The Effect of Giving Ethanol Extract of Palm Fruit (Arenga pinnata Merr.) on Morphology and Liver Function of White Rats (Rattus norvegicus L.) Induced by Carbon Tetrachloroide
DOI:
10.29303/jbt.v25i2.8731Published:
2025-04-22Downloads
Abstract
Carbon tetrachloride is well known as hepatotoxic, including toxic substances commonly used to induce liver damage. Sugar palm (Arenga Pinnata Merr.) is a type of palm plant that is used as a source of antioxidants, one of which is part of the fruit. The aim of this research is to determine the effect of administering ethanol extract of palm fruit (Arenga pinnata Merr.) on the morphology and liver function of rats (Rattus norvegicus L.) which is induced by carbon tetrachloride. This research method used a completely randomized design consisting of 20 mice grouped into 5 groups, namely negative control, positive control, P1 (ethanol extract of palm fruit 90 mg/kg BW), P2 (180 mg/kg BW), P3 (360 mg /kg BW) with each group having four repetitions. Data analysis was carried out using the One Way ANOVA test and continued with the Duncan test. The results of this study show that carbon tetrachloride at a dose of 1 mL/kg BW can damage the morphological appearance of rat liver and increase SGOT and SGPT levels. Giving ethanol extract of palm fruit to the P3 group at a dose of 360 mg/kg BW was the most effective dose to improve liver morphology and reduce SGOT and SGPT levels in white rats induced by carbon tetrachloride.
Keywords:
Arenga pinnata Merr, carbon tetrachloride, liver.References
Abu, Ms, Yakubu, Oe, Onuche, Ji, & Okpe, O. (2022). Profil lipid, parameter hematologi dan analisis histopatologi tikus wistar albino mabuk CCl4 yang diberi ekstrak n-butanol daun Ficus glumosa. Biologi dan Perkembangan Sel , 6 (1), 5-10. https://doi.org/10.13057/cellbioldev/v060102
Adelvia, A. (2020). Pengaruh Ekstrak Buah Aren (Arenga pinnata M) terhadap Tingkat Mortalitas Larva Aedes aegypti. Jurnal ABDI (Sosial, Budaya dan Sains), 2 (1), 20-22. https://journal.unhas.ac.id/index.php/kpiunhas/article/view/9081
Alipin, K., & Azizah, N. R. N. (2021). Morfologis Dan Berat Relatif Organ Hati Tikus Yang Diinduksi Karagenan Setelah Pemberian Ekstrak Kombinasi Rimpang Temulawak Dan Buah Belimbing Wuluh. In Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek). 243-247. https://doi.org/10.24198/ijpst.v0i0.45987
Ayu, S., Harso, W., & Jannah, M. (2020). Profil Toksikologis Ekstrak Daun Tumbuhan Baka-Baka (Hyptis capitata Jacq.) Pada Hati Tikus Putih (Rattus norvegicus). Biocelebes, 14 (1), 10-21. https://doi.org/10.22487/bioceb.v14i1.15082
Dewa, I., Eka, A., Putri, W., Ayu, G., Ratnayanti, D., Sugiritama, W., & Arijana, N. (2021). Analisis Fitokimia Nira Aren dan Tuak Aren (Arenga pinnata (Wurmb) Merr.). https://doi.org/10.24843/MU.2021.V10.i6.P04
Eliah, H. (2022). Aktivitas farmakologi dan fitokimia akar, tangkai daun, buah, dan biji aren (Arenga pinnata) : review tanaman obat. Jurnal Buana Farma, 2 (3), 52-60. http://dx.doi.org/10.35799/jm.6.2.2017.16928
Gunawan, R. O. C., Suryadinata, R. V. & Aditya, D. M. N. (2022). Kandungan Flavonoid Akar Tanaman Solanum torvum dalam Perbaikan Kadar SGOTt Dan SGPT. CALYPTRA, 11 (1). https://journal.ubaya.ac.id/index.php/jimus/article/view/5914
La, EOJ, Sawiji, RT, & Esati, NK. (2021). Efek Ekstrak Etanol Akar Cakar Setan (Martynia annua L) Terhadap Aktivitas SGPT dan SGOT Pada Tikus yang Diinduksi CCl4. Jurnal Ilmiah Manuntung , 7 (1), 40-49. https://doi.org/10.5455/medarh.2024.78.9-11
Muhammadong, M., & Rahmawati, R. (2022). Analisis Kadar Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutmic Pyruvic Transaminase (SGPT) pada Petugas Berisiko Tinggi. Jurnal Keperawatan Profesional (KEPO), 3 (2), 131-137. https://doi.org/10.36590/v3i2.558
Muthiadin, C., Zulkarnain, Z. & Hidayat, A. S. (2020). Pengaruh pemberian tuak terhadap gambaran histopatologi hati mencit (Mus musculus) ICR jantan. Jurnal Pendidikan Matematika dan IPA, 11(2), 193-205. https://doi.org/10.26418/jpmipa.v11i2.36623
Ridanti, C., Dharmono, D., & Riefani, M. K. (2022). Kajian Etnobotani Aren (Arenga pinnata Merr.) Di Desa Sabuhur Kecamatan Jorong Kabupaten Tanah Laut. JUPEIS: Jurnal Pendidikan dan Ilmu Sosial, 1 (3), 200-215. https://doi.org/10.55784/jupeis.Vol1.Iss3.175
Sovia, E., & Anggraeny, D. (2019). Sugar palm fruits (Arenga pinnata) as potential analgesics and anti-inflammatory agent. Molecular and Cellular Biomedical Sciences, 3 (2), 107-14. https://doi.org/10.21705/mcbs.v3i2.63
Syukriah, S., Azhari, M. B., Ningrum, N. A., & Amira, S. (2022). Uji Fitokimiadanantioksidan Ekstrak Etanol Buah Terung (Solanum lasiocarpum) Dengan Metode DPPH. JITEK(Jurnal Ilmiah Teknosains), 8 (2/Nov), 8-13. https://doi.org/10.26877/jitek.v8i2/Nov.13569
Takapaha, V. J., Simbala, H. E., & Antasionasti, I. (2022). Uji In Vivo Ekstrak Bawang Hutan (Eleutherine america Merr.) Terhadap Gambaran Makroskopis Organ Hati Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Pharmacon, 11(1), 1335-1341. http://dx.doi.org/10.35799/pha.10.2021.34043
Teschke, R. (2018). Liver injury by carbon tetrachloride intoxication in 16 patients treated with forced ventilation to accelerate toxin removal via the lungs: A clinical report. Toxics, 6 (2), 25. https://doi.org/10.3390/toxics6020025
License
Copyright (c) 2025 Widya Ramadhani Lubis, Efrida pima Sari Tambuna, Syukriah Syukriah
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
