The Relationship of Medication Adherence in Type 2 Diabetes Mellitus Patients with HbA1c Profile at Mataram University
DOI:
10.29303/jbt.v25i4.10407Published:
2025-10-17Downloads
Abstract
Type 2 Diabetes Mellitus (DM) requires optimal glycemic control. Medication adherence is key to achieving HbA1c targets, but local data at Universitas Mataram Hospital is still limited. This study aimed to analyze the relationship between medication adherence and HbA1c profiles in type 2 DM patients. An analytical cross-sectional study was conducted in May 2025 with 40 randomly selected samples. Adherence was measured using the MMAS-8 questionnaire, and HbA1c data came from medical records. Data analysis used the Chi-Square test. Results showed 50% of subjects were adherent and 50% were non-adherent. Regarding glycemic control, 70% had controlled HbA1c. Statistical analysis found no significant relationship between adherence and HbA1c profile (p-value = 0.490). However, a proportional trend showed the adherent group had a higher percentage of HbA1c control (75%) than the non-adherent group (65%). Conclusion, there was no statistically significant relationship between medication adherence and HbA1c profiles. Despite this, the observed clinical trend indicates that adherence remains an important factor to consider in DM management, alongside other determinants like diet and physical activity.
Keywords:
HbA1c Medication Adherence MMAS-8 Type 2 Diabetes MellitusReferences
Al-Saleh, Y., Sabico, S., Al-Furqani, A., Jayyousi, A., Alromaihi, D., Ba-Essa, E., ... & Al-Daghri, N. M. (2021). sulfonylureas in the current practice of type 2 diabetes management: are they all the same? consensus from the gulf cooperation council (gcc) countries advisory board on sulfonylureas (may, 10.1007/s13300-021-01059-1, 2021). Diabetes Therapy, 12(8), 2265-2266. https://doi.org/10.1007/s13300-021-01109-8.
Dludla, P. V et al. (2023) ‘Pancreatic β-cell dysfunction in type 2 diabetes: Implications of inflammation and oxidative stress’, World Journal of Diabetes, 14(3), pp. 130–146. Available at: https://doi.org/10.4239/wjd.v14.i3.130.
Goyal R, Singhal M, Jialal I. Type 2 Diabetes. [Updated 2023 Jun 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK513253/
Hasanah, L., Ariyani, H. and Hartanto, D. (2022) ‘Hubungan Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Dengan Kepatuhan Minum Obat Di RSUD Ulin Banjarmasin’, Journal of Current Pharmaceutical Sciences, 6(1), pp. 2598–2095.
IDF (2022) International Diabetes Federation, Diabetes Research and Clinical Practice. Available at: https://doi.org/10.1016/j.diabres.2013.10.013.
Kemenkes (2023) ‘Survei Kesehatan Indonesia 2023 (SKI)’, Kemenkes, p. 235.
Lopez-Pedrosa, J. M., Camprubi-Robles, M., Guzman-Rolo, G., Lopez-Gonzalez, A., Garcia-Almeida, J. M., Sanz-Paris, A., & Rueda, R. (2024). The vicious cycle of type 2 diabetes mellitus and skeletal muscle atrophy: clinical, biochemical, and nutritional bases. Nutrients, 16(1), 172.
Pratama, R., Putra, C. Y. L., Budiarti, R., Putra, O. N., Kresnamurti, A., & Sulistiawati, S. (2023). Medication Compliance in Type 2 Diabetes Patients: HbA1c and Lipid Profile at Aulia Jombang Clinic 2020. Journal of Pharmaceutical and Sciences, 1888-1896. https://doi.org/10.36490/journal-jps.com.v6i4.230.
Sapra, A. and Bhandari, P. (2023) ‘Continuing Education Activity’, NCBI Bookshelf. A service of the National Library of Medicine, National Institute of Health., (iv), pp. 3–5. https://www.ncbi.nlm.nih.gov/books/NBK551501/
Wibowo, M. I. N. A., Yasin, N. M., Kristina, S. A., & Prabandari, Y. S. (2021). Systematic Review: Determinan Faktor yang Memengaruhi Kepatuhan Pengobatan Pasien Diabetes Tipe 2 di Indonesia. Media Penelitian dan Pengembangan Kesehatan, 31(4), 281-300. https://doi.org/10.22435/mpk.v31i4.4855
Kumar, R., Saha, P., Kumar, Y., Sahana, S., Dubey, A., & Prakash, O. (2020). A review on diabetes mellitus: type1 & Type2. World Journal of Pharmacy and Pharmaceutical Sciences, 9(10), 838-850. 10.20959/wjpps202010-17336
Meilani, D. A., Widiharti, W., Sari, D. J. E., & Suminar, E. (2023). Perbedaan Kadar Gula Darah Pada Penderita DM Sebelum Dan Setelah Intervensi Latihan Fisik Senam Diabetes Di Wilayah Kerja Puskesmas Duduksampeyan. Indonesian Journal of Professional Nursing, 4(2), 129-134. https://doi.org/10.30587/ijpn.v4i2.6788
Indirawaty, I., Adrian, A., Sudirman, S., & Syarif, K. R. (2021). Hubungan pengetahuan dan dukungan keluarga dengan rutinitas dalam mengontrol gula darah pada penderita diabetes melitus tipe 2. Aksara: Jurnal Ilmu Pendidikan Nonformal, 7(1), 67-78. http://dx.doi.org/10.37905/aksara.7.1.67-78.2021
Wandilla, I., Juliyanti, J., & Anwar, A. (2025). Hubungan Kepatuhan Minum Obat Dan Efektifitas Pengobatan Melalui Nilai Hba1c Pada Pasien Diabetes Melitus Tipe 2 Di Puskesmas Segiri Kota Samarinda. Journal of Sustainable Transformation, 3(02), 105-111. https://doi.org/10.59310/jst.v3i02.37
License
Copyright (c) 2025 Syalsa Hudhori, Indah Sapta Wardani, Wilya Isnaeni
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.
