Relationship Between Patients with Hypertension Stage 2 and Chronic Kidney Disease (CKD) at Harapan Keluarga Hospital
DOI:
10.29303/jbt.v25i2.8806Published:
2025-04-22Downloads
Abstract
Hypertension and chronic kidney disease (CKD) are interrelated global health challenges with rising prevalence, particularly in low-resource settings such as Indonesia. This retrospective cohort study aimed to investigate the association between hypertension stage 2 and CKD among 65 patients treated at Harapan Keluarga Hospital between 2023 and 2024. Data were obtained through medical record reviews, and statistical analysis was conducted using Chi-square testing and odds ratio (OR) calculations. A significant association was found between stage 2 hypertension and CKD (p = 0.001), although the OR value of 0.888 (95% CI: 0.821–0.920) suggests a negative correlation, potentially influenced by variations in treatment adherence, demographic characteristics, or other confounding factors. Differences in BMI and blood pressure between male and female patients were also observed, highlighting the role of sex-specific physiological and lifestyle variables in disease progression. The findings emphasize the importance of tailored clinical management strategies for hypertensive patients to prevent CKD progression, particularly in healthcare settings with limited diagnostic and therapeutic resources.
Keywords:
Chronic Kidney Disease (CKD), disease progression, hypertension stage 2, risk factor.References
Abalos, E., Duley, L., Steyn, D. W., & Gialdini, C. (2018). Antihypertensive drug therapy for mild to moderate hypertension during pregnancy. In Cochrane Database of Systematic Reviews (Vol. 2018, Issue 10). John Wiley and Sons Ltd. https://doi.org/10.1002/14651858.CD002252.pub4
Basolo, A., Salvetti, G., Giannese, D., Genzano, S. B., Ceccarini, G., Giannini, R., Sotgia, G., Fierabracci, P., Piaggi, P., & Santini, F. (2023). Obesity, Hyperfiltration, and Early Kidney Damage: A New Formula for the Estimation of Creatinine Clearance. Journal of Clinical Endocrinology and Metabolism, 108(12), 3280–3286. https://doi.org/10.1210/clinem/dgad330
Connelly, P. J., Currie, G., & Delles, C. (2022). Sex Differences in the Prevalence, Outcomes and Management of Hypertension. In Current Hypertension Reports (Vol. 24, Issue 6, pp. 185–192). Springer. https://doi.org/10.1007/s11906-022-01183-8
de Bhailis, Á. M., & Kalra, P. A. (2022). Hypertension and the kidneys. In British Journal of Hospital Medicine (Vol. 83, Issue 5). MA Healthcare Ltd. https://doi.org/10.12968/hmed.2021.0440
Ettehad, D., Emdin, C. A., Kiran, A., Anderson, S. G., Callender, T., Emberson, J., Chalmers, J., Rodgers, A., & Rahimi, K. (2016). Blood pressure lowering for prevention of cardiovascular disease and death: A systematic review and meta-analysis. The Lancet, 387(10022), 957–967. https://doi.org/10.1016/S0140-6736(15)01225-8
Franco, C., Sciatti, E., Favero, G., Bonomini, F., Vizzardi, E., & Rezzani, R. (2022). Essential Hypertension and Oxidative Stress: Novel Future Perspectives. International Journal of Molecular Sciences, 23(22). https://doi.org/10.3390/ijms232214489
Hill, N. R., Fatoba, S. T., Oke, J. L., Hirst, J. A., O’Callaghan, C. A., Lasserson, D. S., & Hobbs, F. D. R. (2016). Global prevalence of chronic kidney disease - A systematic review and meta-analysis. In PLoS ONE (Vol. 11, Issue 7). Public Library of Science. https://doi.org/10.1371/journal.pone.0158765
Hustrini, N. M. (2023). Chronic Kidney Disease Care in Indonesia: Challenges and Opportunities. 55.
Jafarnejad, S., Mirzaei, H., Clark, C. C. T., Taghizadeh, M., & Ebrahimzadeh, A. (2020). The hypotensive effect of salt substitutes in stage 2 hypertension: A systematic review and meta-analysis. In BMC Cardiovascular Disorders (Vol. 20, Issue 1). BioMed Central Ltd. https://doi.org/10.1186/s12872-020-01347-x
Kalantar-Zadeh, K., Jafar, T. H., Nitsch, D., Neuen, B. L., & Perkovic, V. (2021). Chronic kidney disease. In The Lancet (Vol. 398, Issue 10302, pp. 786–802). Elsevier B.V. https://doi.org/10.1016/S0140-6736(21)00519-5
Kreiner, F. F., Schytz, P. A., Heerspink, H. J. L., von Scholten, B. J., & Idorn, T. (2023). Obesity-Related Kidney Disease: Current Understanding and Future Perspectives. In Biomedicines (Vol. 11, Issue 9). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/biomedicines11092498
Kulkarni, S., Glover, M., Kapil, V., Abrams, S. M. L., Partridge, S., McCormack, T., Sever, P., Delles, C., & Wilkinson, I. B. (2023). Management of hypertensive crisis: British and Irish Hypertension Society Position document. In Journal of Human Hypertension (Vol. 37, Issue 10, pp. 863–879). Springer Nature. https://doi.org/10.1038/s41371-022-00776-9
Landi, F., Calvani, R., Picca, A., Tosato, M., Martone, A. M., Ortolani, E., Sisto, A., D’angelo, E., Serafini, E., Desideri, G., Fuga, M. T., & Marzetti, E. (2018). Body mass index is strongly associated with hypertension: Results from the longevity check-up 7+ study. Nutrients, 10(12). https://doi.org/10.3390/nu10121976
Liyanage, T., Toyama, T., Hockham, C., Ninomiya, T., Perkovic, V., Woodward, M., Fukagawa, M., Matsushita, K., Praditpornsilpa, K., Hooi, L. S., Iseki, K., Lin, M. Y., Stirnadel-Farrant, H. A., Jha, V., & Jun, M. (2022). Prevalence of chronic kidney disease in Asia: A systematic review and analysis. BMJ Global Health, 7(1). https://doi.org/10.1136/bmjgh-2021-007525
Lu, Q., Zhang, Y., Geng, T., Yang, K., Guo, K., Min, X., He, M., Guo, H., Zhang, X., Yang, H., Wu, T., Pan, A., & Liu, G. (2022). Association of Lifestyle Factors and Antihypertensive Medication Use with Risk of All-Cause and Cause-Specific Mortality among Adults with Hypertension in China. JAMA Network Open. https://doi.org/10.1001/jamanetworkopen.2021.46118
Mallamaci, F., & Tripepi, G. (2024). Risk Factors of Chronic Kidney Disease Progression: Between Old and New Concepts. In Journal of Clinical Medicine (Vol. 13, Issue 3). Multidisciplinary Digital Publishing Institute (MDPI). https://doi.org/10.3390/jcm13030678
Minutolo, R., Gabbai, F. B., Agarwal, R., Garofalo, C., Borrelli, S., Chiodini, P., Signoriello, S., Paoletti, E., Ravera, M., Bellizzi, V., Conte, G., & De Nicola, L. (2021). Sex difference in ambulatory blood pressure control associates with risk of ESKD and death in CKD patients receiving stable nephrology care. Nephrology Dialysis Transplantation, 36(11), 2000–2007. https://doi.org/10.1093/ndt/gfab017
Ojangba, T., Boamah, S., Miao, Y., Guo, X., Fen, Y., Agboyibor, C., Yuan, J., & Dong, W. (2023). Comprehensive effects of lifestyle reform, adherence, and related factors on hypertension control: A review. In Journal of Clinical Hypertension (Vol. 25, Issue 6, pp. 509–520). John Wiley and Sons Inc. https://doi.org/10.1111/jch.14653
Oktamianti, P., Kusuma, D., Amir, V., Tjandrarini, D. H., & Paramita, A. (2022). District-Level Inequalities in Hypertension among Adults in Indonesia: A Cross-Sectional Analysis by Sex and Age Group. International Journal of Environmental Research and Public Health, 19(20). https://doi.org/10.3390/ijerph192013268
Pugh, D., Gallacher, P. J., & Dhaun, N. (2019). Management of Hypertension in Chronic Kidney Disease. Drugs, 79(4), 365–379. https://doi.org/10.1007/s40265-019-1064-1
Sarfika, R., Sulistiawati, Afriyanti, E., & Yanuar Saifudin, I. M. M. (2023). Self-care behavior among adult patients with hypertension in Padang, West Sumatra, Indonesia: A cross-sectional study. Belitung Nursing Journal, 9(6), 595–602. https://doi.org/10.33546/bnj.2915
Soenarta, A. A., Buranakitjaroen, P., Chia, Y. C., Chen, C. H., Nailes, J., Hoshide, S., Minh, H. Van, Park, S., Shin, J., Siddique, S., Sison, J., Sogunuru, G. P., Sukonthasarn, A., Tay, J. C., Teo, B. W., Turana, Y., Verma, N., Wang, T. D., Zhang, Y. Q., … Kario, K. (2020). An overview of hypertension and cardiac involvement in Asia: Focus on heart failure. In Journal of Clinical Hypertension (Vol. 22, Issue 3, pp. 423–430). Blackwell Publishing Inc. https://doi.org/10.1111/jch.13753
Teo, B. W., Chan, G. C., Leo, C. C. H., Tay, J. C., Chia, Y. C., Siddique, S., Turana, Y., Chen, C. H., Cheng, H. M., Hoshide, S., Minh, H. Van, Sogunuru, G. P., Wang, T. D., & Kario, K. (2021). Hypertension and chronic kidney disease in Asian populations. In Journal of Clinical Hypertension (Vol. 23, Issue 3, pp. 475–480). John Wiley and Sons Inc. https://doi.org/10.1111/jch.14188
Yu, E. S., Hong, K., & Chun, B. C. (2021). A longitudinal analysis of the progression from normal blood pressure to stage 2 hypertension: A 12-year Korean cohort. BMC Public Health, 21(1). https://doi.org/10.1186/s12889-020-10115-7
Zhang, C., He, X., Murphy, S. R., Zhang, H., Wang, S., Ge, Y., Gao, W., Williams, J. M., Geurts, A. M., Roman, R. J., & Fan, F. (2019). Knockout of dual-specificity protein phosphatase 5 protects against hypertension-induced renal injury. Journal of Pharmacology and Experimental Therapeutics, 370(2), 206–217. https://doi.org/10.1124/jpet.119.258954
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