The Potential of Active Compounds in Traditional Herbal Plants from Lombok for Their Use in Dyslipidemia
DOI:
10.29303/jbt.v24i2b.7788Published:
2024-12-26Downloads
Abstract
Dyslipidemia is a condition characterized by abnormal lipid levels in the blood, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This condition can lead to complications such as cardiovascular diseases and stroke. The purpose of this study is to explore the potential of herbal plants from the Sasak tribe, as recorded in Lontar Usada, for managing dyslipidemia. Lontar Usada documents various medicinal plants that are traditionally used by the Sasak people, making it essential to investigate their active compounds and how they influence lipid profiles. This research employs a qualitative approach, focusing on a literature review and analysis of the plants mentioned in Lontar Usada, followed by a biochemical evaluation of their active compounds and mechanisms in regulating lipid metabolism. The findings reveal that several plants listed in Lontar Usada contain bioactive compounds with potential lipid-lowering effects, supporting their traditional use in managing dyslipidemia. In conclusion, the study confirms that the plants from Lontar Usada could offer a natural alternative for dyslipidemia management, aligning with the high cultural acceptance and availability of these plants within the Sasak community.
Keywords:
Dyslipidemia, Tinospora crispa, Gynura divaricate, Andrographis paniculata, Tridax procumbens, Hibiscus tiliaceus.References
Afra, D.N. & Iskandar, Y., (2019). Aktivitas Andrographolida dan Senyawa Turunannya dari Tanaman Sambiloto (Andrographis paniculata) sebagai Antihiperlipidemia. Farmaka, 17(2), pp.118-122.
Anneke, R. & Sulistiyaningsih, S., (2018). Terapi Herbal sebagai Alternatif Pengobatan Dislipidemia. Farmaka Suplemen, 16(1), pp.316-321.
Astuti, Y.P., Utami, N.V. & Rostini, T., (2014). Efek Ekstrak Etanol Daun Gynura procumbens dalam Menghambat Peningkatan Kadar Trigliserida Tikus Model Hipertrigliseridemia. Acta Pharmaceutica Indonesia, 39(1-2), pp.1-5.
Bereda, G. (2022). Pathophysiology and Management of Dyslipidemia. Biomedical Journal of Scientific and Technology, 43(2). doi: https://doi.org/10.26717/BJSTR.2022.43.006869.
Chen, C.-C., Wu, M.-L., Doerksen, R. J., Ho, C.-T., & Huang, T.-C. (2015). Andrographolide induces apoptosis via down-regulation of glyoxalase 1 and HMG-CoA reductase in HL-60 cells. Journal of Functional Foods, 14, 226–235. https://doi.org/10.1016/j.jff.2015.01.048
Devi, Pritika (2021). Role of Tinospora cordifolia in metabolic health disorders: An updated review. Himalayan Journal of Sciences. 2021; 6(1). 15-23. 10.22270/hjhs.v6i1.91.
Dewashish Kaushik (2020) ‘Ethnopharmacological and Phytochemical Studies of Tridax Procumbens Linn: A Popular Herb in Ayurveda Medicine’, International Journal of Engineering Research and, V9(09), pp. 758–768. doi: 10.17577/ijertv9is090426.
Feitosa, M. F., Lunetta, K. L., Wang, L., Wojczynski, M. K., Kammerer, C. M., Perls, T., Schupf, N., Christensen, K., Murabito, J. M., & Province, M. A. (2020). Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies. Atherosclerosis, 297, 102–110. https://doi.org/10.1016/j.atherosclerosis.2020.02.005
Han, T., Lv, Y., Wang, S., Hu, T., Hong, H., & Fu, Z. (2019). PPARγ overexpression regulates cholesterol metabolism in human L02 hepatocytes. Journal of Pharmacological Sciences, 139(1), 1–8. https://doi.org/10.1016/j.jphs.2018.09.013
Ingole, V. V., Mhaske, P. C. & Katade, S. R. (2022) ‘Phytochemistry and pharmacological aspects of Tridax procumbens (L.): A systematic and comprehensive review’, Phytomedicine Plus, 2(1), p. 100199. doi: 10.1016/j.phyplu.2021.100199.
Islam, M. T. (2017). Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00571
Jeffery, Richardson. (2021) ‘A review of the effectiveness of hibiscus for treatment of metabolic syndrome’, Journal of Ethnopharmacology, 270. https://doi.org/10.1016/j.jep.2020.113762
Joglekar, Aishwarya, Vyas, Mahesh & Bhojani, Meera (2022). Potential of Guduchi-Tinospora cordifolia (Willd.) Miers. (.) in the management of lifestyle disorders: a comprehensive review. Journal of Indian System of Medicine. 10. 90. 10.4103/jism.jism_24_22.
Kao, E. S., Yang, M. Y., Hung, C. H., Huang, C. N., & Wang, C. J. (2016). Polyphenolic extract from Hibiscus sabdariffa reduces body fat by inhibiting hepatic lipogenesis and preadipocyte adipogenesis. Food & function, 7(1), 171–182. https://doi.org/10.1039/c5fo00714c
Kemenkes (2018). Laporan Nasional Riskesdas 2018. Lembaga Penerbit Balitbangkes.
Li, X. et al. (2022) ‘The Bioavailability and Biological Activities of Phytosterols as’, molecules MDPI, pp. 1–15.
Lomenick, B. et al. (2016) ‘Identification and Characterization of β-Sitosterol Target Proteins’, Bioorg Med Chem Lett.
Mohammed, S. K., & Mutlag, S. H. (2023). Potential anti-obesity effects of two-graded doses of Iraqi Hibiscus tiliaceus leaves extract, alone and in combination with orlistat, on high-fat diet-induced obesity in male rats. Journal of medicine and life, 16(9), 1338–1342. https://doi.org/10.25122/jml-2023-0140
Murugaiyah, V. et al. (2018) ‘Lipid-lowering Effect of Hydroalcoholic Extracts of Gynura procumbens in Chemical- and High-fat Diet-induced Hyperlipidemic Rats’, Pharmacognosy Magazine, 14(55), pp. 179–188. doi: 10.4103/pm.pm_451_17.
Nanisa, A.T.A. & Bakhtiar, R., (2020). Dislipidemia dengan Riwayat Pengobatan Tradisional: Studi Kasus dengan Pendekatan Kedokteran Keluarga. Jurnal Kedokteran Mulawarman, 7(3), pp.34-38
Nazri, K. A. A. et al. (2019) ‘Gynura procumbens standardised extract reduces cholesterol levels and modulates oxidative status in postmenopausal rats fed with cholesterol diet enriched with repeatedly heated palm oil’, Evidence-based Complementary and Alternative Medicine, 2019. doi: 10.1155/2019/7246756.
PERKENI (2019). Pedoman Pengelolaan Dislipidemia di Indonesia. PB PERKENI.
Rajaratinam, H., & Mohd Nafi, S. N. (2019). Andrographolide is an Alternative Treatment to Overcome Resistance in ER-Positive Breast Cancer via Cholesterol Biosynthesis Pathway. Malaysian Journal of Medical Sciences, 26(5), 6–20. https://doi.org/10.21315/mjms2019.26.5.2
WHO (n.d.). Raised Cholesterol. [online] Available at: https://www.who.int/data/gho/indicator-metadata-registry/imr-details/3236.
License
Copyright (c) 2024 Steven Christian, I Made Tobias Abdiman, Annisa Risqi Amaliya, Dhiya Atsila Shofa, Ananda Amirah Balqis, Mayumi Agestia Sesariana, Rahmah Dara Ayunda

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.























