Estrogenic Effects of Tapak Dara (Catharantus roseus) Leaf Methanol Extract on The Estrus Cycle of Adult Female Mice (Mus musculus) Balb/C Strain
DOI:
10.29303/jbt.v22i3.3604Published:
2022-08-18Downloads
Abstract
Tapak dara plant is a plant that contains several active compounds, such as phenolic acids, flavonoids and alkaloids. The tapak dara plant can act as a sedative, urinary laxative, stop bleeding, and neutralize toxins. In addition, tapak dara leaf extract contains ingredients that can act as antifertilization. This study aimed to determine the effect of methanol extract of tapak dara leaf on the estrus cycle of adult female mice (Mus musculus) Balb/C strain. This research is an experimental research by testing cause and effect. The hypothesis test used in this study was one-way ANOVA and BNT test. The significance value of giving tapak dara leaf methanol extract to female mice showed a significant value so that it can be said that the administration of tapak dara leaf methanol extract caused the estrus cycle of female mice to be longer. The significance value of estrogenic activity in mice shows a significant value of 0.047, so it can be said that estrogen activity also affects the length of the estrus cycle. The results of hypothesis testing using the one-way ANOVA test were significant, so it can be concluded that the methanol extract of tapak dara leaves can cause the estrus cycle of female mice to be longer.
Keywords:
Estrus cycle, Estrogenic activity, Tapak daraReferences
Bahri, S., Irmayani, Aulia, J., Lathifah, M. F., & Adawiyah. R. (2021). Efek Estrogenik Ekstrak Buah Tomat (Lycopersicum Esculentum) Terhadap Mencit Betina Dewasa (Mus Musculus) Galur Balb/C. Jurnal Pijar MIPA. Vol. 16. No. 2: 222-227. DOI: https://doi.org/10.29303/jpm.v1612.2420
Busman, H. (2013). Histologi Ulas vagina Dan Waktu Siklus Estrus Masa Subur Mencit Betina Setelah Pemberian Ekstrak Rimpang Rumput Teki. Prosiding Seminar FMIPA Universitas lampung: 371-375. http://repository.lppm.unila.ac.id/id/eprint/13443
Carolin, B.T., Salni, & Nita, S. (2019). Pengaruh Ekstrak Bunga Kembang Sepatu (Hibiscus Rosa-Sinensis Linn.) Terhadap Epididimis, Prostat Dan Vesikula Seminalis. Biomedical Journal of Indonesia: Jurnal Biomedik Fakultas Kedokteran Universitas Sriwijaya. Vol. 5, no. 1: 1-9. https://www.jurnalkedokteranunsri.id/index.php/BJI/article/download/351/223
Lusiana, Nova (2017). Pengaruh Fitoestrogen Daging Buah Kurma Ruthab (Phoenix Dactylifera L.) Terhadap Sinkronisasi Siklus Estrus Mencit (Mus Musculus L.) Betina. Klorofil. Vol. 1, No. 1: 24-31. DOI: http://dx.doi.org/10.30821/kfl:jibt.v1i1.1238
Rosa, Yunilda, & Aprilia Lestari (2018). Uji Efektivitas Ekstrak Daun Tapak Dara (Catharanthus Roseus L.) Terhadap Penurunan Kadar Gula Darah Pada Tikus Putih Jantan Galur Wistar. Jurnal Kesehatan: Jurnal Ilmiah Multi Sciences. 8(02): 153-158. DOI: https://doi.org/10.52395/jkjims.v8i02.58
Sumarmin, Ramadhan, & Siska A Ramdhani (2014). Uji In Vivo Ekstrak Biji Kapas (Gossypium hirsutum L.) Terhadap Siklus Reproduksi Mencit (Mus musculus L., Swiss Webster). EKSAKTA. 2:74-81. http://ejournal.unp.ac.id/index.php/eksakta/article/view/4118
Susanto, Bela Novita Amaris, Nofri Zayani, & Nindita Clouris Amaris Ssusanto (2022). Batang Pohon Bajakah Tampala. Pekalongan: PT Nasya Expading Management
Yekti, Aulia Puspita Anugra, Trinil Susilawati, & Muhammad Nur Ihsan (2017). Fisiologi Reproduksi Ternak. Malang: UB Press.
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