Potential Bioactive Compounds of Plant as Anticancers in Lung Cancer A549 Cell Line: A Systematic Review

Elzam Naufal Zulfikri; Muhammad Hamdi Ibrahim; Tasya Putri Pratama Elisa; Dennisa Arra Nelvi; Kurniadi Ilham; Rita Maliza

doi:10.29303/jbt.v24i3.7008

Potential Bioactive Compounds of Plant as Anticancers in Lung Cancer A549 Cell Line: A Systematic Review

Authors

Elzam Naufal Zulfikri , Muhammad Hamdi Ibrahim , Tasya Putri Pratama Elisa , Dennisa Arra Nelvi , Kurniadi Ilham , Rita Maliza

DOI:

10.29303/jbt.v24i3.7008

Published:

2024-07-31

Issue:

Vol. 24 No. 3 (2024): July - September

Keywords:

Anticancer; A549; bioactive compounds; lung cancer

Articles

Downloads

How to Cite

Zulfikri, E. N., Ibrahim, M. H., Elisa, T. P. P., Nelvi, D. A., Ilham, K., & Maliza, R. (2024). Potential Bioactive Compounds of Plant as Anticancers in Lung Cancer A549 Cell Line: A Systematic Review. Jurnal Biologi Tropis, 24(3), 374–384. https://doi.org/10.29303/jbt.v24i3.7008

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Cancer is one of the non-communicable diseases of global concern the world. Lung cancer is the leading cause of cancer death worldwide, and is the highest cause of death in both men and women at 18% of the world's 9.9 million cancer deaths. Efforts to prevent and cure cancer include using chemotherapy and anti-cancer drugs. Plants are rich in secondary metabolites which are byproducts of plant metabolism that have proven to be useful for the discovery and development of many medicines’ discovery and development of medicines. This article aims to review the potential of plant bioactive compounds that play a role in anticancer activity in lung cancer A549 cell line. In this journal review we used PubMed Centre database to identify articles published between 2014 and 2024. 10 studies were obtained from keywords concerning extracts bioactive compounds of plants used as lung anticancer against A549 cell line. From the results obtained, it was reported that plants containing active compounds such as polyphenols, terpenoids (oleanolic acid, ursolic acid, betulinate, ferruginol), flavonoids (tiliroside), and alkaloids can act as anticancer agents and are proven to inhibit the growth of lung cancer A549 cell line.

References

Fadillah, Rahmi, A., Rahman, A. T., Annisa, N., Ibrahim, M. H., Aisyah, R., & Maliza, R. (2023). Effectiveness of Plant Bioactive Compounds as Colorectal Cancer Cell Line Inhibitors: A Systematic Review. Jurnal Biologi Tropis, 23(1), 288–301. https://doi.org/10.29303/jbt.v23i1.5883

Gao, S. Y., Gong, Y. F., Sun, Q. J., Bai, J., Wang, L., Fan, Z. Q., Sun, Y., Su, Y. J., Gang, J., & Ji, Y. B. (2015). Screening antitumor bioactive fraction from Sauromatum giganteum (Engl.) Cusimano & Hett and sensitive cell lines with the serum pharmacology method and identification by UPLC-TOF-MS. Molecules (Basel, Switzerland), 20(3), 4290–4306. https://doi.org/10.3390/molecules20034290

Garcia, C. S., Menti, C., Lambert, A. P., Barcellos, T., Moura, S., Calloni, C., Branco, C. S., Salvador, M., Roesch-Ely, M., & Henriques, J. A. (2016). Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells. Anais da Academia Brasileira de Ciencias, 88(1), 281–292. https://doi.org/10.1590/0001-3765201520150344

Gunawan, H. (2019). 100 Spesies Pohon Nusantara: Target Konservasi Ex Situ Taman Keanekaragaman Hayati. IPB Press. Bogor. ISBN: 9786024407711.

Ho, S. T., Tung, Y. T., Kuo, Y. H., Lin, C. C., & Wu, J. H. (2015). Ferruginol inhibits non-small cell lung cancer growth by inducing caspase-associated apoptosis. Integrative cancer therapies, 14(1), 86–97. https://doi.org/10.1177/1534735414555806

Hsu, T. I., Chen, Y. J., Hung, C. Y., Wang, Y. C., Lin, S. J., Su, W. C., Lai, M. D., Kim, S. Y., Wang, Q., Qian, K., Goto, M., Zhao, Y., Kashiwada, Y., Lee, K. H., Chang, W. C., ... & Hung, J. J. (2015). A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy. Oncotarget, 6(15), 13671–13687. https://doi.org/10.18632/oncotarget.3701

Intan, P. R., Winarno, M. W., & Prihatini, N. (2016). Efek ekstrak campuran kulit batang pulai (Alstonia scholaris) dan Meniran (Phyllanthus niruri) pada mencit Swiss Webster yang diinfeksi Plasmodium berghei. Jurnal Kefarmasian Indonesia, 6(2) 79-88. http://dx.doi.org/10.22435/jki.v6i2.6229.79-88

Juwita, Amalita, N., & Dewi, M. P. (2020). Faktor-Faktor Risiko yang Mempengaruhi Kanker Paru-Paru dengan Menggunakan Analisis Regresi Logistik. UNPjoMath. 4(1): 38-42. http://dx.doi.org/10.24036/unpjomath.v6i1.11550

Khyade, M. S., Kasote, D. M., & Vaikos, N. P. (2014). Alstonia scholaris (L.) R. Br. and Alstonia macrophylla Wall. ex G. Don: A comparative review on traditional uses, phytochemistry and pharmacology. Journal of ethnopharmacology, 153(1), 1–18. https://doi.org/10.1016/j.jep.2014.01.025

Kooti, W., Servatyari, K., Behzadifar, M., Asadi-Samani, M., Sadeghi, F., Nouri, B., & Zare Marzouni, H. (2017). Effective Medicinal Plant in Cancer Treatment, Part 2: Review Study. Journal of evidence-based complementary & alternative medicine, 22(4), 982–995. https://doi.org/10.1177/2156587217696927

Liao, C. R., Kuo, Y. H., Ho, Y. L., Wang, C. Y., Yang, C. S., Lin, C. W., & Chang, Y. S. (2014). Studies on cytotoxic constituents from the leaves of Elaeagnus oldhamii Maxim. in non-small cell lung cancer A549 cells. Molecules (Basel, Switzerland), 19(7), 9515–9534. https://doi.org/10.3390/molecules19079515

Liu, W., Kang, S., Chen, H., Bahetjan, Y., Zhang, J., Lu, R., Zheng, N., Yang, G., & Yang, X. (2024). A composition of ursolic acid derivatives from Ludwigia hyssopifolia induces apoptosis in throat cancer cells via the Akt/mTOR and mitochondrial signaling pathways and by modulating endoplasmic reticulum stress. Journal of ethnopharmacology, 319(Pt 3), 117351. https://doi.org/10.1016/j.jep.2023.117351

Meoni, G., Cecere, F. L., Lucherini, E., & Di Costanzo, F. (2013). Medical treatment of advanced non-small cell lung cancer in elderly patients: a review of the role of chemotherapy and targeted agents. Journal of geriatric oncology, 4(3), 282–290. https://doi.org/10.1016/j.jgo.2013.04.005

Petpiroon, N., Sritularak, B., & Chanvorachote, P. (2017). Phoyunnanin E inhibits migration of non-small cell lung cancer cells via suppression of epithelial-to-mesenchymal transition and integrin αv and integrin β3. BMC complementary and alternative medicine, 17(1), 553. https://doi.org/10.1186/s12906-017-2059-7

Rodríguez-Hernandez, Carlos & Torres-García, Saúl & Olvera, Carlos & Ramírez Castillo, Flor & Loera Muro, Abraham & González, Francisco & Guerrero-Barrera, Alma,. (2014). Cell culture: History, Development and Prospects. International Journal of Current Research and Academic Review. 2(12). 188-200. http://www.ijcrar.com/

Rosdiana, A. dan Hadisaputri, Y. E. 2016. Review Artikel: Studi Pustaka Tentang Prosedur Kultur Sel. Farmaka. 14(1): 236-249. https://doi.org/10.24198/jf.v14i1.10781

Śliwiński, T., Kowalczyk, T., Sitarek, P., & Kolanowska, M. (2022). Orchidaceae-Derived Anticancer Agents: A Review. Cancers, 14(3), 754. https://doi.org/10.3390/cancers14030754

Sugiharto, S., Simanjuntak, R. A. P. S., & Larissa, O. 2021. Kanker Paru, Faktor Risiko dan Pencegahannya. Senapenmas. 613-620. https://doi.org/10.24912/psenapenmas.v0i0.15060

Wang, C. M., Yeh, K. L., Tsai, S. J., Jhan, Y. L., & Chou, C. H. (2017). Anti-Proliferative Activity of Triterpenoids and Sterols Isolated from Alstonia scholaris against Non-Small-Cell Lung Carcinoma Cells. Molecules (Basel, Switzerland), 22(12), 2119. https://doi.org/10.3390/molecules22122119

Wang, D., Jiang, Y., Wu, K., Wang, S., & Wang, Y. (2015). Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action. BMC complementary and alternative medicine, 15, 29. https://doi.org/10.1186/s12906-015-0551-5

Wang, W. D., Liu, Y., Su, Y., Xiong, X. Z., Shang, D., Xu, J. J., & Liu, H. J. (2017). Antitumor And Apoptotic Effects Of Cucurbitacin A In A-549 Lung Carcinoma Cells Is Mediated Via G2/M Cell Cycle Arrest And M-Tor/Pi3k/Akt Signalling Pathway. African journal of traditional, complementary, and alternative medicines: AJTCAM, 14(2), 75–82. https://doi.org/10.21010/ajtcam.v14i2.9

Wardhani, C. T., Gayatri, D., & Nuraini, T. (2022). Perbandingan Skoring Kualitas Hidup Pasien Kanker dengan Menggunakan EORTC QLQ C30 dan FACT G: Literatur Review. Jurnal Kesehatan Vokasional,7(1): 61-69. https://doi.org/10.22146/jkesvo.64393

Wijaya, C. A. & Muchtaridi, M. (2017). Pengobatan Kanker Melalui Metode Gen Terapi. Farmaka, 15(1): 53-68. https://doi.org/10.24198/jf.v15i1.12285

Yi, J., Wang, Z., Bai, H., Yu, X., Jing, J., & Zuo, L. (2015). Optimization of Purification, Identification and Evaluation of the in Vitro Antitumor Activity of Polyphenols from Pinus Koraiensis Pinecones. Molecules (Basel, Switzerland), 20(6), 10450–10467. https://doi.org/10.3390/molecules200610450

Zhang, J. Y., Huang, W. J., Sun, H. M., Liu, Y., Zhao, X. Q., Tang, S. L., Sun, M. N., Wang, S., Li, J. J., Zhang, L. L., Zhou, J. H., Pan, Q. R., ... & Chen, H. B. (2017). Structure Identification and In Vitro Anticancer Activity of Lathyrol-3-phenylacetate-5,15-diacetate. Molecules (Basel, Switzerland), 22(9), 1412. https://doi.org/10.3390/molecules22091412

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Most read articles by the same author(s)

Rita Maliza, Hevi Horiza, Isolation and Identification of Gram Negative Bacteria in The Lumen Fluid of Colorectal Cancer Patients , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Afdhal Raihan, Angga Kurnia Illahi, Siti Rokhimah, Tasya Putri Pratama Elisa, Rita Maliza, Identification of Bioactive Solutions of Corn Silk (Zea mays L.) Extract and Biological Activity Test By Bioinformatics , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Feskaharny Alamsjah, Zozy Aneloi Noli, Hesti Dwi Marcellinna, Anthoni Agustien, Suwirmen, Kurniadi Ilham, Antagonist Test of Bacillus subtilis ATTC 6633 and Trichoderma harzianum on the Growth of Magnaphorte oryzae on Several Varieties of Priming Rice Seeds , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Rilwan Efendi, Puti Khairunnajwa Amar, Resti Rahayu, Putra Santoso, Zozy Aneloi Noli, Rita Maliza, Organoid Culture Applications: Mini Systematic Review , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Wardatul Aini, Azizah Amatu Zikrah, Sutri Wulansari Safril, Zozy Aneloi Noni, Rita Maliza, Antitumor from Several Plant Compounds Against Hepatocellular Carcinoma Cell Line Hep3B: Mini Systematic Review , Jurnal Biologi Tropis: Vol. 23 No. 4 (2023): October - December
Fadillah, Aulia Rahmi, Aldi Tamara Rahman, Nurul Annisa, Muhammad Hamdi Ibrahim, Rihadatul Aisyah, Reziq Marchellino Irwan, Rita Maliza, Effectiveness of Plant Bioactive Compounds as Colorectal Cancer Cell Line Inhibitors: A Systematic Review , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Husna Fitri, Rizma Nurul Akhlas, Liana Fairuzannah Mahdiana, Rita Maliza, Effects of Arabika Coffee (Coffea arabica L.) Pulp Extracts on Anopheles sp. Larva Mortality , Jurnal Biologi Tropis: Vol. 23 No. 1 (2023): Special Issue
Riris Srikandi Mahardika, Fadilatul Rahmi Putri, Layla Azzahra, Rita Maliza, Kurniadi Ilham, Afif Hamdani, Effectiveness of Bioactive Compounds Against T47D Breast Ductal Carcinoma Cell Line: A Systematic Review , Jurnal Biologi Tropis: Vol. 24 No. 4 (2024): Oktober - Desember
Azizah Amatu Zikrah, Putra Santoso, Rita Maliza, Effects of Low Protein Diet on Body Weight and Hematological Parameters in Rats , Jurnal Biologi Tropis: Vol. 24 No. 3 (2024): July - September
Fadillah Fadillah, Reziq Marchellino Irwan , Muhamad Afif , Allimuddin Tofrizal , Elvina Zuhir, Rita Maliza, Effects of Glyphosate on Cognitive Development, Sensory Sensitivity and Locomotor Balance in Male Rats , Jurnal Biologi Tropis: Vol. 24 No. 3 (2024): July - September

1 2 > >>

Potential Bioactive Compounds of Plant as Anticancers in Lung Cancer A549 Cell Line: A Systematic Review

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow