The Role of Neutrophil in The Pathophysiology of Frailty Syndrome
Authors
Muhammad Ghifari Rifanhsa , Ilsa Hunaifi , Ika PrimayantiDOI:
10.29303/jbt.v23i4.5780Published:
2023-10-14Issue:
Vol. 23 No. 4 (2023): October - DecemberKeywords:
Frailty syndrome, immune system, innate immunity, neutrophil.Articles
Downloads
How to Cite
Downloads
Metrics
Abstract
Neutrophils, also known as polymorphonuclear leukocytes, play a significant role in fueling systemic inflammation and tissue damage within the context of frailty, a clinical syndrome associated with increased susceptibility to stressors and decreased functional performance typically linked to aging. This literature review delves into the interplay between neutrophils and frailty, shedding light on their contribution to age-related systemic inflammation. The investigation explored the correlation between heightened neutrophil levels, diminished physical activity, increased frailty, and elevated white blood cell counts. These findings underscore the substantial role of neutrophils in the development of frailty, necessitating further research to enhance comprehension of their involvement for more effective prevention and intervention strategies. The implications of this study emphasize the importance of tailored exercise regimens, promoting optimal nutrition practices, efficiently managing chronic inflammation, and improving the control of chronic diseases as essential approaches to address frailty among older individuals.
References
Bandeen-Roche, K., Xue, Q.L., Ferrucci, L., Walston, J., Guralnik, J.M., Chaves, P., Zeger, S.L., Fried, L.P., (2006). Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. Journals Gerontol. Ser. A 61, 262–266. DOI: https://doi.org/10.1093/GERONA/61.3.262
Barzilay, J.I., Blaum, C., Moore, T., Qian, L.X., Hirsch, C.H., Walston, J.D., Fried, L.P., (2007). Insulin resistance and inflammation as precursors of frailty: the Cardiovascular Health Study. Arch. Intern. Med. 167, 635–641. DOI: https://doi.org/10.1001/ARCHINTE.167.7.635
Baylis, D., Bartlett, D.B., Syddall, H.E., Ntani, G., Gale, C.R., Cooper, C., Lord, J.M., Sayer, A.A., (2013). Immune-endocrine biomarkers as predictors of frailty and mortality: A 10-year longitudinal study in community-dwelling older people. Age (Omaha). 35, 963–971. DOI: https://doi.org/10.1007/S11357-012-9396-8/METRICS
Butcher, S.K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O’Mahony, D., Lord, J.M., (2001). Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans. J. Leukoc. Biol. 70, 881–886. DOI: https://doi.org/10.1189/JLB.70.6.881
Campbell, A.J., Reinken, J., Allan, B.C., Martinez, G.S., (1981). Falls in Old Age: A Study of Frequency and Related Clinical Factors. Age Ageing, 10, 264–270. DOI: https://doi.org/10.1093/AGEING/10.4.264
Chen, F., Wu, W., Millman, A., Craft, J.F., Chen, E., Patel, N., Boucher, J.L., Urban, J.F., Kim, C.C., Gause, W.C., (2014). Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion. Nat. Immunol. 2014 1510 15, 938–946. DOI: https://doi.org/10.1038/ni.2984
Collerton, J., Martin-Ruiz, C., Davies, K., Hilkens, C.M., Isaacs, J., Kolenda, C., Parker, C., Dunn, M., Catt, M., Jagger, C., von Zglinicki, T., Kirkwood, T.B.L., (2012). Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study. Mech. Ageing Dev. 133, 456–466. DOI: https://doi.org/10.1016/J.MAD.2012.05.005
Deffy Siallagan, Joudy Gessal. (2021). Geriatric Frailty Syndrome. J. Med. dan Rehabil. 3.
Drew, W., Wilson, D., Sapey, E., 2017. Frailty and the Immune System. J. Aging Res. Healthc. 2, 1. DOI: https://doi.org/10.14302/ISSN.2474-7785.JARH-17-1578
Ensrud, K.E., Ewing, S.K., Cawthon, P.M., Fink, H.A., Taylor, B.C., Cauley, J.A., Dam, T.T., Marshall, L.M., Orwoll, E.S., Cummings, S.R., (2009). A comparison of frailty indexes for the prediction of falls, disability, fractures, and mortality in older men. J. Am. Geriatr. Soc. 57, 492–498. DOI: https://doi.org/10.1111/J.1532-5415.2009.02137.X
Fried, L.P., Tangen, C.M., Walston, J., Newman, A.B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W.J., Burke, G., McBurnie, M.A. (2001). Frailty in older adults: evidence for a phenotype. J. Gerontol. A. Biol. Sci. Med. Sci. 56. DOI: https://doi.org/10.1093/GERONA/56.3.M146
Gill, T.M., Gahbauer, E.A., Allore, H.G., Han, L., (2006). Transitions between frailty states among community-living older persons. Arch. Intern. Med. 166, 418–423. DOI: https://doi.org/10.1001/ARCHINTE.166.4.418
Graham, J.E., Snih, S. Al, Berges, I.M., Ray, L.A., Markides, K.S., Ottenbacher, K.J., (2009). Frailty and 10-year mortality in community-living Mexican American older adults. Gerontology, 55, 644–651. DOI: https://doi.org/10.1159/000235653
Greenlee-Wacker, M.C., (2016). Clearance of apoptotic neutrophils and resolution of inflammation. Immunol. Rev. 273, 357–370. DOI: https://doi.org/10.1111/IMR.12453
Harris, T.B., Ferrucci, L., Tracy, R.P., Corti, M.C., Wacholder, S., Ettinger, W.H., Heimovitz, H., Cohen, H.J., Wallace, R., (1999). Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly. Am. J. Med. 106, 506–512. DOI: https://doi.org/10.1016/S0002-9343(99)00066-2
Hazeldine, J., Harris, P., Chapple, I.L., Grant, M., Greenwood, H., Livesey, A., Sapey, E., Lord, J.M., (2014). Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals. Aging Cell, 13, 690–698. https://doi.org/10.1111/ACEL.12222
Hubbard, R.E., O’Mahony, M.S., Savva, G.M., Calver, B.L., Woodhouse, K.W., (20090. Inflammation and frailty measures in older people. J. Cell. Mol. Med. 13, 3103–3109. DOI: https://doi.org/10.1111/J.1582-4934.2009.00733.X
Huifen Li, Bhavish Manwani, Sean X Leng, (2011). Frailty, inflammation, and immunity - PubMed [WWW Document]. URL https://pubmed.ncbi.nlm.nih.gov/22396895/ (accessed 2.24.23).
Leng, S., Chaves, P., Koenig, K., Walston, J., 2002. Serum interleukin-6 and hemoglobin as physiological correlates in the geriatric syndrome of frailty: a pilot study. J. Am. Geriatr. Soc. 50, 1268–1271. DOI: https://doi.org/10.1046/J.1532-5415.2002.50315.X
Leng, S., Chen, X., Mao, G. (2014). Frailty syndrome: an overview. Clin. Interv. Aging 9, 433. DOI: https://doi.org/10.2147/CIA.S45300
Leng, S.X., Hung, W., Cappola, A.R., Yu, Q., Xue, Q.L., Fried, L.P. (2009). White blood cell counts, insulin-like growth factor-1 levels, and frailty in community-dwelling older women. J. Gerontol. A. Biol. Sci. Med. Sci. 64, 499–502. DOi: https://doi.org/10.1093/GERONA/GLN047
Leng, S.X., Xue, Q.L., Tian, J., Walston, J.D., Fried, L.P. (2007). Inflammation and frailty in older women. J. Am. Geriatr. Soc. 55, 864–871. DOI: https://doi.org/10.1111/J.1532-5415.2007.01186.X
Liguori, I., Russo, G., Coscia, V., Aran, L., Bulli, G., Curcio, F., Della-Morte, D., Gargiulo, G., Testa, G., Cacciatore, F., Bonaduce, D., Abete, P. (2018). Orthostatic Hypotension in the Elderly: A Marker of Clinical Frailty? J. Am. Med. Dir. Assoc. 19, 779–785. DOI: https://doi.org/10.1016/J.JAMDA.2018.04.018
MacIntyre, D.L., Reid, W.D., Lyster, D.M., McKenzie, D.C., (2000). Different effects of strenuous eccentric exercise on the accumulation of neutrophils in muscle in women and men. Eur. J. Appl. Physiol. 81, 47–53. DOi: https://doi.org/10.1007/PL00013796
Mayadas, T.N., Cullere, X., Lowell, C.A. (2014). The Multifaceted Functions of Neutrophils. https://doi.org/10.1146/annurev-pathol-020712-164023 9, 181–218. DOI: https://doi.org/10.1146/ANNUREV-PATHOL-020712-164023
Michelon, E., Blaum, C., Semba, R.D., Xue, Q.L., Ricks, M.O., Fried, L.P. (2006). Vitamin and carotenoid status in older women: associations with the frailty syndrome. J. Gerontol. A. Biol. Sci. Med. Sci. 61, 600–607. DOI: https://doi.org/10.1093/GERONA/61.6.600
Miller, R.A., (1996). The aging immune system: primer and prospectus. Science 273, 70–74. DOI: https://doi.org/10.1126/SCIENCE.273.5271.70
Nauseef, W.M., Borregaard, N., (2014). Neutrophils at work. Nat. Immunol. 2014 157 15, 602–611. DOI: https://doi.org/10.1038/ni.2921
Netea, M.G., Joosten, L.A.B., Latz, E., Mills, K.H.G., Natoli, G., Stunnenberg, H.G., O’Neill, L.A.J., Xavier, R.J. (2016). Trained immunity: A program of innate immune memory in health and disease. Science (80-. ). 352, 427. DOI: https://doi.org/10.1126/SCIENCE.AAF1098/ASSET/1906CC7D-18B2-4A5A-865D-40C50CB78907/ASSETS/GRAPHIC/352_AAF1098_FA.JPEG
Niwa, Y., Kasama, T., Miyachi, Y., Kanoh, T., (1989). Neutrophil chemotaxis, phagocytosis and parameters of reactive oxygen species in human aging: Cross-sectional and longitudinal studies. Life Sci. 44, 1655–1664. DOI: https://doi.org/10.1016/0024-3205(89)90482-7
Oldenburg, H.S.A., Rogy, M.A., Lazarus, D.D., van Zee, K.J., Keeler, B.P., Chizzonite, R.A., Lowry, S.F., Moldawer, L.L., (1993). Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur. J. Immunol. 23, 1889–1894. DOI: https://doi.org/10.1002/EJI.1830230824
Panza, F., Lozupone, M., Solfrizzi, V., Sardone, R., Dibello, V., Di Lena, L., D’Urso, F., Stallone, R., Petruzzi, M., Giannelli, G., Quaranta, N., Bellomo, A., Greco, A., Daniele, A., Seripa, D., Logroscino, G., (2018). Different Cognitive Frailty Models and Health- and Cognitive-related Outcomes in Older Age: From Epidemiology to Prevention. J. Alzheimers. Dis. 62, 993–1012. DOI: https://doi.org/10.3233/JAD-170963
Payette, H., Roubenoff, R., Jacques, P.F., Dinarello, C.A., Wilson, P.W.F., Abad, L.W., Harris, T. (2003). Insulin-like growth factor-1 and interleukin 6 predict sarcopenia in very old community-living men and women: the Framingham Heart Study. J. Am. Geriatr. Soc. 51, 1237–1243. DOI: https://doi.org/10.1046/J.1532-5415.2003.51407.X
Qu, T., Walston, J.D., Yang, H., Fedarko, N.S., Xue, Q.L., Beamer, B.A., Ferrucci, L., Rose, N.R., Leng, S.X. (2009a). Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults. Mech. Ageing Dev. 130, 161–166. DOI: https://doi.org/10.1016/J.MAD.2008.10.005
Qu, T., Yang, H., Walston, J.D., Fedarko, N.S., Leng, S.X. (2009b). Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. Cytokine 46, 319. DOI: https://doi.org/10.1016/J.CYTO.2009.02.015
Quindry, J.C., Stone, W.L., King, J., Broeder, C.E. (2003). The effects of acute exercise on neutrophils and plasma oxidative stress. Med. Sci. Sports Exerc. 35, 1139–1145. DOI: https://doi.org/10.1249/01.MSS.0000074568.82597.0B
Rosales, C. (2018). Neutrophil: A cell with many roles in inflammation or several cell types? Front. Physiol. 9, 113. DOI: https://doi.org/10.3389/FPHYS.2018.00113/BIBTEX
Sahin, E., Depinho, R.A. (2010). Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464, 520–528. DOI: https://doi.org/10.1038/NATURE08982
Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R.H., Stockley, R.A., Lord, J.M. (2014). Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence. Blood 123, 239–248. DOI: https://doi.org/10.1182/BLOOD-2013-08-519520
Scapini, P., Cassatella, M.A. (2014). Social networking of human neutrophils within the immune system. Blood 124, 710–719. DOI: https://doi.org/10.1182/BLOOD-2014-03-453217
Schaap, L.A., Pluijm, S.M.F., Deeg, D.J.H., Visser, M. (2006). Inflammatory markers and loss of muscle mass (sarcopenia) and strength. Am. J. Med. 119. DOI: https://doi.org/10.1016/J.AMJMED.2005.10.049
Semba, R.D., Nicklett, E.J., Ferrucci, L. (2010). Does accumulation of advanced glycation end products contribute to the aging phenotype? J. Gerontol. A. Biol. Sci. Med. Sci. 65, 963–975. DOI: https://doi.org/10.1093/GERONA/GLQ074
Shavlakadze, T., McGeachie, J., Grounds, M.D., (2010). Delayed but excellent myogenic stem cell response of regenerating geriatric skeletal muscles in mice. Biogerontology, 11, 363–376. DOI: https://doi.org/10.1007/S10522-009-9260-0
Shubert, T.E. (2011). Evidence-based exercise prescription for balance and falls prevention: a current review of the literature. J. Geriatr. Phys. Ther. 34, 100–108. DOI: https://doi.org/10.1519/JPT.0B013E31822938AC
Smith, L.L., Bond, J.A., Holbert, D., Houmard, J.A., Israel, R.G., McCammon, M.R., Smith, S.S. (1998). Differential white cell count after two bouts of downhill running. Int. J. Sports Med. 19, 432–437. DOI: https://doi.org/10.1055/S-2007-971941
Van Doorn, C., Gruber-Baldini, A.L., Zimmerman, S., Hebel, J.R., Port, C.L., Baumgarten, M., Quinn, C.C., Taler, G., May, C., Magaziner, J. (2003). Dementia as a risk factor for falls and fall injuries among nursing home residents. J. Am. Geriatr. Soc. 51, 1213–1218. DOI: https://doi.org/10.1046/J.1532-5415.2003.51404.X
Visser, M., Pahor, M., Taaffe, D.R., Goodpaster, B.H., Simonsick, E.M., Newman, A.B., Nevitt, M., Harris, T.B., (2002). Relationship of Interleukin-6 and Tumor Necrosis Factor-α With Muscle Mass and Muscle Strength in Elderly Men and WomenThe Health ABC Study. Journals Gerontol. Ser. A 57, M326–M332. DOI: https://doi.org/10.1093/GERONA/57.5.M326
Walston, J., McBurnie, M.A., Newman, A., Tracy, R.P., Kop, W.J., Hirsch, C.H., Gottdiener, J., Fried, L.P. (2002). Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch. Intern. Med. 162, 2333–2341. DOI: https://doi.org/10.1001/ARCHINTE.162.20.2333
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., Hörl, W. (2000). Effect of age on human neutrophil function. J. Leukoc. Biol. 67, 40–45. DOI: https://doi.org/10.1002/JLB.67.1.40
Wilson, D., Jackson, T., Sapey, E., Lord, J.M., (2017). Frailty and sarcopenia: The potential role of an aged immune system. Ageing Res. Rev. 36, 1–10. DOI: https://doi.org/10.1016/j.arr.2017.01.006
Xue, Q.L. (2011). The frailty syndrome: definition and natural history. Clin. Geriatr. Med. 27, 1–15. DOI: https://doi.org/10.1016/J.CGER.2010.08.009
Yao, X., Li, H., Leng, S.X. (2011). Inflammation and Immune System Alterations in Frailty. Clin. Geriatr. Med. 27, 79–87. DOI: https://doi.org/10.1016/j.cger.2010.08.002
License
Copyright (c) 2023 Muhammad Ghifari Rifanhsa, Ilsa Hunaifi, Ika Primayanti
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.