Precocious Puberty: Etiology and Current Treatment
DOI:
10.29303/jbt.v23i1.5926Published:
2023-11-16Downloads
Abstract
Precocious puberty also known as premature puberty is an abnormal pubertal development that can affect a child's growth and development. The clinical manifestations of precocious puberty are generally diverse and based on etiology are classified into central precocious puberty (GnRH dependent) and peripheral precocious puberty (GnRH independent). The main concern with precocious puberty is that precocious puberty can be a clinical symptom of an underlying serious disease such as a brain tumor, adrenal or gonadal tumor and others. Early identification of etiology plays an important role in prevention, diagnosis, and treatment of this disease. This literature review aims to determine the etiology and current management of precocious puberty. This literature review uses the keywords "Precocious Puberty AND etiology AND treatment" through the National Center for Biotechnology Information (NCBI) and Google Scholar databases. This article uses 11 articles that were used as references in its preparation. In conclusion, it is necessary to know the etiology of precocious puberty using imaging examinations for optimal management and excluding malignant abnormalities. The current treatment for central precocious puberty is GnRH agonists (gold-standard) and surgery in cases of intracranial lesions and peripheral precocious puberty using a combination of androgen antagonists (spironolactone) and aromatase inhibitors (anastrozole, testolactone) and surgery is indicated for gonadal and adrenal tumors. The role of parents is very important in early detection of precocious puberty, because the earlier the therapy, the better the prognosis.
Keywords:
Current treatment, etiology, precocious, puberty central precocious puberty, peripheral precocious puberty.References
Aftab, Sommayya, Jaida Manzoor, Qaiser Mahmood, and Tahir Shaheen. (2022). “Precocious Puberty: The Clinical Profile and the Etiological Classification of Children Presented at a Tertiary Care Children’s Hospital.” Pakistan Journal of Medical Sciences 38(4): 955–59. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9121963/pdf/PJMS-38-955.pdf.
Bradley, Stephen H., Neil Lawrence, Caroline Steele, and Zainaba Mohamed. (2020). “Precocious Puberty.” The BMJ 368(January). DOI: http://dx.doi.org/doi:10.1136/bmj.l6597.
Eugster, Erica A. (2019). “Treatment of Central Precocious Puberty.” Journal of the Endocrine Society 3(5): 965–72.
Gracjasz-Palikij, Izabela, Justyna Paprocka, and Aneta Gawlik. (2020). “Central Precocious Puberty - Etiology with Particular Consideration of Neurological Causes.” Archives of Medical Science: 1–8.
Han, X. X., Zhao, F. Y., Gu, K. R., Wang, G. P., Zhang, J., Tao, R., ... & Yu, J. Q. (2022). “Development of Precocious Puberty in Children: Surmised Medicinal Plant Treatment.” Biomedicine and Pharmacotherapy 156(October): 113907. DOI: https://doi.org/10.1016/j.biopha.2022.113907.
IDAI. (2013). “Masalah Pubertas Pada Anak Dan Remaja.”
IDAI. (2017). “Diagnosis Dan Tata Laksana Pubertas Prekoks Sentral.” Badan Penerbit Ikatan Dokter Anak Indonesia: 1–15.
Kletter, Gad B., Karen O. Klein, and Yolanda Y. Wong. (2015). “Precocious Puberty - StatPearls - NCBI Bookshelf.” StatPearls [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK544313/.
Lasmi, Anjely Doni, Dhila Thasliyah, and Ratih Fitriati. (2022). “Manifestasi Klinis, Diagnosis, Dan Tatalaksana Pubertas Prekoks.” Jurnal Ilmiah Kesehatan Media Husada 11(1): 34–43.
Maione, Luigi, Claire Bouvattier, and Ursula B. Kaiser. (20210. “Central Precocious Puberty: Recent Advances in Understanding the Aetiology and in the Clinical Approach.” Clinical Endocrinology 95(4): 542–55.
Qudsiya, Zainab, and Vikas Gupta. (2023). “Precocious Pseudopuberty.” https://www.ncbi.nlm.nih.gov/books/NBK560588/.
Rowan, Shon P., and Pamela J. Murray. (2015). “Precocious Puberty.” Clinical Gynecology, Second Edition 36(7): 506–19.
Santosa, Putu Adi, Anik Widijanti, Hani Susianti, and Katherina Alfa Engli. (2020). “Pubertas Prekoks Perifer Isoseksual Akibat Juvenile Granulosa Cell Tumor.” MEDICINUS, 33(3): 6–13.
Shim, Young Suk, Hae Sang Lee, and Jin Soon Hwang. (2022). “Genetic Factors in Precocious Puberty.” Clinical and Experimental Pediatrics 65(4): 172–81.
Sugihartiningsih. (2022). Media Neliti Prekoks Pubertas. URL: https://media.neliti.com/media/publications/161630-ID-prekoks-pubertas.pdf
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Copyright (c) 2023 Jihan Alifa Rahma, Adinda Ilsa Maulida, Alma Dyah Perwita, Baiq Ayu Rahmawati, Clara Nadila, Herodya Lajunee Fesmia, Ni Made Utami Wulandari, Zhayyin Palna Rial Novsyaini, Indana Eva Ajmala
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