Gingerol: Anti-inflammatory Compound in Ginger (Zingiber officinale) as Potential Drug Ingredient for Rheumatoid Arthritis

Naurah Arika Azmi; Lazuardi Arsy; Fauzan Faqih; Dian Azizah Lukman; Alifia Intan Fariztia; Andi Muhammad Al Fatih Haq; Sabila Izzatina Azmy Mujahid

doi:10.29303/jbt.v24i1b.7948

Gingerol: Anti-inflammatory Compound in Ginger (Zingiber officinale) as Potential Drug Ingredient for Rheumatoid Arthritis

Authors

Naurah Arika Azmi , Lazuardi Arsy , Fauzan Faqih , Dian Azizah Lukman , Alifia Intan Fariztia , Andi Muhammad Al Fatih Haq , Sabila Izzatina Azmy Mujahid

DOI:

10.29303/jbt.v24i1b.7948

Published:

2024-12-14

Issue:

Vol. 24 No. 1b (2024): Special Issue

Keywords:

Anti-inflammatory, inflammation, ginger, gingerol, rheumatoid arthritis, Zingiber officinale.

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Azmi, N. A., Arsy, L., Faqih, F., Lukman, D. A., Fariztia, A. I., Haq, A. M. A. F., & Mujahid, S. I. A. (2024). Gingerol: Anti-inflammatory Compound in Ginger (Zingiber officinale) as Potential Drug Ingredient for Rheumatoid Arthritis. Jurnal Biologi Tropis, 24(1b), 349–357. https://doi.org/10.29303/jbt.v24i1b.7948

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Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints, with a global prevalence of approximately 0.5-1% of the adult population. Conventional RA treatments often have side effects, prompting the exploration of alternative options. This study aims to explore and review the potential of gingerol, an anti-inflammatory compound found in ginger (Zingiber officinale), as a treatment for RA. The method used was a literature review of 39 relevant articles. The results indicate that gingerol exhibits anti-inflammatory activity by inhibiting pro-inflammatory cytokines and modulating inflammatory pathways. In conclusion, gingerol from ginger shows significant potential as an alternative treatment for RA, although further research is needed to overcome challenges in the extraction process and product development.

References

Ameer, K., Shahbaz, H. M., & Kwon, J. (2017). Green Extraction Methods for Polyphenols from Plant Matrices and Their Byproducts: A Review. Comprehensive Reviews in Food Science and Food Safety, 16(2): 295-315. DOI: https://doi.org/10.1111/1541-4337.12253

Anwar, N. H., & Azizah, N. (2020). Respon Pertumbuhan dan Hasil Tanaman Jahe Merah (Zingiber officinale var. rubrum) pada Berbagai Jenis dan Komposisi Media Tanam Substrat. Journal of Agricultural Science, 5(1): 37–42. DOI: https://doi.org/10.21776/ub.jpt.2020.005.1.5

Aryaeian, N., Shahram, F., Mahmoudi, M., Tavakoli, H., Yousefi, B., Arablou, T., & Jafari Karegar, S. (2019). The Effect of Ginger Supplementation on Some Immunity and Inflammation Intermediate Genes Expression in Patients with Active Rheumatoid Arthritis. Gene, 698(1): 179–185. DOI: https://doi.org/10.1016/j.gene.2019.01.048

Ayustaningwarno, F., Anjani, G., Ayu, A. M., & Fogliano, V. (2024). A Critical Review of Ginger’s (Zingiber officinale) Antioxidant, Anti-inflammatory, and Immunomodulatory Activities. Frontiers in Nutrition, 11(1): 1–16. DOI: https://doi.org/10.3389/fnut.2024.1364836

Azmir, J., Zaidul, I. S. M., Rahman, M. M., Sharif, K. M., Mohamed, A., Sahena, F., Jahurul, M. H. A., Ghafoor, K., Norulaini, N. A. N., & Omar, A. K. M. (2013). Techniques for Extraction of Bioactive Compounds from Plant Materials: A Review. Journal of Food Engineering, 117(4): 426–436. DOI: https://doi.org/10.1016/j.jfoodeng.2013.01.014

Azwanida, N. (2015). A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation. Medicinal & Aromatic Plants, 4(3): 1–6. DOI: https://doi.org/10.4172/2167-0412.1000196

Ballester, P., Cerdá, B., Arcusa, R., Marhuenda, J., Yamedjeu, K., & Zafrilla, P. (2022). Effect of Ginger on Inflammatory Diseases. Molecules, 27(21): 7223–7227. DOI: https://doi.org/10.3390/molecules27217223

Burmester, G. R., & Pope, J. E. (2017). Novel treatment strategies in rheumatoid arthritis. The Lancet, 389(10086): 2338–2348. DOI: https://doi.org/10.1016/S0140-6736(17)31491-5

Catrina, A. I., Svensson, C. I., Malmström, V., Schett, G., & Klareskog, L. (2017). Mechanisms Leading from Systemic Autoimmunity to Joint-specific Disease in Rheumatoid Arthritis. Nature Reviews Rheumatology, 13(2): 79–86. DOI: https://doi.org/10.1038/nrrheum.2016.200

Chaves, J. O., de Souza, M. C., da Silva, L. C., Lachos-Perez, D., Torres-Mayanga, P. C., Machado, A. P. da F., Forster-Carneiro, T., Vázquez-Espinosa, M., González-de-Peredo, A. V., Barbero, G. F., & Rostagno, M. A. (2020). Extraction of Flavonoids From Natural Sources Using Modern Techniques. Frontiers in Chemistry, 8(507887): 1–25. DOI: https://doi.org/10.3389/fchem.2020.507887

Chemat, F., Abert Vian, M., Fabiano-Tixier, A.-S., Nutrizio, M., Režek Jambrak, A., Munekata, P. E. S., Lorenzo, J. M., Barba, F. J., Binello, A., & Cravotto, G. (2020). A Review of Sustainable and Intensified Techniques for Extraction of Food and Natural Products. Green Chemistry, 22(8): 2325–2353. DOI: https://doi.org/10.1039/C9GC03878G

Firestein, G. S., & McInnes, I. B. (2017). Immunopathogenesis of Rheumatoid Arthritis. Immunity, 46(2): 183–196. DOI: https://doi.org/10.1016/j.immuni.2017.02.006

Foudah, A. I., Shakeel, F., Yusufoglu, H. S., Ross, S. A., & Alam, P. (2020). Simultaneous Determination of 6-Shogaol and 6-Gingerol in Various Ginger (Zingiber officinale Roscoe) Extracts and Commercial Formulations Using a Green RP-HPTLC-Densitometry Method. Foods, 9(8): 1136–1150. DOI: https://doi.org/10.3390/foods9081136

Funk, J. L., Frye, J. B., Oyarzo, J. N., Chen, J., Zhang, H., & Timmermann, B. N. (2016). Anti-inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis. PharmaNutrition, 4(3): 123–131. DOI: https://doi.org/10.1016/j.phanu.2016.02.004

Garavand, F., Rahaee, S., Vahedikia, N., & Jafari, S. M. (2019). Different Techniques for Extraction and Micro/Nanoencapsulation of Saffron Bioactive Ingredients. Trends in Food Science & Technology, 89(1): 26–44. DOI: https://doi.org/10.1016/j.tifs.2019.05.005

Gonzalez-Gonzalez, M., Yerena-Prieto, B. J., Carrera, C., Vázquez-Espinosa, M., González-de-Peredo, A. V., García-Alvarado, M. Á., Palma, M., Rodríguez-Jimenes, G. del C., & Barbero, G. F. (2023). Determination of Gingerols and Shogaols Content from Ginger (Zingiber officinale Rosc.) through Microwave-Assisted Extraction. Agronomy: 13(9), 2288–2300. DOI:https://doi.org/10.3390/agronomy13092288

Hughes, C. D., Scott, D. L., & Ibrahim, F. (2018). Intensive Therapy and Remissions in Rheumatoid Arthritis: A Systematic Review. BMC Musculoskeletal Disorders, 19(1), 389–404. https://doi.org/10.1186/s12891-018-2302-5

Hwang, Y.-H., Kim, T., Kim, R., & Ha, H. (2018). The Natural Product 6-Gingerol Inhibits Inflammation-Associated Osteoclast Differentiation via Reduction of Prostaglandin E2 Levels. International Journal of Molecular Sciences, 19(7), 2068. https://doi.org/10.3390/ijms19072068

Jeimy, S., McRae, K., & Pattani, R. (2018). A 63 Year Old Returned Traveller with Fever, Rash, Hepatitis and Eosinophilia. Canadian Medical Association Journal, 190(27): 831–835. DOI: https://doi.org/10.1503/cmaj.171134

Jeyaraj, E. J., Lim, Y. Y., & Choo, W. S. (2021). Extraction Methods of Butterfly Pea (Clitoria ternatea) Flower and Biological Activities of Its Phytochemicals. Journal of Food Science and Technology, 58(6), 2054–2067. DOI: https://doi.org/10.1007/s13197-020-04745-3

Kawamoto, Y., Ueno, Y., Nakahashi, E., Obayashi, M., Sugihara, K., Qiao, S., Iida, M., Kumasaka, M. Y., Yajima, I., Goto, Y., Ohgami, N., Kato, M., & Takeda, K. (2016). Prevention of Allergic Rhinitis by Ginger and the Molecular Basis of Immunosuppression by 6-gingerol through T Cell Inactivation. The Journal of Nutritional Biochemistry, 27(1): 112–122. DOI:https://doi.org/10.1016/j.jnutbio.2015.08.025

Listing, J., Kekow, J., Manger, B., Burmester, G.-R., Pattloch, D., Zink, A., & Strangfeld, A. (2015). Mortality in Rheumatoid Arthritis: The Impact of Disease Activity, Treatment with Glucocorticoids, TNFα Inhibitors and Rituximab. Annals of the Rheumatic Diseases, 74(2): 415–421. DOI: https://doi.org/10.1136/annrheumdis-2013-204021

Mao, Q.-Q., Xu, X.-Y., Cao, S.-Y., Gan, R.-Y., Corke, H., Beta, T., & Li, H.-B. (2019). Bioactive Compounds and Bioactivities of Ginger (Zingiber officinale Roscoe). Foods, 8(6): 185. DOI: https://doi.org/10.3390/foods8060185

McInnes, I. B., & Schett, G. (2017). Pathogenetic Insights from the Treatment of Rheumatoid Arthritis. The Lancet, 389(10086): 2328–2337. DOI: https://doi.org/10.1016/S0140-6736(17)31472-1

Mena-García, A., Ruiz-Matute, A. I., Soria, A. C., & Sanz, M. L. (2019). Green techniques for extraction of bioactive carbohydrates. Trends in Analytical Chemistry, 119: 115612. DOI: https://doi.org/10.1016/j.trac.2019.07.023

Safiri, S., Kolahi, A. A., Hoy, D., Smith, E., Bettampadi, D., Mansournia, M. A., Almasi-Hashiani, A., Ashrafi-Asgarabad, A., Moradi-Lakeh, M., Qorbani, M., Collins, G., Woolf, A. D., March, L., & Cross, M. (2019). Global, Regional and National Burden of Rheumatoid Rrthritis 1990–2017: A Systematic Analysis of the Global Burden of Disease Study 2017. Annals of the Rheumatic Diseases, 78(11): 1463–1471. DOI: https://doi.org/10.1136/annrheumdis-2019-215920

Sari, D., & Nasuha, A. (2021). Kandungan Zat Gizi, Fitokimia, dan Aktivitas Farmakologis pada Jahe (Zingiber officinale Rosc.): Review. Tropical Bioscience: Journal of Biological Science, 1(2): 11–18. DOI: https://doi.org/10.32678/tropicalbiosci.v1i2.5246

Semwal, R. B., Semwal, D. K., Combrinck, S., & Viljoen, A. M. (2015). Gingerols and Shogaols: Important Nutraceutical Principles from Ginger. Phytochemistry, 117: 554–568. DOI: https://doi.org/10.1016/j.phytochem.2015.07.012

Septiani, F., Susanti, I. H., Yuanita, S., Nabila, N., Thurfah, P. A., Adelia, P. S., Gumanti, R., Pratami, R. W., Saputri, S., & Yuda, S. T. B. (2024). Pendidikan Kesehatan tentang Rhematoid Arthritis dan Senam Rematik Pada Lansia di Posyandu Lansia Mugi Sehat. Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM), 7(3): 1401–1407. DOI: https://doi.org/10.33024/jkpm.v7i3.14032

Singh, J. A., Saag, K. G., Bridges, S. L., Akl, E. A., Bannuru, R. R., Sullivan, M. C., Vaysbrot, E., McNaughton, C., Osani, M., Shmerling, R. H., Curtis, J. R., Furst, D. E., Parks, D., Kavanaugh, A., O’Dell, J., King, C., Leong, A., Matteson, E. L., Schousboe, J. T., & McAlindon, T. (2016). 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis & Rheumatology, 68(1): 1–26. DOI: https://doi.org/10.1002/art.39480

Smolen, J. S., Aletaha, D., & McInnes, I. B. (2016). Rheumatoid Arthritis. The Lancet, 388(10055): 2023–2038. DOI: https://doi.org/10.1016/S0140-6736(16)30173-8

Smolen, J. S., Landewé, R. B. M., Bijlsma, J. W. J., Burmester, G. R., Dougados, M., Kerschbaumer, A., McInnes, I. B., Sepriano, A., van Vollenhoven, R. F., de Wit, M., Aletaha, D., Aringer, M., Askling, J., Balsa, A., Boers, M., den Broeder, A. A., Buch, M. H., Buttgereit, F., Caporali, R., … van der Heijde, D. (2020). EULAR Recommendations for the Management of Rheumatoid Arthritis with Synthetic and Biological Disease-modifying Antirheumatic Drugs: 2019 Update. Annals of the Rheumatic Diseases, 79(6): 685–699. DOI: https://doi.org/10.1136/annrheumdis-2019-216655

Srikandi, S., Humaeroh, M., & Sutamihardja, R. (2020). Kandungan Gingerol dan Shogaol dari Ekstrak Jahe Merah (Zingiber Officinale Roscoe) dengan Metode Maserasi Bertingkat. Al-Kimiya, 7(2): 75–81. DOI: https://doi.org/10.15575/ak.v7i2.6545

Szymczak, J., Grygiel-Górniak, B., & Cielecka-Piontek, J. (2024). Zingiber Officinale Roscoe: The Antiarthritic Potential of a Popular Spice—Preclinical and Clinical Evidence. Nutrients, 16(5): 741. DOI: https://doi.org/10.3390/nu16050741

Teng, H., Seuseu, K. T., Lee, W.-Y., & Chen, L. (2019). Comparing the Effects of Microwave Radiation on 6-gingerol and 6-shogaol from Ginger Rhizomes (Zingiber officinale Rosc). PLOS ONE, 14(6): e0214893. DOI: https://doi.org/10.1371/journal.pone.0214893

Vidana-Gamage, G. C., Lim, Y. Y., & Choo, W. S. (2021). Anthocyanins from Clitoria ternatea Flower: Biosynthesis, Extraction, Stability, Antioxidant Activity, and Applications. Frontiers in Plant Science, 12(792303): 1–17. DOI: https://doi.org/10.3389/fpls.2021.792303

Wang, H., Chen, Y., Wang, L., Liu, Q., Yang, S., & Wang, C. (2023). Advancing Herbal Medicine: Enhancing Product Quality and Safety through Robust Quality Control Practices. Frontiers in Pharmacology, 14(1265178): 1–16. DOI: https://doi.org/10.3389/fphar.2023.1265178

Zhang, J., Wen, C., Zhang, H., Duan, Y., & Ma, H. (2020). Recent Advances in the Extraction of Bioactive Compounds with Subcritical Water: A Review. Trends in Food Science & Technology, 95(1): 183–195. DOI: https://doi.org/10.1016/j.tifs.2019.11.018

Zhang, Q.W., Lin, L.G., & Ye, W.C. (2018). Techniques for Extraction and Isolation of Natural Products: A Comprehensive Review. Chinese Medicine, 13(20): 1–26. DOI: https://doi.org/10.1186/s13020-018-0177-x

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Gingerol: Anti-inflammatory Compound in Ginger (Zingiber officinale) as Potential Drug Ingredient for Rheumatoid Arthritis

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