Vol. 24 No. 1b (2024): Special Issue
Open Access
Peer Reviewed

Physical Quality and Organoleptic Testing of Golden Apple Snail Pomacea canaliculata) Mucus Gel as a Burn Treatment

Authors

Diana Fadhilah , Mikail Nadjmir , Ardis Trianita Adilla , Putra Santoso , Rita Maliza

DOI:

10.29303/jbt.v24i1b.8023

Published:

2024-12-14

Downloads

Abstract

Golden Apple Snail (Pomacea canaliculata) secretion has traditionally been used for wound healing due to its high protein content, which promotes cell regeneration and inhibits inflammation. This study aims to utilize this secretion to formulate a topical gel for burn treatment, providing a controlled use for the abundant, invasive species in agricultural areas. Gel formulations with varying secretion concentrations (10%, 15%, and 20%) were evaluated for organoleptic properties, homogeneity, pH, adhesion, spreadability, and viscosity. Results indicated that all formulations were homogeneous and had pH values within the acceptable range (4.5-6.5). The 15% secretion gel showed the highest user acceptance and optimal balance between spreadability and adhesion, but all formulations had higher than standard viscosity and lower spreadability. Adjusting carbopol concentration is recommended to improve the gel's physical properties. The 15% formulation is the most promising for effective topical application.

Keywords:

Pomacea canaliculata, snail secretion, burn treatment, gel formulation, wound healing.

References

Ali, J., Khan, A., Kotta, S., Ansari, S., Sharma, R., & Kumar, A. (2013). Formulation development, optimization and evaluation of aloe vera gel for wound healing. Pharmacognosy Magazine 9(36): 6. DOI: https://doi.org/10.4103/0973-1296.117849

Bhuyan, C., Saha, D., & Rabha, B. (2021). A brief review on topical gels as drug delivery system. Journal of Pharmaceutical Research International 33(47A): 344 – 357. DOI: https://doi.org/10.9734/jpri/2021/v33i47A33020

Boraldi, F., Lofaro, F.D, Accorsi, A., Ross, E., & Malagoli, D. (2018). Toward the molecular deciphering of Pomacea canaliculata immunity: first proteomic analysis of circulating hemocytes. Proteomics 19 (1800314): 1 – 5. DOI: 10.1002/pmic.201800314

Brown, M. B., Turner, R., & Lim, S. T. (2011). Topical product formulation development. Topical and Transdermal Drug Delivery: Principles and Practice: 255 – 286. DOI: https://doi.org/10.1002/9781118140505.ch14

Cook, K. A., Martinez-Lozano, E., Sheridan, R., Rodriguez, E. K., Nazarian, A., & Grinstaff, M. W. (2022). Hydrogels for the management of second-degree burns: currently available options and future promise. Burns & Trauma 10. DOI: https://doi.org/10.1093/burnst/tkac047

Cui, T., Yu, J., Wang, C., Chen, S., Li, Q., Guo, K., Qing, R., Wang, G., & Ren, J. (2022). Micro‐gel ensembles for accelerated healing of chronic wound via ph regulation. Advanced Science: 9(22), 2201254. DOI: https://doi.org/10.1002/advs.202201254

Forestryana, D., Hayati. A., & Putri, A.N. (2022). Formulation and evaluation of natural gel containing extract of Pandanus amaryllifolius R. using various gelling agents. Borneo Journal of Pharmacy 5(4): 345 – 356. DOI: https://doi.org/10.33084/bjop.v5i4.1411

Haris, A., Arisanty, A., & Prayitno, S. (2022). Formulasi dan uji efek penyembuhan luka bakar sediaan gel ekstrak daun kedondong hutan (Spondias pinnata L) kombinasi dengan madu terhadap kelinci (Oryctolagus cuniculus). Fito Medicine: Journal Pharmacy and Sciences 14(1): 48 – 55. DOI: https://doi.org/10.47650/fito.v14i1.465

Harti, A.S., Sulisetyawati, S.D., Murharyati, A., & Oktariani, M. (2016). The effectiveness of snail slime and chitosan in wound healing. International Journal of Pharma Medicine and Biological Sciences 5(1): 76 – 81. DOI: 10.18178/ijpmbs.5.1.76-80

Jones, A., & Vaughan, D. (2005). Hydrogel dressings in the management of a variety of wound types: A review. Journal of Orthopaedic Nursing 9: S1–S11. https://doi.org/10.1016/s1361-3111(05)80001-9

Liu, Q., Zhao, L.L., Yang, S., Zhang, J.E., Zhao, N.Q., Wu, H., He, Z., Yan, T.M., & Guo, J. (2016). Regeneration of excised shell by the invasive apple snail Pomacea canaliculata. Marine and Freshwater Behaviour and Physiology: 1 – 13. DOI: http://dx.doi.org/10.1080/10236244.2016.1261455

Moen, I., Ugland, H., Strömberg, N., Sjöström, E., Karlson, A., Ringstad, L., Bysell, H., Amiry-Moghaddam, M., & Haglerød, C. (2018). Development of a novel in situ gelling skin dressing: Delivering high levels of dissolved oxygen at pH 5.5. Health Science Reports, 1(7): e57. DOI: https://doi.org/10.1002/hsr2.57

Nadeak, V and Siregar, A.Z. (2019). Penggunaan atraktan daun talas dengan variasi pestisida nabati terhadap populasi keong mas (Mollusca: Ampullariidae) pada padi di Sumatera Utara. Jurnal Agroteknologi 9(2): 6 – 11. DOI: http://dx.doi.org/10.24014/ja.v9i2.3935

Nurman, S., Yulia, R., Irmayanti, Noor, E., & Candra Sunarti, T. (2019). The optimization of gel preparations using the active compounds of arabica coffee ground nanoparticles. Scientia Pharmaceutica 87(4): 32. DOI: https://doi.org/10.3390/scipharm87040032

Patil, P. B., Datir, S.K., & Saudagar, R.B. (2019). A review on topical gels as drug delivery system. Journal of Drug Delivery and Therapeutics, 9 (3-s): 989 – 994. DOI: http://dx.doi.org/10.22270/jddt.v9i3-s.2930

Rinatha, E., Ulfa, A.M., & Tutik, T. (2023). Stability testing and determination of sun protection factor (spf) value in gel formulation combining Moringa oleifera L. leaf extract with Citrus aurantifolia peel. Jurnal Fitofarmaka Indonesia 10(3): 53 – 60. DOI: 10.33096/jffi.v10i3.1000

Safitri, F. I., Nawangsari, D., & Febrina, D. (2021). Overview: Application of Carbopol 940 in Gel. Www.atlantis-Press.com; Atlantis Press. https://doi.org/10.2991/ahsr.k.210127.018

Saputra, K., Sutriyono, S., & Brata, B. (2018). Populasi dan distribusi keong mas (Pomacea canaliculata l.) sebagai sumber pakan ternak pada ekosistem persawahan di Kota Bengkulu. Jurnal Sain Peternakan Indonesia, 13(2): 189–201. DOI: https://doi.org/10.31186/jspi.id.13.2.189-201

Shoviantari, F., Fajriyah, S., Agustin, E., & Khairani, S. (2021). Aktivitas gel lendir bekicot (Achatina fulica) sebagai penyembuhan luka sayat. As-Syifaa Jurnal Farmasi 13(1): 12 – 19. DOI: https://doi.org/10.56711/jifa.v13i1.761

Song, Y., Cui, Y., Hao, L., Zhu J., Yi, J., Kang, Q., Huang, J. & Lu, J. (2021). Wound-healing activity of glycoproteins from white jade snail (Achatina fulica) on experimentally burned mice. International Journal of Biological Macromolecules 175: 313 – 321. DOI: https://doi.org/10.1016/j.ijbiomac.2021.01.193

Trapella, C., Rizzo, R., Gallo, S., Alogna, A., Bortolotti, D., Casciano, F., Zauli, G., Secchiero, P., & Voltan, R. (2018). HelixComplex snail mucus exhibits pro-survival, proliferative and promigration effects on mammalian fibroblasts. Scientific Reports 8 (17665): 1 – 10. DOI:10.1038/s41598-018-35816-3

Ulagesan, S., Sankaranarayanan, K., & Kuppusamy, A. (2017). Functional characterisation of bioactive peptide derived from terrestrial snail Cryptozona bistrialis and its wound-healing property in normal and diabetic-induced Wistar albino rats. International Wound Journal 15(3): 350 – 362. DOI: https://doi.org/10.1111/iwj.12872

Author Biographies

Diana Fadhilah, Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University

Author Origin : Indonesia

Mikail Nadjmir, Faculty of Medicine, Andalas University

Author Origin : Indonesia

Ardis Trianita Adilla, Faculty of Medicine, Andalas University

Author Origin : Indonesia

Putra Santoso, Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University

Author Origin : Indonesia

Rita Maliza, Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University

Author Origin : Indonesia

Downloads

Download data is not yet available.

How to Cite

Fadhilah, D., Nadjmir, M., Adilla, A. T., Santoso, P., & Maliza, R. (2024). Physical Quality and Organoleptic Testing of Golden Apple Snail Pomacea canaliculata) Mucus Gel as a Burn Treatment. Jurnal Biologi Tropis, 24(1b), 405–411. https://doi.org/10.29303/jbt.v24i1b.8023

Most read articles by the same author(s)

1 2 3 > >> 

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.