Tonicum Activity of Red Ginger (Zingiber officinale var. Rubrum) and Elephant Ginger (Zingiber officinale var.Roscoe) Ethanol Extract in Vivo
Authors
Sitti Fauziah Noer , Ayu Wandira , Asri Mulya Ashari , Rita Kurnia Apindiati , Gusti Eva Tavita , Sri Zha Zha DillaDOI:
10.29303/jbt.v23i2.4703Published:
2023-03-16Issue:
Vol. 23 No. 2 (2023): April-JuneKeywords:
in vivo, natatary exhaustin, tonic, Zingiber officinale Var Rubrum, Zingiber officinale var Roscoe.Articles
Downloads
How to Cite
Downloads
Metrics
Abstract
The increase in side effects due to the use of chemical drugs encourages people to return to nature, utilize the plants around them in dealing with health problems. Red ginger (Z. officinale Var Rubrum) and elephant ginger (Z. officinale var Roscoe) have been used empirically in medicine especially to boost immunity. This study aims to determine the tonic activity of the ethanol extract of red ginger and elephant ginger in vivo using the natatary exhaustin method with white rats (Rattus norvegicus) as test animals. The natural fatigue method was based on the resistance of the test animals to swimming in water after being treated with ethanol extract of red ginger and elephant ginger rhizome at a dose of 70 mg/kg body weight, using Na-CMC solution as a blank and caffeine solution as a positive comparison. Based on research data testing the tonic activity of red ginger and elephant ginger extracts in vivo showed that the tonic activity of red ginger ethanol extract with the swimming endurance of the test animals was for 27.72 seconds, longer than the swimming endurance of the treated animals. with elephant ginger ethanol extract which is only 16.46 seconds.
References
Agustien, G.S. & Susanti, S. (2020). Uji Aktivitas Tonikum Infusa Buah Kapolaga (Amomum cardamomum) Pada Mencit (Mus musculus). J. Farmagazine, 7(1): 32-36. DOI: http://dx.doi.org/10.47653/farm.v7i1.152
Akoso, T.B. (2009). Bebas Kelelahan. Penerbit Kanisius, Yogyakarta. ISBN 978-979-21-2049-3
Andriyani, R., Budiati, T.A. & Pudjiraharti, S. (2015). Effect of Extraction Method on Total Flavonoid, Total Phenolic Content, Antioxidant and Anti-bacterial Activity of Zingiberis Officinale Rhizome. Procedia Chem., 16(1): 149-154. DOI: https://doi.org/10.1016/j.proche.2015.12.023
Davis, J.M., Zhao, Z., Stock, H.S., Mehl, K.A., Buggy, J. & Hand, G.A. (2003). Central Nervous System Effects Of Caffeine And Adenosine On Fatigue. Am. J. Physiol. - Regul. Integr. Comp. Physiol., 284(1): 399-404. DOI: 10.1152/ajpregu.00386.2002
Herlina, R., Murhananto, Endah, J., Listyarini, S.P. & Pribadi, S.T. (2004). Khasiat Dan Manfaat Jahe Merah si Rimpang Ajaib. Agromedia Pustaka, Jakarta. ISBN 979-3084-76-6
Kaban, A.N., Daniel & Saleh, C. (2016). Uji Fitokimia, Toksisitas dan Aktivitas Antioksidan Fraksi n-Heksana dan Etil Asetat Terhadap Ekstrak Jahe Merah. J. Kim. Mulawarman, 14(1): 24–28. URL: http://jurnal.kimia.fmipa.unmul.ac.id/index.php/JKM/article/view/259
Kariem, V. E. & Maesaroh, I. (2022). Standarisasi Mutu Simplisia Jahe (Zingiber officinale Roscoe) Dengan Pengeringan Sinar Matahari Dan Oven. Herbapharma J. Herb Farmacol. 4(1):1–10. DOI: https://doi.org/10.55093/herbapharma.v4i1.178
Lallo, S., Mirwan, M., Palino, A., Nursamsiar & Hardianti, B. (2018). Aktivitas Ekstrak Jahe Merah dalam Menurunkan Asam Urat pada Kelinci serta Isolasi dan Identifikasi Senyawa Bioaktifnya. Fitofarmaka Indones., 5(1):271–278. DOI: https://doi.org/10.33096/jffi.v5i1.319
Listiana, A. & Herlina (2015). Karakterisasi Minuman Herbal Celup Dengan Perlakuan Komposisi Jahe Merah : Kunyit Putih, Dan Jahe Merah : Temulawak. AGRITEPA J. Ilmu dan Teknol. Pertan., 1(2):171-181. DOI: https://doi.org/10.37676/agritepa.v2i1.105
Maulida, K. P. & Indradi, B. (2019). Aktivitas Farmakologis Zingiber Officinale Rosc., Curcuma Longa L., dan Curcuma Xanthorrhiza Roxb. : Review. Farmaka, 17(2):150–160. DOI : https://doi.org/10.24198/jf.v17i2.21939
McLellan, T.M., Caldwell, J.A. & Lieberman, H.R. (2016). A Review Of Caffeine’s Effects On Cognitive, Physical And Occupational Performance. Neurosci. Biobehav. Rev., 71(1):294–312. DOI: 10.1016/j.neubiorev.2016.09.001
Ningsih, P.W., Jalaluddin, M. & Chalil, A. (2022). Pengaruh Konsumsi Kafein terhadap Premenstrual Syndrome pada Mahasiswi Fakultas Kedokteran Universitas Muhammadiyah Sumatera Utara. J. Implementa Husada, 3(2):72-83. URL: http://repository.umsu.ac.id/handle/123456789/17505
Sabariman, M., Sandrasari, D.A., Azni, I.N. & Permata, T.D. (2021). Aplikasi Metode Mixture Design Pada Formulasi Minuman Fungsional Serbuk Temulawak, Jahe Merah Dan Gula Merah. J. Teknol. Pangan dan Kesehat. (The J. Food Technol. Heal., 3(1):41–48. DOI: https://doi.org/10.36441/jtepakes.v3i1.533
Sari, D. & Nasuha, A. (2021). Kandungan Zat Gizi, Fitokimia, dan Aktivitas Farmakologis pada Jahe (Zingiber officinale Rosc.): Review. Trop. Biosci. J. Biol. Sci., 1(2): 11–18. URL: https://doi.org/10.32678/tropicalbiosci.v1i2.5246
Sidoretno, W.M. & Rz O. I. (2018). Edukasi Bahaya Bahan Kimia Obat Yang Terdapat Didalam Obat Tradisional. J. Pengabdi. Masy. Multidisiplin 1(2):177–123. DOI: https://doi.org/10.36341/jpm.v1i2.453
Turner, A.R. (1965). Screening Methods In Pharmacology. Academic Press, New York. e-Book ISBN: 9781483264233
Wiyanti, W.R. & Endrawati, S. (2017). Pengaruh Uji Efek Tonikum Ekstrak Etanol Rimpang Temu Giring (Curcuma heyneana Val) terhadap Mencit. Indonesia Journal of Medical Science, 4(1):25–32. URL: http://ejournal.poltekkesbhaktimulia.ac.id/index.php/ijms/article/view/95
License
Copyright (c) 2023 Sitti Fauziah Noer , Ayu Wandira, Asri Mulya Ashari, Rita Kurnia Apindiati, Gusti Eva Tavita, Sri Zha Zha Dilla
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Jurnal Biologi Tropis is licensed under a Creative Commons Attribution 4.0 International License.
The copyright of the received article shall be assigned to the author as the owner of the paper. The intended copyright includes the right to publish the article in various forms (including reprints). The journal maintains the publishing rights to the published articles.
Authors are permitted to disseminate published articles by sharing the link/DOI of the article at the journal. Authors are allowed to use their articles for any legal purposes deemed necessary without written permission from the journal with an acknowledgment of initial publication to this journal.