Computational Study of N-Hexane Extract of Jotang Herba (Acmella uliginosa)
DOI:
10.29303/jbt.v24i1b.8268Published:
2024-12-25Downloads
Abstract
The study investigates the in silico toxicity of n-hexane extract from Acmella uliginosa (Jotang) herb, a plant widely used in traditional medicine. In silico methods, such as molecular docking, toxicity prediction, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis, were employed to assess the potential harmful effects of the extract’s chemical constituents. The primary aim was to evaluate the safety profile of the extract in terms of cytotoxicity, mutagenicity, and organ toxicity. The study used computational tools like Pre.ADMET to predict various toxicological endpoints based on the molecular properties of the compounds identified in the n-hexane extract. The results suggested that while some compounds exhibited low toxicity risk, others showed potential mutagenic or hepatotoxic effects. This in silico approach provides a rapid and cost-effective method for preliminary toxicity assessment, offering valuable insights for further in vivo or clinical studies. The findings underscore the importance of integrating computational techniques into the safety evaluation of herbal medicines.
Keywords:
Silico, N-Hexan Extract of Jotang Herb (Acmella uliginosa), toxicity.References
Departemen Kesehatan Republik Indonesia. (1989). Materi medika Indonesia Jilid V. Jakarta. Departemen Kesehatan Republik Indonesia.
Departemen Kesehatan RI. (2000). Parameter standar umum ekstrak tumbuhan obat. Kementerian Kesehatan RI. Jakarta. .
Devi, L., & Mb, S. (2017). 115 Citation: Lavanya DK, Shivanna MB, Ganeshan S. Total Phenolic Content and Antioxidant Activity of Spilanthes Species from Peninsular India. Int J Pharm Pharmacol, 1(3), 115. https://doi.org/10.31531/2581
Farmakope Herbal Indonesia Edisi I 2008 Departemen Kesehatan Republik Indonesia. (n.d.).
Gairola, K., Gururani, S., Kumar, R., Prakash, O., Agrawal, S., & Dubey, S. K. (2022). Composition, Antioxidant and Anti-inflammatory activities of Hexane and Methanol extracts of Acmella uliginosa from Terai region of Uttarakhand. Brazilian Journal of Pharmaceutical Sciences, 58. https://doi.org/10.1590/s2175-97902022e20353
Harbone JB. (1987). Metode fitokimia, penuntun cara modern menganalisa tumbuhan, Terjemahan K. Padmawinata , Edisi II. Bandung: ITB Press. 6(71), 84–85.
Henny Nurhasnawati, S. F. H. (2017). Perbandingan Metode Ekstraksi Maserasi Dan Sokletasi Terhadap Aktivitas Antioksidan Ekstrak Etanol Daun Jambu Bol (Syzygium malaccense L.). Jurnal Ilmiah Manuntung, 3((1)), 91–95.
Hofbauer, W. K. (2021). Toxic or otherwise harmful algae and the built environment. Toxins, 13(7). https://doi.org/10.3390/toxins13070465
Kholifah E, E. (2022). Analisis Profil Fisika Kimia Dan Farmakokinetik Senyawa Pentagamavunon-1 Secara Komputasi. In Duta Pharma Journal (Vol. 2, Issue 1). www.swissadme.ch
Kholifah, E., Marlina Kurnia, N., Insani, N., Kunci, K., Uliginosa, A., Obat Diterbitkan oleh, P., Tinggi Ilmu Kesehatan Salsabila, S., & Banten, S. (2022). Minat Konsumen terhadap Penggunaan Hand Sanitizer di Komplek Margahayu Raya. Jurnal Ilmiah Kesehatan Delima, 4(2), 125–131. https://doi.org/10.60010/jikd/v4i2.82
Lagnika, L., Amoussa, A. M. O., Adjileye, R. A. A., Laleye, A., & Sanni, A. (2016). Antimicrobial, antioxidant, toxicity and phytochemical assessment of extracts from Acmella uliginosa, a leafy-vegetable consumed in Bénin, West Africa. BMC Complementary and Alternative Medicine, 16(1). https://doi.org/10.1186/s12906-016-1014-3
Lalthanpuii, P. B., Sailo, N., Lalruatfela, B., Lalremsanga, H. T., & Lalchhandama, K. (2019). Some Phytochemical, Antimicrobial and Anticancer Tests for an Aqueous extract of Acmella oleracea . Research Journal of Pharmacy and Technology, 12(6), 3033. https://doi.org/10.5958/0974-360x.2019.00513.4
Maimulyanti, A., & Prihadi, A. R. (2016). Chemical composition of essential oil and hexane extract and antioxidant activity of various extracts of Acmella uliginosa (Sw.) Cass flowers from Indonesia. Agriculture and Natural Resources, 50(4), 264–269. https://doi.org/10.1016/j.anres.2015.11.002
Maimulyanti, A., Prihadi, A. R., & Safrudin, I. (2016). 62 Chemical Composition, Phytochemical Screening and Antioxidant Activity of Acmella uliginosa (Sw.) Cass Leaves. In Indones. J. Chem (Vol. 16, Issue 2).
Meyer, B. N., Ferrigni, N. A., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., & Mclaughlin, J. L. (1982). Brine Shrimp: A Convenient General Bioassay for Active Plant Constituents (Vol. 45).
Paul, S., Sarkar, S., Dutta, T., & Bhattacharjee, S. (2016). Assessment of anti-inflammatory and anti-arthritic properties of Acmella uliginosa (Sw.) Cass. based on experiments in arthritic rat models and qualitative gas chromatography-mass spectrometry analyses. Journal of Intercultural Ethnopharmacology, 5(3), 257–262. https://doi.org/10.5455/jice.20160521010145
Rahayu Putri, D., Ramdani, W., Farmasi, S., Tinggi Ilmu Kesehatan Yayasan Lembaga Pendidikan Prada, S., Barat, J., Jl Cideng Raya No, I., & Cirebon, K. (2023). JIFMI Literatur Review: Uji Farmakologi dan Toksikologi pada Acmella sp.
Raies, A. B., & Bajic, V. B. (2016). In silico toxicology: computational methods for the prediction of chemical toxicity. Wiley Interdisciplinary Reviews: Computational Molecular Science, 147–172. https://doi.org/10.1002/wcms.1240
Sharma, R., & Arumugam, N. (2021). N-alkylamides of Spilanthes (syn: Acmella): Structure, purification, characterization, biological activities and applications – a review. In Future Foods (Vol. 3). Elsevier B.V. https://doi.org/10.1016/j.fufo.2021.100022
Tkaczyk, A., Bownik, A., Dudka, J., Kowal, K., & Ślaska, B. (2021). Daphnia magna model in the toxicity assessment of pharmaceuticals: A review. In Science of the Total Environment (Vol. 763). Elsevier B.V. https://doi.org/10.1016/j.scitotenv.2020.143038
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