Analysis of Malondialdehyde (MDA) Levels Based on Body Mass Index, Waist Circumstances, and Body Fat Percentage in Students of Medicine Program Faculty of Medicine Mataram University

Ida Ayu Eka Widiastuti; Fitriannisa Faradina Zubaidi; Basuki Rahmat; Gede Wira Buanayuda

doi:10.29303/jbt.v22i4.4513

Analysis of Malondialdehyde (MDA) Levels Based on Body Mass Index, Waist Circumstances, and Body Fat Percentage in Students of Medicine Program Faculty of Medicine Mataram University

Authors

Ida Ayu Eka Widiastuti , Fitriannisa Faradina Zubaidi , Basuki Rahmat , Gede Wira Buanayuda

DOI:

10.29303/jbt.v22i4.4513

Published:

2022-12-19

Issue:

Vol. 22 No. 4 (2022): October - December

Keywords:

body mass index; body fat percentage; oxidative stress; waist circumference; MDA level.

Articles

Downloads

Pdf

How to Cite

Widiastuti, I. A. E., Zubaidi, F. F., Rahmat, B., & Buanayuda, G. W. (2022). Analysis of Malondialdehyde (MDA) Levels Based on Body Mass Index, Waist Circumstances, and Body Fat Percentage in Students of Medicine Program Faculty of Medicine Mataram University. Jurnal Biologi Tropis, 22(4), 1455–1461. https://doi.org/10.29303/jbt.v22i4.4513

Download Citation

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Abstract

Obesity can cause chronic oxidative stress. Oxidative stress occurs when the formation of free radicals is greatly increased or the protective antioxidant mechanisms are disrupted. Previous studies have concluded that there is a relationship between oxidative stress and excess body weight and obesity. One of the products of oxidative stress is malondialdehyde (MDA). This study aims to determine the correlation between malondialdehyde (MDA) levels and body mass index (BMI), waist circumference (LP), and body fat percentage. The subjects were 55 students of the Medical Education Study Program, Faculty of Medicine, University of Mataram, class of 2021. The BMI variable was calculated by dividing body weight (kg) by the square of height (m), waist circumference was measured using a tape measure (cm), and body fat percentage measured by body composition monitor (%). Serum MDA levels were measured using the ELISA method. Data were analyzed statistically with the Spearman correlation test. The results showed that the average MDA level in subjects with overweight and obesity was higher than normal, however there was no significant correlation between body mass index, waist circumference, and body fat percentage with MDA levels, with each significance value :p=0.230; p=0.276; and p=0.666. Body mass index, waist circumference, and body fat percentage cannot be ruled out as risk factors for oxidative stress.

References

Al Amin, M. (2017). Klasifikasi kelompok umur manusia berdasarkan analisis dimensi fraktal box counting dari citra wajah dengan deteksi tepi canny. MATHunesa: Jurnal Ilmiah Matematika, 2(6).

Al Hazmy, A., Doewes, M., Rachma, N., & Kristiyanto, A., (2018). Correlation of body mass index and cardiorespiratory fitness with metabolic syndrome in adolescents. Journal of Education, Health, and Sport. 8(5): 83-94. DOI: http://dx.doi.org/10.5281/zenodo.1239395

Altoum, A. E. A., Osman, A. L. & Babker, A. M. A. (2019) ‘Impact of body mass index in malondialdehyde, antioxidant vitamins A, E, C and plasma zinc among type 2 diabetic patients’, Kuwait Medical Journal, 51(1), pp. 16–20.

Ayala, A., Muñoz, M. F. & Argüelles, S. (2014) ‘Lipid peroxidation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal’, Oxidative Medicine and Cellular Longevity, 2014. DOI: 10.1155/2014/360438.

CDC. (2009). QuickStats: Mean percentage body fat, by age group and sex – National Health and Nutrition Examination Survey, United States, 1999–2004. URL: https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5751a4.htm

Davi G, Guagnano M, Ciabattoni G, Basili, S., Falco, A., Marinopiccoli, M., Nutini, M., Sensi, S., & Patrono, C. (2002). Platelet activation in obese women: Role of inflammation and oxidant stress. JAMA. Vol.288, pp. 2008–2014, DOI:10.1001/jama.288.16.2008

Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, & Shimomura I. (2004). Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest, 114: 1752–1761. DOI: https://doi.org/10.1172/JCI21625.

Halliwell B. (1989). Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun, 5(5):315–318. DOI: https://doi.org/10.3109/10715768909073413

Janssen, I, Katzmarzyk P.T, & Ross, R. (2002). Body mass index, waist circumfernce, and health risk. Arch Intern Med., 162, (18):2074-2079. DOI: 10.1001/archinte.162.18.2074

Keaney J, Larson M, Vasan R, Wilson, P.W.F., Lipinska, I., Corey, D., Massaro, J.M., Sutherland, P., Vita, J.A., … & Benjamin, E.J. (2003). Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol. Vol. 23, pp. 434–439. DOI: https://doi.org/10.1161/01.ATV.0000058402.34138.11

Midah, Z, Fajriansyah, F., Makmun, A., & Rasfahyana (2021). Hubungan Obesitas dan Stress Oksidatif’. UMI Medical Journal, 6(1), pp. 62–69. DOI: 10.33096/umj.v6i1.140.

Niki E. (2000). Free radicals in the 1900’s: from in vitro to in vivo. Free Radic Res. Vol. 33, pp. 693–704, DOI: https://doi.org/10.1080/10715760000301221

Prazny M, Skrha J, & Hilgertova J. (1999). Plasma malondialdehyde and obesity: is there a relationship? Clin Chem Lab Med, 37: 1129–1130, DOI: https://doi.org/10.1515/CCLM.1999.164

Sankhla, M., Sharma, T.K., Mathur, K., Rathor. J.S., Butolia, V., Gadhok, A.K., Vardey,S.K., Sinha, M., & Kaushik, G.G. (2012). Relationship of oxidative stress with obesity and its role in obesity induced metabolic syndrome. Clinical Laboratory. Vol. 38, pp. 385-392.

Savini I, Catani MV, Evangelista D, Gasperi V, & Avigliano L. (2013). Obesity-associated oxidative stress: strategies finalized to improve redox state. Int J Mol Sci, 14: 10497–538. DOI: https://doi.org/10.3390/ijms140510497

Sheehan, K. (2022). The Nest: American Council on Exercise Body Fat Percentage. URL: https://woman.thenest.com/american-council-exercise-body-fat-percentage-16636.html [Diakses pada 22 November 2022].

Sun, M., Huang, X., Yan, Y., Chen, J., Wang, Z., Xie, & M., Li, J. (2012). Rac1 is a possible link between obesity and oxidative stress in Chinese overweight adolescents. Obesity (Silver Spring), 20, pp. 2233–40. DOI: https://doi.org/10.1038/oby.2012.63

Vincent H, Powers S, Dirks A, & Scarpace P. (2001). Mechanism for obesity-induced increase in myocardial lipid peroxidation. Int J Obes (Lond). 25, pp. 378–388, DOI: https://doi.org/10.1038/sj.ijo.0801536

Vincent HK, & Taylor AG. (2006). Biomarkers and potential mechanisms of obesityinduced oxidant stress in humans. Int J Obes (Lond), 30: 400–418. DOI: https://doi.org/10.1038/sj.ijo.0803177

WHO: World Health Organization obesity and overweight, Fact sheet N°311. (2021). Updated 9 June 2021. Available online: http://www.who.int/mediacentre/factsheets/fs311/en/. [Last accessed on 2022 February 10].

WHO (2022) Obesity. Available from https://www.who.int/health-topics/obesity#tab=tab_1 [Last accessed on 2022 February 10].

Yesilbursa, D., Serdar, Z., Serdar, A., Sarac, M., Coskun, S., & Jale, C. (2005). Lipid peroxides in obese patients and effect of weight loss with orlistat on lipid peroxides levels. International Journal of Obesity, Vol. 29, pp. 142-145, DOI: https://doi.org/10.1038/sj.ijo.0802794

Youn, J.Y., Siu, K.L., Lob, H.E., Itani, H., Harrisn, D.G., & Cai, H. (2014). Role of vascular oxidative stress in obesity and metabolic syndrome. Diabetes. Vol.63. pp. 2344–55, DOI: https://doi.org/10.2337/db13-0719

License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.

The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.

Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.

Analysis of Malondialdehyde (MDA) Levels Based on Body Mass Index, Waist Circumstances, and Body Fat Percentage in Students of Medicine Program Faculty of Medicine Mataram University

Authors

DOI:

Published:

Issue:

Keywords:

Articles

Downloads

How to Cite

Downloads

Metrics

Abstract

References

License

Most read articles by the same author(s)

Similar Articles

Menu

Manuscript Template

visitor

Keywords

Mitra Kerja sama

Open Access Journals

Contact Us

Information

Share & Follow