Differences in Scube1 and Scube2 Gene Expression in Type II Diabetes Mellitus Patients with Dyslipidemia
DOI:
10.29303/jbt.v25i4.9875Published:
2025-10-09Downloads
Abstract
The Scube1 gene is expressed in atherosclerosis (plaque buildup in blood vessels), while Scube2 is expressed in DIT (Diffuse Intimal Thickening) which is used to describe diffuse thickening of the intima of blood vessels. This study aims to determine the differences in the expression of the scube1 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia and differences in the expression of the scube2 gene in blood samples of type II DM patients with dyslipidemia and type II DM with non-dyslipidemia. With a comparative cross-sectional research method, the sample size of this study was determined based on the Lameshow hypothesis test formula which obtained 18 blood samples of type II DM with dyslipidemia, and 18 blood samples of type II DM with non-dyslipidemia. Blood samples of type II DM patients with dyslipidemia and blood samples of type II DM patients without dyslipidemia showed significantly different expression of the scube1 gene, with a p-value of 0.000. Similarly, blood samples from type II DM patients with dyslipidemia and those from type II DM patients without dyslipidemia showed a significant difference in scube2 gene expression (p = 0.001). Thus, it can be said that the expression of the Scube1 and Scube2 genes is significantly influenced by the complications of diabetes mellitus with dyslipidemia. This happens because it is believed that hyperglycemia in type II DM contributes to endothelial cell dysfunction, which occurs prior to blood vessel damage and results in progressively more severe blood vessel problems. Along with hyperglycemia, type II diabetes also results in dyslipidemia, an alteration in the normal lipid profile. Both dyslipidemia and hyperglycemia contribute to macrovascular and microvascular problems in type II diabetes.
Keywords:
Scube1 Gene, Scube2 Gene, type II diabetes mellitus, Dyslipidemia.References
[PERKENI] Perkumpulan Endokrinologi Indonesia (2011). Konsensus pengolahan dan pencegahan diabetes melitus tipe 2 di Indonesia. Jakarta.
[PERKENI] Perkumpulan Endokrinologi Indonesia (2019). Pedoman Pengelolaan Dislipidemia Di Indonesia. Jakarta.
Afandi., Rafli, M., Ferdy., & Royland, M. (2019). Correlation Between Apoprotein B/Apoprotein A-I Ratio With Homa Ir Value (Homeostatic Model Assesment Insulin Resistance) In Type 2 Diabetes Mellitus. Journal of Vocational Health Studies 3(2):78-82.
Ali H, Rustam R, Aprilia D, Arizal C, Gusadri IB, & Utami PR, (2019). Peningkatan ekspresi SCUBE2 pada diabetes melitus tipe 2 dislipidemia dikaitkan dengan endothelin-1, Diabetes & Sindrom Metabolik: Penelitian & Tinjauan Klinis (2019), doi: https://doi.org/ 10.1016/j.dsx.2019.07.058.
Ali, H., N. Emoto., K. Yagi., VZ. Weger., Nakayama, N. & Hatakeyama, K. (2013). ‘Localization and characterization of a novel secreted protein, SCUBE 2, in the development and progression of atherosclerosis’. Kobe J Med Sci, Vol. 59, hh. E122-E131.
Biswas S, Feng B, Thomas A, Chen S, Aref-Eshghi E, Sadikovic B, Chakrabarti S. (2018). Pengaturan endothelin-1 terjerat dalam jaringan kompleks mekanisme epigenetik pada diabetes. Jurnal Fisiol 2018; 67: S115-S125.
Chen S, Apostolova MD, Cherian MG, Chakrabarti S. (2000). Interaksi Endotelin-1 dengan Faktor Vasoaktif dalam Menengahi Peningkatan Permeabilitas yang Diinduksi Glukosa pada Sel Endotel. Lab Investasi 2000; 8:1311-21.
Dai, DF., Thajeb, P., Tu, CF., Chen, CH., Yang, RB., & Chen, JJ. (2008). ‘Plasma concentration of SCUBE1: a Novel Platetet Protein is elevated in Patients with acute coronary syndrome and Ischemic stroke’, Journal of American College of Cardiology, Vol. 51, hh. 2174-2180.
Lüscher, T.F., Creager, M.A., Beckman J, A., & Cosentino, F. (2003). ‘Review Clinical Cardiology New Frontiers Diabetes and Vascular Disease Pathophysiology, Clinical Consequences, and Medical Therapy: Part II’, Circulation, hh. 1655-1661
PERKI PDSKI. (2013). Pedoman Tatalaksana Dislipidemia. Jurnal of Cardiology, 34(4):245-70, Doi: 10.30701/ijc.v34i4.385
Tu, CF, Su., YH, Huang., YN, Tsai., MT, Chen, YL, & Cheng, CJ. (2006). ’Localization and characterization of a novel secreted protein SCUBE1 in human platelets’, Cardiovasc Res. Vol.71, hh.486-495
Tu, CF., Yan, YT., Wu, SY., Djoko, B., Tsai, MT., & Cheng, CJ. (2008). Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE 1. J Biol Chem. 283(18), hh. 12478-12488.
Yang, R., Domingos, C., Waserman, S.M., Colman, S.D., Shenoy, S., & Mahraban, F. (2002). ‘Identification of a Novel Family of Cell-surface Proteins Expressed in Human Vascular Endothelium ‘. Journal of biologycal chemistry. hh.46364-46373.
Yang, RB. Ng. CK., Wasserman, SM., Colman, SD., Shenoy, S., Mehraban, F., Komuves, LG., Tomlison, JE., & Topper, JN. (2002). Identifikasi keluarga baru protein permukaan sel yang diekspresikan dalam Endotelium pembuluh darah manusiaIdentifikasi keluarga baru protein permukaan sel yang diekspresikan dalam endotel pembuluh darah manusia. J Biol Kimia. 48 (46), hh.364-373.
Zhuang, J., Deane, JA., Yang, RB., Li, J., & Ricardo, SD., (2009). SCUBE 1, a novel developmental gene involved in renal regeneration and repair. Nephrol Dial Transplant. 25: 1421-1428.
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