Human Papillomavirus (HPV) Infection and The Spectrum of Diseases It Causes: A Literature Review
Authors
Hanum Retno Hanifah , Yunita Hapsari , Shira Putri Wardana , Muhammad HaikalDOI:
10.29303/jbt.v25i4.10158Published:
2025-10-08Issue:
Vol. 25 No. 4 (2025): in ProgressKeywords:
Human Papillomavirus, HPV Infection Diseases, Pathogenesis, Clinical Presentation, Treatment, HPV VaccineArticles
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Abstract
Human Papillomavirus (HPV) is a sexually transmitted infection (STI) pathogen that plays a significant role in the development of benign and malignant diseases. This study used a literature review of national and international articles (2015–2025) obtained through Google Scholar, PubMed, and accredited journals. HPV is classified into high-risk types associated with cancer (primarily HPV 16 and 18) and low-risk types that commonly cause genital warts. Initial infection is often asymptomatic, but persistent infection can lead to cell transformation due to the activity of the oncoproteins E6 and E7. Globally, HPV prevalence remains high, with regional variations and a strong association with low vaccination coverage. Management includes pharmacological therapy, surgery, and a combination of chemotherapy and radiotherapy. While the primary prevention strategy is HPV vaccination (bivalent, quadrivalent, and nonavalent), which is currently being expanded to primary school-aged girls in Indonesia. Recent developments include new-generation therapeutic vaccines (Vvax001, PANHPVAX) that promise broader protection. It can be concluded that primary vaccination remains the most effective strategy to reduce the burden of disease caused by HPV, so that increased immunization coverage, public education, and further research related to new generation vaccines are needed.
References
Alkatout, I., Schubert, M., Garbrecht, N., Weigel, M. T., Jonat, W., Mundhenke, C., & Günther, V. (2015). Vulvar cancer: epidemiology, clinical presentation, and management options. International Journal of Women’s Health, 7, 305–313. https://doi.org/10.2147/IJWH.S68979
Andriana, R., & Zulfadli, Z. (2024). Condyloma Acuminata in Pregnancy: A Review and Case Management. Medical Profession Journal of Lampung, 14(2), 343–350. https://doi.org/10.53089/medula.v14i2.1019
Baba, S. K., Alblooshi, S. S. E., Yaqoob, R., et al. (2025). Human papilloma virus (HPV) mediated cancers: an insightful update. Journal of Translational Medicine, 23, 483. https://doi.org/10.1186/s12967-025-06470-x
Centers for Disease Control and Prevention (CDC) . (2023). Human Papillomavirus (HPV) Vaccine Safety. CDC. https://www.cdc.gov/vaccine-safety/vaccines/hpv.html#:~:text=CDC%20recommends%20HPV%20vaccination%20for,ages%209%20through%2026%20years. (Accessed on September 04, 2025)
Chen, S. H., Song, Y. Y., Gan, N., Wang, P. T., Yan, K., Wang, S. F., Zu, Y. E., & Peng, X. W. (2025). Human papillomavirus infection and screening strategies. World Journal of Clinical Oncology, 16(5), 105055. https://doi.org/10.5306/wjco.v16.i5.105055
Cheng, L., Wang, Y., & Du, J. (2020). Human Papillomavirus Vaccines: An Updated Review. Vaccines, 8(3), 391. https://doi.org/10.3390/vaccines8030391
Eerkens, A. L., Esajas, M. D., Brummel, K., Vledder, A., van Rooij, N., Plat, A., Avalos Haro, S. B., Paijens, S. T., Slagter-Menkema, L., Schuuring, E., Werner, N., Kosterink, J. G. W., Kroesen, B.–J., Wilschut, J. C., Daemen, T., Bart, J., Nijman, H. W., de Bruyn, M., & Yigit, R. (2025). Vvax001, a therapeutic vaccine, for patients with HPV16-positive high-grade cervical intraepithelial neoplasia: A Phase II trial. Clinical Cancer Research, 31(6), 1016–1026. https://doi.org/10.1158/1078-0432.CCR-24-1662
Egawa, N., & Doorbar, J. (2017). The low-risk papillomaviruses. Virus Research, 231, 119–127. https://doi.org/10.1016/j.virusres.2016.12.017
English K. J. (2024). Anal carcinoma - exploring the epidemiology, risk factors, pathophysiology, diagnosis, and treatment. World journal of experimental medicine, 14(3), 98525. https://doi.org/10.5493/wjem.v14.i3.98525
Hammer, A., Rositch, A., Qeadan, F., Gravitt, P. E., & Blaakaer, J. (2016). Age-specific prevalence of HPV16/18 genotypes in cervical cancer: A systematic review and meta-analysis. International Journal of Cancer, 138(12), 2795–2803. https://doi.org/10.1002/ijc.29959
Jensen, J. E., Becker, G. L., Jackson, J. B., & Rysavy, M. B. (2024). Human Papillomavirus and Associated Cancers: A Review. Viruses, 16(5), 680. https://doi.org/10.3390/v16050680
KEMENKES RI. (2015). Panduan pelayanan klinis kanker serviks. KEMENKES RI. https://www.poijaya.org/wp-content/uploads/2021/03/PPKServiks.pdf. (Accessed on September 04, 2025)
KEMENKES RI. (2022). Kemenkes tambah 3 jenis vaksin imunisasi rutin, salah satunya HPV. KEMENKES RI. https://kemkes.go.id/id/39708. (Accessed on September 04, 2025)
Kusuma, F., Suryoadji, K. A., Abdullah, M. R. T., Fauzi, A., Ridwan, A. S., Purwoto, G., Winarto, H., Anggraeni, T. D., & Utami, T. W. (2023). Prevalensi infeksi Human Papilloma Virus risiko tinggi pada wanita dengan positif Human Immunodeficiency Virus di dunia: Tinjauan sistematis berdasarkan studi terkini. Jurnal Ilmiah Kesehatan, 22(2). https://doi.org/10.33221/jikes.v22i02.2652
Liu, M., Zhang, X., Guo, L., Sun, W., & Jiang, X. (2023). HPV prevalence and genotype distribution among 38 056 women in Weifang, China: a cross-sectional study. BMJ open, 13(9), e073332. https://doi.org/10.1136/bmjopen-2023-073332
Magalhães, G. M., Vieira, É. C., Garcia, L. C., De Carvalho-Leite, M. de L. R., Guedes, A. C. M., & Araújo, M. G. (2021). Update on human papilloma virus – part I: epidemiology, pathogenesis, and clinical spectrum. Anais Brasileiros de Dermatologia, 96(1), 1–16. https://doi.org/10.1016/j.abd.2020.11.003
Mlynarczyk-Bonikowska, B., & Rudnicka, L. (2024). HPV Infections-Classification, Pathogenesis, and Potential New Therapies. International journal of molecular sciences, 25(14), 7616. https://doi.org/10.3390/ijms25147616
Moore, K. A., & Mehta, V. (2015). The growing epidemic of HPV-positive oropharyngeal carcinoma: A clinical review for primary care providers. Journal of the American Board of Family Medicine, 28(4), 498–503. https://doi.org/10.3122/jabfm.2015.04.140301
Muršić, I., Včev, A., Kotrulja, L., Kuric, I., Milavić, T., Šustić, N., & Tolušić Levak, M. (2020). Treatment of verruca vulgaris in traditional medicine. Acta Clinica Croatica, 59(4), 745–750. https://doi.org/10.20471/acc.2020.59.04.22
Okoye, J. O., Chukwukelu, C. F., Okekpa, S. I., Ogenyi, S. I., Onyekachi-Umah, I. N., & Ngokere, A. A. (2021). Racial disparities associated with the prevalence of vaccine and non-vaccine HPV types and multiple HPV infections between Asia and Africa: A systematic review and meta-analysis. Asian Pacific Journal of Cancer Prevention, 22(9), 2729–2741. https://doi.org/10.31557/APJCP.2021.22.9.2729
Putri, R. H., & Aryati, T. (2021). Deteksi dini kanker serviks melalui pemeriksaan HPV DNA. Jurnal Kedokteran Brawijaya, 33(1), 45–52. https://doi.org/10.21776/ub.jkb.2021.033.01.8
Shen, Y., Meng, X., Wang, L., Wang, X., & Chang, H. (2022). Advanced primary vaginal squamous cell carcinoma: A case report and literature review. Frontiers in Immunology, 13, 1007462. https://doi.org/10.3389/fimmu.2022.1007462
Suryoadji, K. A., Ridwan, A. S. S., & Kusuma, F. (2022). Vaksin HPV sebagai strategi pencegahan kanker serviks di Indonesia. Jurnal Ilmiah Mahasiswa Kedokteran Indonesia (JIMKI), 10(1), 114–119. https://doi.org/10.53366/jimki.v10i1.521
Symer, M. M., & Yeo, H. L. (2018). Recent advances in the management of anal cancer. F1000Research, 7, F1000 Faculty Rev-1572. https://doi.org/10.12688/f1000research.14518.1
Utami TW, Nuranna L, Rahman SA, Irzami R, Utama A, Purwoto G, Suarthana E. Data satu dekade genotipe HPV di wilayah metropolitan Indonesia: membuka jalan bagi strategi eliminasi kanker serviks nasional. J Gynecol Oncol. 2025 Maret;36:e85. https://doi.org/10.3802/jgo.2025.36.e85
Williamson, A. L. (2023). Recent developments in human papillomavirus (HPV) vaccinology. Viruses, 15(7), 1440. https://doi.org/10.3390/v15071440
World Health Organization (WHO). (2024). WHO, UNFPA commend Indonesia’s efforts to eliminate cervical cancer, urge streamlined vaccine strategy and enhanced screening. WHO. https://www.who.int/indonesia/news/detail/15-11-2024-who--unfpa-commend-indonesia-s-efforts-to-eliminate-cervical-cancer--urge-streamlined-vaccine-strategy-and-enhanced-screening. (Accessed on September 04, 2025)
Zhao, X., Zhang, Y., Trejo-Cerro, O., Zhou, J., He, L., He, D., Wang, J., Hu, Z., & Chen, X. (2024). A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity. NPJ Vaccines, 9, 119. https://doi.org/10.1038/s41541-024-00914-z
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