Vol. 26 No. 4 (2026): in Progress
Open Access
Peer Reviewed

Early Pain and Functional Recovery Following Endoscopic Lumbar Discectomy for Lumbar Disc Herniation: A Systematic Review

Authors

Ni Putu Ayu Sanchita Ardyani , Atiella Denisa Puriarta Lazuara

DOI:

10.29303/jbt.v26i4.12970

Published:

2026-10-15

Downloads

Abstract

Lumbar disc herniation (LDH) is a common cause of low back and radicular pain that may require surgery when conservative treatment fails. This systematic review evaluated early postoperative pain and functional outcomes following endoscopic lumbar discectomy (ELD) compared with conventional discectomy or other surgical approaches. The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. PubMed/MEDLINE, ScienceDirect, Springer Nature, and Scopus were searched for English-language studies published between August 31, 2016, and August 31, 2026. Eligible studies involved adults with primary LDH undergoing transforaminal ELD and assessed pain and/or function using the Visual Analog Scale (VAS) or Oswestry Disability Index (ODI) within three months after surgery. Risk of bias was assessed using the Cochrane Risk of Bias 2 tool. Owing to clinical and methodological heterogeneity, findings were synthesized narratively. Five randomized controlled trials involving 1,720 participants were included. All reported early improvements in pain and/or function, although between-group differences varied. Some trials found greater early functional improvement with ELD, particularly in ODI, whereas others reported outcomes comparable to conventional discectomy. All trials raised some concerns regarding risk of bias. ELD was associated with early postoperative improvement; however, its superiority over conventional discectomy remains inconclusive. Further multicenter randomized trials using standardized outcome measures and follow-up protocols are warranted.

 

Keywords:

Endoscopic lumbar discectomy Functional recovery Lumbar disc herniation Transforaminal endoscopic discectomy Postoperative pain Systematic review

References

Ali, R., Hagan, M. J., Bajaj, A., Alastair Gibson, J. N., Hofstetter, C. P., Waschke, A., Lewandrowski, K.-U., & Telfeian, A. E. (2023). Impact of the learning curve of percutaneous endoscopic lumbar discectomy on clinical outcomes: a systematic review. Interdisciplinary Neurosurgery, 32, 101738. https://doi.org/10.1016/j.inat.2023.101738

Beighley, A., Zhang, A., Huang, B., Carr, C., Mathkour, M., Werner, C., Scullen, T., Kilgore, M. D., Maulucci, C. M., Dallapiazza, R. F., & Kalyvas, J. (2022). Patient-Reported Outcome Measures in Spine Surgery: A Systematic Review. Journal of Craniovertebral Junction and Spine, 13(4), 378–389. https://doi.org/10.4103/jcvjs.jcvjs_101_22

Bratescu, R., Robayo, A., Wang, E., Ikwuegbuenyi, C. A., Chung, L. K., Willett, N., Demetriades, A. K., Lee, S. H., & Härtl, R. (2026). Socioeconomic Implications of Recurrent Lumbar Disc Herniation: A Narrative Review. Neurospine, 23(1), 94–108. https://doi.org/10.14245/ns.2551644.822

Cai, B.-T., Yang, F., & Wang, D.-C. (2025). Is Endoscopic Surgery a Safe and Effective Treatment for Lumbar Disc Herniation? A Meta-Analysis of Randomized Controlled Trials. Global Spine Journal, 15(3), 1855–1868. https://doi.org/10.1177/21925682241299326

Charron, B., Ross, M., & Thornley, P. (2025). Patient-Reported Outcomes Measures in Spine Surgery. Current Reviews in Musculoskeletal Medicine, 18(11), 491–503. https://doi.org/https://doi.org/10.1007/s12178-025-09981-8

Costa, F., Oertel, J., Zileli, M., Restelli, F., Zygourakis, C. C., & Sharif, S. (2024). Role of Surgery in Primary Lumbar Disk Herniation: WFNS Spine Committee Recommendations. World Neurosurgery: X, 22. https://doi.org/10.1016/j.wnsx.2024.100276

Gadjradj, P. S., Rubinstein, S. M., Peul, W. C., Depauw, P. R., Vleggeert-Lankamp, C. L., Seiger, A., van Susante, J. L. C., de Boer, M. R., van Tulder, M. W. & Harhangi, B. S. (2022). Full Endoscopic Versus Open Discectomy for Sciatica: Randomised Controlled Non-Inferiority Trial. BMJ, 376, e065846. https://doi.org/10.1136/bmj-2021-065846

Gao, X., Tang, K., Xia, Y., Zhang, X., Wang, K., Yan, Z., Du, Y., & Chen, L. (2020). Efficacy Analysis of Percutaneous Endoscopic Lumbar Discectomy Combined with PEEK Rods for Giant Lumbar Disc Herniation: A Randomized Controlled Study. Pain Research and Management, 2020. https://doi.org/10.1155/2020/3401605

Gibson, J. N. A., Subramanian, A. S. & Scott, C. E. H. (2017). A Randomised Controlled Trial of Transforaminal Endoscopic Discectomy vs Microdiscectomy. European Spine Journal, 26(3), 847–856. https://doi.org/10.1007/s00586-016-4885-6

Jitpakdee, K., Liu, Y., Kotheeranurak, V., & Kim, J. S. (2023). Transforaminal Versus Interlaminar Endoscopic Lumbar Discectomy for Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Global Spine Journal, 13(2), 575–587. https://doi.org/10.1177/21925682221120530

Kandeel, M. M., Yousef, M. G. A. K., Saoud, A. M. F., & Abu-Elghait, Z. H. I. (2024). Percutaneous Full-Endoscopic Transforaminal Discectomy Versus Open Microdiscectomy in The Treatment of Lumbar Disc Herniation: Randomized Controlled Trial. Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 60(1). https://doi.org/10.1186/s41983-024-00788-x

Kapetanakis, S., Chatzivasiliadis, M., Gkantsinikoudis, N., & Pazarlis, K. (2025). Full-Endoscopic Lumbar Discectomy: A Review of the Surgical Techniques, Indications and Anatomical Considerations. Journal of Clinical Medicine, 14(24). https://doi.org/https://doi.org/10.3390/jcm14248961

Li, W. S., Yan, Q., & Cong, L. (2022). Comparison of Endoscopic Discectomy Versus Non-Endoscopic Discectomy for Symptomatic Lumbar Disc Herniation: A Systematic Review and Meta-Analysis. Global Spine Journal, 12(5), 1012–1026. https://doi.org/10.1177/21925682211020696

Lian, X., Chen, Z., Wang, X., Cui, X., Zhang, G., & Xu, J. (2022). Randomized Controlled Trial Transforaminal Versus Interlaminar Approach of Full-Endoscopic Lumbar Discectomy Under Local Anesthesia for L5/S1 Disc Herniation: A Randomized Controlled Trial. Pain Physician Journal, 25, E1191–E1198. www.painphysicianjournal.com

Meyer, G., da Rocha, I. D., Cristante, A. F., Marcon, R. M., Coutinho, T. P., Torelli, A. G., Petersen, P. A., Letaif, O. B., & de Barros Filho, T. E. P. (2020). Percutaneous Endoscopic Lumbar Discectomy Versus Microdiscectomy for The Treatment of Lumbar Disc Herniation: Pain, disability, and Complication Rate-A randomized Clinical Trial. International Journal of Spine Surgery, 14(1), 72–78. https://doi.org/10.14444/7010

Patel, T., Farhan, M., Nashaat Hamza, D., Daneshpazhouh, M., Nahar, O. Al, Serafy, A. El, Mohamed Hasan, A. G., Bnaian, L., Ali, M. H., & Sobhi, A. (2025). Comparative Effectiveness of Minimally Invasive Endoscopic Discectomy Versus Conventional Surgical Techniques for Lumbar Disc Herniation: A Systematic Review and Meta-analysis. Annals of Medicine & Surgery, 87(10), 6661–6674. https://doi.org/http://dx.doi.org/10.1097/MS9.0000000000003689

Sharma, M., Chhawra, S., Jain, R. & Singh, G. (2024). Full Transforaminal Endoscopic Discectomy Versus Microlumbar Discectomy for Lumbar Disc Herniation: 2-Year Results. Indian Spine Journal, 7(1), 50–58. https://doi.org/10.4103/isj.isj_25_23

Tao, X.-Z., Jing, L. & Li, J.-H. (2018). Therapeutic Effect of Transforaminal Endoscopic Spine System in the Treatment of Prolapse of Lumbar Intervertebral Disc. European Review for Medical and Pharmacological Sciences, 22(1 Suppl), 103–110.

Young, K., Steinhaus, M., Gang, C., Vaishnav, A., Jivanelli, B., Lovecchio, F., Qureshi, S., McAnany, S., Kim, H. J., & Iyer, S. (2021). The Use of Patient-Reported Outcomes Measurement Information System in Spine: A Systematic Review. International Journal of Spine Surgery, 15(1), 186–194. https://doi.org/https://doi.org/10.14444/8024

Yue, L., Zhang, F., Mu, G., Shang, M., Lin, Z., & Sun, H. (2023). Effectiveness and Safety of Intrathecal Morphine for Percutaneous Endoscopic Lumbar Discectomy Under Low-Dose Ropivacaine: A Prospective, Randomized, Double-Blind Clinical Trial. The Spine Journal, 23(7), 954–961. https://doi.org/10.1016/j.spinee.2023.03.001

Author Biographies

Ni Putu Ayu Sanchita Ardyani, Universitas Mataram

Author Origin : Indonesia

Atiella Denisa Puriarta Lazuara, Universitas Mataram

Author Origin : Indonesia

Downloads

Download data is not yet available.

How to Cite

Ardyani, N. P. A. S., & Lazuara, A. D. P. (2026). Early Pain and Functional Recovery Following Endoscopic Lumbar Discectomy for Lumbar Disc Herniation: A Systematic Review. Jurnal Biologi Tropis, 26(4), 614–625. https://doi.org/10.29303/jbt.v26i4.12970