Use of the GnRH Antagonist Elagolix for Endometriosis in Relation to Hypoestrogenic Effect in Women
DOI:
10.29303/jbt.v22i2.3344Published:
2022-05-26Downloads
Abstract
The female reproductive system is a system related to reproduction, which includes hormones and reproductive organs. Endometriosis is a disease that attacks the female reproductive organs. Endometriosis is the growth of endometrial cells that are not in place so that it interferes with the female reproductive system. Endometriosis causes pelvic pain and infertility in women. Endometriosis can be treated in several ways. One is to use drugs such as the GnRH antagonist Elagolix. This study aims to find out more about endometriosis and the Elagolix treatment in dealing with it. The method used in this study is a literature review method by discussing four focus studies to achieve the objectives of the study. Endometriosis is caused by several causes such as genetics, immunology, retrograde menstruation, coelomic metaplasia and vascular and lymphatic spread. The result of Endometriosis is the occurrence of dysmenorrhea, dyspareunia to infertility for the sufferers. The treatment that can be applied to endometriosis is surgical and medical surgery. One treatment with medical therapy is using Elagolix to inhibit the growth of endometriosis tissue by suppressing the hormone estrogen. Through this research, researchers are grateful that humans are given reason and thoughts by God so that humans can further research endometriosis and continue to try and try various alternative treatments to cure sufferers. The knowledge gained by humans is also very helpful for each other, namely the women sufferers so that they can live a better life to get rid of endometriosis. The conclusion obtained is that Elagolix is one of the latest alternative treatments that can treat endometriosis.
Keywords:
Elagolix Endometriosis Endometrium GnRH ReproductionReferences
Archer, D. F., Soliman, A. M., Agarwal, S. K., & Taylor, H. S. (2020). Elagolix in the treatment of endometriosis: impact beyond pain symptoms. Theraputic Advances in Reproductive Health, 2.
Arifianti, I. R., & Samaria, D. (2021 ). Gambaran Pengetahuan, Sikap, dan Motivasi Terkait Vulva Hygiene Pada Remaja Wanita di RW 02 Bojong Menteng, Bekasi . Jurnal Keperawatan Widya Gantari Indonesia Vol.5 No.1, 30-36 .
Ariviani, F., Annas, J. Y., & Sari, G. M. (2021). Karakteristik Dismenore pada Pasien Endometriosis di RSUD Dr. Soetomo Surabaya. Jurnal Ilmiah Ilmu Kesehatan.
Ariyanti, H., & Apriliana, E. (2016). Pengaruh Fitoestrogen Terhadap Gejala Menopause. Medical Journal of Lampung University.
Ariyantini, D., Lutfi, M., & Hadiati, D. R. (2018). Kadar Hormon LH Basal sebagai Prediktor Keberhasilan Stimulasi Ovarium pada Program Bayi Tabung. Jurnal Kesehatan Reproduksi.
Carr, B., Giudice, L., Dmowski, W. P., O'Brien, C., Jiang, P., Burke, J., . . . Chwalisz, K. (2013). Elagolix, an Oral GnRH Antagonist for Endometriosis Associated Pain: a Randomized Controlled Study. Journal of Endometriosis and Pelvic Pain Disorder.
Ekowati, S. W. (2018 ). Upaya Meningkatkan Prestasi Belajar IPA Materi Memahami Sistem Reproduksi Manusia Melalui Pendekatan Kontekstual Pada Siswa Kelas IX C SMP Negeri 6 Sukoharjo Semester I Tahun Pelajaran 2017/2018 . Edunomika ââ¬â Vol. 02, No. 01, 103-117 .
Gezer, A., & Oral, E. (2015). Progestin therapy in endometriosis. Women's Health.
Gultom, A., & Simanjuntak, E. G. (2020). Elagolix pada Endometriosis. Jurnal Ilmiah WIDYA Kesehatan dan Lingkungan.
Harlita, Probosari, R. M., & Ariyanto, J. (2015). Perubahan Histologis Uterus Tikus Putih (Rattus norvegicus) Galur Wistar: Aktivitas Antifertilitas Ekstrak Kulit Biji Mete (Anacardium occidentale L.). Bioedukasi.
Havis, M. (2013). Dua Sistem Tubuh: Reproduksi dan Endokrin . Sainstek Vol. V No.2 , 153-168 .
Hendarto, H. (2016). Endometriosis: Dari aspek teori sampai penanganan klinis. Surabaya: Airlangga University Press.
Hidayati, F., Alibasya, R. A., & Bahar, E. (2015). Perbedaan Derajat Nyeri Haid Pasien Endometriosis Sebelum dan Sesudah Tindakan Laparoskopi di RSUP Dr. Mohammad Hoesin Palembang. MKS, 46.
Kusmiyati, Khairuddin, Sedijani, P., & Merta, I. W. (2020). Pengenalan Struktur Fungsi Organ Reproduksi sebagai Upaya Pencegahan Kekerasan Seksual pada Anak. Jurnal Pendidikan dan Pengabdian Masyarakat, 184.
Luqyana, S. D., & Moekroni, R. (2019). Diagnosis dan Tatalaksana Terbaru Endometriosis. JIMKI, 69.
Marzali, A. (2016). Menulis Kajian Literatur. Jurnal Etnosia, 27.
Mukti, P. (2014). Faktor Risiko Kejadian Endometriosis. Unnes Journal of Public Health.
Nani, D. (2018). Fisiologi Manusia: Siklus Reproduksi Wanita. Jakarta: Penebar Plus.
Pramesti, P. A., Dewi, I. A., Sumadi, I. J., & Sriwidyani, N. (2020). Karakteristik Klinikopatologi Penderita Endometriosis di RSUP Sanglah Denpasar Tahun 2017-2018. Jurnal Medika Udayana, 104.
PS, P., Herryadi, N., Rusman, A. A., & Linasari, D. (2017). Aspek Medikolegal Pemeriksaan Selaput Dara Pada Korban Dugaan "Perkosaan" di RSUP Dr. Hasan Sadikin Bandung . Proceeding Annual Scientific Meeting I S B N 978-602-50127-0-9, 217-224 .
Ratnaningrum, K., Handaria, D., & Octavianny, A. (2016). Kista Endometriosis Meningkatkan Risiko terhadap Terjadinya Infertilitas pada Wanita Usia Reproduktif. Jurnal Kedokteran Muhammadiyah.
Ruiz-Alonso, M., Blesa, D., & Simón, C. (2012). The genomics of the human endometrium. Biochimica et Biophysica Acta, 1931.
Soli, E. D., Surber, B. W., & Reed, A. D. (2021). Synthesis of [H-3]- and [C-14]-labeled elagolix. Wiley Analytical Science.
Suparman, E. (2012). Penatalaksanaan Endometriosis. Jurnal Biomedik, 70.
Suparman, E., & Suparman, E. (2016). Peran GnRH Agonis. Jurnal Biomedik, 1.
Suryana. (2010). Metodologi Penelitian: Model Prakatis Penelitian Kuantitatif dan Kualitatif. Bandung: UPI.
Sutanto, R. L. (2021). Hiperplasia Prostat Jinak: Manajemen Tatalaksana dan Pencegahan. JIMKI.
Syarif, R. A., Soejono, S. K., Meiyanto, E., & Wahyuningsih, M. S. (2016). Efek Kurkumin terhadap Sekresi Estrogen dan Ekspresi Reseptor B Kultur Sel Granulosa Babi Folikel Sedang. Jurnal Kedokteran Brawijaya.
Tifani, N. U., Hendry, D., & Ilhamdi, Y. R. (2020). Karakteristik Endometriosis di RSUP Dr. M. Djamil Padang Periode 2017-2019. Jurnal Ilmu Kesehatan Indonesia, 290.
Wu, I. B., Tendean, H. M., & Mewengkang, M. E. (2017). Gambaran Karakteristik Penderita Endometriosis di RSUP Prof. Dr. R. D. Kandou Manado. Jurnal e-Clinic (eCl), 280.
Zahri, A., Sudrajat, A. O., & Junior, M. Z. (2017). Profil hormon FSH, LH dan estradiol serta kadar glukosa darah sidat, Anguilla bicolor bicolor (Mc Clelland, 1844) yang dirangsang hormon HCG, MT, E2 dan anti dopamin. Jurnal Iktiologi Indonesia.
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