Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

B. Novia Rahmadita Sutanti; Ika Salsabila Ramdha; Alpha Alfi Rizki; Latifa Rahma  Putri; Neli Aulia Lestari; Ninda Syaharani; Anggit Listyacahyani Sunarwidhi

doi:10.29303/jbt.v25i4a.10884

Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

Authors

B. Novia Rahmadita Sutanti , Ika Salsabila Ramdha , Alpha Alfi Rizki , Latifa Rahma Putri , Neli Aulia Lestari , Ninda Syaharani , Anggit Listyacahyani Sunarwidhi

DOI:

10.29303/jbt.v25i4a.10884

Published:

2025-12-06

Issue:

Vol. 25 No. 4a (2025): Special Issue

Keywords:

BCG, New vaccine development, Tuberculosis, Subunit vaccines, Vaccine alternatives

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Sutanti, B. N. R., Ramdha, I. S., Rizki, A. A., Putri, L. R., Lestari, N. A., Syaharani, N., & Sunarwidhi, A. L. (2025). Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine. Jurnal Biologi Tropis, 25(4a), 377–386. https://doi.org/10.29303/jbt.v25i4a.10884

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Abstract

Tuberculosis (TB) remains a significant global public health threat. The existing BCG vaccine has limited effectiveness, particularly in preventing pulmonary TB in adults. This study aims to review the recent developments in the creation of new TB vaccines as alternatives to BCG. This research employs a systematic review method by collecting articles from the Google Scholar database. Inclusion criteria included articles published between 2014-2024 that are relevant to the development of new TB vaccines. Data analysis was conducted descriptively to identify potential vaccine candidates. Several new TB vaccine candidates have shown promising results, including TAT-Ag85B, MTBVAC, rBCG-LTAK63, and subunit vaccines such as Ag85A and LT70. These vaccines demonstrated increased immune responses and better protection compared to BCG in preclinical trials. Innovative approaches like the use of nanocarriers and prime-boost strategies also show potential in enhancing vaccine efficacy. The development of new TB vaccines indicates significant progress with several potential candidates that could replace or complement the BCG vaccine. However, further research is needed to evaluate the efficacy and safety of these vaccines in clinical trials in humans before they can be widely implemented.

References

Carvalho Dos Santos, C., Rodriguez, D., Kanno Issamu, A., Cezar De Cerqueira Leite, L., & Pereira Nascimento, I. (2020). Recombinant BCG expressing the LTAK63 adjuvant induces increased early and long-term immune responses against Mycobacteria. Human Vaccines & Immunotherapeutics, 16(3), 673–683. https://doi.org/10.1080/21645515.2019.1669414

Dockrell, H. M., & Smith, S. G. (2017). What have we learnt about BCG vaccination in the last 20 years? Frontiers in Immunology, 8(SEP), 1–10. https://doi.org/10.3389/fimmu.2017.01134

Dong, H., Jing, W., Yingru, X., Wenyang, W., Ru, C., Shengfa, N., Congjing, X., Jingjing, D., Wan, W., Jiang, H., & Rongbo, Z. (2015). Enhanced anti-tuberculosis immunity by a TAT-Ag85B protein vaccine in a murine tuberculosis model. Pathogens and Global Health, 109(8), 363–368. https://doi.org/10.1080/20477724.2015.1111658

Fransiska, M., & Hartati, E. (2019). Faktor Resiko Kejadian Tuberculosis. Jurnal Kesehatan, 10(3), 252–260. http://dx.doi.org/10.35739/jk.v10i3.459

Liu, X., Peng, J., Hu, L., Luo, Y., Niu, H., Bai, C., Wang, Q., Li, F., Yu, H., Wang, B., Chen, H., Guo, M., & Zhu, B. (2016). A multistage mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Human Vaccines and Immunotherapeutics, 12(7), 1670–1677. https://doi.org/10.1080/21645515.2016.1141159

Pabreja, S., Garg, T., Rath, G., & Goyal, A. K. (2016). Mucosal vaccination against tuberculosis using Ag85A-loaded immunostimulating complexes. Artificial Cells, Nanomedicine, and Biotechnology, 44(2), 532–539. https://doi.org/10.3109/21691401.2014.966195

Pambudi, S., Widayanti, T., & Stephanie, N. (2020). EKPRESI ANTIGEN Ag85B DARI Mycobacterium tuberculosis PADA GALUR SEL MAMALIA. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(1), 86–95. https://doi.org/10.29122/jbbi.v7i1.3840

Pérez, I., Uranga, S., Sayes, F., Frigui, W., Samper, S., Arbués, A., Aguiló, N., Brosch, R., Martín, C., & Gonzalo-Asensio, J. (2020). Live attenuated TB vaccines representing the three modern Mycobacterium tuberculosis lineages reveal that the Euro–American genetic background confers optimal vaccine potential. EBioMedicine, 55, 1–10. https://doi.org/10.1016/j.ebiom.2020.102761

Prabowo, S. A., Painter, H., Zelmer, A., Smith, S. G., Seifert, K., Amat, M., Cardona, P. J., & Fletcher, H. A. (2019). RUTI vaccination enhances inhibition of mycobacterial growth ex vivo and induces a shift of monocyte phenotype in mice. Frontiers in Immunology, 10(APR), 1–10. https://doi.org/10.3389/fimmu.2019.00894

Putri, T. R., Hilmi, I. L., & Salman, S. (2023). Review Artikel : Hubungan Pemberian Imunisasi Bcg Terhadap Penyakit Tuberkulosis Pada Anak. Journal of Pharmaceutical and Sciences, 6(1), 237–242. https://doi.org/10.36490/journal-jps.com.v6i1.16

Saidah, I., Istiani, H. G., & Shifa, N. A. (2023). Hubungan Riwayat Asi Eksklusif Dan Usia Pemberian Imunisasi Bcg Dengan Kejadian Tbc Pada Anak Di Rsud Khidmat Sehat Afiat Kota Depok Tahun 2022. Jurnal Masyarakat Sehat Indonesia, 2(02), 44–49. https://doi.org/10.70304/jmsi.v2i02.33

Sathkumara, H. D., Pai, S., De Jesús Aceves-Sánchez, M., Ketheesan, N., Flores-Valdez, M. A., & Kupz, A. (2019). BCG vaccination prevents reactivation of latent lymphatic murine tuberculosis independently of CD4+ T cells. Frontiers in Immunology, 10(MAR), 1–11. https://doi.org/10.3389/fimmu.2019.00532

Sethi, G., Varghese, R. P., Lakra, A. K., Nayak, S. S., Krishna, R., & Hwang, J. H. (2024). Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis. Scientific Reports, 14(1), 1–17. https://doi.org/10.1038/s41598-024-66858-5

Tanner, R., Villarreal-Ramos, B., Vordermeier, H. M., & McShane, H. (2019). The humoral immune response to BCG vaccination. Frontiers in Immunology, 10(JUN), 5–7. https://doi.org/10.3389/fimmu.2019.01317

Wang, L., Kang, J., & Jiang, H. (2024). Intranasal Immunization with a Recombinant Adenovirus Encoding Multi-Stage Antigens of Mycobacterium tuberculosis Preferentially Elicited CD8+ T Cell Immunity and Conferred a Superior Protection in the Lungs of Mice than Bacillus Calmette–Guerin. Vaccines, 12(9), 1022. https://doi.org/10.3390/vaccines12091022

Wang, R., Fan, X., Xu, D., Li, M., Zhao, X., Cao, B., Qian, C., Yu, J., Fang, D., Gu, Y., Wan, K., & Liu, H. (2023). Comparison of the Immunogenicity and Efficacy of rBCG-EPCP009, BCG Prime-EPCP009 Booster, and EPCP009 Protein Regimens as Tuberculosis Vaccine Candidates. Vaccines, 11(12). https://doi.org/10.3390/vaccines11121738

Wulanda, A. F., & Delilah, S. (2013). Efektivitas Imunisasi BCG terhadap Kejadian Tuberkulosis Anak di Kabupaten Bangka. Jurnal Kesehatan Poltekkes Kemenkes RI Pangkalpinang, 9(1), 37–41. https://doi.org/10.32922/jkp.v9i1.333

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Article Review: Development of a new type of TB vaccine as a replacement for the BCG vaccine

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