Potential of Ulva lactuca and Sargassum duplicatum as Antihyperglycemic Agents in Type 2 Diabetes Mellitus

Muhammad Rezky Audia Aunurrahman; Atina Rizki Putri; Salsabila Dinda Nuril Ishlahi; Radiah Meilani Putri; Anak Agung Bagus Tito I.P.N; Muhammad Hilman Rizaldi; Citranggana Prajnya Dewi

doi:10.29303/jbt.v24i4.7756

Potential of Ulva lactuca and Sargassum duplicatum as Antihyperglycemic Agents in Type 2 Diabetes Mellitus

Authors

Muhammad Rezky Audia Aunurrahman , Atina Rizki Putri , Salsabila Dinda Nuril Ishlahi , Radiah Meilani Putri , Anak Agung Bagus Tito I.P.N , Muhammad Hilman Rizaldi , Citranggana Prajnya Dewi

DOI:

10.29303/jbt.v24i4.7756

Published:

2024-11-09

Issue:

Vol. 24 No. 4 (2024): Oktober - Desember

Keywords:

Antihyperglycemic, insulin resistance, insulin deficiency, β-cell dysfunction, seaweed, Sargassum duplicatum; type 2 diabetes mellitus, Ulva lactuca.

Articles

Downloads

pdf

How to Cite

Aunurrahman, M. R. A., Putri, A. R., Ishlahi, S. D. N., Putri, R. M., Tito I.P.N, A. A. B., Rizaldi, M. H., & Dewi, C. P. (2024). Potential of Ulva lactuca and Sargassum duplicatum as Antihyperglycemic Agents in Type 2 Diabetes Mellitus. Jurnal Biologi Tropis, 24(4), 887–894. https://doi.org/10.29303/jbt.v24i4.7756

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Type 2 diabetes mellitus (DM) is a metabolic disease that occurs chronically and is characterized by elevated blood glucose levels. Current treatment of type 2 DM is with long-term oral hypoglycemic drug therapy, which is known to have side effects, such as kidney and liver disorders, so there is a need for drugs that have minimal potential side effects such as the use of Ulva lactuca and Sargassum duplicatum from seaweed. This paper will summarize the antihyperglycemic effects of Ulva lactuca and Sargassum duplicatum. The method used by researchers in this research is a literature study writing method that uses literature sources through Google Scholar and several credible websites such as Pubmed with the last 10 years of searches for articles and journals in Indonesian and English. The results of this study indicate that there is antidiabetic content in seaweed with Ulva lactuca and Sargassum duplicatum so that its use can be used as a complementary medicine. Therefore, treatment using seaweed with Ulva lactuca and Sargassum duplicatum has the potential to be developed to become a drug with minimal side effects in the treatment of type 2 DM in Indonesia.

References

Achmadi, R., & Arisandi, A. (2021). The difference in the distribution of brown algae (Sargassum sp.) in the waters of Srau beach and Pidakan Pacitan District. Juvenil: Journal Science of Marine and Fisheries, 2(1). https://doi.org/http://doi.org/10.21107/juvenil.v2i1.9766 ABSTRAK

Azm, N. A. El, Fleita, D., Rifaat, D., Mpingirika, E. Z., Amleh, A., & El-Sayed, M. M. H. (2019). Production of Bioactive Compounds from the Sulfated Polysaccharides Extracts of Ulva lactuca : Post-Extraction Enzymatic Hydrolysis Followed by. Molecules. https://doi.org/https://doi.org/10.3390/molecules24112132

Banday, M. Z., Sameer, A. S., & Nissar, S. (2020). Pathophysiology of diabetes: An overview. Avicenna Journal of Medicine, 10(04). https://doi.org/10.4103/ajm.ajm_53_20

Bappenas. (2024). Pemetaan Area Budidaya Rumput Laut di Lesser Sunda. https://www.icctf.or.id/wp-content/uploads/2024/06/Pemetaan-Area-Budidaya-Rumput-Laut-di-Lesser-Sunda.pdf

Batubara, L., Kristina, T. N., & Rachmawati, B. (2016). Effectiveness of Brown Algae Extract to Reduce Serum Malondialdehyde and Protein Carbonyl Levels in Streptozotocin-Induced Sprague Dawley Rats. Sains Medika : Jurnal Kedokteran Dan Kesehatan, 7(2), 43–48. http://lppm-unissula.com/jurnal.unissula.ac.id/index.php/sainsmedika/article/view/1172

Belhadj, S., Hentati, O., Elfeki, A., & Hamden, K. (2013). Inhibitory activities of Ulva lactuca polysaccharides on digestive enzymes related to diabetes and obesity. The Journal of Metabolic Diseases, 119(2). https://doi.org/https://doi.org/10.3109/13813455.2013.775159

Cahyana, Y., & Adiyanti, T. (2021). Review: Flavonoids as antidiabetic agents. Indonesian Journal of Chemistry, 21(2), 512–526. https://doi.org/10.22146/ijc.58439

Chellappan, D. K., Chellian, J., Rahmah, N. S. N., Gan, W. J., Banerjee, P., Sanyal, S., Banerjee, P., Ghosh, N., Guith, T., Das, A., Gupta, G., Singh, S. K., Dua, K., Kunnath, A. P., Norhashim, N. A., Ong, K. H., & Palaniveloo, K. (2023). Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources. Diabetes, Metabolic Syndrome and Obesity, 16(July 2023), 2187–2223. https://doi.org/10.2147/DMSO.S390741

Decroli, E. (2019). DIABETES MELITUS TIPE 2. In A. Kam, Y. P. Efendi, G. P. Decroli, & A. Rahmadi (Eds.), Jurnal Sains dan Seni ITS (Vol. 6, Issue 1). Pusat Penerbitan Bagian Ilmu Penyakit Dalm Fakultas Kedokteran Universitas Andalas Padang. http://repositorio.unan.edu.ni/2986/1/5624.pdf%0Ahttp://fiskal.kemenkeu.go.id/ejournal%0Ahttp://dx.doi.org/10.1016/j.cirp.2016.06.001%0Ahttp://dx.doi.org/10.1016/j.powtec.2016.12.055%0Ahttps://doi.org/10.1016/j.ijfatigue.2019.02.006%0Ahttps://doi.org/10.1

Decroli, E., Nagara Guptaja Kusumah, & Alexander, K. (2022). Mekanisme Molekuler dari Resistensi Insulin pada Diabetes Melitus Tipe Dua. Majalah Kedokteran Andalas, 45(4), 610–618. http://jurnalmka.fk.unand.ac.id

Dewi, E. N. (2018). Ulva lactuca. In Universitas Diponegoro. http://eprints.undip.ac.id/67364/1/BUKU_ULVA_FIX.pdf

Dinas Kesehatan NTB. (2023). Pelayanan Kesehatan Penderita Diabetes Melitus (DM) di Provinsi NTB. Dinas Kesehatan. https://data.ntbprov.go.id/dataset/pelayanan-kesehatan-penderita-diabetes-melitus-dm-di-provinsi-ntb

Disnakkeswan. (2020). Sargassum SP Primadona Ekspor Rumput Laut NTB. Dinas Peternakan Dan Kesehatan Hewan Provinsi Nusa Tenggara Barat. https://disnakkeswan.ntbprov.go.id/sargassum-sp-primadona-ekspor-rumput-laut-ntb/

Galicia-garcia, U., Benito-vicente, A., Jebari, S., & Larrea-sebal, A. (2020). Pathophysiology of Type 2 Diabetes Mellitus. International Journal of Molecular Sciences, 1–34. https://doi.org/10.3390/ijms21176275

Gheda, S., Hamouda, R. A., Naby, M. A., Mohamed, T. M., Al-Shaikh, T. M., & Khamis, A. (2023). Potent Effect of Phlorotannins Derived from Sargassum linifolium as Antioxidant and Antidiabetic in a Streptozotocin-Induced Diabetic Rats Model. Applied Sciences (Switzerland), 13(8), 1–16. https://doi.org/10.3390/app13084711

Gunathilaka, T. L., Samarakoon, K., Ranasinghe, P., & Peiris, L. D. C. (2020). Antidiabetic Potential of Marine Brown Algae - A Mini Review. Journal of Diabetes Research, 2020. https://doi.org/10.1155/2020/1230218

Gurzov, E. N., Stanley, W. J., Pappas, E. G., Thomas, H. E., & Gough, D. J. (2016). The JAK/STAT pathway in obesity and diabetes. FEBS Journal, 283, 3002–3015. https://doi.org/10.1111/febs.13709

Hardoko, Siratantri, T., Eveline, Yogabuana, M., & Olivia, S. (2014). An In Vitro Study of Antidiabetic Activity of Sargassum Duplicatum and Turbinaria Decurens Seaweed. International Journal of Pharmaceutical Science Invention ISSN (Online, 3(2), 2319–6718. https://www.ijpsi.org/Papers/Vol3(2)/C032013018.pdf

International Diabetes Federation. (2021). IDF Diabetes Atlas 2021 (10th ed.). https://diabetesatlas.org/atlas/tenth-edition/

Karuppusamy, S., Rajauria, G., Fitzpatrick, S., Lyons, H., McMahon, H., Curtin, J., Tiwari, B. K., & O’Donnell, C. (2022). Biological Properties and Health-Promoting Functions of Laminarin: A Comprehensive Review of Preclinical and Clinical Studies. Marine Drugs, 20(12). https://doi.org/10.3390/md20120772

Kerper, N., Ashe, S., & Hebrok, M. (2022). Pancreatic β-Cell Development and Regeneration. Cold Spring Harbor Perspectives in Biology, 14(5). https://doi.org/10.1101/cshperspect.a040741

Lee, S. H., Park, S. Y., & Choi, C. S. (2022). Insulin Resistance: From Mechanisms to Therapeutic Strategies. Diabetes and Metabolism Journal, 46(1), 15–37. https://doi.org/10.4093/DMJ.2021.0280

Litaay, C., Arfah, H., & Pattipeilohy, F. (2022). The Potential of Seaweed Resources on the Coastal of Ambon Island as Food Ingredient. Jurnal Pengolahan Hasil Perikanan Indonesia, 25(3), 405–417. https://doi.org/10.17844/jphpi.v25i3.41647

Lopes, G., Andrade, P. B., & Valentão, P. (2017). Phlorotannins: Towards new pharmacological interventions for diabetes mellitus type 2. Molecules, 22(1), 1–21. https://doi.org/10.3390/molecules22010056

Mabate, B., Daub, C. D., Malgas, S., Edkins, A. L., & Pletschke, B. I. (2021). Fucoidan structure and its impact on glucose metabolism: Implications for diabetes and cancer therapy. Marine Drugs, 19(1), 1–20. https://doi.org/10.3390/md19010030

Neary, S. L., & Ottmann, A. (2020). Diagnostic Approach to Differentiating Diabetes Types. Physician Assistant Clinics, 5(2), 109–120. https://doi.org/10.1016/j.cpha.2019.11.012

Ode, I., & Wasahua, J. (2014). Jenis-Jenis Alga Coklat Potensial di Perairan Pantai Desa Hutumuri Pulau Ambon. Jurnal Ilmiah Agribisnis Dan Perikanan (Agrikan UMMU-Ternate), 7(2), 39–45. https://doi.org/https://doi.org/10.29239/j.agrikan.7.2.39-45

Ojo, O. A., Ibrahim, H. S., Rotimi, D. E., Ogunlakin, A. D., & Ojo, A. B. (2023). Diabetes mellitus: From molecular mechanism to pathophysiology and pharmacology. Medicine in Novel Technology and Devices. https://doi.org/10.1016/j.medntd.2023.100247

Pakidi, C. S., & Suwoyo, H. S. (2016). Potensi dan Pemanfaatan Bahan Aktif Alga Coklat. Octopus, 5(2), 488–498. https://journal.unismuh.ac.id/index.php/octopus/article/view/720

Putra, N. R., Fajriah, S., Qomariyah, L., Dewi, A. S., Rizkiyah, D. N., Irianto, I., Rusmin, D., Melati, M., Trisnawati, N. W., Darwati, I., & Arya, N. N. (2024). Exploring the potential of Ulva Lactuca: Emerging extraction methods, bioactive compounds, and health applications – A perspective review. South African Journal of Chemical Engineering, 47(December 2023), 233–245. https://doi.org/10.1016/j.sajce.2023.11.017

Putra, R. J. S., Achmad, A., & Pramestuti, H. R. (2017). Kejadian Efek Samping Potensial Terapi Obat Anti Diabetes Pada Pasien Diabetes Melitus Berdasarkan Algoritme Naranjo. Pharmaceutical Journal of Indonesia, 2(2), 45–50. https://doi.org/10.21776/ub.pji.2017.002.02.3

Riskesdas. (2019). LAPORAN NASIONAL RISKESDAS 2018. In Lembaga Penerbit Balitbangkes. https://repository.badankebijakan.kemkes.go.id/id/eprint/3514/

Ruan, Q., Chen, Y., Qiu, Y., Huang, Y., Zhang, Y., Farag, M. A., & Zhao, C. (2023). Regulatory mechanisms of the edible alga Ulva lactuca polysaccharide via modulation of gut microbiota in diabetic mice. Food Chemistry, 409. https://doi.org/https://doi.org/10.1016/j.foodchem.2022.135287

Soelistijo, S. A. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2021. https://pbperkeni.or.id/catalog-buku/pedoman-pengelolaan-dan-pencegahan-diabetes-melitus-tipe-2-di-indonesia-2021

Subagio, & Kasim, M. S. H. (2019). Identifikasi Rumput Laut (Seaweed) di Perairan Pantai Cemara, Jerowaru Lombok Timur Sebagai Bahan Informasi Keanekaragaman Hayati Bagi Masyarakat. Jurnal Ilmu Sosial Dan Pendidikan, 3(1). https://doi.org/https://doi.org/10.58258/jisip.v3i1.945

Tanase, D. M., Gosav, E. M., Costea, C. F., Ciocoiu, M., Lacatusu, C. M., Maranduca, M. A., Ouatu, A., & Floria, M. (2020). The Intricate Relationship between Type 2 Diabetes Mellitus (T2DM), Insulin Resistance (IR), and Nonalcoholic Fatty Liver Disease (NAFLD). Journal of Diabetes Research, 2020. https://doi.org/10.1155/2020/3920196

Tangvarasittichai, S. (2015). Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World Journal of Diabetes, 6(3). https://doi.org/DOI: 10.4239/wjd.v6.i3.456

Zhang, X., Wang, J., Zhang, T., Li, S., Liu, J., Li, M., Lu, J., Zhang, M., & Chen, H. (2024). Updated Progress on Polysaccharides with Anti-Diabetic Effects through the Regulation of Gut Microbiota: Sources, Mechanisms, and Structure–Activity Relationships. Pharmaceuticals, 17(4). https://doi.org/10.3390/ph17040456

License

Copyright (c) 2024 Muhammad Rezky Audia Aunurrahman, Atina Rizki Putri, Salsabila Dinda Nuril Ishlahi, Radiah Meilani Putri, Anak Agung Bagus Tito I.P.N, Muhammad Hilman Rizaldi, Citranggana Prajnya Dewi

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Potential of Ulva lactuca and Sargassum duplicatum as Antihyperglycemic Agents in Type 2 Diabetes Mellitus

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow