Factors That Determine the Successful Management of Ectopic Pregnancy Through Methotrexate Injections
Authors
Baiq Ayu Rahmawati , Amelia Wahyu Maharani , Ali Ramzi , Muhammad Rizkinov JumsaDOI:
10.29303/jbt.v23i4b.5907Published:
2023-11-07Issue:
Vol. 23 No. 1 (2023): Special IssueKeywords:
Ectopic pregnancy, factors, methotrexate.Articles
Downloads
How to Cite
Downloads
Metrics
Abstract
Ectopic pregnancy is a pregnancy that occurs when the gestational sac is located outside the uterus. Methotrexate administered intramuscularly (IM) is the standard management in the therapy of ectopic pregnancies. The success of managing ectopic pregnancies using methotrexate is influenced by various factors. This literature review aims to provide related information because a sufficient understanding of the factors that affect the success of methotrexate use in ectopic pregnancies is crucial to prevent complications, reduce morbidity and mortality rates resulting from ectopic pregnancies. In this literature review we conducted a search on the National Center for Biotechnology Information (NCBI) and Google Scholar database using the search keyword factors, methotrexate, and ectopic pregnancy. The success of treating ectopic pregnancies using methotrexate is influenced by various factors, such as the initial β-hCG levels, the size of the ectopic mass, peritoneal fluid, maternal age, gestational age, previous spontaneous miscarriage, gravida, parity, abortion, and the percentage of a history of previous ectopic pregnancies. However, most studies have found that the primary factor influencing success is the initial β-hCG levels.
References
Amudha, P., G., S. & C., R. (2022) ‘Analysis of risk factors and treatment outcome following methotrexate therapy in ectopic pregnancy’, International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 11(3), p. 746. DOI: 10.18203/2320-1770.ijrcog20220370.
Aravianti, N. L. S. et al. (2022) ‘Gambaran Kejadian Kehamilan Ektopik Terganggu’, Oksitosin : Jurnal Ilmiah Kebidanan, 9(1), pp. 1–13. DOI: 10.35316/oksitosin.v9i1.1361.
Mirbolouk, F., Yousefnezhad, A. & Ghanbari, A. (2015) ‘Predicting factors of medical treatment success with single dose methotrexate in tubal ectopic pregnancy: A retrospective study’, Iranian Journal of Reproductive Medicine, 13(6), pp. 351–354. URL: https://pubmed.ncbi.nlm.nih.gov/26330849/.
Mullany, K. et al. (2023) ‘Overview of ectopic pregnancy diagnosis, management, and innovation’, Women’s Health, 19, pp. 1–13. DOI: 10.1177/17455057231160349.
Ozyuncu, O. et al. (2018) ‘Methotrexate Therapy for Ectopic Pregnancies: A Tertiary Center Experience’, Revista Brasileira de Ginecologia e Obstetricia, 40(11), pp. 680–685. DOI: 10.1055/s-0038-1675807.
Pulatoglu, C. et al. (2018) ‘Predictive Factors of Methotrexate Treatment Success in Ectopic Pregnancy: A Single Tertiary Center Study’, Northern Clinics of Istanbul, 5(3), pp. 227–231. DOI: 10.14744/nci.2017.04900.
Ranji, G. G., Usha Rani, G. & Varshini, S. (2018) ‘Ectopic Pregnancy: Risk Factors, Clinical Presentation and Management’, Journal of Obstetrics and Gynecology of India, 68(6), pp. 487–492. DOI: 10.1007/s13224-017-1075-3.
Wang, Xia et al. (2020) ‘Adrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy’, Mucosal Immunology, 13(5), pp. 743–752. doi: 10.1038/s41385-020-0278-6.
Widiasari, K. R. & Lestari, N. M. S. D. (2021) ‘Kehamilan Ektopik’, Ganesha Medicine, 1(1), pp. 20–27. DOI: 10.23887/gm.v1i1.31699.
Zhang, J. et al. (2020) ‘Predictors and clinical features of methotrexate (MTX) therapy for ectopic pregnancy’, BMC Pregnancy and Childbirth, 20(1), pp. 1–9. DOI: 10.1186/s12884-020-03350-8.
License
Copyright (c) 2023 Baiq Ayu Rahmawati, Amelia Wahyu Maharani, Ali Ramzi, Muhammad Rizkinov Jumsa
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.