Understanding Thyroid Carcinoma: Clinical Manifestations, Diagnosis, and Management

Authors

Rima Cahyati Kusumadewi , Rukmanggana Satya Pratiwi , Artiani Tresna Imut Exhasna , Gina Aulia Azizaturrahmah , I Gede Pande Devin Agastya Sastrawan , Rosita Wenilia , Syihabul Muttaqin , Dita Supriantarini , M. Arya Rifqi Ilham , Walid Rivaldi Fatahillah , Eva Triani

DOI:

10.29303/jbt.v24i4.7664

Published:

2024-10-28

Downloads

Abstract

Thyroid carcinoma holds the 11th place in the incidence of new cancers, with a prevalence of 586,202 cases worldwide. The incidence of thyroid cancer in Indonesia reached 13,114 cases with 2,224 mortality in 2020. This literature review aims to provide information on thyroid cancer's clinical manifestations, diagnosis, and management. We conducted a literature searching from books, literature reviews, case studies, and guidelines from professional organizations such as the AJCC (American Joint Committee on Cancer) and European Society for Medical Oncology (ESMO) guideline. The initially noticed clinical manifestation of thyroid cancer is usually a painless lump or enlargement at the front-lower part of the neck. Diagnosis of thyroid cancer is done step-by-step from history taking, physical examination, laboratory testing of thyroid stimulating hormone and thyroglobulin, thyroid ultrasonography, and fine needle aspiration biopsy (FNAB). Management of thyroid cancer include pharmacological management, surgery, or/and radiotherapy according to the type and stage of the thyroid cancer. Early diagnosis and therapy of thyroid cancer are expected to improve the prognosis of thyroid cancer.

Keywords:

Cancer, carcinoma, fine needle aspiration, thyroid.

References

Adham, M. and Aldino, N. (2019) ‘Diagnosis Dan Tatalaksana Karsinoma Tiroid Berdiferensiasi’, Oto Rhino Laryngologica Indonesiana, 48(2), p. 197. doi: 10.32637/orli.v48i2.270.

Albi, E., Cataldi, S., Lazzarini, A., Codini, M., Beccari, T., Saverio, F., & Curcio, F. (2017). Radiation and Thyroid Cancer. International Journal of Molecular Sciences, 18(5), 911. https://doi.org/10.3390/ijms18050911.

American Joint Committee on Cancer. (2018). AJCC Cancer Staging Manual. 8th Edition. Springer, Chicago. ISBN 978-0-9968262-9-7, DOI 10.1007/978-3-319-40618-3, pp: 881-910.

Amir, N. A. B., Kasprata, H. N., Priyahita, P. D., Syahla, T., and Triani, E. (2023). Clinical Diagnosis and Management of Thyroid Cancer. Jurnal Kedokteran Unram, DOI: 10.29303/jku.v12i3.96.

Baloch, Z. W., Asa, S. L., Barletta, J. A., Ghossein, R. A., Juhlin, C. C., Jung, C. K., LiVolsi, V. A., Papotti, M. G., Sobrinho-Simões, M., Tallini, G., & Mete, O. (2022). Overview of the 2022 WHO Classification of Thyroid Neoplasms. Endocrine pathology, 33(1), 27–63. https://doi.org/10.1007/s12022-022-09707-3.

Bickley, L.S. & Szilagyi, P.G. (2017). Bates’ Guide to Physical Examination and History Taking. 12th Ed. Wolters Kluwer, Philadelphia. ISBN 9781469893419.

Carling, T., & Udelsman, R. (2014). Thyroid cancer. Annual review of medicine, 65, 125–137. https://doi.org/10.1146/annurev-med-061512-105739.

Coca-Pelaz, A., Rodrigo, J. P., Shah, J. P., Sanabria, A., Al Ghuzlan, A., Silver, C. E., Shaha, A. R., Angelos, P., Hartl, D. M., Mäkitie, A. A., Olsen, K. D., Owen, R. P., Randolph, G. W., Simó, R., Tufano, R. P., Kowalski, L. P., Zafereo, M. E., Rinaldo, A., & Ferlito, A. (2021). Hürthle Cell Carcinoma of the Thyroid Gland: Systematic Review and Meta-analysis. Advances in therapy, 38(10), 5144–5164. https://doi.org/10.1007/s12325-021-01876-7.

Columbia Surgery (2024). Thyroid Cancer Diagnosis. Columbia University Irving Medical Center, Department of Surgery. https://columbiasurgery.org/thyroid/thyroid-cancer-diagnosis.

Denaro, N., Romanò, R., Alfieri, S., Dolci, A., Licitra, L., Nuzzolese, I., Ghidini, M., Bareggi, C., Bertaglia, V., Solinas, C., & Garrone, O. (2023). The Tumor Microenvironment and the Estrogen Loop in Thyroid Cancer. Cancers, 15(9). https://doi.org/10.3390/cancers15092458.

Dideban, S., Abdollahi, A., Meysamie, A., Sedghi, S., & Shahriari, M. (2015). Thyroid Papillary Microcarcinoma: Etiology, Clinical Manifestations,Diagnosis, Follow-up, Histopathology and Prognosis. Iranian Journal of Pathology, 11(1), 1-19. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4749190/.

Fefar, A.D., Gohel, U., Mistry, S.N., Khavdu, P.J., Mehta, M.R. (2016). Papillary carcinoma of thyroid-an unusual lateral neck presentation. Indian Journal of Anatomy and Surgery of Head, Neck and Brain, 2(4), 114–115. https://doi.org/10.18231/2455-846X.2016.0008.

Filetti, S., Durante, C., Hartl, D., Leboulleux, S., Locati, L. D., Newbold, K., Papotti, M. G., Berruti, A., & ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org (2019). Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†. Annals of oncology : official journal of the European Society for Medical Oncology, 30(12), 1856–1883. https://doi.org/10.1093/annonc/mdz400.

Ganly, I., Makarov, V., Deraje, S., Dong, Y., Reznik, E., Seshan, V., Nanjangud, G., Eng, S., Bose, P., Kuo, F., Morris, L. G. T., Landa, I., Carrillo Albornoz, P. B., Riaz, N., Nikiforov, Y. E., Patel, K., Umbricht, C., Zeiger, M., Kebebew, E., Sherman, E., … Chan, T. A. (2018). Integrated Genomic Analysis of Hürthle Cell Cancer Reveals Oncogenic Drivers, Recurrent Mitochondrial Mutations, and Unique Chromosomal Landscapes. Cancer cell, 34(2), 256–270.e5. https://doi.org/10.1016/j.ccell.2018.07.002.

Haddad, R. I., Bischoff, L., Ball, D., Bernet, V., Blomain, E., Busaidy, N. L., Campbell, M., Dickson, P., Duh, Q. Y., Ehya, H., Goldner, W. S., Guo, T., Haymart, M., Holt, S., Hunt, J. P., Iagaru, A., Kandeel, F., Lamonica, D. M., Mandel, S., Markovina, S., … Darlow, S. (2022). Thyroid Carcinoma, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN, 20(8), 925–951. https://doi.org/10.6004/jnccn.2022.0040.

Hao, Z., Cui, H., Li, Y., Wu, W., Wang, Y., Dan, H., Lou, L., Wang, H., & Zhao, P. (2024). Simultaneous occurrence of papillary thyroid carcinoma, medullary thyroid carcinoma, and lymphoma: A case report. Medicine, 103(33), e39363. https://doi.org/10.1097/MD.0000000000039363.

Harari, A., & Singh, R. K. (2016). Increased rates of advanced thyroid cancer in California. Journal of Surgical Research, 201(1), 244-252. https://doi.org/10.1016/j.jss.2015.10.037

Ito, Y., Hirokawa, M., Fujishima, M., Masuoka, H., Higashiyama, T., Kihara, M., Onoda, N., Miya, A., & Miyauchi, A. (2021). Prognostic significance of vascular invasion and cell-proliferation activity in widely invasive follicular carcinoma of the thyroid. Endocrine journal, 68(8), 881–888. https://doi.org/10.1507/endocrj.EJ21-0064.

Jannin, A., Escande, A., Al Ghuzlan, A., Blanchard, P., Hartl, D., Chevalier, B., ... & Dupuy, C. (2022). Anaplastic thyroid carcinoma: an update. Cancers 2022 14 1061. Endocrine and Neuroendocrine Cancers, 103. https://doi.org/10.3390/ cancers14041061.

Jiang, L., Chu, H., & Zheng, H. (2016). B-Raf mutation and papillary thyroid carcinoma patients. Oncology letters, 11(4), 2699–2705. https://doi.org/10.3892/ol.2016.4298.

Khan, S. A., Aziz, A., Esbhani, U. A., & Masood, M. Q. (2022). Medullary Thyroid Cancer: An Experience from a Tertiary Care Hospital of a Developing Country. Indian journal of endocrinology and metabolism, 26(1), 68–72. https://doi.org/10.4103/ijem.ijem_474_21.

Kitahara, C. M., K Rmendiné Farkas, D., Jørgensen, J. O. L., Cronin-Fenton, D., & Sørensen, H. T. (2018). Benign Thyroid Diseases and Risk of Thyroid Cancer: A Nationwide Cohort Study. The Journal of clinical endocrinology and metabolism, 103(6), 2216–2224. https://doi.org/10.1210/jc.2017-02599.

Kure, S., & Ohashi, R. (2020). Thyroid Hürthle Cell Carcinoma: Clinical, Pathological, and Molecular Features. Cancers, 13(1), 26. https://doi.org/10.3390/cancers13010026.

Lam A. K. (2022). Papillary Thyroid Carcinoma: Current Position in Epidemiology, Genomics, and Classification. Methods in molecular biology (Clifton, N.J.), 2534, 1–15. https://doi.org/10.1007/978-1-0716-2505-7_1.

Marcello, M. A., Cunha, L. L., Batista, F. A., & Ward, L. S. (2014). Obesity and thyroid cancer. Endocrine-Related Cancer, 21(5), T255-T271. Retrieved Oct 14, 2024, https://doi.org/10.1530/ERC-14-0070.

National Cancer Institute. (2024). Thyroid Cancer Treatment (PDQ®)-Health Professional Version. US Department of Health and Human Services. https://www.cancer.gov/types/thyroid/hp/thyroid-treatment-pdq.

Nguyen, Q. T., Lee, E. J., Huang, M. G., Park, Y. I., Khullar, A., & Plodkowski, R. A. (2015). Diagnosis and Treatment of Patients with Thyroid Cancer. American Health & Drug Benefits, 8(1), 30-40. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415174/.

Park, S. Y., Kim, H. I., Kim, J. H., Kim, J. S., Oh, Y. L., Kim, S. W., Chung, J. H., Jang, H. W., & Kim, T. H. (2018). Prognostic significance of gross extrathyroidal extension invading only strap muscles in differentiated thyroid carcinoma. The British journal of surgery, 105(9), 1155–1162. https://doi.org/10.1002/bjs.10830.

Raman, P., & Koenig, R. J. (2014). PAX8-PPARγ fusion protein in thyroid carcinoma. Nature Reviews. Endocrinology, 10(10), 616. https://doi.org/10.1038/nrendo.2014.115

Shah, J. P. (2015). Thyroid Carcinoma: Epidemiology, Histology, and Diagnosis. Clinical Advances in Hematology & Oncology : H&O, 13(4 Suppl 4), 3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5526593/.

Shen, J., Yan, M., Chen, L., Ou, D., Yao, J., Feng, N., Zhou, X., Lei, Z., & Xu, D. (2023). Prognosis and influencing factors of follicular thyroid cancer. Cancer Medicine, 13(1). https://doi.org/10.1002/cam4.6727.

Siregar, K. B. (2023) ‘Kanker Tiroid: Penjelasan Komprehensif Tentang Kanker Tiroid’, Perpustakaan Nasional : Katalog Dalam Terbitan (KDT), pp. 1–23.

Sung, H., Ferlay, J., Siegel, R. L., Laversanne, M., Soerjomataram, I., Jemal, A., & Bray, F. (2021). Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660.

Author Biographies

Rima Cahyati Kusumadewi, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Rukmanggana Satya Pratiwi, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Artiani Tresna Imut Exhasna, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Gina Aulia Azizaturrahmah, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

I Gede Pande Devin Agastya Sastrawan, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Rosita Wenilia, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Syihabul Muttaqin, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Dita Supriantarini, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

M. Arya Rifqi Ilham, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Walid Rivaldi Fatahillah, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Eva Triani, Program Studi Pendidikan Dokter, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Mataram, Mataram, Indonesia

Author Origin : Indonesia

Downloads

Download data is not yet available.

How to Cite

Kusumadewi, R. C., Rukmanggana Satya Pratiwi, Artiani Tresna Imut Exhasna, Gina Aulia Azizaturrahmah, Sastrawan, I. G. P. D. A., Rosita Wenilia, … Eva Triani. (2024). Understanding Thyroid Carcinoma: Clinical Manifestations, Diagnosis, and Management. Jurnal Biologi Tropis, 24(4), 645–656. https://doi.org/10.29303/jbt.v24i4.7664

Most read articles by the same author(s)

Similar Articles

1 2 3 4 5 6 7 8 9 > >> 

You may also start an advanced similarity search for this article.