Association Between Molecular Subtypes and Histopathological Features in Breast Cancer at NTB Provincial Hospital
DOI:
10.29303/jbt.v26i4.13370Published:
2026-10-18Downloads
Abstract
Breast cancer ranks second in global cancer incidence among women and is the leading cancer type and cause of cancer-related mortality among women in Indonesia. Four molecular subtypes Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer (TNBC) are identified through immunohistochemistry (IHC) and differ in clinical behavior and prognosis, but their relationship with histopathological features remains unexamined in this region. This study evaluated associations between IHC-defined molecular subtypes and histopathological type and grade among breast cancer patients at NTB Provincial Hospital. This cross-sectional study used medical records from 361 consecutive patients who underwent IHC testing in 2023-2024. Subtypes were compared using Pearson’s chi-square test, with Cramér’s V measuring effect size; luminal and non-luminal groups were also analyzed separately. Luminal B was most common (47.1%), followed by HER2-enriched (18.8%), TNBC (18.0%), and Luminal A (16.1%). Ductal carcinoma accounted for 85.6% of cases, and 72.3% were Grade 3. Histological grade differed significantly across subtypes (p=0.019; V=0.17), with the lowest proportion of high-grade tumors in Luminal A and the highest in TNBC. Histological type did not differ significantly (p=0.063; V=0.14). Luminal versus non-luminal status was associated with histological type (p=0.026), but not grade (p=0.154).
Keywords:
Breast cancer Histopathology Immunohistochemistry Molecular subtype NTB Provincial HospitalReferences
Bouferraa, Y., Haibe, Y., Chedid, A., Jabra, E., Charafeddine, M., Temraz, S., Mukherji, D., Saghir, N. El, & Shamseddine, A. (2022). The Impact Of Young Age ( < 40 Years ) On The Outcome Of A Cohort Of Patients With Primary Non-Metastatic Breast Cancer : Analysis Of 10-Year Survival Of A Prospective Study. Bmc Cancer, 1–12. Https://Doi.Org/10.1186/S12885-021-09100-Z
Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global Cancer Statistics 2022: Globocan Estimates Of Incidence And Mortality Worldwide For 36 Cancers In 185 Countries. Ca: A Cancer Journal For Clinicians, 74(3), 229–263. Https://Doi.Org/10.3322/Caac.21834
Cai, S., Zuo, W., Lu, X., Gou, Z., Zhou, Y., & Liu, P. (2020). The Prognostic Impact Of Age At Diagnosis Upon Breast Cancer Of Different Immunohistochemical Subtypes : A Surveillance , Epidemiology , And End Results ( Seer ) Population-Based Analysis. 10(September), 1–10. Https://Doi.Org/10.3389/Fonc.2020.01729
Erber, R., & Hartmann, A. (2020). Histology Of Luminal Breast Cancer. 327–336. Https://Doi.Org/10.1159/000509025
Goldhirsch, A., Wood, W. C., Coates, A. S., Gelber, R. D., Thürlimann, B., & Senn, H. J. (2011). Strategies For Subtypes-Dealing With The Diversity Of Breast Cancer: Highlights Of The St Gallen International Expert Consensus On The Primary Therapy Of Early Breast Cancer 2011. Annals Of Oncology, 22(8), 1736–1747. Https://Doi.Org/10.1093/Annonc/Mdr304
Howlader, N., Cronin, K. A., Kurian, A. W., & Andridge, R. (2018). Differences In Breast Cancer Survival By Molecular Subtypes In The United States. Cancer Epidemiology Biomarkers And Prevention, 27(6), 619–626. Https://Doi.Org/10.1158/1055-9965.Epi-17-0627
Kemenkes Ri. (2022). Profil Kesehatan Indonesia 2022. Https://Drive.Google.Com/File/D/1ia83fjk-Tgjkdmyjlqckuvynqkox-C60/View?Usp=Sharing
Mahastuti, N. M., Kedokteran, F., & Udayana, U. (2021). Jurnal Medika Udayana. 10(6), 11–17. Https://Www.Researchgate.Net/Publication/398867467_Karakteristik_Klinikopatologi_Dan_Imunohistokimia_Penderita_Karsinoma_Payudara_Di_Rumah_Sakit_Umum_Pusat_Sanglah_Denpasar_Bali_Tahun_2017-2018
Manuscript, A. (2014). Nih Public Access. 3(844848), 1105–1110. Https://Doi.Org/10.1039/C2sc00975g
Mega, Et All. (2024). Pissn:2355-7583 | Eissn:2549-4864 Http://Ejurnalmalahayati.Ac.Id/Index.Php/Kesehatan. Ejurnalmalahayati.Ac.Id/, 11(12), 2246–2251. Https://Ejurnalmalahayati.Ac.Id/Index.Php/Kesehatan/Article/View/18890/Pdf
Pemerintah Provinsi Ntb. (2022). Laporan Tahunan Rsud Prov Ntb-2022 | Pdf | Bisnis | Teknologi & Rekayasa. Https://Id.Scribd.Com/Document/699208368/Laporan-Tahunan-Rsud-Prov-Ntb-2022
Probert, J., Broggio, J., Darby, S. C., Dodwell, D., Mcgale, P., & Taylor, C. (2025). Histological Types Of Invasive Breast Cancer In 830 , 000 Women Diagnosed In England During 1988 – 2016. September. Https://Doi.Org/10.1002/2056-4538.70043
Rahman, H., Ali, I., & Susilo, D. H. (2023). The Relationship Between The Difference Neutrophto Lymphocyte Ratio Before And After Anthracycline-Based Neoadjuvant Chemotherapy With Clinical Response In Locally Advanced Breast Cancer. Bali Medical Journal, 12(3), 3088–3092. Https://Doi.Org/10.15562/Bmj.V12i3.4797
Rakha, E. A., Reis-Filho, J. S., Baehner, F., Dabbs, D. J., Decker, T., Eusebi, V., Fox, S. B., Ichihara, S., Jacquemier, J., Lakhani, S. R., Palacios, J., Richardson, A. L., Schnitt, S. J., Schmitt, F. C., Tan, P., Tse, G. M., Badve, S., & Ellis, I. O. (2010). Breast Cancer Prognostic Classifi Cation In The Molecular Era : The Role Of Histological Grade. Https://Pubmed.Ncbi.Nlm.Nih.Gov/20804570/
Romadonika, F., & Amrah, N. (2021). Efektifitas Pendidikan Kesehatan Terhadap Tingkat Pengetahuan Remaja Putri Tentang Sadari Di Pondok Pesantren Nurul Haramain Narmada Lombok Barat. Jurnal Mutiara Kesehatan Masyarakat, 6(2), 89–94. Https://Doi.Org/10.51544/Jmkm.V6i2.2391
Rs, D. I., Sina, I., Tahun, M., Nirmalasari, D., Julyani, S., & Rijal, S. (2025). Analisis Hubungan Jenis Dan Grading Histopatologi Dengan Pemberian Kemoterapi Penderita Kanker Payudara Di Rs. Ibnu Sina Makassar Tahun 2022-2024. 5, 5587–5597.
Rusdi, N. K., Sulistyaningsih, E., & Ndang. (2024). Kualitas Hidup Pasien Kanker Payudara Menggunakan Kuesioner Qlq Br-23 Di Rumah Sakit Kanker Dharmais Jakarta Barat. 9(2), 186–199. Https://Doi.Org/10.20961/Jpscr.V9i2.84445
Serrano-Gomez, S. J., Sanabria-Salas, M. C., Hernández-Suarez, G., García, O., Silva, C., Romero, A., Mejía, J. C., Miele, L., Fejerman, L., & Zabaleta, J. (2016). High Prevalence Of Luminal B Breast Cancer Intrinsic Subtype In Colombian Women. 37(7), 669–676. Https://Doi.Org/10.1093/Carcin/Bgw043
Setyorini, G., Sasmithae, L., Fianza, P. I., & Kurnia, D. (2023). Hubungan Subtipe Molekuler Kanker Payudara Dengan Grading Histopatologi Di Rsud M Yunus Bengkulu. Intisari Sains Medis, 14(2), 519–524. Https://Doi.Org/10.15562/Ism.V14i2.1738
Suanjaya, M. A., & Utami, S. (2021). Jurnal Aisyah : Jurnal Ilmu Kesehatan Prevalence And Characteristics Of Breast Cancer Patients In Mataram City For The 2015-2020 Period. 6(2), 403–408.Https://Doi.Org/10.30604/Jika.V6i2.958
Subiyanto, D., Kadi, T. A., Ismaiyah, I., Abdurrahman, N., Utomo, Y. P., Alifiansyah, A. R., & Fidianingsih, I. (2021). Subtipe Molekuler Kanker Payudara Di Rsud Madiun Dan Hubungannya Dengan Grading Histopatologi. Media Penelitian Dan Pengembangan Kesehatan, 31(3), 193–202. Https://Doi.Org/10.22435/Mpk.V31i3.4986
Suganda, A., Wiratmoko, W., Marhayuni, E., & Yuniastini. (2021). Grading Grade 3 Grade 2 Grade 1 Total Frekuensi. Medika Malahayati, 5(2), 77–82. Https://Ejurnalmalahayati.Ac.Id/Index.Php/Medika/Article/Download/4150/Pdf
Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates Of Incidence And Mortality Worldwide For 36 Cancers In 185 Countries. CA: A Cancer Journal For Clinicians, 71(3), 209–249. Https://Doi.Org/10.3322/CAAC.21660,
WHO. (2020). Breast Cancer. Organization, World Health(WHO ). Https://Www.Who.Int/News-Room/Fact-Sheets/Detail/Breast-Cancer
World Health Organization. (2019). Breast Tumor (W. C. Of T. E. Board (Ed.); 5th Editio). International Agency For Research On Cancer (IARC). Https://Publications.Iarc.Who.Int/Book-And-Report-Series/Who-Classification-Of-Tumours/Breast-Tumours-2019/1000?Utm_T.Com
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