Diagnosis and Management of Post Traumatic Epilepsy

Ali Ramzi; Ilsa Hunaifi

doi:10.29303/jbt.v24i4.7667

Diagnosis and Management of Post Traumatic Epilepsy

Authors

Ali Ramzi , Ilsa Hunaifi

DOI:

10.29303/jbt.v24i4.7667

Published:

2024-10-16

Issue:

Vol. 24 No. 4 (2024): Oktober - Desember

Keywords:

Biomarkers, diagnosis, management, post traumatic epilepsy.

Articles

Downloads

How to Cite

Ramzi, A., & Hunaifi, I. (2024). Diagnosis and Management of Post Traumatic Epilepsy. Jurnal Biologi Tropis, 24(4), 403–412. https://doi.org/10.29303/jbt.v24i4.7667

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Traumatic brain injury (TBI) is a leading cause of disability and death, particularly among children and young adults, and can result in serious complications such as post-traumatic epilepsy (PTE). PTE develops after TBI and is characterized by recurrent seizures without external triggers, with the risk influenced by the location and severity of the injury. Therefore, the authors raise this topic to help improve diagnostic acuity and highlight the importance of laboratory modalities in diagnosing PTE. The literature search was conducted using Google Scholar with the keywords "Post-Traumatic Epilepsy, Biomarkers, Management, Diagnosis." Based on the inclusion and exclusion criteria, 17 publications were identified as suitable for our literature review. Diagnostic tools such as CT scans, MRIs, and EEGs are essential for assessing risk. Although antiepileptic drugs (AEDs) can reduce early seizures, they are not effective for the long-term prevention of PTE. Long-term approaches, including lamotrigine, carbamazepine, and vagus nerve stimulation (VNS), may be beneficial, but further research is needed to optimize treatment.

References

Anwer, Fatima, Federico Oliveri, Fotios Kakargias, Priyanka Panday, Ana P Arcia Franchini, Beshoy Iskander, and Pousette Hamid. (2021). “Post-Traumatic Seizures: A Deep-Dive Into Pathogenesis.” Cureus 13 (4): 1–7. https://doi.org/10.7759/cureus.14395.

Beghi, Ettore. (2020). “The Epidemiology of Epilepsy.” Neuroepidemiology 54 (2): 185–91. https://doi.org/10.1159/000503831.

Foerschner, L., K. G. Kanz, Peter Biberthaler, and Viktoria Bogner-Flatz. (2020). Clinical Risk Factors of Traumatic Brain Injury. Biomarkers for Traumatic Brain Injury. INC. https://doi.org/10.1016/B978-0-12-816346-7.00022-1.

Fordington, Surina, and Mark Manford. (2020). “A Review of Seizures and Epilepsy Following Traumatic Brain Injury.” Journal of Neurology 267 (10): 3105–11. https://doi.org/10.1007/s00415-020-09926-w.

Gupta, Rakesh K., Sona Saksena, Atul Agarwal, Khader M. Hasan, Mazhar Husain, Vikas Gupta, and Ponnada A. Narayana. (20050. “Diffusion Tensor Imaging in Late Posttraumatic Epilepsy.” Epilepsia 46 (9): 1465–71. https://doi.org/10.1111/j.1528-1167.2005.01205.x.

Jackson, Edwin K., Detlev Boison, Michael A. Schwarzschild, and Patrick M. Kochanek. (2016). “Purines: Forgotten Mediators in Traumatic Brain Injury.” Journal of Neurochemistry 137 (2): 142–53. https://doi.org/10.1111/jnc.13551.

Karlander, Markus, Johan Ljungqvist, and Johan Zelano. (2021). “Post-Traumatic Epilepsy in Adults: A Nationwide Register-Based Study.” Journal of Neurology, Neurosurgery and Psychiatry 92 (6): 617–21. https://doi.org/10.1136/jnnp-2020-325382.

Kazis, Dimitrios, Symela Chatzikonstantinou, Alin Ciobica, Fatima Zahra Kamal, Vasile Burlui, Gabriela Calin, and Ioannis Mavroudis. (2024). “Epidemiology, Risk Factors, and Biomarkers of Post-Traumatic Epilepsy: A Comprehensive Overview.” Biomedicines 12 (2): 1–19. https://doi.org/10.3390/biomedicines12020410.

Koenig, Jenny B., and Chris G. Dulla. (2018). “Dysregulated Glucose Metabolism as a Therapeutic Target to Reduce Post-Traumatic Epilepsy.” Frontiers in Cellular Neuroscience 12 (October): 1–19. https://doi.org/10.3389/fncel.2018.00350.

Lucke-Wold, Brandon P., Linda Nguyen, Ryan C. Turner, Aric F. Logsdon, Yi Wen Chen, Kelly E. Smith, Jason D. Huber, et al. (20150. “Traumatic Brain Injury and Epilepsy: Underlying Mechanisms Leading to Seizure.” Seizure 33: 13–23. https://doi.org/10.1016/j.seizure.2015.10.002.

Pearn, Matthew L., Ingrid R. Niesman, Junji Egawa, Atsushi Sawada, Angels Almenar-Queralt, Sameer B. Shah, Josh L. Duckworth, and Brian P. Head. (2017). “Pathophysiology Associated with Traumatic Brain Injury: Current Treatments and Potential Novel Therapeutics.” Cellular and Molecular Neurobiology 37 (4): 571–85. https://doi.org/10.1007/s10571-016-0400-1.

Piccenna, Loretta, Graeme Shears, and Terence J. O’Brien. (2017). “Management of Post-Traumatic Epilepsy: An Evidence Review over the Last 5 Years and Future Directions.” Epilepsia Open 2 (2): 123–44. https://doi.org/10.1002/epi4.12049.

Pingue, Valeria, Chiara Mele, and Antonio Nardone. (2021). “Post-Traumatic Seizures and Antiepileptic Therapy as Predictors of the Functional Outcome in Patients with Traumatic Brain Injury.” Scientific Reports 11 (1): 1–12. https://doi.org/10.1038/s41598-021-84203-y.

Sharma, Rishabh, Wai Lam Leung, Akram Zamani, Terence J. O’brien, Pablo M.Casillas Espinosa, and Bridgette D. Semple. (2019). “Neuroinflammation in Post-Traumatic Epilepsy: Pathophysiology and Tractable Therapeutic Targets.” Brain Sciences 9 (11). https://doi.org/10.3390/brainsci9110318.

Teasell, Robert, Nestor Bayona, Corbin Lippert, James Villamere, and Chelsea Hellings. (2007). “Post-Traumatic Seizure Disorder Following Acquired Brain Injury.” Brain Injury 21 (2): 201–14. https://doi.org/10.1080/02699050701201854.

Tubi, M. A., Lutkenhoff, E., Blanco, M. B., McArthur, D., Villablanca, P., Ellingson, B., ... & Vespa, P. M. (2019). Early seizures and temporal lobe trauma predict post-traumatic epilepsy: a longitudinal study. Neurobiology of disease, 123, 115-121. https://doi.org/10.1016/j.nbd.2018.05.014.

Verellen, Rebecca M., and Jose E. Cavazos. (2010). “Post-Traumatic Epilepsy: An Overview.” Therapy 7 (5): 527–31. https://doi.org/10.2217/thy.10.57.

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Ali Ramzi, Chikungunya: Diagnostic, Treatment and Challenge in Indonesia , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Gintis Dhimar Ginuluh, Alya Syafa Kamila, Anang Muh Naufal Humam, Putri Fatimah Helmiana, Rukmanggana Satya Pratiwi, Ilsa Hunaifi, Lazuardi Arsy, Pathophysiology of Rabies Encephalitis and Treatment of Rabies : A Literature Review , Jurnal Biologi Tropis: Vol. 24 No. 1b (2024): Special Issue
Rika Kamila Salsabila, Nilam Nurmilatun Kamilah, Atina Rizki Putri, Prananda Rizki Pramudia, Rian Pramudya, Ni Wayan Citra Ayu Saraswati, Tazkiyah Arafah Amatullah, Ilsa Hunaifi, Emergencies in The Maritime Field A Literatur Review , Jurnal Biologi Tropis: Vol. 24 No. 2b (2024): Special Issue
Alma Dyah Perwita, Adam Trojan Alisyahbana, Adinda Ilsa Maulida, Alfia Mawaddah, Ali Ramzi, Legis Ocktaviana Saputri, The Marine Organisms as Potential Sources of Inhibits ACE on Hypertension Patient , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Baiq Ayu Rahmawati, Amelia Wahyu Maharani, Ali Ramzi, Muhammad Rizkinov Jumsa , Factors That Determine the Successful Management of Ectopic Pregnancy Through Methotrexate Injections , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Nur Feby Febiana Agistany, Ananda Karunia Ramadhan, Dira Kurnia Rizki, Raditya Bayu Farizil Akhyar, Ilsa Hunaifi, Protein S Deficiency and The Mechanism of Protein S in Hemostasis and Atherosclerosis , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Adinda Ilsa Maulida, Ali Ramzi, Amrullah Muliawan H, Baiq Ghassani Kayla, Clara Nadila, Dinda Salsabila, Febbi Anggy, Herodya Lajunee Fesmia, Jihan Alifa Rahma, Trisna Ayu Kurnia Putri, Wina Aryslia Fakar, Zulfa Hasyimiyyah Ihtisyam, Nurhidayati Nurhidayati, Giant Cell Tumor: Pathogenesis and Clinical Manifestation , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
M. Arya Rifqi Ilham, Ilsa Hunaifi, Bayu Tirta Dirja, Effect of MLC901 on Red Cell Distribution Width (RDW) in Acute Ischemic Stroke: Literature Review , Jurnal Biologi Tropis: Vol. 24 No. 2 (2024): April - Juni
Muhammad Ghifari Rifanhsa, Ilsa Hunaifi, Ika Primayanti, The Role of Neutrophil in The Pathophysiology of Frailty Syndrome , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
I Made Arya Yogiswara Mahayasa, Ilsa Hunaifi, Stephanie Elizabeth Gunawan, Setyawati Asih Putri, Clipping Pada Aneurisma Intrakranial , Jurnal Biologi Tropis: Vol. 23 No. 3 (2023): July - September

1 2 > >>

Diagnosis and Management of Post Traumatic Epilepsy

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow