Vol. 26 No. 4 (2026): in Progress
Open Access
Peer Reviewed

Sleep Disorders in Adolescents and Their Impact on Mental Health: A Literature Review

Authors

Fiyna ’Alyatun Afifah , Rafi Radityo Daniswara , Alia Alia , Aisya Ayudia Azharani

DOI:

10.29303/jbt.v26i4.13227

Published:

2026-09-28

Downloads

Abstract

Adolescent development is a critical period marked by intensive neurobiological maturation, particularly in the prefrontal cortex and limbic system. Concurrently, sleep architecture undergoes physiological changes, making sleep quality inherently fragile and increasing vulnerability to chronic sleep deprivation. This narrative literature review aims to comprehensively examine adolescent brain maturation, sleep characteristics, the bidirectional relationship between sleep disruption and psychiatric disorders, as well as therapeutic interventions. Based on a review of literature published between 2016 and 2026 retrieved from databases such as PubMed, ScienceDirect, and Google Scholar, sleep deprivation and irregular sleep patterns (social jetlag) are significantly associated with structural brain alterations. These include reduced grey matter volume in the prefrontal cortex, amygdala, and hippocampus, along with disrupted fronto-limbic functional connectivity. Such neurostructural changes impair emotional regulation, executive function, and impulse control. Clinically, sleep disturbances-particularly insomnia-act as bidirectional risk factors and transdiagnostic markers for anxiety, depression, substance abuse, and heightened suicidality in adolescents. Non-pharmacological interventions, specifically Cognitive BehavioralTherapy for Insomnia (CBT-I), demonstrate high efficacy in restoring sleep continuity while simultaneously mitigating psychiatric symptoms. In conclusion, sleep is a clinically relevant marker of adolescent well-being and a modifiable target for early interventionand prevention of adolescent mental health disorders.

Keywords:

Adolescent sleep Insomnia Mental health Brain development Neurobiology

References

Alimoradi, Z., Jafari, E., Broström, A., Ohayon, M. M., Lin, C.-Y., Griffiths, M. D., Blom, K., Jernelöv, S., Kaldo, V., & Pakpour, A. H. (2022). Effects of cognitive behavioral therapy for insomnia (CBT-I) on quality of life: A systematic review and meta-analysis. Sleep Medicine Reviews, 64, 101646. https://doi.org/10.1016/j.smrv.2022.101646

Alvaro, P. K., Roberts, R. M., Harris, J. K., & Bruni, O. (2017). The direction of the relationship between symptoms of insomnia and psychiatric disorders in adolescents. Journal of Affective Disorders, 207, 167–174. https://doi.org/10.1016/j.jad.2016.08.032

Amelia, B., & Annisa, F. (2022). Gambaran sleep hygiene pada usia remaja. Jurnal Ilmiah Kesehatan Keris Husada, 6(2), 211–213.

Baena, D., Toor, B., Ray, L., Smith, D., Kong, P., Lopez, J., Hoffmann, R., Bertram, H., Robillard, R., Armitage, R., & Fogel, S. (2023). Sleep spindles in adolescents with major depressive disorder. Journal of Affective Disorders, 344, 535–545. https://doi.org/10.1016/j.jad.2023.10.039

Blake, M. J., Trinder, J. A., & Allen, N. B. (2018). Mechanisms underlying the association between insomnia, anxiety, and depression in adolescence: Implications for behavioral sleep interventions. Clinical Psychology Review, 63, 25–40. https://doi.org/10.1016/j.cpr.2018.05.006

Casement, M. D., Keenan, K. E., Hipwell, A. E., Guyer, A. E., & Forbes, E. E. (2016). Neural reward processing mediates the relationship between insomnia symptoms and depression in adolescence. Sleep, 39(2), 439–447. https://doi.org/10.5665/sleep.5460

Caspi, A., Houts, R. M., Ambler, A., Danese, A., Elliott, M. L., Hariri, A., Harrington, H., Hogan, S., Poulton, R., Ramrakha, S., Rasmussen, L. J. H., Reuben, A., Richmond-Rakerd, L., Sugden, K., Wertz, J., Williams, B. S., & Moffitt, T. E. (2020). Longitudinal assessment of mental health disorders and comorbidities across 4 decades among participants in the Dunedin birth cohort study. JAMA Network Open, 3(4), e203221. https://doi.org/10.1001/jamanetworkopen.2020.3221

Castelnovo, A., D’Agostino, A., Mayeli, A., Albantakis, L., Tononi, G., & Ferrarelli, F. (2025). Sleep spindle abnormalities as neurophysiological biomarkers of schizophrenia spectrum disorders: From cellular mechanisms and neural circuits to clinical implications. Biological Psychiatry, 98(11), 809–818. https://doi.org/10.1016/j.biopsych.2025.06.014

Chaput, J.-P., & Dutil, C. (2016). Lack of sleep as a contributor to obesity in adolescents: Impacts on eating and activity behaviors. International Journal of Behavioral Nutrition and Physical Activity, 13, 103. https://doi.org/10.1186/s12966-016-0428-0

Chiu, H.-Y., Lee, H.-C., & Chen, P.-Y. (2018). Associations between sleep duration and suicidality in adolescents: A systematic review and dose–response meta-analysis. Sleep Medicine Reviews, 42, 119–126. https://doi.org/10.1016/j.smrv.2018.07.003

Comsa, M., Anderson, K. N., Sharma, A., Yadav, V. C., & Watson, S. (2022). The relationship between sleep and depression and bipolar disorder in children and young people. BJPsych Open, 8, e27. https://doi.org/10.1192/bjo.2021.1076

Delahoyde, M.-K., Tyack, C., Kugarajah, S., & Joseph, D. (2024). Insomnia and other sleep disorders in adolescence. BMJ Paediatrics Open, 8, e001229. https://doi.org/10.1136/bmjpo-2021-001229

Dimitriades, M. E., Markovic, A., Gefferie, S. R., Buckley, A., Driver, D. I., Rapoport, J. L., Nosadini, M., Rostasy, K., Sartori, S., Suppiej, A., Kurth, S., Franscini, M., Walitza, S., Huber, R., Tarokh, L., Bölsterli, B. K., & Gerstenberg, M. (2023). Sleep spindles across youth affected by schizophrenia or anti-N-methyl-D-aspartate-receptor encephalitis. Frontiers in Psychiatry, 14, 1055459. https://doi.org/10.3389/fpsyt.2023.1055459

Galván, A. (2020). The need for sleep in the adolescent brain. Trends in Cognitive Sciences, 24(1), 79–89. https://doi.org/10.1016/j.tics.2019.11.002

Gregory, A. M., & Sadeh, A. (2016). Annual research review: Sleep problems in childhood psychiatric disorders—A review of the latest science. Journal of Child Psychology and Psychiatry, 57(3), 296–317. https://doi.org/10.1111/jcpp.12469

Hedin, G., Norell-Clarke, A., Hagell, P., Tønnesen, H., Westergren, A., & Garmy, P. (2020). Insomnia in relation to academic performance, self-reported health, physical activity, and substance use among adolescents. International Journal of Environmental Research and Public Health, 17(17), 6433. https://doi.org/10.3390/ijerph17176433

Henderson, S. E. M., Brady, E. M., & Robertson, N. (2019). Associations between social jetlag and mental health in young people: A systematic review. Chronobiology International, 36(10), 1316–1333. https://doi.org/10.1080/07420528.2019.1636813

Hickman, R., D’Oliveira, T. C., Davies, A., & Shergill, S. (2024). Monitoring daily sleep, mood, and affect using digital technologies and wearables: A systematic review. Sensors, 24(14), 4701. https://doi.org/10.3390/s24144701

Jamieson, D., Broadhouse, K. M., Lagopoulos, J., & Hermens, D. F. (2020). Investigating the links between adolescent sleep deprivation, fronto-limbic connectivity and the onset of mental disorders: A review of the literature. Sleep Medicine, 66, 61–67. https://doi.org/10.1016/j.sleep.2019.08.013

Kalat, J. W. (2017). Biological psychology. Langara College.

Kementerian Kesehatan Republik Indonesia. (2019). Laporan nasional Riskesdas 2018. Badan Penelitian dan Pengembangan Kesehatan.

Lapidaire, W., Urrila, A. S., Artiges, E., Miranda, R., Vulser, H., Bézivin-Frere, P., Lemaître, H., Penttilä, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Büchel, C., Conrod, P. J., Desrivières, S., Frouin, V., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., ... Ittermann, B. (2021). Irregular sleep habits, regional grey matter volumes, and psychological functioning in adolescents. PLOS ONE, 16(2), e0243720. https://doi.org/10.1371/journal.pone.0243720

Liu, R. T., Steele, S. J., & Hamilton, J. L. (2020). Sleep and suicide: A systematic review and meta-analysis of longitudinal studies. Clinical Psychology Review, 81, 101895. https://doi.org/10.1016/j.cpr.2020.101895

Lukman, M., Cahyaningsih, H., Shalahuddin, I., & Rostianti. (2025). Dampak gangguan tidur terhadap kesehatan pada remaja: A scoping review. Malahayati Nursing Journal, 7(7), 3045–3058. https://doi.org/10.33024/mnj.v7i7.20264

Lovato, N., & Gradisar, M. (2014). A meta-analysis and model of the relationship between sleep and depression in adolescents: Recommendations for future research and clinical practice. Sleep Medicine Reviews, 18(6), 521–529. https://doi.org/10.1016/j.smrv.2014.03.006

Master, L., Nahmod, N. G., Mathew, G. M., Hale, L., Chang, A., & Buxton, O. M. (2023). Why so slangry (sleepy and angry)? Shorter sleep duration and lower sleep efficiency predict worse next-day mood in adolescents. Journal of Adolescence, 95(6), 1140–1151. https://doi.org/10.1002/jad.12182

Markovic, A., Buckley, A., Driver, D. I., Dillard-Broadnax, D., Gochman, P. A., Hoedlmoser, K., Rapoport, J. L., & Tarokh, L. (2020). Sleep spindle activity in childhood onset schizophrenia: Diminished and associated with clinical symptoms. Schizophrenia Research, 223, 327–336. https://doi.org/10.1016/j.schres.2020.08.022

Mars, B., Heron, J., & Klonsky, E. D. (2019). Predictors of future suicide attempt among adolescents with suicidal thoughts or non-suicidal self-harm: A population-based birth cohort study. The Lancet Psychiatry, 6(4), 327–337. https://doi.org/10.1016/S2215-0366(19)30030-6

McCall, W. V., Benca, R. M., Rosenquist, P. B., Youssef, N. A., McCloud, L., Newman, J. C., Case, D., Rumble, M. E., Szabo, S. T., Phillips, M., & others. (2019). Reducing suicidal ideation through insomnia treatment (REST-IT): A randomized clinical trial. American Journal of Psychiatry, 176(12), 957–965. https://doi.org/10.1176/appi.ajp.2019.19030267

Markovic, A., Kaess, M., & Tarokh, L. (2022). Heritability of REM sleep neurophysiology in adolescence. Translational Psychiatry, 12, 399. https://doi.org/10.1038/s41398-022-02106-6

Mayeli, A., Sanguineti, C., & Ferrarelli, F. (2024). Recent evidence of non-rapid eye movement sleep oscillation abnormalities in psychiatric disorders. Current Psychiatry Reports, 27(12), 765–781. https://doi.org/10.1007/s11920-024-01544-x

Menghini, L., Yuksel, D., Prouty, D., Baker, F. C., King, C., & De Zambotti, M. (2023). Wearable and mobile technology to characterize daily patterns of sleep, stress, presleep worry, and mood in adolescent insomnia. Sleep Health, 9(1), 108–116. https://doi.org/10.1016/j.sleh.2022.11.006

Meyer, H. C., & Lee, F. S. (2019). Translating developmental neuroscience to understand risk for psychiatric disorders. American Journal of Psychiatry, 176(3), 179–185. https://doi.org/10.1176/appi.ajp.2019.19010091

Morishima, R., Yamasaki, S., & Ando, S. (2020). Long and short sleep duration and psychotic symptoms in adolescents: Findings from a cross-sectional survey of 15,786 Japanese students. Psychiatry Research, 293, 113440. https://doi.org/10.1016/j.psychres.2020.113440

O’Connell, K. S., Frei, O., Bahrami, S., Smeland, O. B., Bettella, F., Cheng, W., Chu, Y., Hindley, G., Lin, A., Shadrin, A., Barrett, E. A., Lagerberg, T. V., Steen, N. E., Dale, A. M., Djurovic, S., & Andreassen, O. A. (2021). Characterizing the genetic overlap between psychiatric disorders and sleep-related phenotypes. Biological Psychiatry, 90(9), 621–631.

Palagini, L., Aquino, G., Alfi, G., Massoni, L., Gambini, M., Miniati, M., Marazziti, D., Riemann, D., Gemignani, A., & Geoffroy, P. A. (2024). CBT-I for prevention and early intervention in mental disturbances: A systematic review and meta-analysis. Sleep Medicine, 124, 650–658. https://doi.org/10.1016/j.sleep.2024.10.033

Palagini, L., Domschke, K., Benedetti, F., Foster, R. G., Wulff, K., & Riemann, D. (2019). Developmental pathways towards mood disorders in adult life: Is there a role for sleep disturbances? Journal of Affective Disorders, 243, 121–132. https://doi.org/10.1016/j.jad.2018.09.011

Paruthi, S., Brooks, L. J., D’Ambrosio, C., Hall, W. A., Kotagal, S., Lloyd, R. M., Malow, B. A., Maski, K., Nichols, C., Quan, S. F., Rosen, C. L., Troester, M. M., & Wise, M. S. (2016). Recommended amount of sleep for pediatric populations: A consensus recommendation of the American Academy of Sleep Medicine. Journal of Clinical Sleep Medicine, 12(6), 785–786. https://doi.org/10.5664/jcsm.5866

Pesonen, A.-K., Gradisar, M., Kuula, L., Short, M., Merikanto, I., Tark, R., Räikkönen, K., & Lahti, J. (2019). REM sleep fragmentation associated with depressive symptoms and genetic risk for depression in a community-based sample of adolescents. Journal of Affective Disorders, 245, 757–763. https://doi.org/10.1016/j.jad.2018.11.077

Raniti, M. B., Allen, N. B., Schwartz, O., Waloszek, J. M., Byrne, M. L., Woods, M. J., Bei, B., Nicholas, C. L., & Trinder, J. (2017). Sleep duration and sleep quality: Associations with depressive symptoms across adolescence. Behavioral Sleep Medicine, 15(3), 198–215. https://doi.org/10.1080/15402002.2015.1120198

Reicher, V., Szalárdy, O., Bódizs, R., Vojnits, B., Magyar, T. Z., Takács, M., Réthelyi, J. M., & Bunford, N. (2024). NREM slow-wave activity in adolescents is differentially associated with ADHD levels and normalized by pharmacological treatment. International Journal of Neuropsychopharmacology, 27(7), pyae025. https://doi.org/10.1093/ijnp/pyae025

Roberts, R. E., & Duong, H. T. (2017). Is there an association between short sleep duration and adolescent anxiety disorders? Sleep Medicine, 30, 82–87. https://doi.org/10.1016/j.sleep.2016.02.007

Scott, J., Kallestad, H., Vedaa, Ø., Sivertsen, B., & Etain, B. (2021). Sleep disturbances and first onset of major mental disorders in adolescence and early adulthood: A systematic review and meta-analysis. Sleep Medicine Reviews, 57, 101429. https://doi.org/10.1016/j.smrv.2021.101429

Short, M. A., & Weber, N. (2018). Sleep duration and risk-taking in adolescents: A systematic review and meta-analysis. Sleep Medicine Reviews, 41, 185–196. https://doi.org/10.1016/j.smrv.2018.03.006

Sukhera, J. (2022). Narrative reviews: Flexible, rigorous, and practical. Journal of Graduate Medical Education, 14(4), 414–417. https://doi.org/10.4300/JGME-D-22-00480.1

Tarokh, L., & Guiterrez Herrera, C. (2025). Adolescent sleep disruption: Implications for psychiatric morbidity. Biological Psychiatry, 98(11), 854–862. https://doi.org/10.1016/j.biopsych.2025.08.010

Uccella, S., Cordani, R., Salfi, F., Gorgoni, M., Scarpelli, S., Gemignani, A., Geoffroy, P. A., De Gennaro, L., Palagini, L., Ferrara, M., & Nobili, L. (2023). Sleep deprivation and insomnia in adolescence: Implications for mental health. Brain Sciences, 13(4), 569. https://doi.org/10.3390/brainsci13040569

Ugurlu, M., Ugurlu, G. K., Sahin, E. K., Kamis, G. Z., & Caykoylu, A. (2024). Short- and long-term effects of cognitive behavioral therapy on sleep problems and psychotic symptoms in patients with psychotic disorders: A meta-analysis. Brazilian Journal of Psychiatry, 47, e20243623. https://doi.org/10.47626/1516-4446-2024-3623

Vandekerckhove, M., & Wang, Y. L. (2018). Emotion, emotion regulation and sleep: An intimate relationship. AIMS Neuroscience, 5(1), 1–17. https://doi.org/10.3934/Neuroscience.2018.1.1

Waloszek, J. M., Schwartz, O., Simmons, J. G., Blake, M., Blake, L., Murray, G., Raniti, M., Dahl, R. E., O’Brien-Simpson, N., Dudgeon, P., Trinder, J., & Allen, N. B. (2015). The SENSE Study (Sleep and Education: Learning New Skills Early): A community cognitive-behavioural therapy and mindfulness-based sleep intervention to prevent depression and improve cardiac health in adolescence. BMC Psychology, 3, 39. https://doi.org/10.1186/s40359-015-0096-x

Wheaton, A. G., Jones, S. E., Cooper, A. C., & Croft, J. B. (2018). Short sleep duration among middle school and high school students—United States, 2015. MMWR. Morbidity and Mortality Weekly Report, 67(3), 85–90. https://doi.org/10.15585/mmwr.mm6703a1

Wright, L., & Kutcher, S. P. (2016). Adolescent brain development. Morgan & Claypool.

Yang, F. N., Xie, W., & Wang, Z. (2022). Effects of sleep duration on neurocognitive development in early adolescents in the USA: A propensity score matched, longitudinal, observational study. The Lancet Child & Adolescent Health, 6(10), 661–672. https://doi.org/10.1016/S2352-4642(22)00188-2

Yeo, S. C., Jos, A. M., Erwin, C., Lee, S. M., & Gooley, J. J. (2019). Associations of sleep duration on school nights with self-rated health, overweight, and depression symptoms in adolescents: Problems and possible solutions. Sleep Medicine, 60, 96–108. https://doi.org/10.1016/j.sleep.2018.10.041

Zambotti, M. de. (2019). Insomnia disorder in adolescence: Diagnosis, impact, and treatment. Sleep Medicine Reviews, 39, 12–24. https://doi.org/10.1016/j.smrv.2017.06.009

Zendrato, L. N., Adam, H., & Malonda, N. S. H. (2025). Hubungan antara stres dengan kualitas tidur pada peserta didik di SMA. Holistik Jurnal Kesehatan, 19(8), 2305–2313. https://doi.org/10.33024/hjk.v19i8.1393

Author Biographies

Fiyna ’Alyatun Afifah, Universitas Mataram

Author Origin : Indonesia

Rafi Radityo Daniswara, Universitas Mataram

Author Origin : Indonesia

Alia Alia, Universitas Mataram

Author Origin : Indonesia

Aisya Ayudia Azharani, Universitas Mataram

Author Origin : Indonesia

Downloads

Download data is not yet available.

How to Cite

Afifah, F. ’Alyatun, Daniswara, R. R., Alia, A., & Azharani, A. A. (2026). Sleep Disorders in Adolescents and Their Impact on Mental Health: A Literature Review. Jurnal Biologi Tropis, 26(4), 136–147. https://doi.org/10.29303/jbt.v26i4.13227