Evaluation of The Quality of Antibiotic Use in Urinary Tract Infection Patients in hospitalization installations of NTB Provincial Hospital in 2019
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Husnul Marifah , Candra Eka Puspitasari , Ida Ayu Eka WidiastutiDOI:
10.29303/jbt.v22i3.3488Published:
2022-07-26Issue:
Vol. 22 No. 3 (2022): July - SeptemberKeywords:
Antibiotics; gyssens method; urinary tract infectionArticles
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Abstract
Urinary Tract Infection (UTI) is a nosocomial infection with several occurrences around 39-60 % in Indonesia. Antibiotics are the main therapy for UTIs. The use of poor quality antibiotics can cause irrational antibiotics therapy which leads to the risk of resistance. This research aims to recognize the patterns of antibiotics use and determine the percentage of the appropriate use of antibiotics. This research is an observational type of research with a cross-sectional design. The data were obtained retrospectively from July to September 2021 using 53 medical records of UTI hospitalized patients. The obtained data were analyzed descriptively and quantitatively using the Gyssens method. The result shows the characteristics of UTI patients are dominated by males (54,72%) and occurred in toddlers at age of 0 -5 years (20,75%) and the elderly at age 56- 65 years (15,09%). The antibiotics used in this research were dominated by ceftriaxone (37,50%). Of 53 patients using 80 antibiotics, the percentage of use accuracy of antibiotics in UTI patients in RSUD Provinsi NTB (category 0) is 23,75%. The inappropriate use of antibiotics is 76,25% was found in various categories, namely category VI medical record data incomplete (32,50%), IVA where there were more effective antibiotics (10%), IVC there were cheaper antibiotics (1,25%), IIIA too long duration of antibiotics use (8,75%), IIIB too short duration of antibiotics use (7,50%), IIA improper dosage of antibiotics (11,25%), and IIB improper giving interval (5%). Therefore, it can be concluded that there is still irrational use of antibiotics, especially improper dosage category.
References
Anggraini, W., Candra, T. M., Maimunah, S., & Sugihantoro, H. (2020). Evaluasi Kualitatif Penggunaan Antibiotik pada Pasien Infeksi Saluran Kemih dengan Metode Gyssens. Jurnal Kesehatan Dan Kedokteran, 2(1), 1–8.
Catto, G. R. D. (2012). Urinary Tract Infection: New Clinical Applications Nephrology. Kluwer Academic Publisher, New York. ISBN: 9401068712.
Dipiro & Wells. (2015). Pharmacotherapy handbook 7th Ed. McGraw Hill Education, New York.
Dipiro, J. T., Gary C. Yee, L. Michael Posey, Stuart T Haines, Thomas D. & Nolin, V. E. (2020). Pharmacotherapy A Pathophysiologic Approach 11th Ed. McGraw Hill, New York. ISBN: 978-1-26-01168-2.
Girard, R., Gaujard, S., Pergay, V., Pornon, P., Gaujard, G. M., Bourguignon, L., & Group, U. (2017). Risk Factors For Urinary Tract Infections in Geriatric Hospital. Journal of Hospital Infection, 97(1), 74–78. https://doi.org/10.1016/j.jhin.2017.05.007
Gilman & Goodman. (2012). Dasar Farmakologi Terapi, Edisi 10. Diterjemahkan oleh Tim Alih Bahasa Sekolah Farmasi ITB. Penerbit Buku Kedokteran EGC, Jakarta.
Herlina, D. (2019). Pola Peresepan Antibiotik Pada Pasien Infeksi Saluran Kemih di Instalasi Rawat Jalan RSUD Provinsi NTB Tahun 2017. Program Studi Farmasi Universitas Mataram.
IAUI (2020). Penatalaksanaan Infeksi Saluran Kemih dan Genitalia Pria 2020. Ikatan Ahli Urologi Indonesia.
IDAI (2011). Konsensus Infeksi Saluran Kemih Pada Anak. Badan Penerbit Ikatan Dokter Anak Indonesia.
Kementerian Kesehatan Republik Indonesia. (2011). Peraturan Menteri Kesehatan Republik Indonesia Nomor 2406/MENKES/PER/XII/2011 tentang Pedoman Umum Penggunaan Antibiotik. Kementerian Kesehatan Republik Indonesia.
Kementerian Kesehatan Republik Indonesia. (2015). Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 tahun 2015 tentang Program Pengendalian Resistensi di Rumah Sakit.
Kementerian Kesehatan Republik Indonesia. (2017). Petunjuk Teknis Evaluasi Penggunaan Obat di Fasilitas Kesehatan. Kementerian Kesehatan Republik Indonesia.
Khanal, P. (2020). Antibiotic Resistance: Causes and Consequences. European Journal of Biomedical and Pharmaceutical Sciences, 7(8), 327-331.
Kurniasari, S., Fauzan Humaidi, I. S. (2020). Penggunaan Antibiotik Oleh Penderita Infeksi Saluran Kemih Di Instalasi Rawat Inap (Irna) 2 Rsud Dr. H. Slamet Martodirdjo Pamekasan Tahun 2018. Jurnal Ilmiah Farmasi Attamaru, 1(1), 15–27.https://doi.org/10.31102/attamru.v1i1.918
Lim, C., Takahashi, E., Hongsuwan, M., & Wuthiekanun, V. (2016). Epidemiology and Burden of Multidrug- Resistant Bacterial Infection In A Developing Country. ELIFE Research Article, 1(1), 1–18. https://doi.org/10.7554/eLife.18082
Maknunnah, L., Pudjo, W., & Andrei, R. (2016). Faktor Risiko Kejadian Infeksi Saluran Kemih Pada Anak di Poli Anak RSUD Blambangan Kabupaten Banyuwangi. Artikel Ilmiah Penelitian Mahasiswa 2016, 1(1), 1-9.
Maragakis, L. L., Perencevich, E. N., & Cosgrove, S. E. (2008). Clinical and Economic Burden of Antimicrobial Resistance. Expert Review of Anti-Infective Therapy,6(5),751–763. https://doi.org/10.1586/14787210.6.5.751
Musdalipah (2018). Identifikasi Drug Related Problem (DRP) Pada Pasien Infeksi Saluran Kemih di Rumah Sakit Bhayangkara Kendari. Jurnal Kesehatan, 11(1),39–50. https://doi.org/10.24252/jkesehatan.v11i1.4908
Nawakasari, N., & Nugraheni, A. Y. (2019). Evaluasi Penggunaan Antibiotik pada Pasien Infeksi Saluran Kemih di Instalasi Rawat Inap RSUP X di Klaten Tahun 2017. Pharmacon: Jurnal Farmasi Indonesia, 16(1),38–48. https://doi.org/10.23917/pharmacon.v16i1.8113
Prasetyoningsih, D. A. (2018). Studi Penggunaan Antibiotik Ciprofloxacin Pada Pasien Infeksi Saluran Kemih Di Instalasi RSPAU Dr. S. Hardjolukito Yogyakarta Tahun 2014 (Skripsi). Fakultas Farmasi Universitas Muhammadiyah Surakarta.
Purnomo, B. B. (2014). Dasar-dasar urologi Edisi Ketiga. Penerbit CV Sagung Seto, Jakarta: ISBN: 978-602-8674-43-0.
Rosso-fernández, C., Sojo-dorado, J., Barriga, A., Lavín-alconero, L., Palacios, Z., López-hernández, I., Merino, V., Camean, M., Pascual, A., … & Rodríguez-baño, J. (2015). Fosfomycin Versus Meropenem In Bacteraemic Urinary Tract Infections Caused By Extended-Spectrum Β -Lactamase-Producing Escherichia Coli (FOREST): Study Protocol For An Investigator-Driven Randomised Controlled Trial. BMJ Open, 1–10. https://doi.org/10.1136/bmjopen-2014-007363
RSUD. (2019). Panduan Penggunaan Antimikroba RSUD Provinsi Nusa Tenggara Barat. Rumah Sakit Umum Daerah Provinsi NTB, Mataram: pp. 18–34.
Sitompul, F., Radji, M., & Bahtiar, A. (2016). Evaluasi Penggunaan Antibiotik dengan Metode Gyssens pada Pasien Stroke Rawat Inap di RSUD Koja secara Retrospektif ( Periode KJS dan BPJS ) Evaluation of Antibiotic used with Gyssens Method on Stroke Inpatient at RSUD Koja using Retrospective Approach. Jurnal Kefarmasian Indonesia, 6(1), 30–38.
Tjay & Rahardja (2010). Obat-Obat Penting Khasiat, Penggunaan, dan Efek-Efek Sampingnya (VII). PT Elex Media Komputindo, Jakarta.
Touat, M., Brun-Buisson, C., Opatowski, M., Salomon, J., Guillemot, D., Tuppin, P., de Lagasnerie, G., & Watier, L. (2021). Costs And Outcomes Of 1-Year Post-Discharge Care Trajectories Of Patients Admitted With Infection Due To Antibiotic-Resistant Bacteria. Journal of Infection, 82(3), 339–345.https://doi.org/10.1016/j.jinf.2021.02.001
Xue, Z., Ying, X., Yutao, L., Q. (2021). A Systematic Review and Meta-Analysis of Levofloxacin and Ciprofloxacin in The Treatment Of Urinary Tract Infection. Annals of Palliative Medicine, 10(9), 9765–9771.
Yagiela, J.A., Dowd, F.J., Johnson, B., Mariottti, A., dan Neidle, E.A, Dowd, F.J., Johnson, B., Mariottti, A., dan Neidle, E. (2011). Pharmacology and Therapeutics for Dentistry. Elsevier.
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