Nucleoside Antiviral Therapy for Herpes Zoster: A Literature Review

Nisrina Huurul Ain; Lalu Mas’ud Rahmatullah; Widi Gustita Utari; Imasayu Nuralyza; Baiq Rani Salsabiella; Reivirly Khairadaty Maghfirahandini; Siti Rahmatul Aini; Nurhidayati Nurhidayati

doi:10.29303/jbt.v25i3.10006

Nucleoside Antiviral Therapy for Herpes Zoster: A Literature Review

Authors

Nisrina Huurul Ain , Lalu Mas’ud Rahmatullah , Widi Gustita Utari , Imasayu Nuralyza , Baiq Rani Salsabiella , Reivirly Khairadaty Maghfirahandini , Siti Rahmatul Aini , Nurhidayati Nurhidayati

DOI:

10.29303/jbt.v25i3.10006

Published:

2025-08-26

Issue:

Vol. 25 No. 3 (2025): Juli-September

Keywords:

Aacyclovir, Brivudine, Herpes zoster, Nucleoside analogs, Varicella-zoster virus

Articles

How to Cite

Ain, N. H., Rahmatullah, L. M., Utari, W. G., Nuralyza, I., Salsabiella, B. R., Maghfirahandini, R. K., … Nurhidayati, N. (2025). Nucleoside Antiviral Therapy for Herpes Zoster: A Literature Review . Jurnal Biologi Tropis, 25(3), 4634–4643. https://doi.org/10.29303/jbt.v25i3.10006

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Abstract

Herpes zoster is a viral skin infection caused by the reactivation of the varicella-zoster virus, which remains latent in the dorsal root ganglia of the spinal cord and the cranial sensory ganglia. One of the most widely used classes of antiviral agents in the treatment of herpes zoster is nucleoside analogs. This study aims to review the use of nucleoside analogs in the management of herpes zoster. The method employed was a literature review of relevant research articles. The findings indicate that nucleoside analogs commonly used in herpes zoster therapy include acyclovir, valacyclovir, famciclovir, and brivudine. These agents are administered in various doses, routes, and therapeutic purposes, such as alleviating acute symptoms, accelerating skin lesion healing, preventing postherpetic neuralgia, and serving as prophylactic therapy in special conditions such as cancer or organ transplantation. Overall, the use of nucleoside analogs has proven effective in inhibiting varicella-zoster virus replication, reducing symptom intensity, and minimizing the risk of complications.

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Copyright (c) 2025 Nisrina Huurul Ain, Lalu Mas’ud Rahmatullah, Widi Gustita Utari, Imasayu Nuralyza, Baiq Rani Salsabiella, Reivirly Khairadaty Maghfirahandini, Siti Rahmatul Aini, Nurhidayati Nurhidayati

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Nucleoside Antiviral Therapy for Herpes Zoster: A Literature Review

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