Fernandez-Llimos, F., Alonso, A., Harrison, C., Hurding, S., Kempen, T., ... & Simpathy Consortium. (2017). Polypharmacy management by 2030: a patient safety challenge.
Mancia, G., Kreutz, R., Brunström, M., Burnier, M., Grassi, G., Januszewicz, A., et al. (2023). 2023 ESH guidelines for the management of arterial hypertension. Journal of Hypertension, 41(12), 1874–2071. https://doi.org/10.1097/HJH.0000000000003480
Mantang, A., Useng, Y., & Pusmarani, J. (2023). Hubungan drug-related problems kategori interaksi obat pada penggunaan obat pasien hipertensi di Puskesmas Lalonggasumeeto Kabupaten Konawe. Jurnal Pharmacia Mandala Waluya, 2(5), 286–294. https://doi.org/10.54883/jpmw.v2i5.60
Midão, L., Giardini, A., Menditto, E., Kardas, P., Costa, E., Oliveira, J. A., Fernandez-Llimos, F., & Costa, F. A. (2022). Prevalence and factors associated with polypharmacy: A systematic review and meta-analysis. BMC Geriatrics, 22, 601. https://doi.org/10.1186/s12877-022-03279-x
Nwia, S. M., Leite, A. P. O., Li, X. C., & Zhuo, J. L. (2023). Sex differences in the renin–angiotensin–aldosterone system and its roles in hypertension, cardiovascular, and kidney diseases. Frontiers in Cardiovascular Medicine, 10, Article 1198090. https://doi.org/10.3389/fcvm.2023.1198090
Polónia, J. (1997). Interaction of antihypertensive drugs with anti-inflammatory drugs. Cardiology, 88(Suppl. 3), 47–51. https://doi.org/10.1159/000177507
Setiadi, A. P., Febriandini, A., Trinanda, E., Aryaguna, W., Chusna, I. M., Nurlaili, Y., Sunderland, B., & Wibowo, Y. I. (2022). Knowing the gap: Medication use, adherence and blood pressure control among patients with hypertension in Indonesian primary care settings. PeerJ, 10, e13171. https://doi.org/10.7717/peerj.13171
Sumartin, Y., & Sukandar, E. Y. (2024). Studi interaksi obat-obat jantung yang dilakukan terhadap orang sehat: Tinjauan sistematis. Kartika: Jurnal Ilmiah Farmasi, 9(2), 128–146. https://doi.org/10.26874/kjif.v9i2.669
Suwarsi, S., Arsyad, A., Sari, W., Yusnidar, A., Helmizar, R., Yenny, S. W., ... & Birman, Y. (2025). Fisiologi Usia Lanjut. CV Eureka Media Aksara.
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