Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus)

I Wayan Radityakara Wirasena Yassa; Anak Agung Ayu Niti Wedayani; Novia Andansari Putri Restuningdyah; Linda Silvana Sari; Eka Arie Yuliyani

doi:10.29303/jbt.v24i1b.8173

Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus)

Authors

I Wayan Radityakara Wirasena Yassa , Anak Agung Ayu Niti Wedayani , Novia Andansari Putri Restuningdyah , Linda Silvana Sari , Eka Arie Yuliyani

DOI:

10.29303/jbt.v24i1b.8173

Published:

2024-12-17

Issue:

Vol. 24 No. 1b (2024): Special Issue

Keywords:

Dysplasia, dosage, degree of dysplasia, formaldehyde.

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Yassa, I. W. R. W., Anak Agung Ayu Niti Wedayani, Restuningdyah, N. A. P., Linda Silvana Sari, & Eka Arie Yuliyani. (2024). Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus). Jurnal Biologi Tropis, 24(1b), 519–525. https://doi.org/10.29303/jbt.v24i1b.8173

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Abstract

Formaldehyde, a known carcinogen prevalent in everyday environments, poses significant health risks, particularly through inhalation exposure. This study investigates the histopathological changes in the lungs of Wistar rats induced by formaldehyde at doses of 20, 30, and 40 parts per million (ppm) over a three-month period. The research aims to elucidate the onset of dysplasia, a cellular defense mechanism characterized by abnormal epithelial proliferation, as a response to carcinogenic exposure. Utilizing a post-test only control group experimental design, we observed that increased formaldehyde exposure correlates with a heightened severity of dysplasia, with a statistically significant result (p = 0.002). Our findings indicate that varying doses of formaldehyde lead to differential degrees of dysplasia, underscoring the importance of dose-response relationships in assessing the carcinogenic effects of formaldehyde on lung tissue.

References

Bernardini, L., Barbosa, E., Charão, M. F., & Brucker, N. (2022). Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data. Drug and chemical toxicology, 45(3), 972–984. https://doi.org/10.1080/01480545.2020.1795190

Kadriyan, H., Yudhanto, D., Cahyawati, T. D., Putri R, N. A., & Wedayani, N. (2022). Pengenalan Gejala Nasopharyngeal Cancer pada Populasi Beresiko di Lombok Utara 2021 pada saat Pandemi Covid19. Jurnal Pengabdian Magister Pendidikan IPA, 5(3), 231–234. https://doi.org/10.29303/jpmpi.v5i3.2134

Kang, D. S., Kim, H. S., Jung, J. H., Lee, C. M., Ahn, Y. S., & Seo, Y. R. (2021). Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach. Genes and environment : the official journal of the Japanese Environmental Mutagen Society, 43(1), 13. https://doi.org/10.1186/s41021-021-00183-5

Kwon, S. C., Kim, I., Song, J., & Park, J. (2018). Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?. Annals of occupational and environmental medicine, 30, 5. https://doi.org/10.1186/s40557-018-0218-z

Payani, S., Mamatha, C., Chandraprakash, C., & Bhaskar, M. (2019). Protective role of (Bronco-T) against formaldehyde induced antioxidant, oxidative and histopathological changes in lung of male Wistar rats. Toxicology Reports, 6, 718-726. https://doi.org/10.1016/j.toxrep.2019.07.002

Ranganath, K., Feng, A. L., Franco, R. A., Varvares, M. A., Faquin, W. C., Naunheim, M. R., & Saladi, S. V. (2022). Molecular Biomarkers of Malignant Transformation in Head and Neck Dysplasia. Cancers, 14(22), 5581. https://doi.org/10.3390/cancers14225581

Sari, R. K., Hendarti, H. T., Soebadi, B., Hadi, P., & Radithia, D. (2019). Correlation of Ki67 Expression to Degree of Dysplasia in Lingual Epithelial Dysplasia in Rattus norvegicus Exposured by Cigarette Smoke (Hubungan Ekspresi Ki67 Terhadap Derajat Displasia pada Epitel Mukosa Lidah Rattus Norvegicus yang Dipapar Asap Rokok). Odonto: Dental Journal, 6(2), 76-87. http://dx.doi.org/10.30659/odj.6.2.76-87.

Schneider, G., Schmidt-Supprian, M., Rad, R., & Saur, D. (2017). Tissue-specific tumorigenesis: context matters. Nature reviews. Cancer, 17(4), 239–253. https://doi.org/10.1038/nrc.2017.5

Srividhya, E., Anjana, T. S. R., Jalaja, Y., & Gurusamy, V. (2024). Effects of formaldehyde on Wistar albino rat lung following exposure through inhalation: Histo-logical study. International Journal of Academic Medicine and Pharmacy, 6(1), 546-549. https://doi.org/10.47009/jamp.2024.6.1.108

Sulistyo, H. (2008) ‘Inhibisi Aktivitas Proliferasi Sel dan Perubahan Histopatologik Epitelial Mukosa Nasofaring Mencit C3H dengan Pemberian Ekstrak Benalu Teh’, Universitas Diponegoro [Preprint].

Susilawati, N. K., Yasa, I. W. P. S., Suardana, W., Maliawan, S., Jawi, I. M., Romdhoni, A. C., Kadriyan, H., Putra, I. W. G. A. E., & Arijana, I. G. K. N. (2022). Purple Sweet Potato Reduces Malondialdehyde and TNF-a, Increases p53, and Protects Histopathological Appearance in Formaldehyde-induced Nasopharyngeal Carcinoma Rats. Indonesian Biomedical Journal, 14(2), 211-217. https://doi.org/10.18585/inabj.v14i2.1906

Wedayani, A. A. A. N., Punagi, A. Q., Pieter, N. A. L., Cangara, M. H., Sudharmawan, A. A. K., Kadriyan, H., & Andansari, N. (2023). Edukasi bahaya paparan zat karsinogenik melalui inhalasi terhadap risiko terjadinya keganasan pada pekerja pabrik tembakau di Dengen Daya. Jurnal Pengabdian Magister Pendidikan IPA, 6(1),284–287. https://doi.org/10.29303/jpmpi.v6i1.310

Wedayani, A. A. A. N., Punagi, A. Q., Pieter, N. A. L., Cangara, M. H., Kadriyan, H., et al. (2023) ‘Kandang Tikus Ekonomis Sebagai Media Induksi Displasia Untuk Studi Kesehatan’. Indonesia: Kementerian Hukum dan Hak Asasi Manusia.

Wedayani, A. A. A. N., Punagi, A. Q., Pieter, N. A. L., Cangara, M. H., et al. (2023) ‘Prosedur Penginduksian Formaldehida untuk Terjadinya Displasia pada Tikus Wistar’. Indonesia: Kementerian Hukum dan Hak Asasi Manusia.

Wedayani, A. A. A. N., Putri, N. A., Kadriyan, H., Yuliani, E. A., Hasbi, N., Ayunda, R. D., Rosyunita, Rahim, A. R., Punagi, A. Q., Pieter, N. A. L., & Cangara, M. H. (2023). Edukasi pengenalan faktor risiko serta tanda dan bahaya dari keganasan pada nasofaring di RSUDP NTB tahun 2023. Jurnal Pengabdian Magister Pendidikan IPA, 6(2), 17–20. https://doi.org/10.29303/jpmpi.v6i2.3420.

Zhang, Q., Tian, P., Zhai, M., Lei, X., Yang, Z., Liu, Y., Liu, M., Huang, H., Zhang, X., Yang, X., Zhao, Y., & Meng, Z. (2018). Formaldehyde regulates vascular tensions through nitric oxide-cGMP signaling pathway and ion channels. Chemosphere, 193, 60–73. https://doi.org/10.1016/j.chemosphere.2017.11.013

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Effect of Formaldeyde Induction of Histopathological Features of The Lungs of Wistar Rats (Rattus Norvegicus)

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