Esophageal Acalasia: Pathophysiology, Diagnosis and Management
DOI:
10.29303/jbt.v23i4.5567Published:
2023-09-08Downloads
Abstract
Achalasia is a rare disease, but it can lead to loss of the lower esophageal sphincter (LES) causing many complications in the gastrointestinal tract. Achalasia has a good prognosis if treated promptly, but the symptoms are non-specific. The aim of this study was to find out more about the pathophysiology, diagnosis and management of esophageal achalasia. This study was conducted on databases, such as PubMed, Google Schoolar, and Sience Direct. Inclusion criteria were free full text published in 2017-2022. The results of the literature review obtained by achalasia can cause functional obstruction at the gastroesophageal junction. Gradual neurodegeneration due to lack of non-cholinergic inhibitory ganglion cells results in an imbalance of inhibitory and excitatory neurotransmission, resulting in over-contraction of the lower esophageal sphincter and loss of regulation leading to achalasia. Although the incidence of achalasia is very rare, if not treated promptly, it will lead to airway obstruction and cause sudden death. Therapy in patients with achalasia requires long-term follow-up, as the nature of available therapy is palliative, meaning recurrence will often occur. In conclusion, achalasia is an esophageal motility disorder that causes disruption of esophageal peristalsis and malfunction of the esophageal sphincter characterized by difficulty swallowing. Although the incidence of achalasia is very rare, if not treated immediately, it will lead to respiratory obstruction and death.
Keywords:
Achalasia esophageal, diagnosis, pathophysiology, treatment.References
Bright, T. (2020). Pneumatic balloon dilatation for achalasia-How and why I do it. Annals of Esophagus, 3, 2–5. DOI: https://doi.org/10.21037/aoe.2020.04.02
Gupta, S. J., Gaikwad, N. R., Samarth, A. R., & Gattewar, S. R. (2017). Pneumatic Balloon Dilatation for Achalasia Cardia: Outcome, Complications, Success, and Long-term Follow-up. Euroasian Journal of Hepato-Gastroenterology, 7(2), 138–141. DOI: https://doi.org/10.5005/jp-journals-10018-1234
Khairunnisa, N. (2020). Esophageal Myotomy pada Achalasia. Medula, 10, 234–240. http://journalofmedula.com/index.php/medula/article/view/61
Mari, A., Baker, F. A., Pellicano, R., & Khoury, T. (2021). Diagnosis and management of achalasia: Updates of the last two years. Journal of Clinical Medicine, 10(16). DOI: https://doi.org/10.3390/jcm10163607
Momodu, I. I., & Wallen, J. M. (2023). Achalasia Pathophysiology.
Peric, K. T., Bcvanda, D., Zgodic, S., Pausak, B., Madunic, M., & Llasanec, M. (2021). How To Distinguish Idiopathic Achalasia From Pseudoachalasia? Psychiatria Danubina, 33(2), 199–203.
Rachmanio, N., & Alam, G. S. (2019). Penatalaksanaan Akalasia Esophagus dengan Prosedur Pembedahan Heller Dilanjutkan Fundoplikasi. 19(1), 32–36. DOI: https://doi.org/10.18196/mm.190126
Soiza, R. L., Donaldson, A. I. C., & Myint, P. K. (2018). Vaccine against arteriosclerosis: an update. Therapeutic Advances in Vaccines, 9(6), 259–261. DOI: https://doi.org/10.1177/https
Swanström, L. L. (2019). Achalasia: Treatment, current status and future advances. Korean Journal of Internal Medicine, 34(6), 1173–1180. https://doi.org/10.3904/kjim.2018.439
Wadhwa, V., Thota, P. N., Parikh, M. P., Lopez, R., & Sanaka, M. R. (2017). Changing Trends in Age, Gender, Racial Distribution and Inpatient Burden of Achalasia. Gastroenterology Research, 10(2), 70–77. DOI: https://doi.org/10.14740/gr723w
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Copyright (c) 2023 Nabila Indah Shofiyanti, M. Diaz Nursyamsu, Rifki Ahmad Eka Putra, Rieke Delya Rizkina, Shalsa Damai Akelba
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