Abstract
Gastric lymphoma is the second most common finding in gastric malignancies worldwide. Gastric lymphoma is a lymphoproliferative disorder that originates in the stomach and encompasses various histological findings. In cases of gastric lymphoma, the most frequently diagnosed types are diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma. There is a known association between Helicobacter pylori infection and genetic mutations with the occurrence of gastrointestinal lymphoma. Treatment options for gastric lymphoma include observation, antibiotic therapy, radiation therapy, surgery, and chemotherapy. The therapy provided can be either monotherapy or a combination of treatments.
Keywords:
DLBCL, gastric lymphoma, gastrointestinal, lymphatic, MALT, malignancy.References
Ahluwalia, B., Magnusson, M. K., & Öhman, L. (2017). Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad. Scandinavian Journal of Gastroenterology, 52(11), 1185–1193. https://doi.org/10.1080/00365521.2017.1349173
Al-Ghazzawi, K., Mairinger, F. D., Pförtner, R., Horstmann, M., Bechrakis, N., Mohr, C., Eckstein, A., & Oeverhaus, M. (2022). Novel Insights into Pathophysiology of Orbital Inflammatory Diseases and Progression to Orbital Lymphoma by Pathway Enrichment Analysis. Life, 12(10), 1660. https://doi.org/10.3390/life12101660
Alvarez-Lesmes, J., Chapman, J. R., Cassidy, D., Zhou, Y., Garcia-Buitrago, M., Montgomery, E. A., Lossos, I. S., Sussman, D., & Poveda, J. (2021). Gastrointestinal tract lymphomas a review of the most commonly encountered lymphomas. Archives of Pathology and Laboratory Medicine, 145(12), 1585–1596. https://doi.org/10.5858/arpa.2020-0661-RA
Chey, W. D., Leontiadis, G. I., Howden, C. W., & Moss, S. F. (2017). ACG Clinical Guideline: Treatment of Helicobacter pylori Infection. The American Journal of Gastroenterology, 112(2), 212–239. https://doi.org/10.1038/ajg.2016.563
Diamantidis, M. D., Papaioannou, M., & Hatjiharissi, E. (2021). Primary gastric non-Hodgkin lymphomas: Recent advances regarding disease pathogenesis and treatment. World Journal of Gastroenterology, 27(35), 5932–5945. https://doi.org/10.3748/wjg.v27.i35.5932
Gomes, R. R. (2022). Primary Gastric Lymphoma: A Silent Assassin. Journal of Cancer Research Reviews & Reports, 1–3. https://doi.org/10.47363/jcrr/2022(4)157
Gouveia, G. R., Siqueira, S. a. C., & Pereira, J. (2012). Pathophysiology and molecular aspects of diffuse large B-cell lymphoma. Revista Brasileira De Hematologia E Hemoterapia, 34(6), 447–451. https://doi.org/10.5581/1516-8484.20120111
Ikoma, N., Badgwell, B. D., & Mansfield, P. F. (2017). Multimodality Treatment of Gastric Lymphoma. Surgical Clinics of North America, 97(2), 405–420. https://doi.org/10.1016/j.suc.2016.11.012
Juárez-Salcedo, L. M., Sokol, L., Chavez, J. C., & Dalia, S. (2018). Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. Cancer Control, 25(1), 1–12. https://doi.org/10.1177/1073274818778256
Lee, C. M., Lee, D. H., Ahn, B. K., Hwang, J. J., Yoon, H., Park, Y. S., Shin, C. M., & Kim, N. (2016). Correlation of Endoscopic Findings of Gastric Mucosa-Associated Lymphoid Tissue Lymphoma with Recurrence after Complete Remission. Clinical Endoscopy, 50(1), 51–57. https://doi.org/10.5946/ce.2016.015
Maharani Tasyandita, R., Yulianti, H., & Suryawathy Hernowo, B. (2023). Clinical and Histopathological Features of Non-Hodgkin Lymphoma in Gastrointestinal System at RSUP Dr. Hasan Sadikin Bandung 2018-2020. Majalah Patologi Indonesia, 32(1), 542–547. https://doi.org/10.55816/mpi.v32i1.562
Mescher, A. L. (2017). Histologi Dasar Junqueira (12th ed.). EGC.
Miftahussurur, M., Waskito, L. A., Fauzia, K. A., Mahmudah, I., Doohan, D., Adnyana, I. K., Khomsan, A., Ratnasari, N., & Rezkitha, Y. a. A. (2020). Overview of Helicobacter pylori Infection in Indonesia: What Distinguishes It from Countries with High Gastric Cancer Incidence? Gut And Liver, 15(5), 653–665. https://doi.org/10.5009/gnl20019
Moleiro, J., Ferreira, S., Lage, P., & Pereira, A. D. (2015). Gastric malt lymphoma: Analysis of a series of consecutive patients over 20 years. United European Gastroenterology Journal, 4(3), 395–402. https://doi.org/10.1177/2050640615612934
Nakamura, S., & Hojo, M. (2022). Diagnosis and treatment for gastric Mucosa-Associated lymphoid tissue (MALT) lymphoma. Journal of Clinical Medicine, 12(1), 120. https://doi.org/10.3390/jcm12010120
Nakamura, S., & Matsumoto, T. (2013). Gastrointestinal lymphoma: Recent advances in diagnosis and treatment. Digestion, 87(3), 182–188. https://doi.org/10.1159/000350051
Olszewska-Szopa, M., & Wróbel, T. (2019). Gastrointestinal non-Hodgkin lymphomas. Advances in Clinical and Experimental Medicine, 28(8), 1119–1124. https://doi.org/10.17219/acem/94068
Palmela, C., Fonseca, C., Faria, R., Baptista, R. B., Ribeiro, S., & Ferreira, A. O. (2016). Increased risk for metachronous gastric adenocarcinoma following gastric MALT lymphoma—A US population‐based study. United European Gastroenterology Journal, 5(4), 473–478. https://doi.org/10.1177/2050640616671643
Park, J. B., & Koo, J. S. (2014). Helicobacter pylori infection in gastric mucosa-associated lymphoid tissue lymphoma. World Journal of Gastroenterology, 20(11), 2751–2759. https://doi.org/10.3748/wjg.v20.i11.2751
Sugizaki, K., Tari, A., Kitadai, Y., Oda, I., Nakamura, S., Yoshino, T., & Sugiyama, T. (2018). Anti‐ Helicobacter pylori therapy in localized gastric mucosa‐associated lymphoid tissue lymphoma: A prospective, nationwide, multicenter study in Japan. Helicobacter, 23(2). https://doi.org/10.1111/hel.12474
Vodicka, P., Klener, P., & Trneny, M. (2022). Diffuse Large B-Cell lymphoma (DLBCL): early patient management and emerging treatment options. OncoTargets and Therapy, Volume 15, 1481–1501. https://doi.org/10.2147/ott.s326632
Wang, W., Lin, P., Yao, H., Jia, X., & Sun, J. (2017). Clinical analysis of primary gastrointestinal non-hodgkin’s lymphoma. Pakistan Journal of Medical Sciences, 33(6), 1406–1411. https://doi.org/10.12669/pjms.336.13631
Wyllie, R., Hyams, J. S., & Kay, M. (2016). Pediatric Gastrointestinal and Liver Disease (5 (ed.)). Elsevier Inc.
Zenzri, Y., Charfi, L., Sahraoui, G., Yahyaoui, Y., Mrad, K., Boujelbene, N., & Doghri, R. (2020). Gastric mucosa-associated lymphoid tissue (MALT) lymphoma: clinicopathological study and treatment outcome in 50 patients. Pan African Medical Journal, 37. https://doi.org/10.11604/pamj.2020.37.372.27094
Zhou, L., Hu, H., Zhou, L., & Zhou, Y. (2022). Abdominal Computed Tomography Enhanced Image Features under an Automatic Segmentation Algorithm in Identification of Gastric Cancer and Gastric Lymphoma. Computational and Mathematical Methods in Medicine, 2022, 1–11. https://doi.org/10.1155/2022/2259373
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