Test The Activity of Microgel Preparations from Skin Extract Jengkol (Pithecellobium lobatum Benth) on The Healing of Cut Wounds in White Rats (Rattus novergicus)
DOI:
10.29303/jbt.v24i3.7609Published:
2024-09-06Downloads
Abstract
The skin is the largest and heaviest organ in the body, covering its outer surface. Wounds are often experienced by everyone due to the loss of epithelial integrity of the skin. Jengkol fruit skin is useful as a burn medicine and antiseptic to test the activity of microgel preparations from jengkol skin extract (Pithecellobium lobatum Benth) on healing cuts in white rats (Rattus novergicus). This study was a true experimental, post test control only design using the Completely Randomized Design (CRD) statistical method. The data were analyzed statistically using SPSS and continued with ANOVA test to see significant differences between the 5 treatment groups. The results of the study obtained microgel preparations that had activity for healing cuts on the backs of white rats, namely the F3 preparation with a concentration of 15% jengkol skin extract with wound observation for 12 days. In conclusion, cuts on the backs of white rats can be healed with jengkol skin extract.
Keywords:
Cut wounds, jackfruit skin extract, microgel.References
Asadi, S. Y., Parsaei, P., Karimi, M., Ezzati, S., Zamiri, A., Mohammadizadeh, F., & Rafieian-Kopaei, M. (2013). Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat. International Journal of Surgery, 11(4), 332-337. 10.1016/j.ijsu.2013.02.014
Daud, N. S., & Suryanti, E. (2017). Formulasi Emulgel Antijerawat Minyak Nilam (Patchouli oil) Menggunakan Tween 80 dan Span 80 sebagai Pengemulsi dan HPMC sebagai Basis Gel. Jurnal Mandala Pharmacon Indonesia, 3(02), 90-95. https://doi.org/10.35311/jmpi.v3i02.3
Depkes. (1995). Farmakope Indonesia edisi V 1995. Jakarta: Departemen Kesehatan Republik Indonesia.
Depkes. (2000). Farmakope Indonesia edisi V 1995. Jakarta: Departemen Kesehatan Republik Indonesia.
Hawilla, A., Zulkarnain, A. K., & Lukitaningsih, E. (2023). Stabilitas dan Sifat Fisik Sediaan Mikroemulgel Resveratrol Sebagai Tabir Surya dan Antiaging Secara In Vitro. Majalah Farmaseutik, 155-163. https://doi.org/10.22146/farmaseutik.v19i2.83497
Ilma, M., Rismawati, E., & Syafnir, L. (2016). Uji Aktivitas Antioksidan Ekstrak Dan Fraksi Kulit Buah Jengkol ( Archidendron jiringa ( Jeck ) Nielsen Dengan Metode Peredaman Radikal Bebas DPPH. Prosiding Farmasi, 2(1), 161–166. https://karyailmiah.unisba.ac.id/index.php/farmasi/article/viewFile/3123/pdf
Indratno, S. H. A., Debora, P. C., Fitri, N. K., Ambarati, T., Zahra, A. A., & Mierza, V. (2023). Artikel Review: Analisis Ekstraksi dan Identifikasi Senyawa Saponin pada Tumbuhan Mahkota Dewa (Phaleria macrocarpa). Jurnal Pendidikan dan Konseling (JPDK), 5(1), 386-394. https://doi.org/10.31004/jpdk.v5i1.10948
Irianto, I. D., Purwanto, & Mardan, M. T. (2020). Aktivitas Antibakteri dan Uji Sifat Fisik Sediaan Gel Dekokta Sirih Hijau (Piper betle L.) Sebagai Alternatif Pengobatan Mastitis Sapi. Majalah Farmaseutik, 202-210. https://doi.org/10.22146/farmaseutik.v16i2.53793
Kumar, V., R. S. Cotran, dan S. L. Robbins. (2007). Buku Ajar Patologi Edisi 7.
Penerbit Buku Kedokteran EGC. Jakarta
Malini, D. M., Madinah, & Kamilawati, F. (2017). Uji potensi sediaan salep ekstrak etanol kulit buah jengkol untuk mempercepat penutupan luka pada kulit mencit model diabet . PROS SEM NAS MASY BIODIV INDON, 205-210. 10.13057/psnmbi/m030207
Meilia, A., Junaedi, C., & Rezaldi, F. (2022). Formulasi Salep Ekstrak Etanol Daun Cocor Bebek (Kalanchoe pinnata (Lam.) Pers) Untuk Penyembuhan Luka Sayat Pada Tikus Putih. Jurnal Medika & Sains [J-MedSains], 2(1), 9-19. https://doi.org/10.30653/medsains.v2i1.99
Moenadjat, Y. (2023). Penyembuhan Luka: Aspek Seluler dan Biomolekuler.
Nijveldt, R. J., Van Nood, E. L. S., Van Hoorn, D. E., Boelens, P. G., Van Norren, K., & Van Leeuwen, P. A. (2001). Flavonoids: a review of probable mechanisms of action and potential applications. The American journal of clinical nutrition, 74(4), 418-425. 10.1093/ajcn/74.4.418
Perdanakusuma, D. S. (2007). Natomi Fisiologi Kulit Dan Penyembuhan Luka. Plastic Surgery Departement Airlangga University School of Medicine – Dr. Soetomo General Hospital. Surabaya: Plastic Surgery Departement..
Priani, S. E., Dewi, W. K., & Gadri, A. (2018). Formulasi sediaan mikroemulsi gel anti jerawat mengandung kombinasi minyak jinten hitam (Nigella sativa L.) dan minyak zaitun (Olea europaea L.). Jurnal Ilmiah Farmasi, 57-64. https://doi.org/10.26874/kjif.v6i2.143
Primadina, N., Basori, A., & Perdanakusuma, D. S. (2019). Proses penyembuhan luka ditinjau dari aspek mekanisme seluler dan molekuler. Qanun Medika-Medical Journal Faculty of Medicine Muhammadiyah Surabaya, 3(1), 31-43. https://doi.org/10.30651/jqm.v3i1.2198
Rezaldi, F., Khodijah, S., & Sumarlin, U. S. (2022). Formulasi dan Uji Efektivitas Sediaan Sirup Ekstrak Daun Kacapiring (Gardenia jasminoides J. Ellis) Sebagai Antipiretik Terhadap Mencit (Mus musculus L) YANG DI INDUKSI VAKSIN DPT. Jurnal Biogenerasi, 7(1), 1-16. https://doi.org/10.30605/biogenerasi.v7i1.1555
Rizal, M., Yusransyah, Y., & Stiani, S. N. (2016). Uji aktivitas antidiare ekstrak etanol 70% kulit buah jengkol (Archidendron pauciflorum (Benth.) IC Nielsen) terhadap mencit jantan yang diinduksi Oleum ricini. Jurnal Ilmiah Manuntung, 2(2), 131-136. https://doi.org/10.51352/jim.v2i2.57
Usman, Y., & Panaungi, A. N. (2024). Uji Aktivitas Salep Ekstrak Etanol Daun Ubi Jalar Ungu (Ipomoea batatas L.) untuk Luka Bakar pada Kelinci. Jurnal MIPA, 13(2), 99-104. https://doi.org/10.35799/jm.v13i2.56352
Wartono, W., Mazmir, M., & Aryani, F. (2021). Analisis Fitokimia Dan Aktivitas Antioksidan Pada Kulit Buah Jengkol (Pithecellobium Jiringga). Buletin Poltanesa, 22(1), 80-85. https://doi.org/10.51967/tanesa.v22i1.472
License
Copyright (c) 2024 Rezza Fikrih Utama, Renni Paska Situmorang, Fahri Husaini, Muhammad Andry, Fitria Eka Resti Wijayanti
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
