Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

B. Novia Rahmadita Sutanti; Ika Salsabila Ramdha; Alpha Alfi Rizki; Latifa Rahma  Putri; Neli Aulia Lestari; Ninda Syaharani; Anggit Listyacahyani Sunarwidhi

doi:10.29303/jbt.v25i4a.10884

Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

Authors

B. Novia Rahmadita Sutanti , Ika Salsabila Ramdha , Alpha Alfi Rizki , Latifa Rahma Putri , Neli Aulia Lestari , Ninda Syaharani , Anggit Listyacahyani Sunarwidhi

DOI:

10.29303/jbt.v25i4a.10884

Published:

2025-12-06

Issue:

Vol. 25 No. 4a (2025): Special Issue

Keywords:

BCG, New vaccine development, Tuberculosis, Subunit vaccines, Vaccine alternatives

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Sutanti, B. N. R., Ramdha, I. S., Rizki, A. A., Putri, L. R., Lestari, N. A., Syaharani, N., & Sunarwidhi, A. L. (2025). Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine. Jurnal Biologi Tropis, 25(4a), 377–386. https://doi.org/10.29303/jbt.v25i4a.10884

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Abstract

Tuberculosis (TB) remains a significant global public health threat. The existing BCG vaccine has limited effectiveness, particularly in preventing pulmonary TB in adults. This study aims to review the recent developments in the creation of new TB vaccines as alternatives to BCG. This research employs a systematic review method by collecting articles from the Google Scholar database. Inclusion criteria included articles published between 2014-2024 that are relevant to the development of new TB vaccines. Data analysis was conducted descriptively to identify potential vaccine candidates. Several new TB vaccine candidates have shown promising results, including TAT-Ag85B, MTBVAC, rBCG-LTAK63, and subunit vaccines such as Ag85A and LT70. These vaccines demonstrated increased immune responses and better protection compared to BCG in preclinical trials. Innovative approaches like the use of nanocarriers and prime-boost strategies also show potential in enhancing vaccine efficacy. The development of new TB vaccines indicates significant progress with several potential candidates that could replace or complement the BCG vaccine. However, further research is needed to evaluate the efficacy and safety of these vaccines in clinical trials in humans before they can be widely implemented.

References

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Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

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