Literature review: Maturity Onset Diabetes of the Young (MODY)
DOI:
10.29303/jbt.v25i4.8362Published:
2025-10-13Downloads
Abstract
Maturity Onset Diabetes of the Young (MODY) is a group of monogenic genetic disorders that cause diabetes with an autosomal dominant inheritance pattern, generally appearing before the age of 25. MODY is caused by gene mutations affecting pancreatic beta cell function, with 14 genetic subtypes identified. Diagnosis is often delayed or incorrect, as symptoms resemble type 1 or type 2 diabetes. The diagnosis of MODY is diagnosed through family history, clinical examination, and genetic analysis. MODY treatment is tailored to the genetic subtype, including lifestyle changes, sulfonylureas, and insulin, is tailored to the genetic subtype. Prognosis and risk of complications vary depending on the subtype, with MODY 2 (GCK) having the best prognosis. Prevention includes genetic testing for individuals with a family history of MODY, as well as lifestyle modifications to reduce the risk of complications. Patient education is important to ensure optimal management and prevention of long-term complications. This journal aims to learn more about the following definitions, to prognosis and education of MODY.
Keywords:
Autosomal dominant, genetic mutation, MODY, monogenic diabetes.References
Anık, A., Çatlı, G., Abacı, A., & Böber, E. (2015).
Maturity-onset diabetes of the young
(MODY): An update. Journal of Pediatric
Endocrinology & Metabolism, 28(3–4), 251–263.
https://doi.org/10.1515/jpem-2014-0384
Hoffman, L. S., Fox, T. J., Anastasopoulou, C., &
Jialal, I. (2018). Maturity-onset diabetes in the
young. In StatPearls [Internet]. Treasure
Island (FL): StatPearls Publishing. Available
from https://www.ncbi.nlm.nih.gov/books/NBK
/
Nkonge, K. M., Nkonge, D. K., & Nkonge, T. N.
(2020). The epidemiology, molecular
pathogenesis, diagnosis, and treatment of
maturity-onset diabetes of the young
(MODY). Clinical Diabetes and Endocrinology,
(1). https://doi.org/10.1186/s40842-020-00112-5
Suwandi, J. F., Angraini, D. I., & Putri, S. D.
(2019). Maturity-onset diabetes of the young
(MODY): Diagnosis and management. Jurnal Kedokteran
–231.
Urakami, T. (2019). Maturity-onset diabetes of
the young (MODY): Current perspectives on
diagnosis and treatment. Diabetes, Metabolic
Syndrome and Obesity: Targets and Therapy, 12,
–1056. https://doi.org/10.2147/DMSO.S179793
Yahaya, T. O., & Ufuoma, S. B. (2020). Genetics
and pathophysiology of maturity-onset
diabetes of the young (MODY): A review of
current trends. Oman Medical Journal, 35(3),
e128. https://doi.org/10.5001/omj.2020.44
Susanto, J. P. (2014). Maturity-onset diabetes of
the young (MODY). Cermin Dunia Kedokteran, 41(12), 1563.
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Copyright (c) 2025 Rofi Bramantyo, Naufal Revaldy Fauzan, Reza Rizwandipa Wahyudi, Dhaifatu Dzulilmi, Septy Rianty Salsabilla Dwi Putri, Devi Shanti Prameswari, Ni Made Shaithanya Gitanjali Dhevi, Alifia Sabira Putri, Baiq Zaskia Maudina, Amanda Suana Rizqi, Ruhaniah Najwa Salsabila, Indah Sapta Wardani
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