The Difference in Malondialdehyde (MDA) Levels among Normoweight, Overweight, and Obesity in Student of Medicine Program Faculty of Medicine, Mataram University
DOI:
10.29303/jbt.v23i3.5429Published:
2023-08-03Downloads
Abstract
Obesity has emerged as a global issue, including in Indonesia. Previous research has shown that obesity causes oxidative stress, which contributes to degenerative diseases such as type II diabetes mellitus, premature aging, cardiovascular disease, tumors and cancer. Malondialdehyde (MDA) is one of the biomarkers used to assess oxidative stress. The aim of this study was to determine differences in MDA levels in medical students at the University of Mataram based on weight criteria: normal, overweight, and obese. The study included 41 students from the 2021 class of the Medical Education program at the University of Mataram who were divided into two groups based on their body mass index (BMI). BMI was determined by isolating body weight (kg) by the square of level (m2), and serum MDA levels were resolved utilizing the ELISA technique. The information were investigated utilizing the Mann-Whitney relative test. The results showed that the MDA level in group 2 (obese and overweight) was 1715.27 ng/ml, higher than group 1 (normoweight) with levels of 902.67 ng/ml. However, this difference was not statistically significant, because the p-value was 0.093 (p > 0.05).
Keywords:
Body mass indeks, malondialdehyde, oxidative stress.References
Abd El-Kader, S. M. and Saiem Al-Dahr, M. H. (2016) ‘Impact of weight loss on oxidative stress and inflammatory cytokines in obese type 2 diabetic patients’, African Health Sciences, 16(3), 725–733. DOI: 10.4314/ahs.v16i3.12.
Adnan MT, Amin MN, Uddin MG, Hussain MS, Sarwar MS, Hossain MK, Uddin SMN, and Islam MS. (2019). ‘Increased concentration of serum MDA, decreased antioxidants and altered trace elements and macro-minerals are linked to obesity among Bangladesh population’ 13(2) :933-938. DOI:10.1016/j.dsx. 2018.12.022.
Altoum, A. E. A., Osman, A. L. and Babker, A. M. A. (2019) ‘Impact of body mass index in malondialdehyde, antioxidant vitamins A, E, C and plasma zinc among type 2 diabetic patients’, Kuwait Medical Journal, 51(1), pp. 16–20.
Ayala, A., Munoz, M. F. and Arguelles, S. (2014) ‘Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal’, Oxidative Medicine and Cellular Longevity, 2014. DOI: 10.1155/2014/360438.
Budi A.R, H Kadri, A Asri. (2019). Perbedaan Kadar Malondialdehid Pada Dewasa Muda Obes Dan Non–Obes Di Fakultas Kedokteran Universitas Andalas. Jurnal Kesehatan Andalas, 2019. 8:21-25
Dalle-Donne I, Rossi R, Colombo R, Giustarini D, and Milzani A.(2006).‘Biomarkers of oxidative damage in human disease’, Clinical Chemistry, 52(4), pp. 601–623. DOI:10.1373/clinchem.2005.061408.
Direktorat Pengendalian Penyakit Tidak Menular.(2015). Pedoman Umum Pengendalian Obesitas. Jakarta: Kementerian Kesehatan Republik Indonesia
Farooqui AA, Horrocks LA and Farooqui T. (2000). Glycerophospholipids in brain: their metabolism, incorporation into membranes, functions, and involvement in neurological disorders. Chemistry and Physics of Lipids; 106(1):1–29.
Habut, M. Y., Nurmawan, I. P. S. and Wiryanthini, I. A. D. (2016) ‘Hubungan Indeks Massa Tubuh dan Aktivitas Fisik terhadap Kesimbangan Dinamis pada Mahasiswa Fakultas Kedokteran Universitas Udayana’, Erepo Unud, 831, pp. 1–14.
Huang CJ, McAllister MJ, Slusher AL, Webb HE, Mock JT, and Acevedo EO. (2015). ‘Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation’. Sports medicine, 1(1),32. DOI: 10.1186/s40798-015-0031-y
Khoubnasabjafari, M., Ansarin, K. and Jouyban, A. (2015) ‘Reliability of malondialdehyde as a biomarker of oxidative stress in psychological disorders’, BioImpacts, 5(3), 123–127. DOI: 10.15171/bi.2015.20.
Kosnayani, A. S. and Aisyah, I. S. (2016) ‘Faktor Risiko Yang Berhubungan Dengan Obesitas Remaja’, Siliwangi, 2(2), 128.
Midah, Z, Fajriansyah, F., Makmun, A., & Rasfahyana (2021). Hubungan Obesitas dan Stress Oksidatif’. UMI Medical Journal, 6(1), pp. 62–69. DOI: 10.33096/umj.v6i1.140.
Riskawati, Y. K., Prabowo, E. D. and Al Rasyid, H. (2018) ‘Tingkat Aktivitas Fisik Mahasiswa Program Studi Pendidikan Dokter Tahun Kedua, Ketiga, Keempat’, Majalah Kesehatan, 5(1), 27–32. DOI: 10.21776/ub.majalahkesehatan.005.01.4.
Riskesdas (2018). Hasil Utama Riset Kesehatan Dasar. Kementrian Kesehat Republik Indonesia. 2018;
Sankhla, M., Sharma, T.K., Mathur, K., Rathor. J.S., Butolia, V., Gadhok, A.K., Vardey, S. K., Sinha, M., & Kaushik, G.G. (2012). Relationship of oxidative stress with obesity and its role in obesity induced metabolic syndrome. Clinical Laboratory, 38, 385-392.
Savini, I., Catani, M. V., Evangelista, D., Gasperi, V., & Avigliano, L. (2013). Obesity-associated oxidative stress: strategies finalized to improve redox state. International journal of molecular sciences, 14(5), 10497-10538. DOI: 10.3390/ijms140510497.
Vincent, H. K. and Taylor, A. G. (2006) ‘Biomarkers and potential mechanisms of obesity-induced oxidant stress in humans’, International Journal of Obesity, 30(3), pp. 400–418. DOI: 10.1038/sj.ijo.0803177.
World Health Organization WHO. (2016). Obesity and Overweight.
License
Copyright (c) 2023 Ni Putu Visty Widhiani, Ida Ayu Eka Widiastuti, Fitriannisa Faradina Zubaidi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
