Difference in Effectiveness Gel Dosage form Green Papaya (Carica papaya L.) Skin Ethanol Extract and Gel Dosage form Green Papaya Seed Against Cutibacterium acnes Bacteria
DOI:
10.29303/jbt.v25i2.9330Published:
2025-06-16Downloads
Abstract
Many things can cause acne, including stress, fatty foods, inappropriate or unsuitable makeup, and pollution. Cosmetics made from plants are safer to use. Papaya skin and seeds (Carica papaya L.) have antibacterial properties in the form of alkaloids, tannins, steroids, saponins, and flavonoids. This study aims to determine the comparison of the antibacterial power of young papaya skin ethanol extract gel and young papaya seed ethanol extract gel against Cutibacterium acnes bacteria. The research method is experimental with various formulas consisting of F0 (0%), F1 (11%), F2 (12%), and F3 (13%). The results of the study obtained antibacterial gel preparations from the three concentrations showed that the organoleptic test of the young papaya fruit skin ethanol extract gel preparation was light brown, blackish brown, dark blackish brown. The homogeneity test was homogeneous. The pH test was 5.9, 6.5, 7.0, and the seed ethanol extract gel preparation was light brown, dark brown, thick dark brown. The homogeneity test was homogeneous. Test pH 5.0, 5.6, 5.5, 5.1. The conclusion of this study is that the antibacterial effectiveness of young papaya fruit skin ethanol extract gel is greater than young papaya fruit seed ethanol extract gel at a concentration of 13% against Cutibacterium acnes bacteria.
Keywords:
Antibacterial gel preparation, antibacterial activity, papaya fruit skin and seeds (Carica papaya L.).References
Buang, A., Isnaeni, D., & Nurhunaida, E. (2019). Uji efektivitas antibakteri ekstrak kulit buah pepaya (Carica Papaya L.) terhadap Propioni bacterium acnes. Majalah Farmasi Nasional, 16(1), 13-20. https://jurnal.uit.ac.id/MFN/article/view/128
Chasanah, Q. O. N. I. T. A. (2017). Formulasi Gel Tabir Surya Ekstrak Kulit Buah Pepaya (Carica Papaya L.) Dan Uji SPF Menggunakan Spektrofotometriuv-Vis. Malang: Universitas Muhammadiyah Malang.
Fikriana, N. A., Chusniasih, D., & Ulfa, A. M. (2021). Uji Efektivitas Ekstrak Etanol Biji Pepaya (Carica papaya L.) Sediaan Krim Terhadap Bakteri Propionibacterium acnes. Jurnal Ilmu Kedokteran Dan Kesehatan, 8(3). https://doi.org/10.33024/jikk.v8i3.4834
Fitri, K., Khairani, T. N., Andry, M., Rizka, N., & Nasution, M. A. (2023). UJI Aktivitas Krim Anti Jerawat Ekstrak Etanol Daun Seroja (Nelumbo Nucifera G.) Terhadap Bakteri Propionibacterium acnes dan Staphylococcus aureus. Journal of Pharmaceutical and Sciences, 37-45. 10.36490/journal-jps.com.v6i1.6
Hidayanti, U. W., Fadraersada, J., & Ibrahim, A. (2015). Formulasi dan Optimasi Basis Gel Carbopol 940 dengan Berbagai Variasi Konsentrasi. In Proceeding of Mulawarman Pharmaceuticals Conferences (Vol. 1, pp. 68-75). 10.25026/mpc.v1i1.10
Indriaty, S., Rizikiyan, Y., Firmansyah, D., Karlina, N., & Ohorella, I. N. A. (2022). Formulasi Dan Uji Stabilitas Lotion Ekstrak Etanol Buah Pepaya (Carica papaya L.): Formulation And Stability Test Of Papaya Ethanol Extract Lotion (Carica papaya L.). Medimuh: Jurnal Kesehatan Muhammadiyah, 2(2), 145-158.
Kumesan, Y. A. N., Yamlean, P. V., & Supriati, H. S. (2013). Formulasi dan uji aktivitas gel antijerawat ekstrak umbi Bakung (Crinum asiaticum L.) terhadap bakteri Staphylococcus aureus secara in vitro. Pharmacon, 2(2). https://doi.org/10.35799/pha.2.2013.1552
Mamahani, A. F. (2016). Etnobotani Tumbuhan Obat Masyarakat Subetnis Tonsawang Di Kabupaten Minahasa Tenggara Provinsi Sulawesi Utara. PHARMACON, 5(2). https://doi.org/10.35799/pha.5.2016.12191
Nailufar, N. P. (2013). Pengaruh Variasi Gelling Agent Carbomer 934 dalam Sediaan Gel Ekstrak Etanolik Bunga Kembang Sepatu (Hibiscus Rosa-Sinensisl.) terhadap Sifat Fisik Gel dan Aktivitas Antibakteri Staphylococcus Aureus (Doctoral dissertation, Universitas Muhammadiyah Surakarta)
Naway, F. S., & Engelen, A. (2023). Minuman Fungsional Pepaya Super Thailand (Carica Pepaya L) Dengan Penambahan Santan Kelapa Dan Gula Aren. Jambura Journal of Food Technology, 5(01), 45-54. https://doi.org/10.37905/jjft.v5i01.20094
NSP, A. S., Mufrod, M., & Purwanto, P. (2015). Antioxidant activity of cream dosage form of tomato extract (Solanum lycopersicum L.). Majalah Obat Tradisional, 18(3), 132-140. https://doi.org/10.22146/tradmedj.8214
Safitri, C. I. N. H. (2020, November). Formulasi dan uji mutu fisik sediaan gel ekstrak bekatul (oryza sativa L.). In Prosiding SNPBS (Seminar Nasional Pendidikan Biologi dan Saintek) (pp. 228-235). https://proceedings.ums.ac.id/snpbs/article/view/768
Saragih, D. F., Opod, H., & Pali, C. (2016). Hubungan tingkat kepercayaan diri dan jerawat (Acne vulgaris) pada siswa-siswi kelas XII di SMA Negeri 1 Manado. eBiomedik, 4(1). https://doi.org/10.35790/ebm.v4i1.12137
Sayuti, N. A. (2015). Formulasi dan uji stabilitas fisik sediaan gel ekstrak daun ketepeng cina (Cassia alata l.). Jurnal Kefarmasian Indonesia, 74-82.
Soediono, J. B., Zaini, M., Sholeha, D. N., & Jannah, N. (2019). Uji Skrinning Fitokimia dan Evaluasi Sifat Fisik Sediaan Salep Ekstrak Etanol Daun Kemangi (Ocimum Sanctum (L.)) dengan Menggunakan Basis Salep Hidrokarbon dan Basis Salep Serap. Jurnal Kajian Ilmiah Kesehatan dan Teknologi, 1(1), 17-33. https://www.jurnal.polanka.ac.id/index.php/JKIKT/article/view/4
Ubah Munthe, R. (2022). Formulasi Sediaan Gel Hand Sanitizer Dari Ekstrak Etanol Daun Malaka (Phyllanthus Emblica L.) Sebagai Antibakteri Terhadap Staphylococcus Aureus. Journal of Health and Medical Science, 21-27. https://pusdikra-publishing.com/index.php/jkes/article/view/584
Wiyanti, D. T., & Agustin, E. W. (2016). Sistem Pakar Diagnosa Kulit untuk Menentukan Kosmetik Perawatan Wajah dengan Metode Certainty Factor dan Fuzzy Logic. In Seminar Nasional Ilmu Komputer (SNIK 2016) (pp. 62-66).
Yapian, S. A. (2014). Uji Efek Antipiretik Ekstrak Daun Pepaya (Carica papaya L.) Pada Tikus Wistar (Rattus norvegicus). eBiomedik, 2(1). https://doi.org/10.35790/ebm.v2i1.3691
Zen, S., & Noor, R. (2018). Pemberdayaan Masyarakat Melalui Pelatihan Diversifikasi Produk Olahan Pepaya California Di Desa Bangunrejo Tanggamus. SINAR SANG SURYA: Jurnal Pusat Pengabdian Kepada Masyarakat, 2(1), 148-157. http://dx.doi.org/10.24127/sss.v2i1.1007
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