Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review

Dara Pitra Syalsabila; Carolina Janicca Winda Manafe

doi:10.29303/jbt.v24i1b.7950

Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review

Authors

Dara Pitra Syalsabila , Carolina Janicca Winda Manafe

DOI:

10.29303/jbt.v24i1b.7950

Published:

2024-12-14

Issue:

Vol. 24 No. 1b (2024): Special Issue

Keywords:

Colorectal cancer, epigallocatechin-3-gallate, potential, therapy, tea, 5-fluorouracil.

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Syalsabila, D. P., & Manafe, C. J. W. (2024). Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review. Jurnal Biologi Tropis, 24(1b), 327–334. https://doi.org/10.29303/jbt.v24i1b.7950

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Abstract

This article reviews the potential of combining Epigallocatechin-3-Gallate (EGCG) from green tea and 5-Fluorouracil (5-Fu) to enhance the effectiveness of colorectal cancer therapy. Colorectal cancer is a common type of cancer with a high mortality rate, particularly due to resistance to standard therapies like 5-Fu. The article aims to explore the potential of EGCG as a combination therapy to overcome resistance and reduce the side effects of chemotherapy. The method used is a narrative literature review, collecting studies from PubMed, google scholar and proquest databases. The review findings show that EGCG can induce apoptosis, inhibit cancer cell growth, and increase cell sensitivity to 5-Fu. The combination of EGCG and 5-Fu has proven effective in suppressing cancer cell proliferation and reducing resistance to 5-Fu, especially in drug-resistant colorectal cancer cells. In conclusion, the EGCG and 5-Fu combination has the potential to become a more effective and safer colorectal cancer therapy with a lower risk of side effects, offering a promising prospect for future cancer therapy development.

References

Azwar, S., Seow, H. F., Abdullah, M., Faisal Jabar, M., & Mohtarrudin, N. (2021). Recent updates on mechanisms of resistance to 5-fluorouracil and reversal strategies in colon cancer treatment. Biology, 10(9), 854. https://doi.org/10.3390/BIOLOGY10090854.

Bracci, L., Fabbri, A., Del Corno, M., & Conti, L. (2021). Dietary polyphenols: promising adjuvants for colorectal cancer therapies. Cancers, 13(18), 4499. https://doi.org/10.3390/CANCERS13184499.

Filippini, T., Malavolti, M., Borrelli, F., Izzo, A. A., Fairweather-Tait, S. J., Horneber, M., & Vinceti, M. (2020). Green tea (Camellia sinensis) for the prevention of cancer. Cochrane Database of Systematic Reviews, (3). https://doi.org/10.1002/14651858.CD005004.pub3.

Fraga, C. G., Croft, K. D., Kennedy, D. O., & Tomás-Barberán, F. A. (2019). The effects of polyphenols and other bioactives on human health. Food & function, 10(2), 514-528. https://doi.org/10.1039/c8fo01997e.

Gmeiner, W.H. and Chidi Okechukwu, C. (2023) ‘Review of 5-FU resistance mechanisms in colorectal cancer: clinical significance of attenuated on-target effects’. Available at: https://doi.org/10.20517/cdr.2022.136.

Hossain, M. S., Karuniawati, H., Jairoun, A. A., Urbi, Z., Ooi, D. J., John, A., ... & Hadi, M. A. (2022). Colorectal cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies. Cancers, 14(7), 1732. https://doi.org/10.3390/CANCERS14071732.

IARC (2020) ‘Angka Kejadian dan Mortalitas Kanker di Indonesia’, International Agency for Research on Cancer [Preprint].

Islam, M. R., Akash, S., Rahman, M. M., Nowrin, F. T., Akter, T., Shohag, S., ... & Simal-Gandara, J. (2022). Colon cancer and colorectal cancer: Prevention and treatment by potential natural products. Chemico-biological interactions, 368, 110170. https://doi.org/10.1016/J.CBI.2022.110170.

Van der Jeught, K., Xu, H. C., Li, Y. J., Lu, X. B., & Ji, G. (2018). Drug resistance and new therapies in colorectal cancer. World journal of gastroenterology, 24(34), 3834. https://doi.org/10.3748/wjg.v24.i34.3834.

Juul, F. E., Cross, A. J., Schoen, R. E., Senore, C., Pinsky, P. F., Miller, E. A., ... & Løberg, M. (2024). Effectiveness of Colonoscopy Screening vs Sigmoidoscopy Screening in Colorectal Cancer. JAMA Network Open, 7(2), e240007-e240007. https://doi.org/10.1001/jamanetworkopen.2024.0007.

Lee, Y. J., Cho, J. M., Sai, S., Oh, J. Y., Park, J. A., Oh, S. J., ... & Kim, E. H. (2019). 5-Fluorouracil as a tumor-treating field-sensitizer in colon cancer therapy. Cancers, 11(12), 1999. https://doi.org/10.3390/cancers11121999.

Li, X., Ma, Y., Wu, J., Ni, M., Chen, A., Zhou, Y., ... & Chen, W. (2023). Thiol oxidative stress-dependent degradation of transglutaminase2 via protein S-glutathionylation sensitizes 5-fluorouracil therapy in 5-fluorouracil-resistant colorectal cancer cells. Drug Resistance Updates, 67, 100930. https://doi.org/10.1016/J.DRUP.2023.100930.

Maida, M., Dahiya, D. S., Shah, Y. R., Tiwari, A., Gopakumar, H., Vohra, I., ... & Facciorusso, A. (2024). Screening and Surveillance of Colorectal Cancer: A Review of the Literature. Cancers, 16(15), 2746. https://doi.org/10.3390/cancers16152746.

Makmun, D., Simadibrata, M., Abdullah, M., Syam, A. F., Shatri, H., Fauzi, A., ... & Nursyirwan, S. A. (2021). Colorectal cancer patients in a tertiary hospital in Indonesia: Prevalence of the younger population and associated factors. World Journal of Clinical Cases, 9(32), 9804. https://doi.org/10.12998/WJCC.V9.I32.9804.

Nosrati, N., Bakovic, M. and Paliyath, G. (2017) ‘Molecular Mechanisms and Pathways as Targets for Cancer Prevention and Progression with Dietary Compounds’, International Journal of Molecular Sciences, 18(10), p. 2050. Available at: https://doi.org/10.3390/ijms18102050.

Rady, I., Mohamed, H., Rady, M., Siddiqui, I. A., & Mukhtar, H. (2018). Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea. Egyptian Journal of Basic and Applied Sciences, 5(1), 1-23. https://doi.org/10.1016/J.EJBAS.2017.12.001.

Samudera, J., Daryanto, A., & Saptono, I. T. (2017). Competitiveness of Indonesian tea in International market. Indonesian Journal of Business and Entrepreneurship (IJBE), 3(1), 14-14. https://doi.org/10.17358/IJBE.3.1.14.

Sawicki, T., Ruszkowska, M., Danielewicz, A., Niedźwiedzka, E., Arłukowicz, T., & Przybyłowicz, K. E. (2021). A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis. Cancers, 13(9), 2025. https://doi.org/10.3390/CANCERS13092025.

Shaukat, A., Kahi, C. J., Burke, C. A., Rabeneck, L., Sauer, B. G., & Rex, D. K. (2021). ACG clinical guidelines: colorectal cancer screening 2021. Official journal of the American College of Gastroenterology| ACG, 116(3), 458-479. https://doi.org/10.14309/ajg.0000000000001122.

Shaukat, A. and Levin, T.R. (2022) ‘Current and future colorectal cancer screening strategies’, Nature Reviews. Gastroenterology & Hepatology, 19(8), p. 521. Available at: https://doi.org/10.1038/s41575-022-00612-y.

Siegel, R. L., Miller, K. D., Wagle, N. S., & Jemal, A. (2023). Cancer statistics, 2023. CA: a cancer journal for clinicians, 73(1), 17-48. https://doi.org/10.3322/caac.21772.

Toden, S., Tran, H. M., Tovar-Camargo, O. A., Okugawa, Y., & Goel, A. (2016). Epigallocatechin-3-gallate targets cancer stem-like cells and enhances 5-fluorouracil chemosensitivity in colorectal cancer. Oncotarget, 7(13), 16158. https://doi.org/10.18632/ONCOTARGET.7567.

Vodenkova, S., Buchler, T., Cervena, K., Veskrnova, V., Vodicka, P., & Vymetalkova, V. (2020). 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacology & therapeutics, 206, 107447. https://doi.org/10.1016/J.PHARMTHERA.2019.107447.

Wolf, A. M., Fontham, E. T., Church, T. R., Flowers, C. R., Guerra, C. E., LaMonte, S. J., ... & Smith, R. A. (2018). Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society. CA: a cancer journal for clinicians, 68(4), 250-281. https://doi.org/10.3322/caac.21457.

Xi, Y., & Xu, P. (2021). Global colorectal cancer burden in 2020 and projections to 2040. Translational oncology, 14(10), 101174. https://doi.org/10.1016/J.TRANON.2021.101174

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Potential of Epigallocatechin-3-Gallate and 5-Fluorouracil Combination in Colorectal Cancer Therapy: Literature Review

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